• Tuberculosis and Respiratory Diseases
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• v.56 no.4
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• pp.381-392
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• 2004

Arsenic trioxide($As_2O_3$) was introduced into the treatment of refractory or relapsed acute promyelocytic Ieukemia. Some investigators have reported that arsenic trioxide had induced apoptosis in a variety of solid human tumor cell lines, including non-small cell lung cancer. Non-steroidal anti-inflammatory drugs(NSAIDs) are powerful chemopreventive agents for gastrointestinal cancers and the growth of established tumors are reduced by inducing apoptosis. It's also reported that NSAIDs enhanced tumor response to chemotherapeutic drugs or radiation. In this study, we aimed to determine whether combination of arsenic trioxide with sulindac augmented its apoptotic potential in NCI-H157 human lung cancer cells. The human lung cancer cell line NCI-H157 was treated with arsenic trioxide and sulindac. Cell viability was measured by the MTT assay. Apoptosis was measured by nuclear staining and flow cytometric analysis. The catalytic activity of the caspase families were measured by the fluorogenic cleavage of biosubstrates. The western blotting were also performed to define the mechanical basis of apoptosis. Combination treatment of arsenic trioxide and sulindac decreased the viability of NCI-H157 human lung cancer cells in a dose-dependent manner. The catalytic activity of caspase-3, 8 and 9 proteases were increased after combination treatment. Consistently PARP was cleaved from 116kDa to 85kDa fragments, and the expression of ICAD was decreased by time-dependent manner. Also combination treatment increased the expression of Fas and Fas/L. Combination therapy of arsenic trioxide with sulindac augments cell death and induces apoptosis via the activation of caspase cascade in NCI-H157 human lung carcinoma cells.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2018.10a
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• pp.338-341
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• 2018

Wireless Power Transfer(WPT) of array antenna applied to beam-forming techniques enables highly efficient WPT when transmitters and receivers are not contacting and even when they are separated. However, this WPT method is possible to use only when human safety restriction by distance between the transmitters and the receivers is satisfied. In the paper, a $4{\times}8$ array antenna for 2.4 GHz is modeled by simulation, then electric field intensity and 10 gram average head SAR(Specific Absorption Rate) by distance away from the array antenna inputted 1 W of 2.4 GHz sinusoidal wave at each single antenna of the array antenna for 2.4 GHz were obtained. And they were compared with human safety restriction of draft of 2018 ICNIRP(International Commission on Non-Ionizing Radiation Protection) guidelines. As the result, power density of far field derived from the electric field intensity was $33.257W/m^2$, which satisfied with occupational human safety restriction but exceeded public's. In addition, the 10 gram average head SAR exceeded the human safety restriction.

• The Journal of the Korea Contents Association
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• v.22 no.6
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• pp.354-368
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• 2022

The purpose of this study was to verify whether there were significant differences in the levels and relationships of emotional intelligence, school adaptation, self-resilience, positive human relationships, and depression between elementary school students who participated in after-school music activities and those who did not. The participants of this study were 379 fourth, fifth, and sixth grade elementary school students in the Capital Area and Gyeongnam Province participated in after-school music activities and 368 students who did not, totaling 747 students. For research analysis, t-test and multi-group analysis were performed, and the analyzed results are as follows. First, the level of emotional intelligence, self-resilience, positive human relationships, and school adaptation were higher in the participating group and the level of depression was lower than the group that did not participate. Second, as a result of multiple group analysis, the participating group had stronger influences on the paths of [emotional intelligence→self-resilience], [emotional intelligence→positive human relationship], [emotional intelligence→depression], [emotional intelligence→school adaptation], and [self-resilience→school adaptation] than those of non-participating group. Third, the participating group showed mediating effects from self-resilience, positive human relationships, and depression in the relationship between emotional intelligence and school adaptation. On the other hand, the non-participating group manifested significant mediating effects only from self-resilience and depression variables in the relationship between emotional intelligence and school adaptation.

• International Journal of Quality Innovation
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• v.8 no.3
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• pp.1-10
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• 2007

A sample of Italian manufacturing companies was selected in order to verify the abilities and effects (relationships) of the management factors human resources, leadership and strategic planning on company performance. The Partial Least Squares (PLS) estimation method was used for analyzing the data collected, where the relationships between the management factors and performance were formalized by a Structural Equation Model (SEM). The analysis of the survey data showed unexpected result regarding the non significant direct relationship between Leadership and Performance. The effect of Leadership is obtained by an indirect relationship through Human Resources. The combination of Leadership and Human Resources has hence been identified as the management factors which have the highest impact on the performance of Italian industrial companies. Another interesting and unexpected result was that there was no significant impact of Strategic Planning on Performance. It seems that the leaders of Italian industrial companies have not understood that good strategic planning is a necessary condition for achieving excellence. So another improvement area is in fact Strategic Planning. This area should have the highest priority of any top management team and the focus should include how to establish a strong relationship between strategic planning and performance. No correlation between strategic planning and performance is a strong indication that something is wrong. It is not enough that Leadership is doing Strategic Planning-Leadership is also about studying and follow up on results in order to assure impacts on performance. This link seems to be missing in Italian industrial companies.

• Nuclear Engineering and Technology
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• v.41 no.5
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• pp.747-752
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• 2009

A vulnerability assessment is essential for the efficient operation of a physical protection system (PPS). Previous assessment codes have used a simple model called an adversary sequence diagram. In this study, the use of a two-dimensional (2D) map of a facility as a model for a PPS is suggested as an alternative approach. The analysis of a 2D model, however, consumes a lot of time. Accordingly, a generalized heuristic algorithm has been applied to address this issue. The proposed assessment method was implemented to a computer code; Systematic Analysis of physical Protection Effectiveness (SAPE). This code was applied to a variety of facilities and evaluated for feasibility by applying it to various facilities. To help upgrade a PPS, a sensitivity analysis of all protection elements along a chosen path is proposed. SAPE will help to accurately and intuitively assess a PPS.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.16
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• pp.7255-7260
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• 2015

Background: Recent reports have shown that DLC-1 is widely expressed in normal tissues and is down-regulated in a wide range of human tumors, suggesting it may act as a tumor suppressor gene. We conducted a meta-analysis to determine the correlation between DLC-1 expression and clinicopathological characteristics in cancers. Materials and Methods: A detailed literature search was made for relevant publications from PubMed, EMBASE, Cochrane library databases, Web of Science, CNKI. The methodological quality of the studies was also evaluated. Analyses of pooled data were performed and odds ratios (ORs) were calculated and summarized. Results: Final analysis was performed of 1,815 cancer patients from 19 eligible studies. We observed that DLC- 1 expression was significantly lower in cancers than in normal tissues. DLC-1 expression was not found to be associated with tumor differentiation status. However, DLC-1 expression was obviously lower in advance stage than in early-stage cancers and was more down-regulated in metastatic than non-metastatic cancers. Conclusions: The results of our meta-analysis suggested that DLC-1 expression is significantly lower in cancers than in normal tissues. Aberrant DLC-1 expression may play an important role in cancer genesis and metastasis.

• IMMUNE NETWORK
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• v.9 no.1
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• pp.4-7
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• 2009

Although the success of trastuzumab and rituximab for treatment of breast cancer and non-Hodgkins lymphoma, respectively, suggests that monoclonal antibodies(mAbs) will become important therapeutic agents against a wider range of cancers, useful therapeutic Abs are not yet available for the majority of the human cancers because of our lack of knowledge of which antigens (Ags) are likely to become useful targets. We established a procedure for comprehensive identification of such Ags through the extensive isolation of human mAbs that may be therapeutic. Using the phage-display Ab library we isolated a large number of human mAbs that bind to the surface of tumor cells. They were individually screened by immunostaining, and clones that preferentially and strongly stained the malignant cells were chosen. The Ags recognized by those clones were isolated by immunoprecipitation and identified by mass spectrometry(MS). We isolated 2,114 mAbs with unique sequences and identified 25 distinct Ags highly expressed on several carcinomas. Of those 2,114 mAbs 434 bound to specifically to one of the 25 Ags. I am going to discuss how we could select proper target Ags for therapeutic Abs and candidate clones are therapeutic agents.

• Journal of Environmental Impact Assessment
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• v.19 no.3
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• pp.259-270
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• 2010

We conducted human risk assessment for exposure to inhalation of chemical substances emitted from the storage tanks of petroleum refineries. To assess human risk, this study calculated chemical emissions from the external floating roofs on storage tank at petroleum refineries, as well as concentrations thereof in the ambient air using the K-SCREEN model, and then determined risk in accordance with the Reference Concentration (RfC) values and Inhalation Unit Risk criteria developed by the US Environmental Protection Agency. The results indicated that non-carcinogenic chemicals have a hazard quotient of less than 1, meaning they have an insignificant effect on human health for residential areas near the storage tanks. Among the known carcinogens, the hazard risk for benzene slightly exceeded $10^{-6}$, indicating the need for corrective reduction measures. The methodology for health impact assessment devised herein provides findings useful in decision making for policy makers and the general public with respect to construction of industrial complexes. However, the methodology proposed herein does have limitations, including discrepancy in results induced by use of U.S. data (due to the lack of usable domestic data). More systematic studies from related researchers will be needed to address these issues and produce more reliable outcomes.

• Korean Journal of Human Ecology
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• v.16 no.1
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• pp.111-121
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• 2007

The purpose of this study was to examine university students' clothing and cosmetics purchasing behaviors according to gender and major. For the study, 337 university students living in Chonbuk area participated in this survey research. The data were analyzed utilizing SPSS statistics package. Exploratory factor analysis, reliability test, and t-test were used. Five factors in each clothing and cosmetics purchasing orientation were generated from the factor analysis. According to gender and major, clothing and cosmetics purchasing behavior were significantly different. Female students showed more impulsive, rational, and economical purchasing orientations than male students did. On the contrary, male students showed more independent and convenient purchasing orientations. The students with fashion design major showed higher tendency in impulsive and rational clothing purchasing orientations than non-fashion design major students. Finally, clothing and cosmetics purchasing behaviors were significantly different by gender and major in terms of information usage and expenditure for clothing and cosmetics.

• The Journal of the Korea Contents Association
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• v.4 no.4
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• pp.171-178
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• 2004

Radio frequency (RF) microwave can be used to predict glucose concentration in a sample. This paper presents preliminary results in determining the concentration by measuring relative permittivity in the solutions of distilled water, saline, human serum, and human blood containing glucose. It was shown that the microwave method has larger penetration depth of about 100times of NIR, than NIR technique in measuring glucose concentration for the tissue like a human muscle. The larger penetration depth of the method has advantages because it is more useful to detect glucose in a human body non-invasively. In the experiments, sensitivity for detecting glucose concentration in blood solutions was almost 57mg/dl at the frequency of approximately 5.8GHz.