Journal of Pharmaceutical Investigation
- Volume 27 Issue 3
- /
- Pages.181-187
- /
- 1997
- /
- 2093-5552(pISSN)
- /
- 2093-6214(eISSN)
Pharmacokinetics of Ethanol After Oral Administration of Aspartate-Containing Compositions
Aspartate함유 복합성분과 Ethanol의 약물동태학적 거동
- Kim, Tae-Wan (College of Pharmacy, Kangwon National University) ;
- Lee, Beom-Jin (College of Pharmacy, Kangwon National University) ;
- Choi, Han-Gon (College of Pharmacy, Seoul National University) ;
- Kim, Chong-Kook (College of Pharmacy, Seoul National University) ;
- Shin, Hee-Jong (Chong Kun Dang Co., Ltd.) ;
- Kim, Jung-Woo (Chong Kun Dang Co., Ltd.)
- 김태완 (강원대학교 약학대학) ;
- 이범진 (강원대학교 약학대학) ;
- 최한곤 (서울대학교 약학대학) ;
- 김종국 (서울대학교 약학대학) ;
- 신희종 (종근당 (주)) ;
- 김정우 (종근당 (주))
- Published : 1997.09.20
Abstract
The purpose of this work was to investigate pharmacokinetics of alcohol as a function of dose and time of administration of ethanol. The pharmacokinetics of alcohol 15 min after and before oral administration of aspartate-containing compositions to rats were also evaluated. The retention time of acetaldehyde, alcohol and isopropyl alcohol an internal standard in gas chromatogram was 3.6, 6.0 and 10.5 min, respectively. The maximum concentration of alcohol