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Characteristics of Vibration Response Imaging in Healthy Koreans

  • Choi, Kyu-Hee;Kim, Kwan-Il;Bang, Ji-Hyun;Kim, Jae-Hwan;Choi, Jun-Yong;Jung, Sung-Ki;Jung, Hee-Jae
    • The Journal of Korean Medicine
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    • v.32 no.6
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    • pp.10-17
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    • 2011
  • Background: Vibration response imaging (VRI) is a new technology that records energy generated by airflow during the respiration cycle. Analysis of lung sound using VRI may overcome the limitations of auscultation. Objectives: To set a VRI standard for healthy Koreans, we conducted a clinical assessment to evaluate breath sound images and quantification in healthy subjects and compared the findings with reported breath sound characteristics. Methods: Recordings were performed using the VRIxp. Eighty subjects took a deep breath four times during a 12-second interval while sitting upright. The quantitative aspect was analyzed using the VRI quantitative lung data (QLD) for total left lung, total right lung and for six lung regions: left upper lung (LUL), left middle lung (LML), left lower lung (LLL), right upper lung (RUL), right middle lung (RML), right lower lung (RLL). The qualitative aspect was provided through image assessments by three reviewers. Results: In all regions the left lung had significantly higher QLD than the right lung (P<0.005, paired t-test). The inter-rater agreement was 0.78. 84% of the images were found normal by the final assessment. Among the 16% (n=13) of images with abnormal final assessment, the most common flawed features were dynamic image (77%, n=10) and maximum energy frame (MEF) shape (77%, n=10). No significant differences were found between males and females for QLD but there were significant differences in qualitative aspects including dynamic images, MEF shape, and missing LLL. Conclusion: The characteristics of healthy Koreans are similar to those of Western subjects reported previously. VRI is easy to use and objective, and so is helpful to diagnose patients with respiratory diseases and to monitor the progress of diseases after medical treatments.

The Construction and Common Use of Old Document DB in the Foreign Countries (해외 소장 고문헌의 DB구축과 공동활용 방안)

  • Kang, Soon-Ae
    • Journal of the Korean Society for Library and Information Science
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    • v.42 no.3
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    • pp.61-79
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    • 2008
  • The purpose of this paper is to investigate the three aspects of the construction and common use of old document DB in the foreign countries: i) the processing of old documents, ii) the problem and improvement of DB systems of old documents. and iii) the common use of old document DB. Results from this research are as follows: The National Library of Korea(NLK) copied old documents in the foreign countries from 1982 to 2006 and published the brief catalog. The Reogang Publishing company issued four volumes catalogs of old document in Japan. The National Research Institute of Cultural Heritage(NRICH) investigated old books and published some catalogs of several organizations in Japan. America. France. and all. The National Institute of Korean History(NIKH) investigated old archives and published some catalogs of several organizations in Japan. The characteristics of the Korean Old and Rare Collection Information System(KORCIS) of the NLK, the Old Books Cultural Heritage in Overseas System of the NRICH. and the Korea History DB System and MF Catalog/ Image System of NIKH were described in the DB systems of old documents, the problems of DB systems were checked over and some alternatives were suggested. In the common use of old document DB, KORMARC format and description rules(draft) for archives should be revised to adopt a new standard such as KS editions. and all the institutes involved should thoroughly follow the standards. when creating bibliographic records and digitizing texts. It is necessary to educate and train the specialists of old documents. A government organization should be established to supervise all the procedures of developing technology for sharing digitized resources. using contents. and cooperating with the related internationl organizations and institutes.

Application of Back Analysis for Tunnel Design by Modified In Situ Rock Model (현장암반 모델을 적용한 터널의 역해석)

  • Kim, Hak-Mun;Lee, Bong-Yeol;Hwang, Ui-Seok;Kim, Tae-Hun
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.2 no.3
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    • pp.25-36
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    • 2000
  • The purpose of this research work is to propose an analytical method of tunnel design based on reasonable site data. Therefore the proposed design method consists of monitoring data and Modified In Situ Rock Model. Also the Rock Mass Rating for very poor quality rock is very difficult to estimate, the balances between the ratings may no longer gives a reliable basis for the rock mass strength. But in reality Rock Mass Rating is only the property which can be obtained from face mapping records of the exposed tunnel face during construction stage. Evaluation of rock parameters for the actual design prior to tunnel construction should be corrected during tunnelling process in particularly complex ground conditions. This study intends to investigate application of in-situ rock model to soft rock tunnelling (weathered rock) by face mapping results and site measurement data that are obtained at the costraction site of Seoul Subway Tunnel. For the preparation of more reliable ground parameters, the Rock Mass Rating values for the weathered rocks were modified and readjusted in accordance with the measurement data. The modified input parameters obtained by the proposed method are used for the prediction of the tunnel behavior at subsequent construction stages. The results of this study revealed that more reasonable feed back tunnel analysis can be possible as suggested. Ample measurement data would be able to confirm the new proposed technique in this research work.

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Motor Imagery Brain Signal Analysis for EEG-based Mouse Control (뇌전도 기반 마우스 제어를 위한 동작 상상 뇌 신호 분석)

  • Lee, Kyeong-Yeon;Lee, Tae-Hoon;Lee, Sang-Yoon
    • Korean Journal of Cognitive Science
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    • v.21 no.2
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    • pp.309-338
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    • 2010
  • In this paper, we studied the brain-computer interface (BCI). BCIs help severely disabled people to control external devices by analyzing their brain signals evoked from motor imageries. The findings in the field of neurophysiology revealed that the power of $\beta$(14-26 Hz) and $\mu$(8-12 Hz) rhythms decreases or increases in synchrony of the underlying neuronal populations in the sensorymotor cortex when people imagine the movement of their body parts. These are called Event-Related Desynchronization / Synchronization (ERD/ERS), respectively. We implemented a BCI-based mouse interface system which enabled subjects to control a computer mouse cursor into four different directions (e.g., up, down, left, and right) by analyzing brain signal patterns online. Tongue, foot, left-hand, and right-hand motor imageries were utilized to stimulate a human brain. We used a non-invasive EEG which records brain's spontaneous electrical activity over a short period of time by placing electrodes on the scalp. Because of the nature of the EEG signals, i.e., low amplitude and vulnerability to artifacts and noise, it is hard to analyze and classify brain signals measured by EEG directly. In order to overcome these obstacles, we applied statistical machine-learning techniques. We could achieve high performance in the classification of four motor imageries by employing Common Spatial Pattern (CSP) and Linear Discriminant Analysis (LDA) which transformed input EEG signals into a new coordinate system making the variances among different motor imagery signals maximized for easy classification. From the inspection of the topographies of the results, we could also confirm ERD/ERS appeared at different brain areas for different motor imageries showing the correspondence with the anatomical and neurophysiological knowledge.

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Analysis of Research Trend on Zoysiagrass (Zoysia spp.) (한국 잔디류의 연구동향 분석)

  • Hyun, Yun-Hea;Choi, Byeong-Jin;Kim, Yoon-Joong;Joo, Young-Kyoo
    • Asian Journal of Turfgrass Science
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    • v.26 no.2
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    • pp.89-95
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    • 2012
  • Korean lawn grass, which belongs to Zoysia genus in Gramineae family, is one of the major turfgrass which is widely adapted to its native niches in the temperate region of the north east Asia through tropical regions including Philippine, Thailand and Australia. The Turfgrass Information Center' database provides 5,340 descriptive records including 638 referred papers and 1,370 technical reports concerning 'Zoysia'. The database focused on researches on golf courses and lawn care industries. The researches provide informations on seed technology and use of plant protectant for pest management in turf management industries. The purpose of this study is to analyze and classify the research contents of zoysiagrasses which have been published in Korean journals. The total number of research papers published in Korean journals were 274 including 102, 38, and 134 in the 'Botanical', 'Environmental' and 'Cultural' researches, respectively. Publication in foreign journals by Korean investigators were not counted in this research. Research fields concerning golf course maintenance and plant protectant are believed to be necessary when compared to international trends. Moreover, advanced research efforts for the development of new cultivars with various environmental and disease resistance should be accomplished.

Clinical Outcome of Turkish Metastatic Breast Cancer Patients with Currently Available Treatment Modalities - Single Center Experience

  • Cabuk, Devrim;Basaran, Gul;Teomete, Mehmet;Dane, Faysal;Korkmaz, Taner;Seber, Selcuk;Telli, Ferhat;Yumuk, Perran Fulden;Turhal, Serdar
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.1
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    • pp.117-122
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    • 2014
  • Background: Breast cancer is the most common malignancy and the second leading cause of cancer-related death among women in the developed countries. Despite advances in screening, improved local therapies and adjuvant systemic treatments, median survival of metastatic breast cancer patients (MBC) is in the range of 2-3 years at most. We aimed to investigate whether the prognostic factors and therapeutic responses of our Turkish patients are similar to those in the literature. Materials and Methods: We reviewed the medical records of MBC patients who had been treated in our institution between 1999-2009 and analyzed their clinicopathological features and survival outcomes retrospectively Results: A hundred and sixty patients were included. Median age was 47 (23-82), median follow up was 24 (2-186) months. At the time of diagnosis 59% of patients were under the age of 50 and 46% were postmenopausal. The majority (37%) had multiple sites of metastases. Forty percent received endocrine therapy and 40% chemotherapy as first line metastatic treatment. Thirty (20%) patients were treated with molecular targeting agents like trastuzumab, lapatinib and sunitinib, frequently combined with a chemotherapy agent. Five-year overall survival (OS) was 32% and median OS was 38 months for the whole group. Five year progression free survival (PFS) was 10% and median PFS was 10 months. Menopausal status, hormone receptor expression and disease free status had a significant impact on overall survival in the multivariate analysis (p 0.018, p 0.018 and p:0.003, respectively). Conclusions: All our patients were treated with the modern oncologic therapies recommended by the international guidelines. From our data, MBC patients live up to 3-4 years, indicating that further improvement beyond that requires development of new treatment modalities. The survival outcomes of our patients were consistent with the data reported in the literature.

Automatic Clock and Time Signal System of the Astronomical Agency in East Asia Area (동아시아 천문관서의 자동 시보와 타종장치 시스템의 고찰 - 수운의상대, 자격루, 옥루, 송이영 혼천시계 등을 중심으로 -)

  • Lee, Yong-Sam;Kim, Sang-Hyuk;Jeong, Jang-Hae
    • Journal of Astronomy and Space Sciences
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    • v.26 no.3
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    • pp.355-374
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    • 2009
  • We analysed the old automatic clock and time signal system that was used by the national astronomical agency in East Asian Area. Jagyeongnu is a kind of water clock that was operated by the flowing water in Joseon Dynasty. Seowoongwan managed the water clock so as to keep the standard time system in the dynasty from the 16th year (1434) of King Sejong's reign. In 1438 the Okru that was invented in the period. Such kind of clock system already was used in China, which was Shui $y\ddot{u}n$ i hsiang t'ai (水運儀象壹) in 1092. During the period Joseon Dynasty, China and Japan had been kept the time system that one day is divided into 12 shin (12辰) or 100 gak (刻). However detailed part of the system had a little difference among the three countries. Though the whole system of water clock in Joseon had manufactured on the basis of Chinese, it had been gradually developed by own method and idea. In this study we show the historical records of the standard time keeping system in East Asian history. And then we can inform materials on the structure and functional devises for the purpose of new restoration models about the automatic clock and time system.

Study on Enhancement of TRANSGUIDE Outlier Filter Method under Unstable Traffic Flow for Reliable Travel Time Estimation -Focus on Dedicated Short Range Communications Probes- (불안정한 교통류상태에서 TRANSGUIDE 이상치 제거 기법 개선을 통한 교통 통행시간 예측 향상 연구 -DSRC 수집정보를 중심으로-)

  • Khedher, Moataz Bellah Ben;Yun, Duk Geun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.18 no.3
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    • pp.249-257
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    • 2017
  • Filtering the data for travel time records obtained from DSRC probes is essential for a better estimation of the link travel time. This study addresses the major deficiency in the performance of TRANSGUIDE in removing anomalous data. This algorithm is unable to handle unstable traffic flow conditions for certain time intervals, where fluctuations are observed. In this regard, this study proposes an algorithm that is capable of overcoming the weaknesses of TRANSGUIDE. If TRANSGUIDE fails to validate sufficient number of observations inside one time interval, another process specifies a new validity range based on the median absolute deviation (MAD), a common statistical approach. The proposed algorithm suggests the parameters, ${\alpha}$ and ${\beta}$, to consider the maximum allowed outlier within a one-time interval to respond to certain traffic flow conditions. The parameter estimation relies on historical data because it needs to be updated frequently. To test the proposed algorithm, the DSRC probe travel time data were collected from a multilane highway road section. Calibration of the model was performed by statistical data analysis through using cumulative relative frequency. The qualitative evaluation shows satisfactory performance. The proposed model overcomes the deficiency associated with the rapid change in travel time.

A Scheme on applying IT technology for TLCSM improvements (TLCSM 개선을 위한 IT기술의 적용방안)

  • Choi, Myoungjin;Kwon, Daeil;Yang, Jeakyung
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.12
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    • pp.26-33
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    • 2016
  • The cost of preparing munitions in weapon system operation and management has been rapidly increasing and current weapon systems have become complicated and diverse due to new warfare pattern changes and the rapid growth of advanced scientific technology. Moreover, as a part of the execution plans of creative economics, the Korean government is actively reviewing how to minimize the costs of preparing munitions. Accordingly, this study derived the issues of munitions management for decreasing munitions preparing costs. First, the issues of munitions management were introduced through review and analysis with respect to the munitions classification criteria, regulations and systems, and equipment maintenance information systems. Second, we proposed the application and necessity for the real-name system which is responsible for munitions management and the fragmentation of the maintenance instructions status classification criteria.. Also, we were analyzed that the effects depending on the application. Finally, we proposed that the linkage system which is currently military active with equipment maintenance information systems as well as the total life-cycle management system (TLCSM) improvements to the itemized data and records management system by utilizing IT technology CMB that must be done in order to improve the issues.

Sitagliptin and Vildagliptin Use Evaluation among Dipeptidyl Peptidase 4 Inhibitors in Adult Koreans with Type 2 Diabetes Mellitus (한국인 제2형 당뇨병 환자에 대한 디펩티딜 펩티다제 4 억제제 중 Sitagliptin과 Vildagliptin의 약물 사용 평가)

  • Park, Hyun-Jung;Lee, Ok-Sang;Lim, Sung-Cil
    • YAKHAK HOEJI
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    • v.56 no.2
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    • pp.136-143
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    • 2012
  • Type 2 Diabetes Mellitus (T2DM) is characterized by high blood glucose in the context of insulin resistance and relative insulin deficiency. Diabetes is often initially managed by increasing exercise and dietary modification. As the condition progresses, medications may be needed such as oral sulfonylurea or others. Recently, dipeptidyl peptidase 4 (DPP- 4) Inhibitor is new drug which can control blood glucose by increasing the active levels of incretin hormone in the body. However, researches have been carried out for mostly Caucasian and Japanese, not for Koreans at all. Therefore, this study was to evaluate the efficacy and safety of DPP-4 inhibitor (Sitagliptin, Vildagliptin) in patients with T2DM in Koreans. This study was carried out retrospectively with reviewing of medical records from the 141 patients who received sitagliptin or vildagliptin over 24 week periods from January 2009, to December 2009. Information including demographics, concomitant medication, disease duration, and exercise was evaluated. $HbA_{1c}$, random blood glucose, post prandial 2 hour glucose, blood pressure, AST, ALT, serum creatinine, total cholesterol, triglyceride levels were also collected at baseline and endpoint (at 24 weeks). In each post-treatment group, $HbA_{1c}$, random blood glucose and post prandial 2 hour glucose levels were decreased significantly from baseline in the sitagliptin group (-0.82%, -28.76 mg/dl, -46.65 mg/dl) and vildagliptin group(-1.22%, -27.96 mg/dl, -67.2 mg/dl). Greater $HbA_{1c}$ mean reductions from baseline to 24 weeks were seen in patients with higher baseline values (>7.0%), with shorter disease durations (${\leq}1$ year) compared with those with lower baseline values (<7.0%), with longer disease durations (>1 year) in both sitagliptin and vildagliptin groups. The incidences of hypoglycemia, headache and upper respiratory infection were 0%, 8.7%, 5.8% in sitagliptin group and 2.8%, 8.3%, 6.9% in vildagliptin group. In conclusion, our results showed DPP-4 inhibitor provided similar efficacy compared with sulfonylurea after 24 weeks of treatment and were safer than sulfonylurea in hypoglycemia for Korean T2DM. Also vildagliptin was associated with significant improvement in $HbA_{1c}$ reduction in Korean patient with subgroup (body mass index<25 $kg/m^2$, metformin dose${\geq}$1000 mg, p<0.05) compared to sitagliptin. Therefore, even though DPP-4 inhibitor use for Korean needs to be studied more consistently in the future, DPP-4 inhibitor is a safe and effective drug for Korean T2DM based on our result.