• Journal of Pharmaceutical Investigation
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• 제27권3호
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• pp.181-187
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• 1997

The purpose of this work was to investigate pharmacokinetics of alcohol as a function of dose and time of administration of ethanol. The pharmacokinetics of alcohol 15 min after and before oral administration of aspartate-containing compositions to rats were also evaluated. The retention time of acetaldehyde, alcohol and isopropyl alcohol an internal standard in gas chromatogram was 3.6, 6.0 and 10.5 min, respectively. The maximum concentration of alcohol $(C_{max})$ and area under the blood concentration (AUC) were significanly increased as a function of ethanol dose in a nonlinear fashion. The significant diurnal variation of alcohol pharmacokinetics was also noted, showing fast metabolism and elimination when given orally in the night time. When APAP was given after administration alcohol (1g/kg) to rats, AUC and $C_{max}$ were increased when compared to alcohol only. However, AUC and $C_{max}$ were decreased when aspartate or standard complex compositions containing aceaminophen (APAP, 250mg). sodium L-aspartate(25 mg), dl-methionine (125 mg) and anhydrous caffeine (25 mg) was orally given by coupling malate/asparate shuttle in hepatocyte. The blood alcohol concentration profiles between aspartate and standard complex compositions were similar when given before or after administration alcohol (1g/kg) to rats. No significant difference of administration sequence was observed. However, it was noted that AUC and $C_{max}$ of standard complex compositions given before alcohol administration were significantly lower when compared with alcohol only. Based on these findings, dose, time of administration and composition of drugs to improve alcohol metabolism and elimination were considered to be important in the pharmacokinetics of alcohol. The administration sequence of drug compositions and alcohol might be also considerd.

• 고전문학과교육
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• 제15호
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• pp.191-243
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• 2008

The purpose of this paper is to develope the husband and wife epic test. The results of this paper are as follows. First, in the epic of dividing mate, , , , , etc, the essential item of diagnosis is qualification criteria of a mate. Second, in the epic of pushing mate, , , , , , etc, the essential item of diagnosis is mistrust about mate, Third, in the epic of recovering mate, , , , , , etc, the essential item of diagnosis is ability of recovering couple relationship, Fourth, in the epic of protecting mate, , , , , , etc, the essential item of diagnosis is sympathy for mate.

• 대한안전경영과학회지
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• 제19권4호
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• pp.157-167
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• 2017

Solar energy has been known as a successful alternative energy source, however it requires a large area to build power generation facilities compared to other energy sources such as nuclear power. Weather factors such as rainy weather or night time impact on solar power generation because of lack of insolation and sunshine. In addition, solar power generation is vulnerable to external elements such as changes in temperature and fine dust. There are four seasons in the Republic of Korea hereby variations of temperature, insolation and sunshine are broad. Currently factors that cause find dust are continuously flowing in to Korea from abroad. In order to build a solar power plant, a large area is required for a limited domestic land hereby selecting the optimal location for the plant that maximizes the efficiency of power generation is necessary. Therefore, this research analyze the optimal site for solar power generation plant by implementing analytic hierarchy process based on weather factors such as fine dust. In order to extract weather factors that impact on solar power generation, this work conducts a case study which includes a correlation analysis between weather information and power generation.

• 문화기술의 융합
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• 제5권3호
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• pp.191-195
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• 2019

우리나라는 정전으로 남북관계가 대치됨에 따라 남북의 MDL(군사분계선)을 기준으로 남북 간의 전쟁이 언제라도 촉발될 수 있는 위험한 상황에 처해 있다. 또한, 타 국가의 국경과는 달리 남북의 접경지역은 전쟁으로 촉발될 수 있는 생명의 위협을 느낄 수 있는 곳이 최전방 접적지역이다. 접적지역과 같은 특수한 지역에서 근무하는 병사들은 지역적 여건상 접근성이 용이하지 못하여 외출, 외박, 면회가 적은 실정이고, 근무 환경은 야밤에 넓은 숲과 적막함이 넘치고 적과 근접하여 언제 어떤 상황이 일어날지 모르기에 불안함과 외로움 그리고 불안함이 과중 되는 지역이다. 따라서 이곳에서 목숨을 내놓고 국방의 의무를 수행하는 병사들에게 관심을 갖고 병영생활을 안전하고 충실히 마칠 수 있도록 많은 도움이 필요할 것이며, 접적지역 복무병사들의 심리적 적응을 위한 지원이 필요하다.

• 국토계획
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• 제54권3호
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• pp.5-14
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• 2019

Starting with the market vitalization project in 2008, The Gwangju Dae-in Art Market has attracted to many artists, changing into cultural and art market. After the project was carried out for a certain period of time, a study was conducted to determine the differing opinions of the artists and merchants in regards to the market. The study also examined and analyzed the factors affecting the artists' continuous activities. The difference in recognition perception between artists and merchants was analyzed through a T-test. PLS-regression analysis was used for the artists' continuing intention to work. As a result, the artists and merchants recognized that the number of visitors increased after the influx of artists. Programs that had a positive impact on the artist's intention for sustainable activities were as follows: the 'Art Products Creation Workshop', where artists, merchants, and citizens collaborate to develop commodities needed for the market; 'Hanpyeong Gallery', where artists directly or indirectly interact with merchants and citizens; the 'Artist-Merchant Workshop', where artists and merchants produce articles required for the market; 'C'est Si Bon', which expresses the placeness of the market into art; and the 'Dae-in Art Night Market', where citizens, merchants and visitors can sell their own works. On the other hand, programs with the negative effect were those where artists' participation was low or none, as the policy implications, they should be actively develop this type of programs, where artists could participate and interact with citizens and merchants, like this visitors and sales can be increased.

• 한국환경과학회지
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• 제30권8호
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• pp.621-628
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• 2021

The characteristics of time changes in air temperature, DI (discomfort index) and WBGT (wet-bulb globe temperature) were investigated for inland city (daegu) and coastal city (pohang) of Gyeongbuk Province during the 2018 consecutive heat wave season. The time when the temperature dropped below 33℃ was around 19h in both regions. As such, the two regions were similar with respect to the time up to which the heatwave warning levels continued. However, the discomfort index (DI) was higher than 27 in Pohang. Most people feel unpleasant when an discomfort index of 27 or higher appears. The results indicated that Korea's night-time thermal environment during the summers is particularly poor in the southern coastal areas. WBGT began at 09:00 and lasted until 21:00, with a score of 31 or higher; this score, in principle, corresponded with the duration of outdoor activity in both regions. Therefore, it was found that outdoor work was at a level where all day long had to be stopped in both areas during the heat wave. Although time changes in temperature and WBGT were similar in both regions, Discomfort Index (DI) differed significantly. The difference refers to the fact that Pohang is strongly affected by the high heat capacity effect and the supply of water vapor from the sea.

• International Journal of Computer Science & Network Security
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• 제22권10호
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• pp.113-130
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• 2022

Sophisticated automation-based electronics world, more electrical and electronic devices are being used by people from different regions across the universe. Different manufacturers and vendors develop and market a wide variety of power generation and utilization devices under different operating parameters and conditions. People use a variety of appliances which use electrical energy as power source. These appliances or gadgets utilize the generated energy in different ratios. Night time the utilization will be less when compared with day time utilization of power. In industrial areas especially mechanical industries or Heavy machinery usage regions power utilization will be a diverse at different time intervals and it vary dynamically. This always causes a fluctuation in the grid lines because of the random and intermittent use of these apparatus while the power generating apparatus is made to operate to provide a steady output. Hence it necessitates designing and developing a method to optimize the power generated and the power utilized. Lot of methodologies has been proposed in the recent years for effective optimization and economical load dispatch. One such technique based on intelligent and evolutionary based is Black Widow Optimization BWO. To enhance the optimization level BWO is hybridized. In this research BWO based optimize the load for multi area is proposed to optimize the cost function. A three type of system was compared for economic loads of 16, 40, and 120 units. In this research work, BWO is used to improve the convergence rate and is proven statistically best in comparison to other algorithms such as HSLSO, CGBABC, SFS, ISFS. Also, BWO algorithm best optimize the cost parameter so that dynamically the load and the cost can be controlled simultaneously and hence effectively the generated power is maximum utilized at different time intervals with different load capacity in different regions of utilization.

• Safety and Health at Work
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• 제11권4호
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• pp.537-542
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• 2020

Background: Personal protective equipment (PPE) has been designed in such a way to reduce accident rates. Unfortunately, existing PPE is rather ineffective as it is not able to provide warning signals when hazard is around. The integration of intelligent systems is envisaged to increase the efficiency of existing PPE. Methods: This project designed a safety vest incorporated with metal detectors which can provide immediate warning to the field workers when there is metal hazard around. This product has greater freedom of design via smart manufacturing as it involves the assembly of few commercially available parts into a single entity. Briefly, the metal detector is a do it yourself (DIY) kit, and the safety vest is purchasable from any local market. The DIY kit was connected to a copper coil and being sewed into the safety vest. Results: The metal detector induces beeping sound when there is metal hazard around. A total of 121 engineering students were introduced to the prototype before being requested to answer a survey associated with the design. Respondents have rated >3.00/5.00 for the design simplicity, ease of usage, and light weight. Meanwhile, respondents suggested that the design should be further improved by increasing the metal detection range. Conclusion: It is envisaged that the introduction of this smart safety vest will allow the workers to carry out their duties securely by reducing the accident rates. Particularly, such design is expected to reduce workplace accident especially during night time at construction sites where the visibility is low.

• 인간식물환경학회지
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• 제24권2호
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• pp.229-244
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• 2021

Background and objective: The purpose of this study was to comprehensively analyze the user behavior in order to cope appropriately with the increasing demand for mountain usage of those in their 20s and 30s and to allocate resources efficiently. Methods: To analyze the behavior of mountain hiking users, an exploratory data analysis (EDA) was conducted on the data which had been collected in the app Tranggle. The main target are users in their 20s and 30s who visited the mountains in the metropolitan area in 2019-2020. Among them, we have selected data on the top 13 mountains based on the frequency of visits. After data pre-processing, mountain usage patterns were analyzed through statistical analysis and visualization. Results: Compared to 2019, the number of users in 2020 increased 1.36 times. The utilization rate of the well-established hiking trails has also increased. The usage of mountain on weekends (Saturday > Sunday) was still the highest, and the difference in the usage between the days of the week decreased. Outside of work hours, early morning usage has increased and night-time usage has decreased. There was no significant change in usages depending on activity type, level (experience point) and exercise properties. Conclusion: Since the COVID-19 outbreak, the usage of mountains has been changing towards low user density and short-distance trip. in the post-COVID-19 era, the function and role of forests in daily life are expected to increase. To cope with this, further research needs to be carried out with consideration of the wider demographic and social characteristics.

• Safety and Health at Work
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• 제14권3호
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• pp.279-286
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• 2023

Background: This study aimed to evaluate the association between exposure to occupational hazards and the metabolic syndrome. A secondary objective was to analyze the additive and multiplicative effects of exposure to risk factors. Methods: This retrospective cohort was based on 31,615 health examinees at the Pusan National University Yangsan Hospital in Republic of Korea from 2012-2021. Demographic and behavior-related risk factors were treated as confounding factors, whereas three physical factors, 19 organic solvents and aerosols, and 13 metals and dust were considered occupational risk factors. Time-dependent Cox regression analysis was used to calculate hazard ratios. Results: The risk of metabolic syndrome was significantly higher in night shift workers (hazard ratio = 1.45: 95% confidence interval = 1.36-1.54) and workers who were exposed to noise (1.15:1.07-1.24). Exposure to some other risk factors was also significantly associated with a higher risk of metabolic syndrome. They were dimethylformamide, acetonitrile, trichloroethylene, xylene, styrene, toluene, dichloromethane, copper, antimony, lead, copper, iron, welding fume, and manganese. Among the 28 significant pairs, 19 exhibited both positive additive and multiplicative effects. Conclusions: Exposure to single or combined occupational risk factors may increase the risk of developing metabolic syndrome. Working conditions should be monitored and improved to reduce exposure to occupational hazards and prevent the development of the metabolic syndrome.