• Archives of Pharmacal Research
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• v.17 no.3
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• pp.135-138
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• 1994

Acyclonucleoside homologues of 1-$(\omega$-cyabnoalkyl)-and 1, 3-bis $(\omega$-cyanoalkyl) uracils were synthesized by the series of alkylation reactions of uracil with the $\omega$-chloroalkyl nitrile ${(Cl-(CH}_2)_n$-CN;n=1, 2, 3, 4) in DMSO under $50-70^circ{C}$ temperature. The 1-$(\omega$-cyanoalkyl)-and 1, 3-bis$(\omega$-cyanoalkyl) uracils were separated either by the fractional crystallization or column chromatography. The antitumor activities for these synthesized compounds were determined against four cell lines (J-82 cell, P388 cell, FM-3A cell and U-937 cell lines). These compounds failed to exhibit any significant antitumor activity.

• The Journal of Korea Robotics Society
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• v.11 no.2
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• pp.100-107
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• 2016

To realize a robot hand interacting like a human hand, there are many tactile sensors sensing normal force, shear force, torque, shape, roughness and temperature. This sensing signal is essential to manipulate object accurately with robot hand. In particular, slip sensors make manipulation more accurate and breakless to object. Up to now several slip sensors were developed and applied to robot hand. Many of them used complicate algorithm and signal processing with vibration data. In this paper, we developed novel principle slip sensor using separation layer. These two layers are moved from each other when slip occur. Developed sensor can sense slip signal by measuring this relative displacement between two layers. Also our principle makes slip signal decoupled from normal force and shear force without other sensors. The sensor was fabricated using the NBR(acrylo-nitrile butadiene rubber) and the Ecoflex as substrate and a paper as dielectric. To verify our sensor, slip experiment and normal force decoupling test were conducted.

• Applied Chemistry for Engineering
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• v.16 no.6
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• pp.842-847
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• 2005

Virgin NBR and recycled NBR particles, which were pulverized from NBR scraps by high temperature shear-crushing technique, were blended with different mixing ratio. The effects of the recycled NBR content on the cure characteristics and physical properties of these blends were investigated and resistance properties of these blends to heat and various fluids were also studied. The study of cure characteristics showed that the viscosity increased but the scorch time decreased. The physical properties of rubber blends were improved with the addition of the recycled NBR for heat resistance and various fluid tests.

• Textile Coloration and Finishing
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• v.7 no.4
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• pp.45-53
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• 1995

Natural rubber(NR)-polyacrylamide(PAAm) graft copolymers(GP)(toluene soluble GP : TSGP, water dispersible GP : WDGP) have been synthesized as coupling agents by pre-emulsification methods based on "inverse emulsion graft polymerization" technique. The polymerization was carried out at $65^{\circ}C$ using Azobisisobytyro nitrile(AIBN) as an initiator in the inverse emulsion system formed by inxing NR toluene solution with inverse emulsion of awueous AAm solution emulsified with $Tween^{\#}$ 80 in toluene. The mechanism of inverse emulsion graft copolymerization was studied on AAm conversion, % grafting, grafting efficiency, NR conversion, production ratio of TSGP and amount of GP(sum of TSGP and WDGP). The reaction has been confirmed through use of optical microscope to proceed via adsorption of emulsifier colloid particles onto the stretched NR molecule. From the analysis of the effects of various polymerization conditions on the grafting, it has also been found that the present rection system can easily yield high(over 90%) grafting efficiency and AAm conversion and relatively high(over 80%) NR conversion.onversion.

• Bulletin of the Korean Chemical Society
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• v.20 no.5
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• pp.535-538
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• 1999

Five coordinated water-soluble iridium(l) complex, IrH(CO)(TPPTS)3 (1) (TPPTS = P(m-C6H4SO3Na)3-xH2O) has been prepared from the reaction of IrCl3·3H2O with TPPTS and HCHO in H2O/EtOH solution. Complex 1 catalyzes the hydration of nitrites (RC ≡ N, R = CH3, CICH2, CH3(CH2)4, Ph) in aqueous solution to give the corresponding amides (RCONH2) at 100℃. The hydration of unsaturated nitrites (R'C ≡ N, R'=CH3CH=CH, CH3OCH=CH, trans-PhCH=CH, CH2=C(CH3)) takes place regioselectively on-C ≡ N group to give unsaturated amides (R'CONH2) leaving the olefinic group intact. The yields of the amides seem to be depending on the electrophilicity of the carbon of nitrile: The more the electron withdrawing ability of the substituents on nitrites, the more amides are obtained. The hydration of dinitriles (NC-R-CN, R=(CH2)4, (CH2)6) with complex 1 initially gives mono-hydration products (NC-R-CONH2) which are slowly hydrated further to give dihydration products (H2NCO-R-CONH2). The hydration of 1,4-dicyanobutane has been found to be somewhat faster than that of 1,6-dicyanohexane.

• Korean Journal of Plant Resources
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• v.31 no.6
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• pp.604-611
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• 2018

This study was conducted to explore the immune activity, anticancer activity and nitrile scavenging activities of methanol extracts from the various organs of four Korean resource plants. The immune responses from both human T and B cell line was significantly enhanced in the cell growth compared to control while the cell growth was influenced at a certain period of culture. The results revealed that the cell growth of both human T and B cell was altered in a time dependent manner. Among tested several resource plants, the flower extract of E. japonicum demonstrated a pronounced cytotoxicity against HCT-116 cell with an IC50 value $132.08{\mu}g\;ml-1$. The flower extract from Corylopsis coreana had a promising scavenging activity against pH 1.2 compared to other species. Taken together, the studied resource plants have influenced significantly in response to immunity and also have the potential cytotoxicity and nitric scavenging activities. However, the species E. japonicum exhibited the pronounced activities from several resource plants. The result from this investigation suggests that the extracts of studied resource plant could be an addition to basic medicine for some diseases.

• Bulletin of the Korean Chemical Society
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• v.18 no.3
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• pp.274-280
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• 1997

The rates and stoichiometry of the reaction of gallane-trimethylamine with selected organic compounds containing representative functional groups were examined in tetrahydrofuran solution under standardized conditions (THF, 0 ℃). And its reducing characteristics were compared with those of aluminum hydride-triethylamine(AHTEA). The rate of hydrogen evolution from active hydrogen compounds varied considerably with the nature of the functional group and the structure of the hydrocarbon moiety. Alcohols, phenol, amines, thiols evolved hydrogen rapidly and quantitatively. Aldehydes and ketones were reduced moderately to the corresponding alcohols. Cinnamaldehyde was reduced to cinnamyl alcohol, which means that the conjugated double bond was not attacked by gallane-trimethylamine. Carboxylic acids, esters, and lactones were stable to the reagent under standard conditions. Acid chlorides also were rapidly reduced to the corresponding alcohols. Epoxides and halides were inert to the reagent. Caproamide and nitrile were stable to the reagent, whereas benzamide was rapidly reduced to benzylamine. Nitropropane, nitrobenzene and azoxybenzene were stable to the reagent, whereas azobenzene was reduced to 1,2-diphenylhydrazine. Oximes and pyridine N-oxide were reduced rapidly. Di-n-butyl disulfide and dimethyl sulfoxide were reduced only slowly, but diphenyl disulfide was reduced rapidly. Finally, sulfones and sulfonic acids were inert to the reagent under the reaction.

• Korean Journal of Materials Research
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• v.33 no.8
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• pp.323-329
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• 2023

There are many types of foam molding methods. The most commonly used methods are the pressure foaming method, in which foam resin is mixed with a foaming agent at high temperature and high pressure, and the normal pressure foaming method, which foams at high temperature without pressure. The polymer resins used for foaming have different viscosities. For foaming under normal pressure, they need to be designed and analyzed for optimal foaming conditions, to obtain resins with low melt-viscosity or a narrow optimal viscosity range. This study investigated how changes in viscosity, molding temperature, and cross-link foaming conditions affected the characteristics of the molded foam, prepared by blending rubber polymer with biodegradable resin. The morphologies of cross sections and the cell structures of the normal pressure foam were investigated by SEM analysis. Properties were also studied according to cross-link/foaming conditions and torque. Also, the correlation between foaming characteristics was studied by analyzing tensile strength and elongation, which are mechanical properties of foaming composites.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2020.12a
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• pp.78-78
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• 2020

Cruciferous plants such as broccoli and radish contain glucosinolate, which is a bioactive precursor that is most often used in Korean foods and is unique as a food ingredient. In addition, it contains various other phytochemicals and is promising as a health-oriented food material. In particular, Sulforaphane is a hydrolyzate of the glucosinolate, which has a more beneficial effect on the human body. Glucosinolate may be hydrolyzed by enzymes called myrosinase, which is voluntarily possessed by cruciferous plants. However, the ESP(Epithiospecifier protein) in broccoli sprouts could acts competitively with myrosinase, and convert to the less bioactive sulforaphane nitrile form. Therefore, we improved the yielding of sulforaphane in broccoli sprouts with a new method. We induce inactivation of the ESP protein by heat treatment. At this time, a myrosinase was introduced from the radish sprout because myrosinase in broccoli sprouts is also denatured by heat treatment. According to the results, we have confirmed by GC / MS that formation of sulforaphane increases more than 7 fold using set heating and mixing conditions.

• Journal of the FoodService Safety
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• v.5 no.1
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• pp.1-4
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• 2024

This study investigated the effect of sodium hypochlorite and ethanol on reducing Staphylococcus aureus on gloves depending on material and food contaminant. S. aureus inoculated onto rubber gloves with various organic substances (pork extract, perilla leaf extract, and 0.2% peptone water) and inoculated rubber gloves were stored in a desiccator at 100% RH and 25℃ for 24 h before treatments with distilled water, ethanol, or sodium hypochlorite. Levels of S. aureus were significantly reduced on both types of rubber gloves when treated with ethanol and sodium hypochlorite. However, sodium hypochlorite treatment resulted in 3.27 log CFU/each of S. aureus in pork extract on nitrile gloves, indicating that the effectiveness of disinfection may vary depending on the glove material and the type of organic substance. The results of this study suggest that ethanol treatment is the most effective disinfection method for S. aureus on rubber gloves, regardless of the material and organic substances.