• 한국발생생물학회:학술대회논문집
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• 한국발생생물학회 2003년도 제3회 국제심포지움 및 학술대회
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• pp.29-48
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• 2003

It is remarkable that nuclear transfer using differentiated donor cells can produce physiologically normal cloned animals, but the process is inefficient and highly prone to epigenetic errors. Aberrant patterns of gene expression in clones contribute to the cumulative losses and abnormal phenotypes observed throughout development. Any long lasting effects from cloning, as revealed in some mouse studies, need to be comprehensively evaluated in cloned livestock. These issues raise animal welfare concerns that currently limit the acceptability and applicability of the technology. It is expected that improved reprogramming of the donor genome will increase cloning efficiencies realising a wide range of new agricultural and medical opportunities. Efficient cloning potentially enables rapid dissemination of elite genotypes from nucleus herds to commercial producers. Initial commercialization will, however, focus on producing small numbers of high value animals for natural breeding especially clones of progeny-tested sires, The continual advances in animal genomics towards the identification of genes that influence livestock production traits and human health increase the ability to genetically modify animals to enhance agricultural efficiency and produce superior quality food and biomedical products for niche markets. The potential opportunities in animal agriculture are more challenging than those in biomedicine as they require greater biological efficiency at reduced cost to be economically viable and because of the more difficult consumer acceptance issues. Nevertheless, cloning and transgenesis are being used together to increase the genetic merit of livestock; however, the integration of this technology into farming systems remains some distance in the future.

• Journal of the Korean Wood Science and Technology
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• 제51권2호
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• pp.145-156
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• 2023

Many skin diseases are caused by microbial infections. Representative pathogenic fungus and bacterium that cause skin diseases are Candida albicans and Staphylococcus aureus, respectively. Malassezia pachydermatis is a fungus that causes animal skin diseases. In this study, we propose a method for removing pathogenic microorganisms from the skin using relatively safe edible herbal extracts. Herbal extracts were screened for skin health through the removal of pathogenic microorganisms, and combinations for effective utilization of the screened extracts were identified. In this study, among methanol extracts of 240 edible plants, C. albicans, S. aureus, and M. pachydermatis were killed by extracts of 10 plants: Acori Gramineri Rhizoma, Angelicae Tenuissimae Radix, Cinnamomi Cortex, Cinnamomi Ramulus, Impatientis Semen, Magnoliae Cortex, Moutan Cortex Radicis, Phellodendri Cortex, Scutellariae Radix, and Syzygii Flos. By evaluating the synergistic antifungal activities against C. albicans using all 45 possible combinations of these 10 extracts, five new synergistic antifungal combinations, Acori Gramineri Rhizoma with Magnoliae Cortex extracts, Acori Gramineri Rhizoma with Phellodendri Cortex extracts, Angelicae Tenuissimae Radix with Magnoliae Cortex extracts, Magnoliae Cortex with Phellodendri Cortex extracts, and Phellodendri Cortex with Syzygii Flos extracts, were identified. By utilizing the selected extracts and five combinations with synergistic antifungal effects, this work provides materials and methods to develop new and safe methods for treating candidiasis using natural products.

• 한국수정란이식학회:학술대회논문집
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• 한국수정란이식학회 2003년도 제3회 발생공학 국제심포지움 및 학술대회
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• pp.29-48
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• 2003

It is remarkable that nuclear transfer using differentiated donor cells can produce physiologically normal cloned animals, but the process is inefficient and highly prone to epigenetic errors. Aberrant patterns of gene expression in clones contribute to the cumulative losses and abnormal phenotypes observed throughout development. Any long lasting effects from cloning, as revealed in some mouse studies, need to be comprehensively evaluated in cloned livestock. These issues raise animal welfare concerns that currently limit the acceptability and applicability of the technology. It is expected that improved reprogramming of the donor genome will increase cloning efficiencies realising a wide range of new agricultural and medical opportunities. Efficient cloning potentially enables rapid dissemination of elite genotypes from nucleus herds to commercial producers. Initial commercialisation will, however, focus on producing small numbers of high value animals for natural breeding especially clones of progeny-tested sires. The continual advances in animal genomics towards the identification of genes that influence livestock production traits and human health increase the ability to genetically modify animals to enhance agricultural efficiency and produce superior quality food and biomedical products for niche markets. The potential opportunities inanimal agriculture are more challenging than those in biomedicine as they require greater biological efficiency at reduced cost to be economically viable and because of the more difficult consumer acceptance issues. Nevertheless, cloning and transgenesis are being used together to increase the genetic merit of livestock; however, the integration of this technology into farming systems remains some distance in the future.

• 한국수소및신에너지학회논문집
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• 제33권2호
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• pp.158-163
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• 2022

The test method on the Type II high-pressure hydrogen storage tanks made of the metal wire hoop winding is a complex and high risk. Also closeup on the tank being test is difficult. In this study, we studied a mechanical test method for a high-pressure hydrogen tanks. This method must be simple, risk-free and possible to observe the change in microscopic behavior of a metal wire on a liner. As the results, it was possible to observe the microscopic behavior on the metal wire by the mechanical test method. Also, a simple and risk-free test was possible compared to the conventional test method for high pressure hydrogen tanks.

• 한국직업건강간호학회지
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• 제22권3호
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• pp.191-197
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• 2013

Purpose: The purpose of this study was to identify the relationship of job stress, state of sleep, and depression and to identify factors influencing depression of emergency medical technicians. Methods: The research was a cross-sectional, descriptive study. Data collection were done using self-report questionnaires with 162 emergency medical technicians working in hospitals who agreed to participate in the study. Data were analyzed using descriptive statistics, t-test, ANOVA, Pearson's correlation coefficients and multiple regression with the SPSS/WIN 18.0 Program. Results: Depression had significant negative correlations with state of sleep, (r=-482, p<.001) and positive correlations with job stress (r=.196,p=.013). State of sleep had significant negative correlations with job stress (r=-.168, p=.033). The variance for life satisfaction was 23.7% (F=25.964, p<.001). Variable of state of sleep significantly predicted depression of emergency medical technicians. Conclusion: Considering these results, for emergency medical technicians' job stress, state of sleep, and depression, further studies are needed. Furthermore, there is a need to develop and implement new strategies to improve depression among emergency medical technicians.

• 한국산학기술학회논문지
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• 제10권4호
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• pp.895-899
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• 2009

본 논문에서는 컨버전스 시대에 새로운 비즈니스 기회를 창출하기 위하여 고령화 사회에 대응하기 위한 로봇사업의 비즈니스 모델을 개발하고자 한다. 컨버전스 사회와 고령화 사회의 마켓 동인을 확인하기 위하여, 이들의 트렌드를 분석한다. 마켓의 가치사슬의 구성과 분석을 통하여 본 연구에서는 유비쿼터스, 헬스 그리고 로봇이 통합된 컨버전스 서비스 형태의 u-health 로봇에 초점을 맞추어 비즈니스 모델을 설계한다. 추가적으로 기술개발과 마켓을 축으로 제안된 비즈니스 모델의 진화 경로에 대하여 기술한다 마지막으로 제안된 비즈니스 모델의 효과성을 측정하고 평가하기 위한 매트릭스 기반의 평가 프레임워크를 개발한다.

• Journal of Preventive Medicine and Public Health
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• 제40권4호
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• pp.278-284
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• 2007

Despite extensive researches and pre-market clinical trials, only limited information on the adverse drug reactions (ADRs) of a drug can be collected at the time of market approval from regulatory agency. ADRs constitute a major public health problem. Post-marketing surveillance of drugs is important to detect signals for ADR. In Korea, one of the main methods for monitoring the safety of marketed drugs is spontaneous reporting system of suspected ADRs. Re-examination and re-evaluation system are in force for monitoring safety of new market approval drugs and currently under marketing drugs, respectively. Recently, regional pharmacovigilance centers were designated from Korean Food and Drug Administration for facilitating ADR surveillance. Over recent years, with the development of information technology, there has been an increased interest in establishing data mining system for detecting signals from Health Insurance Review Agency database. The purpose of this paper is to review the current status of Korean ADR surveillance system and suggest the possible solutions for developing active pharmacovigilance system in Korea.

• 비파괴검사학회지
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• 제27권6호
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• pp.556-562
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• 2007

This paper presents the use of a novel fiber optic accelerometer system to monitor ambient vibration (both wind-induced one and vehicle-induced) of a real bridge structure. This sensor system integrates the $Moir\'{e}$ fringe phenomenon with fiber optics to achieve accurate and reliable measurements. A low-cost signal processing unit implements unique algorithms to further enhance the resolution and increase the dynamic bandwidth of the sensors. The fiber optic accelerometer has two major benefits in using this fiber optic accelerometer system for monitoring civil engineering structures. One is its immunity to electromagnetic (EM) interference making it suitable for difficult applications in such environments involving strong EM fields, electrical spark-induced explosion risks, and cabling problems, prohibiting the use of conventional electromagnetic accelerometers. The other is its ability to measure both low- and high-amplitude vibrations with a constantly high resolution without pre-setting a gain level, as usually required in a conventional accelerometer. The second benefit makes the sensor system particularly useful for real-time measurement of both ambient vibration (that is often used for structural health monitoring) and strong motion such as earthquake. Especially, the semi-strong motion and the small ambient one are successfully simulated and measured by using the new fiber optic accelerometer in the experiment of the structural health monitoring of a real bridge.

• Journal of Information Technology Applications and Management
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• 제28권1호
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• pp.1-12
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• 2021

The purpose of this study is to analyze the medical ecosystem in the post-corona era. In addition, this study introduces a new medical CRM model that allows primary-level hospitals to overcome the economic difficulties and to occupy a competitive advantage in the post-corona era. The medical environment in the post-corona era is expected to be changed by non-face-to-face treatment, reinforcement of public medical care, the transformation of a medical system centered on the primary-level hospitals, and the use of AI and big data technologies. The medical CRM model presented in this study emphasizes the establishment of mutual customer relationships through close information exchange between patients, primary-level hospital, and the government. In the post-corona era, primary-level hospitals should not simply be approached as private hospital pursuing profitability. These should be reestablished as the hospitals that can provide public health care services while ensuring stable profitability.

• Journal of Platform Technology
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• 제10권1호
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• pp.20-28
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• 2022

인공지능기반의 건강 데이터 검증은 임상 연구에 도움을 줄 뿐만 아니라, 새로운 치료법을 개발하는데 필수 요소가 되었다. 미국 식품의약 관리국이 의학진단 분야 중 인공지능을 이용하여 성인 당뇨병 환자의 경증 이상 당뇨병성 망막증을 감지하는 의료기기 마케팅을 승인한 이래, 인공지능을 이용한 테스트가 증가하고 있다. 본 연구에서는 구글에서 지원하는 Teachable Machine 을 이용하여 이미지 분류 기반의 인공지능모델을 생성하고, 학습을 통한 예측 모델을 완성하였다. 이는 현재 만성질환의 환자들 중 발생하는 안구 질환 중 백내장의 조기 발견하는데 용이하게 할 뿐만 아니라, 눈 건강을 위해 헬스케어 프로그램으로 안 질환 예방을 위한 디지털 개인건강 헬스케어 앱을 개발하기 위한 기초 연구로 진행되었다.