• 한국수소및신에너지학회논문집
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• 제27권1호
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• pp.36-41
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• 2016

The development need of new renewable energy is more and more important to resolve exhaustion of chemical fuels and environmental pollution. Polymer electrolyte membrane fuel cell has been widely studied to the extent that it can be used commercially. But there are many problems to be solved. One of them is to enhance the stability of fuel cell stacks. This paper proposes a new fault diagnosis method using Least Square Method (LSM) which is one of parameter estimation methods. The proposed method extracts equivalent circuit parameters from on-line measurements. Parameters of the circuit are estimated according to normal and abnormal states using simulation. The variation of parameters estimated in each states enables the estimation of state in fuel cells. Thus the LSM presented can be a suitable on-line parameter estimation method in PEMFC.

• 한국어병학회지
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• 제16권3호
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• pp.165-173
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• 2003

감성돔 (Acanthopagrus schlegeli)의 비장에서 주화세포인 BSBS를 확립하고 세포의 특성을 검사하였다. BSBS세포는 60회 이상의 계대배양이 가능하였고 형태학적으로는 상피성 세포였다. 세포는 20℃, 10%의 FBS가 든 L-15배지에서 배양하는 조건에서 잘 자랐다. BSBS세포는 해양버나바이러스 (MABV Y-6), 잉어의 봄바이러스병바이러스 (SVCV), 넙치의 랍도바이스 (HIRRV)와 연어바이러스 (CSV)를 접종했을 때 세포변성효과가 나타났다. 새로 확립된 주화세포는 앞으로 많은 바이러스병의 연구에 유용하게 사용할 수 있을 것으로 생각된다.

• 산업공학
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• 제22권2호
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• pp.144-152
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• 2009

Assembly line has been recognized as an efficient production system in mass production. However, the recent production environment characterized as mass customization urges production managers to transform a long assembly line to a number of short assembly cells. To maximize the utilization of resources in an assembly cell, it is important to have the line balanced. This paper presents a bucket brigade-based assembly cell. Bucket brigade is a way of coordinating workers who progressively perform a set of assembly operations on a flow line. Each worker follows a simple rule: perform assembly operations on a product until the next worker downstream takes it over; then go back to the previous worker upstream to take over a new assembly job. In this way, the line balances itself. The bucket brigade assembly cell is analyzed and compared with traditional assembly lines and general assembly cells. The paper also discusses some prerequisite requirements and limitations when the bucket brigade assembly cells are employed.

• 대한약학회:학술대회논문집
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• 대한약학회 2001년도 Proceedings of International Convention of the Pharmaceutical Society of Korea
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• pp.243.3-244
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• 2001

• Industrial Engineering and Management Systems
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• 제7권2호
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• pp.160-170
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• 2008

This paper proposes a mathematical model for converting conveyor assembly line to cellular manufacturing in complex production environments. Complex production environments refer to the situations with multi-products, variant demand, different batch sizes and the worker abilities varying with work stations and products respectively. The model proposed in this paper aims to determine (1) how many cells should be formatted; (2) how many workers should be assigned in each cell; (3) and how many workers should be rested in shortened conveyor line when a conveyor assembly line should be converted, in order to optimize system performances which are defined as the total throughput time and total labor power. We refer the model to a new production system. Such model can be used as an evaluation tool in the cases of (i) when a company wants to change its production system (usually a belt conveyor line) to a new one (including cell manufacturing); (ii) when a company wants to evaluate the performance of its converted system. Simulation experiments based on the data collected from the previous documents are used to estimate the marginal impact that each factor change has had on the estimated performance improvement resulting from the conversion.

• 대한산업공학회지
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• 제41권4호
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• pp.330-337
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• 2015

A bucket-brigade is a way of transporting items where items are passed from one person to the next. The operation of the bucket brigade imitates the cooperative behavior of ants when brood, food or other resources are moved. Koo (2009) presented a bucket brigade-based assembly cell where each worker follows a simple rule: perform assembly operations on a product until the next worker downstream takes it over; then go back to the previous worker upstream to take over a new assembly job. In this way, the flow line is self-balanced without any predetermined job assignment. However, there are some productivity losses related to hand-off and blocking. This paper examines the hand-off and blocking losses and presents a new bucket brigade-based assembly cell where working areas for each assembler is restricted with the help of buffer interfaces. Simulation experiments are used to validate the performance of the new assembly system.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2007년도 추계학술대회 논문집
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• pp.231-231
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• 2007

• Bulletin of the Korean Chemical Society
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• 제33권9호
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• pp.2991-2998
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• 2012

A series of new diarylureas and diarylamides possessing 1,3,4-triarylpyrazole scaffold was synthesized and their in vitro antiproliferative activities against A375P human melanoma cell line and NCI-60 cell line panel were tested. Compounds 9, 11, 12, 14, and 17-21 showed superior potency against A375P to Sorafenib. Over the NCI-60 cancer cell line panel, compound 14 possessing a methoxy group, amide linker, and 4-chloro-3-(trifluoromethyl)phenyl terminal ring showed the highest potency and broad-spectrum anticancer activity. Compound 13 showed high selectivity towards leukemia subpanel over other cancer types.

• Bulletin of the Korean Chemical Society
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• 제31권10호
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• pp.2854-2860
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• 2010

Synthesis of a new series of pyrimidinyl-imidazo[2,1-b]thiazole derivatives is described. Their antiproliferative activity against A375 human melanoma cell line was tested and the effect of substituents on the pyrimidinyl ring side chain was investigated. The biological results indicated that most of the newly synthesized compounds showed moderate activity against A375, compared with Sorafenib. Among all of these derivatives, the cyclic sulfamide derivatives IIIa, IIIb, and IIIe showed the most potent antiproliferative activity against A375 human melanoma cell line. The IC50 values of compounds IIIa,b were in nanomolar scale. In addition, compound IIIe ($IC_{50}=1.9\;{\mu}M$) also demonstrated more potent antiproliferative activity compared with Sorafenib ($IC_{50}=5.6\;{\mu}M$).

• Bulletin of the Korean Chemical Society
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• 제34권8호
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• pp.2311-2316
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• 2013

A series of new diarylamide and diarylurea derivatives possessing pyrimidinylaminobenzene scaffold was synthesized. Their in vitro antiproliferative activities were tested against A375P human melanoma cell line. Among them, compounds 1a-c, k and 2b-d, f, g, j, l showed superior potencies against A375P human melanoma cell line to Sorafenib. In particular, compound 2f possessing 3-fluoro-5-trifluoromethyl moiety exhibited the highest potency with $IC_{50}$ value in nanomolar scale.