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Sequential patient recruitment monitoring in multi-center clinical trials

  • Kim, Dong-Yun;Han, Sung-Min;Youngblood, Marston Jr.
    • Communications for Statistical Applications and Methods
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    • v.25 no.5
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    • pp.501-512
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    • 2018
  • We propose Sequential Patient Recruitment Monitoring (SPRM), a new monitoring procedure for patient recruitment in a clinical trial. Based on the sequential probability ratio test using improved stopping boundaries by Woodroofe, the method allows for continuous monitoring of the rate of enrollment. It gives an early warning when the recruitment is unlikely to achieve the target enrollment. The packet data approach combined with the Central Limit Theorem makes the method robust to the distribution of the recruitment entry pattern. A straightforward application of the counting process framework can be used to estimate the probability to achieve the target enrollment under the assumption that the current trend continues. The required extension of the recruitment period can also be derived for a given confidence level. SPRM is a new, continuous patient recruitment monitoring tool that provides an opportunity for corrective action in a timely manner. It is suitable for the modern, centralized data management environment and requires minimal effort to maintain. We illustrate this method using real data from two well-known, multicenter, phase III clinical trials.

Design of Agro-Livestock Products Traceability System using EPC Network (EPC 네트워크를 응용한 농.축산물 이력관리 시스템 설계)

  • Lee, Meong-Hun;Yoe, Hyun
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.11 no.1
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    • pp.216-221
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    • 2007
  • In this paper, we propose a new traceability system that integrates ubiquitous sensor network for monitoring agricultural environment. The proposed system using EPC network can provide informations of agro-livestock products traceability quickly and efficiently. Moreover, this system with RFID Technology gives intelligence of distribution and record. Because of new agro-livestock products traceability system, farm family's income will increase with customer satisfaction.

New records of three lecanid rotifers(Rotifera: Monogononta: Lecanidae) from Korea

  • Yang, Hee-Min;Min, Gi-Sik
    • Journal of Species Research
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    • v.10 no.3
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    • pp.262-266
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    • 2021
  • In this study, three lecanid rotifer species were newly recorded in Korea: Lecane inermis (Bryce, 1892), L. furcata (Murray, 1913), and L. nana (Murray, 1913). Most of the lecanid rotifers recorded in Korea have been collected from stagnant water, and Lecane furcata and L. nana were collected from a reservoir. In contrast, L. inermis was found in a soil sample. Lecane inermis is the first illoricated lecanid species reported in Korea. This species is distinguished from other illoricated species by its toes with relatively long claws. Lecane furcata is the most common lecanid rotifer in submerged vegetation. The morphological characteristics of its lorica are similar to many other lecanid rotifers, but it can be distinguished by its completely fused toes with a terminal fissure, an absence of antero-lateral spines, and the ratio of lorica/toe length. Lecane nana is most similar to L. tryphema Harring & Myers, 1926, but can be distinguished by the toe tips curved outwards. The three species in this study are considered to have a cosmopolitan distribution and have been recorded in many Asian countries. In this paper, we describe the morphological characteristics of the three lecanid species with trophi structures observed by scanning electron microscope.

The Comparative Study of Software Optimal Release Time Based on Log-Logistic Distribution (Log-Logistic 분포 모형에 근거한 소프트웨어 최적방출시기에 관한 비교연구)

  • Kim, Hee-Cheul
    • Journal of the Korea Society of Computer and Information
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    • v.13 no.7
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    • pp.1-9
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    • 2008
  • In this paper, make a study decision problem called an optimal release policies after testing a software system in development phase and transfer it to the user. When correcting or modifying the software, because of the possibility of introducing new faults when correcting or modifying the software, infinite failure non-homogeneous Poisson process models presented and propose an optimal release policies of the life distribution applied log-logistic distribution which can capture the increasing! decreasing nature of the failure occurrence rate per fault. In this paper, discuss optimal software release policies which minimize a total average software cost of development and maintenance under the constraint of satisfying a software reliability requirement. In a numerical example, after trend test applied and estimated the parameters using maximum likelihood estimation of inter-failure time data, make out estimating software optimal release time.

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The Comparative Study of Software Optimal Release Time Based on Weibull Distribution Property (와이블 분포 특성에 근거한 소프트웨어 최적 방출시기에 관한 비교 연구)

  • Kim, Hee-Cheul;Park, Hyoung-Keun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.10 no.8
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    • pp.1903-1910
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    • 2009
  • In this paper, we were researched decision problem called an optimal release policies after testing a software system in development phase and transferring it to the user. The applied model of release time exploited infinite failure non-homogeneous Poisson process This infinite failure non-homogeneous Poisson process is a model which reflects the possibility of introducing new faults when correcting or modifying the software. The failure life-cycle distribution used the Weibull distribution which has the efficient various property which has the place efficient quality. Thus, optimal software release policies which minimize a total average software cost of development and maintenance under the constraint of satisfying a software reliability requirement becomes an optimal release policies. In a numerical example, after trend test applied and estimated the parameters using maximum likelihood estimation of inter-failure time data, estimated software optimal release time.

Spatio-temporal Distribution Pattern of New Biotypes of Weedy Rice (Oryza sativa L.) in Selangor North-West Project, Malaysia

  • Baki, B.B.;M.M., Shakirin
    • Korean Journal of Weed Science
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    • v.30 no.2
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    • pp.68-83
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    • 2010
  • Weedy rice (Oryza sativa L.) occurred sympatrically with other weeds and the rice crop in Malaysian rice granaries. We conducted field surveys in 2006-2008 seasons in 7 farm blocks of Selangor's North West Project, Malaysia to enlist the new biotypes of weedy rice (NBWR) and assess their spatio-temporal pattern of distribution based on quantitative and dispersion indices. No less than 16 accessions of NBWR were identified based on their special traits, viz. panicle type, pericarp colour, presence or absence of awn, seed type and degree of grain shattering. The NBWR accessions exhibited a combination of morphological traits from open panicle, grain with awns, red pericarp, short grain type, and degrees of grain shattering. Others mimic commercial rices with close panicle, awnless grains, white pericarp, long or short grain-type. Invariably, the NBWRs mimic and stand as tall as cultivated rice namely MR219, MR220, or MR235 and these NBWR accessions stand among equals morphologically vis-a-vis the commercial rice varieties. Most accessions displayed varying degrees of grain shattering in excess of 50%, except Acc9 and Acc12. The seasonal dynamics of on the prevalence of dominant NBWR accessions were also displaying significant differences among farm blocks. While Bagan Terap farm block, for example, did not record any measurable changes in the dominant NBWR accessions over seasons, the Sungai Leman farm block recorded measurable season-mediated changes in the dominant NBWR accessions. Sungai Leman started with NBWR Acc3, Acc4, Acc5, Acc7, Acc8, and Acc12 in season 1 of 2006/2007, but no measurable records of Acc3 and Acc5 were shown in season 2 of 2007. In season 3 of 2007/2008, only Acc8 and Acc12 prevailed in the farm block. In Sawah Sempadan farm block, season 3 of 2007/2008 showed much reduced prevalence of NBWRs leaving only Acc8 and Acc12. Most accessions registered clump or under-dispersed spatial distribution pattern based on quantitative indices: variance-to-mean ratio (VMR) and Lloyd's patchiness values. The dynamics on the extent of infestation and prevalence of dominant NBWR accessions registered both season- and farm-block mediated differences. Most accessions showed VMR >1 thus indicative of having a clump or clustered spatial distribution, as exemplified by Acc3, Acc4, Acc7, Acc8 and Acc12 in all farm blocks throughout three seasons. Some accessions have either random or uniform distribution in a few farm blocks. The Acc8 has the highest population counts based on important value index, followed by Acc12, and both were the most dominant accession while Sawah Sempadan was the worst farm block infested by NBWR compared to other farm blocks. These results were discussed in relation with the current agronomic and weed management practices, water availability and extension services in the granary.

Legalization of Right to be Forgotten and Freedom of Press in the Digital Media Environment (디지털 미디어 환경에서 잊혀질 권리의 법제화와 언론의 자유)

  • Kim, Hyung-Il
    • Journal of Digital Convergence
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    • v.11 no.9
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    • pp.21-27
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    • 2013
  • With the advent of digital media environment, distribution way of information changes, legalization of the right to be forgotten is becoming increasingly necessary. However, too much emphasis on protection of personal information to hinder the development of the Internet industry and constitutional rights, including freedom of speech and right to know might be infringed. Thus, the scope of the right to be forgotten there is a need to clarify the rules. First, the rights of personal information can be divided into two. Right to be forgotten can be applied to the right to self-determination of personal information, but the right to self-determination information about social personality cannot be applied to. Second, in the digital media environment, old news article over the internet repeatedly distribution as the new damage is generating. Because old news article is a historical record, the right to be forgotten can not be applied. Thus, appropriate for digital media environment must find new ways.

Ten new records of vascular plants for the flora of Uzbekistan (Asteraceae)

  • Tojibaev, Komiljon Sh.;Beshko, Natalya Yu.;Batashov, Avazbek R.;Karimov, Farkhod I.;Lee, Dong-Hyuk;Turginov, Orzimat T.;Usmonov, Mansur X.;Kodirov, Ulugbek H.;Tajeddinova, Dilorom
    • Korean Journal of Plant Taxonomy
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    • v.47 no.3
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    • pp.171-179
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    • 2017
  • Ten species of vascular plants newly recorded in Uzbekistan are presented. The first record of Anthemis ruthenica from the northern side of the Alay range is confirmed, and the species was found for the second time in a neighborhood of Tashkent as an alien. Carduus arabicus as a native plant in Central Asia is recorded for the first time from Western Pamir-Alay. Chondrilla brevirostris, C. macrocarpa, and C. phaeocephala are from the desert and adyrs zones. Crinitaria tatarica and Crepis mira collected from Western Tien-Shan are presented, Olgaea baldschuanica first recorded on the Babatag range of mountains as a subendemic species and Erigeron andryaloides from the Hissar range are reported here as among the flora of Uzbekistan. The former Centaurea apiculata Ledeb. was accepted as a synonym of C. scabiosa L. subsp. apiculata. All records were collected in different habitats of Uzbekistan. Taxonomic remarks, pictures and distribution maps for these species are provided.

The Base of Understanding for Interdisciplinary Studies on Cyber Crimes - Centering on Regulations in Criminal Law - (사이버범죄의 학제간 연구를 위한 이해의 기초 - 형법상 규제를 중심으로 -)

  • Lim, Byoung-Rak
    • Journal of the Korea Society of Computer and Information
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    • v.13 no.3
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    • pp.237-242
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    • 2008
  • This study aims to provide theoretical base in criminal law for engineers in the viewpoint of jurists to encourage interdisciplinary studies on cyber crimes. Apart from seriousness of discussion on torrent cyber crimes, a good effect of the internet networks such as sharing of information has bee emphasized while the evil influence of its side effect has been neglected. Therefore, this study suggests that we need to consider reinforcement of cyber ethics, and legal mind of IT technicians, strict security by managers, active efforts to develop legitimate contents by managers of web hardware and P2P, and reinforcement of punishments against crimes by internet users. And this study approaches new norms on computer and cyber crimes in interpretational sense of criminal law, and provides the theoretical base of the criminal law focusing on traditional theories, assumptions, and precedents involved in regulations against computer virus distribution.

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A Study on Designing a Next-Generation Records Management System (차세대 기록관리시스템 재설계 모형 연구)

  • Oh, Jin-Kwan;Yim, Jin-Hee
    • Journal of Korean Society of Archives and Records Management
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    • v.18 no.2
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    • pp.163-188
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    • 2018
  • How do we create a next generation Records Management System? Under a rapidly changing system development environment, the records management system of public institutions has remained stable for the past 10 years. For this reason, it seems to be the key cause of the structural problem of the Records Management System, which makes it difficult to accommodate user requirements and apply a new recording technology. The purpose of this study is to present a redesigned model for a next-generation records management system by analyzing the status of the electronic records management. This study analyzed "A Study on the Redesign of the Next-Generation Electronic Records Management Process," records management technology of advanced records management system, and a case of an overseas system. Based on the analysis results, the improvement direction of the records management system was analyzed from several aspects: functional, software design, and software distribution. This study thus suggests that the creation of a microservice architecture-based (MSA) and an open source software-oriented (OSS) records management system should be the focus of next-generation record management.