An impaired smooth muscle cell (SMC) relaxation of coronary artery by alteration of $K^+$ channels would be the most potential explanation for reduced coronary reserve in left ventricular hypertrophy (LVH), however, this possibility has not been investigated. We performed morphometrical analysis of the coronary artery under electron microscopy and measured $Ca^{2+}-activated\;K\;(K_{Ca})$ currents and delayed rectifier K $(K_{dr})$ currents by whole-cell and inside-out patch-clamp technique in single coronary arterial SMCs from rabbits subjected to isoprenaline-induced cardiac hypertrophy. Coronary arterial SMCs underwent significant changes in ultrastructure. The unitary current amplitude and the open-state probability of $K_{Ca}$ channel were significantly reduced in hypertrophy without open-time and closed-time kinetic. The concentration-response curve of $K_{Ca}$ channel to $Ca^{2+}$ is shifted to the right in hypertrophy. The reduction in the mean single channel current and increase in the open channel noise of $K_{Ca}$ channel by TEA were more sensitive in hypertrophy. $K_{dr}$ current density is significantly reduced in hypertrophy without activation and inactivation kinetics. The sensitivity of $K_{dr}$ current on 4-AP is significantly increased in hypertrophy. This is the first study to report evidence for alterations of $K_{Ca}$ channels and $K_{dr}$ channels in coronary SMCs with LVH. The findings may provide some insight into mechanism of the reduced coronary reserve in LVH.
Journal of Korean Society of Occupational and Environmental Hygiene
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v.26
no.2
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pp.198-209
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2016
Objectives: This study aimed to provide basic data for the improvement of the guidance services for the management of the workplace environment of the specialized health management institution, by making inquiries on the perception and extent of practice by health managers and workers in the workplace. Methods: Workplaces with officially noted environmental hazards of noise, organic compounds and/or dust-metals were selected in a South Korean metropolitan city in 2015. The workplace health managers(hereinafter referred to as 'manager') and workers at 97 workplace were interviewed. Managers are those who are in charge of health management at the corresponding workplace and the workers were subjected to in-depth interviews by sampling one worker for each of the workplace. Results: The majority of the managers acknowledged the guidance services of the specialized health management institution affirmatively. Regarding the extent of practice in accordance with the guidance on engineering improvement, only 23 managers(37.1%) responded. With respect to education, 40 managers(41.2%) responded that it was implemented along with 35 workers(36.1%) who responded that they received education, showing no significant difference between manager and worker. Regarding the actual wearing of the protective equipment, however, 83 of the manager(85.6%) insisted that workers wore the protective devices while only 44 workers(49.5%) responded that they actually wore the devices, thereby illustrating a significant difference between managers and workers. Conclusions: These results suggest the urgent necessity of improvement in the mechanism of guidance services of the specialized health management institution for the workplace environment management.
Home evolved Node-B (HeNB), also called a femtocell or a femto base station, is introduced to provide high data rate to indoor users. However, two main problems arise in femtocell networks: (1) Small coverage area of HeNB, which results in limited cell-splitting gain and ping-pong handover (HO) problems and (2) high inter-femtocell interference because HeNBs may be densely deployed in a small region. In this study, an efficient cooperation mechanism called an HeNB-aided virtual-HO (HaVHO) scheme is proposed to expand the coverage area of femtocells and to reduce inter-femtocell interference. The cooperation among neighbor HeNBs is exploited in HaVHO by enabling an HeNB to relay the data of its neighbor HeNB without an HO. The HaVHO procedure is compatible with the existing long term evolution specification, and the information exchange overhead in HaVHO is relatively low. To estimate the signal to interference plus noise ratio improvement, the area average channel state metric is proposed, and the amount of user throughput enhancement by HaVHO is derived. System-level simulation shows that HaVHO has a better performance than the other four schemes, such as lesser radio link failure, lesser ping-pong handover, lesser short-stay handover, and higher user throughput.
Purpose: This study was to investigate usage satisfaction of multi type handpiece with equipped air-jet function Methods: The subjects of this study through the survey was conducted for fifty-nine dental technicians in Daegu and Gyeongsangbukdo from the May 7 to 19, after the June 23 to July 4 2014. The survey was about the function and quality through user testing environment by cutting zirconia specimens using appliance for zirconia. The collected date was analyzed by the statistical program SPSS Win Ver 19.0 for the satisfaction of handpiece and control system. To test for significance on each item, p<0.05 had been decided a standard. General characteristics and relationship between the handpiece and control system was performed correlation analysis. Results: The results of this study is as follows. 35 dental technicians had 1~2 years career in zirconia part as the highest 59.3%, 95% of subjects expected that the prospects for the zirconia material have bright prospects. The satisfaction of multi type handpiece and control system design and function showed a significant difference. Subjects satisfied with the design and function of the multi type showed negative correlation with those of Standard. The satisfaction of multi type handpiece showed 3.37 points of air jet, 3.05 points of noise level, 2.69 points of water flow rate, and 1.98 points of cruise function. Sample differences in all parameters showed a statistically higher difference. Conclusion: High-speed cutting mechanism of multi-type is recommended working with zirconia materials and the multi-type unit combined handpiece motor, air-turbine and air-gun will be expected the increase of user due to the high satisfaction of air jet.
This paper investigates the Synergetics based Damage Detection Method (SDDM) for frame structures by using surface-bonded PZT (Lead Zirconate Titanate) patches. After analyzing the mechanism of pattern recognition from Synergetics, the operating framework with cooperation-competition-update process of SDDM was proposed. First, the dynamic identification equation of structural conditions was established and the adjoint vector (AV) set of original vector (OV) set was obtained by Generalized Inverse Matrix (GIM).Then, the order parameter equation and its evolution process were deduced through the strict mathematics ratiocination. Moreover, in order to complete online structural condition update feature, the iterative update algorithm was presented. Subsequently, the pathway in which SDDM was realized through the modified Synergetic Neural Network (SNN) was introduced and its assessment indices were confirmed. Finally, the experimental platform with a two-story frame structure was set up. The performances of the proposed methodology were tested for damage identifications by loosening various screw nuts group scenarios. The experiments were conducted in different damage degrees, the disturbance environment and the noisy environment, respectively. The results show the feasibility of SDDM using piezoceramic sensors and actuators, and demonstrate a strong ability of anti-disturbance and anti-noise in frame structure applications. This proposed approach can be extended to the similar structures for damage identification.
Journal of the Institute of Electronics Engineers of Korea TC
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v.43
no.12
s.354
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pp.61-67
/
2006
This paper proposes the algorithm for tracking of the residual phase errors incurred by carrier frequency offset and sampling frequency offset in the orthogonal frequency division multiplexing (OFDM) systems which are suitable for high data rate wireless communications. In the OFDM systems the subcarriers which are orthogonal to each other are modulated by digital data and transmitted simultaneously. The carrier frequency offset causes degradation of signal to noise ratio(SNR) performance and interference between the adjacent subcarriers. The errors in the sampling timing caused by the sampling frequency difference between the transmitter and the receiver sides also cause a major performance degradation in the OFDM systems. The residual error tracking and compensation mechanism is essential in the OFDM system since the carrier and the sampling frequency offset cause the loss of orthogonality resulting in the system performance loss. This paper proposes the scheme where the channel gain and the payload data information are reflected in the residual error tracking process which results in the reduction of the estimation error and the tracking performance improvements under the frequency selective fading wireless channels.
KSII Transactions on Internet and Information Systems (TIIS)
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v.16
no.7
/
pp.2131-2153
/
2022
To achieve accurate detection of tuberculosis (TB) areas in chest radiographs, we design a chest X-ray TB area detection algorithm. The algorithm consists of two stages: the chest X-ray TB classification network (CXTCNet) and the chest X-ray TB area detection network (CXTDNet). CXTCNet is used to judge the presence or absence of TB areas in chest X-ray images, thereby excluding the influence of other lung diseases on the detection of TB areas. It can reduce false positives in the detection network and improve the accuracy of detection results. In CXTCNet, we propose a channel attention mechanism (CAM) module and combine it with DenseNet. This module enables the network to learn more spatial and channel features information about chest X-ray images, thereby improving network performance. CXTDNet is a design based on a sparse object detection algorithm (Sparse R-CNN). A group of fixed learnable proposal boxes and learnable proposal features are using for classification and location. The predictions of the algorithm are output directly without non-maximal suppression post-processing. Furthermore, we use CLAHE to reduce image noise and improve image quality for data preprocessing. Experiments on dataset TBX11K show that the accuracy of the proposed CXTCNet is up to 99.10%, which is better than most current TB classification algorithms. Finally, our proposed chest X-ray TB detection algorithm could achieve AP of 45.35% and AP50 of 74.20%. We also establish a chest X-ray TB dataset with 304 sheets. And experiments on this dataset showed that the accuracy of the diagnosis was comparable to that of radiologists. We hope that our proposed algorithm and established dataset will advance the field of TB detection.
Guaranteeing the quality and integrity of structural health monitoring (SHM) data is very important for an effective assessment of structural condition. However, sensory system may malfunction due to sensor fault or harsh operational environment, resulting in multiple types of data anomaly existing in the measured data. Efficiently and automatically identifying anomalies from the vast amounts of measured data is significant for assessing the structural conditions and early warning for structural failure in SHM. The major challenges of current automated data anomaly detection methods are the imbalance of dataset categories. In terms of the feature of actual anomalous data, this paper proposes a data anomaly detection method based on data-level and deep learning technique for SHM of civil engineering structures. The proposed method consists of a data balancing phase to prepare a comprehensive training dataset based on data-level technique, and an anomaly detection phase based on a sophisticatedly designed network. The advanced densely connected convolutional network (DenseNet) and Transformer encoder are embedded in the specific network to facilitate extraction of both detail and global features of response data, and to establish the mapping between the highest level of abstractive features and data anomaly class. Numerical studies on a steel frame model are conducted to evaluate the performance and noise immunity of using the proposed network for data anomaly detection. The applicability of the proposed method for data anomaly classification is validated with the measured data of a practical supertall structure. The proposed method presents a remarkable performance on data anomaly detection, which reaches a 95.7% overall accuracy with practical engineering structural monitoring data, which demonstrates the effectiveness of data balancing and the robust classification capability of the proposed network.
Background: Recently, a piezoelectric ultrasonic scaler based on a feedback control mechanism was introduced for pain relief. This study aimed to investigate the effects of a new ultrasonic scaler in reducing pain and discomfort in adults. Methods: A newly introduced ultrasonic scaler (Master 700®) was used as the test device and a conventional ultrasonic scaler device (PIEZON®) was used as the control device. Forty-one healthy adults visited the dental clinic for dental scaling but did not undergo scaling or periodontal treatment within 6 months. Intraoral examinations were performed before scaling and 3 months later; before scaling, both devices were randomly assigned on the left or right side of each dentition (split-mouth model) and scaling was performed by a registered dental hygienist. The levels of pain and discomfort during scaling were evaluated subjectively and objectively using the visual analog scale (VAS) and physiological monitoring of the heart rate (HR), respectively. Time was measured for each device. Results: All clinical indicators, except bleeding on probing, significantly improved with both devices. The treatment times were 7 minutes, 13 minutes (control) and 6 minutes, 59 minutes (test). VAS scores for pain were 4.89±2.12 (control) and 4.58±2.77 (test) points out of 10; for noise, these were 4.68±2.33 (control) and 4.55±2.55 (test), and for vibration, the values were 4.26±2.0 (control) and 4.18±2.48 (test). HR averages were 72.34±3.39 (control) and 75.97±9.78 (test) beats/min. No statistically significant differences were observed between the devices. Conclusion:The pain, discomfort levels, and scaling time of the new piezoelectric ultrasonic scaler did not differ from those of the conventional device. Further research and development are necessary for more prominent pain-relief effects of scaling devices.
To determine subglacial topography and internal features of the Fourcade Glacier on King George Island in Antarctica, helicopter-borne and ground-towed ground-penetrating radar (GPR) data were recorded along four profiles in November 2006. Signature deconvolution, f-k migration velocity analysis, and finite-difference depth migration applied to the mixed-phase, single-channel, ground-towed data, were effective in increasing vertical resolution, obtaining the velocity function, and yielding clear depth images, respectively. For the helicopter-borne GPR, migration velocities were obtained as root-mean-squared velocities in a two-layer model of air and ice. The radar sections show rugged subglacial topography, englacial sliding surfaces, and localised scattering noise. The maximum depth to the basement is over 79m in the subglacial valley adjacent to the south-eastern slope of the divide ridge between Fourcade and Moczydlowski Glaciers. In the ground-towed profile, we interpret a complicated conduit above possible basal water and other isolated cavities, which are a few metres wide. Near the terminus, the GPR profiles image sliding surfaces, fractures, and faults that will contribute to the tidewater calving mechanism forming icebergs in Potter Cove.
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