• 한국엔터테인먼트산업학회논문지
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• 제15권7호
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• pp.215-223
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• 2021

본 연구의 목적은 지역사회에 거주하고 있는 경도인지장애를 보이는 노인을 대상으로 한 컴퓨터 기반의 인지재활프로그램의 적용이 인지기능과 도구적 일상생활수행능력에 미치는 영향을 알아보고는 것이다. MCI 노인 22명을 실험군 11명, 대조군 11명으로 무작위 할당하여 진행하였으며, 총 10주간, 주 3회, 회기당 30분씩 실험군은 CoTras, 대조군은 전통적 인지 재활을 받았다. 중재 전후로 인지기능과 수단적 일상생활활동의 수행 능력애 대한 변화를 알아보기 위해 NCSE와 K-IADL을 사용하였다. 연구 결과, 실험군은 집중력과 기억력을 포함한 전반적인 인지기능과 수단적 일상생활활동의 수행능력의 향상을 보였다. 지역사회 경도인지장애 노인들을 대상으로 인지기능과 수단적 일상생활활동의 수행능력 증진을 위해 CoTras의 적용을 고려해 볼 수 있을 것이다.

• 대한물리의학회지
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• 제18권2호
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• pp.103-114
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• 2023

PURPOSE: This study compared the effects of computer-based and virtual reality-based cognitive rehabilitation programs on the cognitive function, upper limb function, activities of daily living, and their impact on the prefrontal cortex in convalescent stroke patients. METHODS: Ten recovering stroke patients were assessed for their cognitive function, upper limb function, and daily living activities using the Neurobehavioral Cognitive Status Examination, the Korean version of the Fugl-Meyer Assessment, and the Korean version of the Modified Barthel Index. The prefrontal cortex activity was measured with functional Near Infrared Spectroscopy. The virtual reality-based cognitive rehabilitation group utilized a program of daily living activities delivered via a laptop and Oculus Rift. The computer-based cognitive rehabilitation group performed various cognitive tasks on an all-in-one PC. Both groups underwent cognitive rehabilitation training for 30 minutes per day, three times a week, for six weeks, with identical conventional rehabilitation therapies in the hospital. RESULTS: Both programs positively impacted the cognitive and physical functions. On the other hand, the virtual reality-based cognitive rehabilitation program had a larger influence on improving the cognitive and physical functions of convalescing stroke patients. CONCLUSION: The virtual reality program suggests its potential to enhance cognitive and physical functions in convalescent stroke patients through increased engagement, focus, real-time feedback, and game elements, making it a promising rehabilitation approach.

• 한국산학기술학회논문지
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• 제15권5호
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• pp.2946-2952
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• 2014

본 연구는 고령사회를 앞두고 증가하고 있는 노인들의 자동차 운전에 대한 실태를 확인하고 향후 노인들의 안전한 자동차 운전에 대한 연구를 하는데 기초적인 자료로 사용하고자 하는 목적을 가지고 있다. P시에 소재하고 있는 노인복지관을 이용하고 있는 노인 128명을 대상으로 설문조사를 실시하였다. 설문조사를 통해서 노인들의 자가운전 현황을 파악하고, 자가운전을 하고 있다고 응답한 41명의 노인들을 대상으로 인지기능을 확인할 수 있는 한국판 몬트리올 인지기능평가(Montreal Cognitive Assessment Korean Version; MoCA-K)와 신경행동학적 인지상태 검사(neurobehavioral cognitive status examination; NCSE)를 실시하였다. 연구결과 대상 노인의 32%가 자동차운전을 하고 있었으며 매일 운전을 하는 경우(56.1%)가 가장 많고, 운전시간은 하루 1-2시간 정도(56.1%) 운전을 하는 경우가 가장 많았다. 차량사용목적으로는 여가활동(46.3%)에 많이 이용을 하였으며, 사고경험이 있는 노인은 31.7%였다. 인지기능검사 결과 개인에 따라서 특정항목에서 평균이하의 점수를 획득하는 경우가 있어 안전한 자동차 운전에 영향을 줄 수 있다는 것을 알 수 있었다. 그러므로 노인들의 안전한 자동차 운전을 위해서는 노인의 감소된 능력을 정확하게 측정할 수 있는 체계적인 평가시스템과 부족한 부분에 대해서 보완할 수 있는 운전재교육시스템의 의무화가 필요할 것으로 생각된다. 또한 향후 운전면허관리제도 및 갱신과 같은 노인의 운전을 위한 정부차원의 제도적 접근도 필요할 것이다.

• 대한한방내과학회지
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• 제32권1호
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• pp.43-55
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• 2011

Objectives : Sokmyeung-tang(SMT) has been used for treatment of CVA in traditional oriental medicine, so this study was designed to evaluate the effect of SMT's protection on brain cell damage against the oxidative stress that was affected by CVA, We also investigated the effect of motor function improvement and neurotrophic factor in ischemic cerebral damaged rats. Methods : We measured cell viability after administrating SMT, chemicals(Paraquat, SNP, rotenone, and $H_2O_2$) which cause oxidative stress, and both SMT and chemicals. We carried out neurobehavioral evaluation(Rotarod test, Beam-walking test, postural reflex test) and observed BDNF (brain-derived neurotrophic factor) expression by injecting SMT into ischemic cerebral damaged rat. Results : Through this study, we observed the following three results. First, brain cell death caused by paraquat, rotenone, and $H_2O_2$ significantly decreased with the treatment of SMT. Second, neuronal movement function in ischemic cerebral damaged rats was significantly improved by the treatment of SMT. Third, BDNF in ischemic cerebral damaged rats increased with the treatment of SMT. Conclusions : SMT protects brain cells from damage induced by oxidative stress (Paraquat, rotenone, $H_2O_2$). SMT also improves neuronal movement function and increases BDNF in ischemic cerebral damaged rats.

• 한국산학기술학회논문지
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• 제18권5호
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• pp.355-365
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• 2017

본 연구의 목적은 급성기 뇌졸중 환자를 대상으로 수공예 작업치료 프로그램 활동을 시행하였을 때 인지기능과 손 기능에 미치는 효과를 알아보고, 추후 급성기 뇌졸중 환자의 중재방법에 대한 유용한 자료를 제공하는 것이다. 본 연구의 진행은 서울 경기도에 위치한 A종합병원, B재활병원에 입원 중인 뇌졸중 환자 30명을 대상으로 2016년 3월부터 2016년 11월까지 두 그룹을 무작위 할당한 후 실험군에는 수공예 프로그램 활동을 4주 동안 주 2회, 30분간 적용하고 그룹 간 비교를 실시하였다. 치료 전 후에 뇌졸중 환자의 인지기능과 손 기능을 평가하기 위해서 사용한 평가도구는 Box & Block Test, Jebsen-Taylor Hand Function Test, Neurobehavioral Cognitive Status Examination(NCSE), Trail-Making Test이다. 결론적으로 중재 전 후 비교에서 수공예 프로그램 활동군의 손 기능 평가가 유의하게 향상되었고(p<.05), 인지기능도 유의하게 향상되었다(p<.05). 본 연구의 결과를 통해서 수공예 프로그램 활동이 급성기 뇌졸중 환자의 인지기능과 손 기능 향상에 더 효과적임을 파악한 점에서 연구의 의의를 지니며, 향후 급성기 뇌졸중 환자의 작업치료 중재 프로그램의 개발 및 적용 시 기초자료로 의미있게 활용될 수 있을 것이다.

• 대한통합의학회지
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• 제9권4호
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• pp.201-210
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• 2021

Purpose : There is a lack of research on this field in the Republic of Korea, especially those that have seen the effect of interaction between transcranial direct current stimulation and computerized cognitive rehabilitation therapy. This study divided 30 dementia patients into a treatment group, which received transcranial direct current stimulation and computerized cognitive rehabilitation, and a control group, which received pseudo-transcranial direct current stimulation and pseudo-computerized cognitive rehabilitation. This study evaluated the effects of these treatments on the visual perception, cognition functions, and daily activities of dementia patients. Methods : Fifteen subjects were allocated to the treatment group and the other 15 subjects were allocated to the control group. Treatments were given at intervals of five sessions per week (30 minutes per session) for six weeks (30 times in total). This study used the Neurobehavioral Cognitive Status Examination (NCSE) to examine cognitive functions, MVPT to evaluate visual perception, and FIM to test daily living activities before and after applying the treatments. Results : The results of this study showed that cognitive functions, visual perception, and daily living activities significantly (p<.05) improved after the intervention in the treatment group and the control group. The changes in cognitive functions, visual perception, and daily living activities due to the treatments were significantly different between the groups (p<.05). Conclusion : The results indicated that transcranial direct current stimulation and computerized cognitive rehabilitation therapy improved visual perception and daily living activities by increasing cognitive functions. Consequently, it was found that the simultaneous application of transcranial direct current stimulation in conjunction with a computerized cognitive rehabilitation program was an intervention method that could positively affect the visual perception, cognitive function, and daily living activities of dementia patients. Based on the results of this study, the study of arbitration protocols for demential will have to be more active.

• 국제물리치료학회지
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• 제3권1호
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• pp.345-355
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• 2012

This study purposed to examine the effect of low power laser on pain response and axonal regeneration. In order to prepare peripheral nerve injury models, we crushed the sciatic nerve of Sprague-Dawley rats and treated them with low power laser for 21 days. The rats were divided into 4 groups: normal group(n=10); control group(n=10) without any treatment after the induction of sciatic nerve crush injury; experimental group I(n=10) treated with low power laser(0.21$mJ/mm^2$) after the induction of sciatic nerve crush injury; and experimental group II(n=10) treated with low power laser(5.25$mJ/mm^2$) after the induction of sciatic nerve crush injury. We measured spontaneous pain behavior(paw withdrawal latency test) and mechanical allodynia(von Frey filament test) for evaluating pain behavioral response, and measured the sciatic function index for evaluating the functional recovery of peripheral nerve before the induction of sciatic nerve crush injury and on day 1, 7, 14 and 21 after the induction. After the experiment was completed, changes in the H & E stain and toluidine blue stain were examined histopathologically, and changes in MAG(myelin associated glycoprotein) and c-fos were examined immunohistologically. According to the results of this study, when low power laser was applied to rat models with sciatic nerve crush injury for 21 days and the results were examined through pain behavior evaluation and neurobehavioral, histopathological and immunohistological analyses, low power laser was found to affect pain response and axonal regeneration in both experimental group I and experimental group II. Moreover, the effect on pain response and axonal regeneration was more positive in experimental group I to which output 0.21$mJ/mm^2$ was applied than in experimental group II to which 5.25$mJ/mm^2$ was applied.

• 대한한방내과학회지
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• 제41권3호
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• pp.326-338
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• 2020

Background: Alzheimer's disease (AD) is a chronic neurodegenerative disease that causes disorientation, mood swings, problems with language, and difficulty remembering recent events. Acetylcholinesterase inhibitors (AchEIs) and memantine have been used to slow the course of the disease, but they can neither modify its progression nor prevent disease onset. Previous studies have suggested that Kami-guibi-tang (KGT) could be beneficial for supporting cognitive function in AD patients, but few clinical trials have been published. This pilot study aimed to evaluate the effect of KGT in improving cognitive function in AD patients. Methods: The study will be a randomized, placebo-controlled, double-blind, single-center trial conducted using subjects diagnosed with mild AD by neurologists. Study subjects will be randomly assigned to either a treatment or control group. The treatment group will receive KGT granules for 24 weeks, while the control group will receive placebo granules. AchEI administration will be maintained in both groups during the entirety of the study. Subjects will be assessed using the following exams: the Seoul Neuropsychologic Screening Battery (SNSB) for cognitive function; brain magnetic resonance imaging (MRI) for brain metabolite, neurotransmitter, and cerebral blood flow (CBF) measurements; the Korean version of Quality of Life-Alzheimer's Disease (KQol-AD) for quality of life; the Caregiver-Administered Neuropsychiatric Inventory (CGA-NPI) for neurobehavioral symptoms; blood tests for amyloid and tau proteins and general blood parameters; and electrocardiography (ECG) before and after taking the medication. Discussion: Our findings will provide insight into the feasibility of large-scale trials to consolidate evidence for the efficacy of KGT for dementia treatment. Registration ID in CRIS: KCT0002904 (Clinical Research Information Service of the Republic of Korea).

• Annals of Clinical Neurophysiology
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• 제16권2호
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• pp.62-69
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• 2014

Background: Neuromodulation therapy has been used to an adjunctive treatment promoting motor recovery in stroke patients. The objective of the study was to determine the effect of repetitive transcranial magnetic stimulation (rTMS) on neurobehavioral recovery and evoked potentials in rats with middle cerebral artery occlusion. Methods: Seventy Sprague-Daley rats were induced permanent middle cerebral artery occlusion (MCAO) stroke model and successful stroke rats (n=56) assigned to the rTMS (n=28) and sham (n=28) group. The 10 Hz, high frequency rTMS gave on ipsilesional forepaw motor cortex during 2 weeks in rTMS group. The somatosensory evoked potential (SSEP) and motor evoked potential (MEP) were used to evaluate the electrophysiological changes. Behavioral function of the stroke rat was evaluated by the Rota rod and Garcia test. Results: Forty rats ($N_{rTMS}=20;\;N_{sham}=20$) completed all experimental course. The rTMS group showed better performance than sham group in Rota rod test and Garcia test at day 11 (p<0.05) but not day 18 (p>0.05). The amplitude of MEP and SSEP in rTMS group was larger than sham group at day 18 (p<0.05). Conclusions: These data confirm that the high frequency rTMS on ipsilesional cerebral motor cortex can help the early recovery of motor performance in permanent middle cerebral artery stroke model and it may simultaneously associate with changes in neurophysiological activity in brain.

• Biomolecules & Therapeutics
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• 제25권2호
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• pp.149-157
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• 2017

The interleukin-1 receptor antagonist (IL-1RA) is a potential stroke treatment candidate. Intranasal delivery is a novel method thereby a therapeutic protein can be penetrated into the brain parenchyma by bypassing the blood-brain barrier. Thus, this study tested whether intranasal IL-1RA can provide neuroprotection and brain penetration in transient cerebral ischemia. In male Sprague-Dawley rats, focal cerebral ischemia was induced by middle cerebral artery occlusion (MCAO) for 1 h. The rats simultaneously received 50 mg/kg human IL-1RA through the intranasal (IN group) or intraperitoneal route (IP group). The other rats were given 0.5 mL/kg normal saline (EC group). Neurobehavioral function, infarct size, and the concentration of the administered human IL-1RA in the brain tissue were assessed. In addition, the cellular distribution of intranasal IL-1RA in the brain and its effect on proinflammatory cytokines expression were evaluated. Intranasal IL-1RA improved neurological deficit and reduced infarct size until 7 days after MCAO (p<0.05). The concentrations of the human IL-1RA in the brain tissue 24 h after MCAO were significantly greater in the IN group than in the IP group (p<0.05). The human IL-1RA was confirmed to be co-localized with neuron and microglia. Furthermore, the IN group had lower expression of $interleukin-1{\beta}$ and tumor necrosis $factor-{\alpha}$ at 6 h after MCAO than the EC group (p<0.05). These results suggest that intranasal IL-1RA can reach the brain parenchyma more efficiently and provide superior neuroprotection in the transient focal cerebral ischemia.