• 한국도서관정보학회지
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• 제13권
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• pp.59-84
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• 1986

This paper is a study of the system of liberal great books selection in universities of Korea. A questionnaire consisted of 14 questions was sent to 46 universities of which 42 universities responded. Results of the study can be summarized as follows: 1) Liberal great books selection system was operated 40% of universities, but 60% was not operated because of not preparation and without perception of necessity. 2) The name of liberal great books was varied in 11 kinds of 16 universities. It is desirable that the name is unified. 3) The founded year of liberal great books selection system was new comparatively with enhanced liberal education. 4) The greater part of liberal great books format were a leaf of catalog, but it is desirable that book form catalog with review for induction of reading interests. 5) It is desirable that renewal of liberal great books are irregularly in answer to a need. 6) It is a n.0, ppeared that selection of liberal great books were by professor, but it is desirable that selection is by many people of all parts without prejudices and subjectivity. 7) The title of liberal great books were 121 titles in average. It is desirable that the titles are about 100 titles for expected results. 8) In a duplicates of liberal great books, 5 copy is much more than other cases. It is desirable that the duplicates depend on students, use rates, budget etc. of universities. 9) Use rates of liberal great books are much more than other books, but it is necessary that public relations and stimulation of reading for most use. 10) In subject analysis, liberal great books consisted of humanities, social sciences and novel mainly. Specially, literature is 33% of the total. 11) Liberal great books consisted of occidental works and literature mainly. 12) It is a n.0, ppeared that analysis of a n.0, ppointment frequency was scattered exceedingly.

• 한국통신학회논문지
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• 제8권4호
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• pp.121-138
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• 1983

STCW協約이 1984年4月28日 國際的으로 發效되므로 이에 對備하기 위하여 우리 나라 電氣通信의 主管聽은 緊急한 課題로서 그가 主管하는 電波管理法의 一部를 改正하여야 함을 提案하였다. 이 主要改正案骨子로서는 船舶局無線從事者證明制度를 創立할 것과, 電波通信技師一般級을 從來의 電波通信技師1級의 上位級資格으로 採擇하자는 것이다. 아울러, 電波通信技師1級이 不足하다는 不當한 핑계로써 船舶通信長의 資格을 下位級인 電波通信技師2級으로 輕延長하겠다는 警態依然한 行政은 是正되어야 함을 具體的數値로써도 論證하였다. 以上의 硏究는 主로 最新의 國內外文獻에 依하였으며 比較考察로서는 우리와 類似點이 많은 日本國의 行政先例를 택하였다. 이렇게 함으로써, WCY'83을 맞은 우리나라 通信政策이 人的要素 挺進으로도 發展되어 先進祖國創造에 寄與할 것을 促求하였다.

• 대한한의학방제학회지
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• 제25권4호
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• pp.471-481
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• 2017

Objectives : Noemyeong-san (NMS) is a novel herbal prescription composed of five oriental medicinal herbs including Prunellae Spica, Betulae Cortex, Foeniculi Fructus, Asiasari Radix, and Clematidis Radix for treating Alzheimer's disease. In the present study, we investigated the effects and molecular mechanisms of NMS on BV2 microglia to evaluate the potential action of this formula for preventing or treating neurodegenerative disease such as Alzheimer's disease. Methods : To determine the cytotoxicity of NMS on BV2 microglia, the MTT assay was performed. The effects of NMS on lipopolysaccharide (LPS)-stimulated BV2 microglia were determined with a nitric oxide (NO) assay and western blots for inflammatory mediator-related proteins, mitogen activated protein kinases (MAPKs), nuclear factor kappa B (NF-${\kappa}B$) pathway-related proteins, and heme oxygenase-1 (HO-1). Result : NMS inhibited induction of iNOS and COX-2 as well as NO production without affecting the cell viability in LPS-stimulated BV2 microglia. NMS also suppressed activation of ERK and p38 MAPK among main kinases of MAPKs as well as NF-${\kappa}B$ by LPS stimulation. Furthermore, NMS dose-dependently induced the expression of HO-1 and the inhibitory effect of NMS on the production of NO were blocked by pretreatment with an HO-1 inhibitor, Snpp. Conclusions : These results demonstrate that NMS has potent anti-neuroinflammatory effect on the LPS-stimulated microglia. These findings provide evidences for NMS to be considered as a new prescription for preventing or treating neurodegenerative disease such as Alzheimer's disease.

• 패션비즈니스
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• 제19권1호
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• pp.77-94
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• 2015

Due to the inflammatory of body exposure it did not become popular to the Korean nation but the body painting as a body art is definitely required for it be become a new pure artwork. In this body painting color is the core factor for visual part and expression and coloring obtained from the color is very important in creating effective image. In Korea beauty industry the researches are limited to the study on coloring expression of general beauty makeup. Therefore, this research analyzes color images in recent body painting artworks by defining characteristics of colors and coloring applied by theme. For the research subjects, dominant and secondary colors were extracted from the artworks presented in preliminary and final rounds of year 2012 and 2013 World Body Painting Festival. For the selection of final coloring stimulation the most frequent coloring by theme was first chosen. Among them, 2 individual coloring bands were selected by theme among the high frequency colors. For the analysis of coloring image shown in body painting works total 8 coloring bands were created and they were compared and analyzed by indicating each divided coloring band on the coloring image scale by theme. In this research coloring image analysis was done after examining colors and coloring of artworks presented in World Body Painting Festival by theme. This research has its meaning that it provides information and guideline for coloring design work of body painting by analyzing coloring image used in color and coloring of body painting by theme.

• 한국미생물·생명공학회지
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• 제26권5호
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• pp.442-449
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• 1998

CGTase를 이용한 당전이 xylitol의 합성과 당전이 xylitol의 비피더스균 생육증식 효과에 대한 연구를 수행하였다. 수종의 세균류가 분비하는 CGTase의 xylitol에 대한 당전이능을 비교하였으며, Thermoanaerobacter sp. 유래의 CGTase가 가장 우수한 당전이능을 보였다. 각종 당공여체를 검토한 결과 압출전분이 가장 우수한 결과를 보였으며, 당전이 효소반응의 최적 조건을 검토하였다. 생성된 당전이 xylitol을 활성탄-셀라이트 칼럼 크로마토그래피를 이용하여 분리하여 두 개의 fraction인 F-I, F-II를 얻었다. 이들의 당쇄결합 양상을 FAB mass spectrometer와 $^{13}$C-NMR spectrometer, 그리고 glucoamylase을 이용한 효소소화법을 이용하여 분석한 결과 xylitol에 glucose와 maltose 분자가 $\alpha$-1,4 결합되어 있는 것으로 유추되었다. 얻어진 당전이 xylitol은 xylitol과는 달리 Bifidobacterium breve에 대한 생육촉진효과를 보였다.

• The Korean Journal of Physiology and Pharmacology
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• 제16권1호
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• pp.49-57
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• 2012

It has been shown that QGC isolated and purified from Rumecis folium found protective effects of gastritis and esophagitis which EXT is an ethanol extract of it. We examined acute toxicity and the general pharmacological action of QGC EXT to search for any side effects of it in rats, mice, guinea pigs, and cats. In a single dose toxicity study, QGC EXT didn't show toxicological effects in rats and mice, and the $LD_{50}$ was over 5 g/kg in both animals, and there were also no changes in weight, feed and water intake during these toxicological experimental periods. We examined the general pharmacological action on central controlled behavior responses, and peripheral organs including blood pressure, heart rate, respiration and gastrointestinal system, We found that there were no significant changes in body temperature, locomotors activity, stereotyped behaviors, sleeping time, and convulsion. In other studies, writhing reaction, normal body temperature, there did not appear to be any changes. The large intestine movement and electrical field stimulation-induced contraction was not changes by its EXT. In addition, the influences on blood pressure, heart rates, and respiration by QGC EXT were not found. These results indicate that QGC EXT may be very safe as a new drug, since its $LD_{50}$ was very high over 5 g/kg and any side effects were not found.

• 한국콘텐츠학회논문지
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• 제18권8호
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• pp.148-156
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• 2018

본 연구는 VR 게임의 담론 활성화를 위한 기초 연구의 입장에서 요한 하위징아와 로제 카이와의 놀이이론을 바탕으로 기존 디지털 게임의 놀이적 특성을 유형화하였고, 해당 유형을 바탕으로 VR 게임의 놀이적 특성을 살펴보았다. 그 결과 VR 게임은 디지털 게임과 놀이적 특성을 상당 부분 공유하고 있는 것으로 나타났다. 그럼에도 불구하고 VR 게임에서는 HMD 착용에 의한 실제 세계와의 완벽한 단절과 새로운 입/출력 장치를 통해 자유로운 신체적 활동이 가능하게 되었다. 결국 놀이 환경의 변화로 인한 여러 감각적 자극을 통해 실재감, 몰입, 정서적 즐거움, 만족도의 증가 등 놀이자 경험에도 큰 영향을 미치게 되었다. 본 연구는 차후 다양하게 형성될 VR 콘텐츠의 특성을 연구하는 중요한 지표로 활용될 수 있을 것으로 기대된다.

• Journal of Korean Neurosurgical Society
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• 제55권5호
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• pp.237-243
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• 2014

Objective : Symptomatic disc degeneration develops from inflammatory reactions in the annulus fibrosus (AF). Although inflammatory mediators during annular inflammation have been studied, the roles of matrix metalloproteinases (MMPs) and their inhibitors have not been fully elucidated. In this study, we evaluated the production of MMPs and tissue inhibitors of metalloproteinase (TIMPs) during annular inflammation using an in vitro co-culture system. We also examined the effect of notochordal cells on annular inflammation. Methods : Human AF (hAF) pellet was co-cultured for 48 hours with phorbol myristate acetate-stimulated macrophage-like THP-1 cells. hAF pellet and conditioned media (CM) from co-cultured cells were assayed for MMPs, TIMPs, and insulin-like growth factor (IGF)-1 levels using real-time reverse-transcriptase polymerase chain reaction and enzyem-linked immunosorbent assay. To evaluate whether notochordal cells affected MMPs or TIMPs production on annular inflammation, hAF co-cultured with notochordal cells from adult New Zealand White rabbits, were assayed. Results : MMP-1, -3, -9; and TIMP-1 levels were significantly increased in CM of hAF co-cultured with macrophage-like cells compared with hAF alone, whereas TIMP-2 and IGF-1 levels were significantly decreased (p<0.05). After macrophage exposure, hAF produced significantly more MMP-1 and -3 and less TIMP-1 and -2. Interleukin-$1{\beta}$ stimulation enhanced MMP-1 and -3 levels, and significantly diminished TIMP-2 levels. Co-culturing with rabbit notochordal cells did not significantly influence MMPs and TIMPs production or COL1A2 gene expression. Conclusion : Our results indicate that macrophage-like cells evoke annular degeneration through the regulation of major degradative enzymes and their inhibitors, produced by hAF, suggesting that the selective regulation of these enzymes provides future targets for symptomatic disc degeneration therapy.

• The Korean Journal of Physiology and Pharmacology
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• 제17권1호
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• pp.51-56
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• 2013

Many intracellular proteins and signaling cascades contribute to the sensitivity of N-methyl-D-aspartate receptors (NMDARs). One such putative contributor is the serine/threonine kinase, protein kinase C (PKC). Activation of PKC by phorbol 12-myristate 13-acetate (PMA) causes activation of extracellular signal-regulated kinase (ERK) and promotes the formation of new spines in cultured hippocampal neurons. The purpose of this study was to examine which PKC isoforms are responsible for the PMA-induced augmentation of long-term potentiation (LTP) in the CA1 stratum radiatum of the hippocampus in vitro and verify that this facilitation requires NMDAR activation. We found that PMA enhanced the induction of LTP by a single episode of theta-burst stimulation in a concentration-dependent manner without affecting to magnitude of baseline field excitatory postsynaptic potentials. Facilitation of LTP by PMA (200 nM) was blocked by the nonspecific PKC inhibitor, Ro 31-8220 ($10{\mu}M$); the selective $PKC{\delta}$ inhibitor, rottlerin ($1{\mu}M$); and the $PKC{\varepsilon}$ inhibitor, TAT-${\varepsilon}V1$-2 peptide (500 nM). Moreover, the NMDAR blocker DL-APV ($50{\mu}M$) prevented enhancement of LTP by PMA. Our results suggest that PMA contributes to synaptic plasticity in the nervous system via activation of $PKC{\delta}$ and/or $PKC{\varepsilon}$, and confirm that NMDAR activity is required for this effect.

• Nutrition Research and Practice
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• 제14권5호
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• pp.463-477
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• 2020

BACKGROUND/OBJECTIVES: Many studies have suggested that Rhus verniciflua Stokes (RVS) and its extract are anticancer agents. However, RVS had limited use because it contains urushiol, an allergenic toxin. By improving an existing allergen-removal extraction method, we developed a new allergen-free Rhus verniciflua Stokes extract (RVSE) with higher flavonoid content. In this study, we examined whether RVSE inhibits the ability of AGS gastric cancer cells to migrate and invade. MATERIALS/METHODS: The flavonoids content of RVSE was analyzed by HPLC. The effects of RVSE on migration and invasion in AGS cells were analyzed by each assay kit. Matrix metalloproteinase (MMP)-9, plasminogen activator inhibitor-1 (PAI-1) and urokinase-type plasminogen activator (uPA) protein expression was analyzed by protein antibody array. The Phosphorylation of signal transducer and activator of transcription (STAT) 3 were assayed by Western blot analysis. RESULTS: RVSE treatment with 0-100 ㎍/mL dose-dependently reduced the ability of AGS cells to migrate and invade. Notably, treatment with RVSE strongly inhibited the expression of MMP-9 and uPA and the phosphorylation of STAT3. In contrast, RVSE treatment dramatically increased the expression of PAI-1. These results indicate that the inhibition of MMP-9 and uPA expression and STAT3 phosphorylation and the stimulation of PAI-1 expression contributed to the decreased migration and invasion of AGS cells treated with RVSE. CONCLUSIONS: These results suggest that RVSE may be used as a natural herbal agent to reduce gastric cancer metastasis.