• 한국전자통신학회논문지
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• 제5권3호
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• pp.262-268
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• 2010

본 논문은 카메라의 고정 초점방식 렌즈를 통해 얻은 영상의 왜곡을 보상하여 왜곡된 이미지 좌표에서 본래의 좌표를 갖는 원영상으로 복원하는 연구이다. 이미지 센서의 다양한 영상 기기 발달과 활용으로 다방면의 산업분야에 확대 이용되고 있으나, 카메라의 소형화와 경량화 필요로 인해 렌즈의 굴곡에 의한 수신 영상의 왜곡이 영향을 미치는 경향이 많다. 특히, 입체 영상 카메라 응용 기기인 경우 좌, 우측 렌즈의 서로 다른 왜곡으로 입체감 저하 및 좌우 이미지 왜곡 등이 수반된다. 좌, 우측 카메라 수신 영상의 각 부분별로 본래의 좌표로 환산하는 근사식을 세우고 이들을 종합하는 방식으로 접근했다. 적응 뉴로-퍼지 추론시스템을 구성하여 소속 함수를 통해 분할하고 1차 Sugeno fuzzy 모델식으로 추정하여 좌, 우측 본래의 영상에 근접한 결과를 얻었다. 이로서 저가이며 소형 렌즈를 활용한 영상으로도 정확한 입체 영상 센싱 기능과 판별을 기대할 수 있게 된다.

• 대한핵의학회지
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• 제32권6호
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• pp.534-541
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• 1998

We describe a 27-year-old man who developed gait disturbance and dysarthria 2 years after the onset of cardinal symptoms of Behcet's disease. Positron emission tomography with $^{18}F$-fluorodeoxyglucose revealed severe hypometabolisrn in the cerebellum, in accordance with cerebellar symptoms and signs of the patient. However, single-photon emission tomography with $^{99m}Tc$-HMPAO and $^{99m}Tc$-ECD did not disclose significant perfusion abnormalities in the brain. Routine brain magnetic resonance imaging did not show signal abnormalities. The findings of imaging studies compared with neurological manifestations of the patient are discussed.

• Journal of Korean Neurosurgical Society
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• 제66권4호
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• pp.465-475
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• 2023

Objective : Our objective is to analyze the occurrence, clinical course and risk factors for glioma patients with leptomeningeal metastasis (LM) according to different metastasis patterns and clinical variables. Methods : We retrospectively reviewed data from 376 World Health Organization (WHO) grade II-IV adult glioma patients who were treated in the National Cancer Center from 2001 to 2020. Patients who underwent surgery at other institutions, those without initial images or those with pathologically unconfirmed cases were excluded. LM was diagnosed based on magnetic resonance imaging (MRI) findings or cerebrospinal fluid (CSF) cytology. The metastasis pattern was categorized as nodular or linear according to the enhancement pattern. Tumor proximity to the CSF space was classified as involved or separated, whereas location of the tumor was dichotomized as midline, for tumors residing in the thalamus, basal ganglia and brainstem, or lateral, for tumors residing in the cerebral and cerebellar hemispheres. Results : A total of 138 patients were enrolled in the study. A total of 44 patients (38%) were diagnosed with LM during a median follow-up of 9 months (range, 0-60). Among the clinical variables, tumor proximity to CSF space, the location of the tumor and the WHO grade were significant factors for LM development in univariate analysis. In multivariate analysis, the midline location of the tumor and WHO grade IV gliomas were the most significant factor for LM development. The hazard ratio was 2.624 for midline located gliomas (95% confidence interval [CI], 1.384-4.974; p=0.003) and 3.008 for WHO grade IV gliomas (95% CI, 1.379-6.561; p=0.006). Conclusion : Midline location and histological grading are an important factor for LM in glioma patients. The proximity to the CSF circulation pathway is also an important factor for WHO grade IV glioma LM. Patients carrying high risks should be followed up more thoroughly.

• Brain Tumor Research and Treatment
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• 제6권2호
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• pp.60-67
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• 2018

Background Recently, modern technology such as diffusion tensor imaging (DTI), neuro-navigation and intraoperative neurophysiological monitoring (IOM) have been actively adopted for the treatment of thalamic tumors. We evaluated surgical outcomes and efficacy of the aforementioned technologies for the treatment of pediatric thalamic tumors. Methods We retrospectively reviewed clinical data from 37 children with thalamic tumors between 2004 and 2017. There were 44 operations (27 tumor resections, 17 biopsies). DTI was employed in 17 cases, neuro-navigation in 23 cases and IOM in 14 cases. All diagnoses were revised according to the 2016 World Health Organization Classification of Tumors of the Central Nervous System. Progression-free survival (PFS) and overall survival (OS) rates were calculated, and relevant prognostic factors were analyzed. The median follow-up duration was 19 months. Results Fifteen cases were gross total resections (GTR), 6 subtotal resections (STR), and 6 partial resections (PR). Neurological status did not worsen after 22 tumor resections. There were statistically significant differences in terms of the extent of resection between the groups with DTI, neuro-navigation and IOM (n=12, GTR or STR=12) and the group without at least one of the three techniques (n= 15, GTR or STR=9, p=0.020). The mean PFS was $87.2{\pm}38.0$ months, and the mean OS $90.7{\pm}36.1$ months. The 5-year PFS was 37%, and the 5-year OS 47%. The histological grade ($p{\leq}0.001$) and adjuvant therapy (done vs. not done, p=0.016) were significantly related to longer PFS. The histological grade (p=0.002) and the extent of removal (GTR/STR vs. PR/biopsy, p=0.047) were significantly related to longer OS. Conclusion Maximal surgical resection was achieved with acceptable morbidity in children with thalamic tumors by employing DTI, neuro-navigation and IOM. Maximal tumor resection was a relevant clinical factor affecting OS; therefore, it should be considered the initial therapeutic option for pediatric thalamic tumors.

• 대한핵의학회지
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• 제38권2호
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• pp.111-114
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• 2004

Molecular imaging provides a visualization of normal as well as abnormal cellular processes at a molecular or genetic level rather than at a anatomical level. Conventional medical imaging methods utilize the imaging signals produced by nonspecific physico-chemical interaction. However, molecular imaging methods utilize the imaging signals derived from specific cellular or molecular events. Because molecular and genetic changes precede anatomical change in the course of disease development, molecular imaging can detect early events in disease progression. in the near future, through molecular imaging we can understand basic mechanisms of disease, and diagnose earlier and, subsequently, treat earlier intractable diseases such as cancer, neuro-degenerative diseases, and immunologic disorders. In beginning period, nuclear medicine started as a molecular imaging, and has had a leading role in the field of molecular imaging. But recently molecular imaging has been rapidly developed. Besides nuclear imaging, molecular imaging methods such as optical imaging, magnetic resonance imaging are emerging. Each imaging modalities have their advantages and weaknesses. The opportunities from molecular imaging look bright. We should try nuclear medicine continues to have a leading role in molecular imaging.

• Clinical and Experimental Pediatrics
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• 제55권9호
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• pp.354-357
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• 2012

Behçet disease (BD) is rare in childhood. We report a 9-year-old boy with neuro-Behçet disease who presented diplopia and weakness on the left side after a cerebral concussion. Brain magnetic resonance imaging (MRI) revealed hyperintensity of the right mesodiencephalic junction on T2-weighted and fluid attenuated inversion recovery images. Prednisolone administration resulted in complete remission and normalization of abnormal MRI finding. Brain MRI is a useful diagnostic tool when the neurological sign is the first symptom of subclinical BD.

• Journal of Korean Neurosurgical Society
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• 제52권5호
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• pp.488-490
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• 2012

Behçet's disease (BD) is an inflammatory systemic disorder with oral and genital ulcers, as well as ophthalmologic and cutaneous symptoms. Neurological manifestations in BD represent between 2.2% to 50% of the cases. The 25-year-old male patient, diagnosed with BD three years earlier, was admitted to our clinic with complaints of recurrent headaches. Tumor-like-parenchimal involvement was detected on a cranial magnetic resonance imaging. The lesion was removed surgically and then he suffered from right hemiparesis and epilepsy. Pathological examination of the lesion noted a demyelinating non-tumoural etiology. A neuro-Beh$\check{g}$et's case with parenchymal involvement has been examined in light of the literature, in terms of a tumor and a demyelinating disease differential diagnosis.

• 한국엔터테인먼트산업학회논문지
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• 제15권5호
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• pp.45-53
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• 2021

디지털 몰핑은 영화의 내러티브를 효과적으로 표현하면서 현실 넘어서는 상상을 사실로 구현한다. <블랙 스완>(2013)에서 디지털적으로 구현된 몰핑 이미지는 포스트 시네마로서 오늘날 영화의 특징을 잘 보여주고 있는데, 컴퓨터 기술을 적극적으로 활용해 마술 같은 환각적 이미지를 제공한다. 디지털 몰핑 기술은 주인공이 발레를 추는 동안 기괴하게 변형되어 가는 신체를 현실과 환영이 구분되지 않게 제시함으로써 충격을 준다. 이러한 이미지는 어트랙션 효과로 그치지 않고 신자유주의 시대의 강도를 정동의 흐름으로 가시화해 낸다. 신체 변형의 기이한 효과는 신자유주의 현실의 징후인 것이다. 또한 이러한 몰핑 이미지는 파트리샤 피스터스가 말한 신경-이미지 체제의 부상을 말해준다. 디지털 스크린에 나타난 신경 병리학적인 양상들은 신경-이미지에 해당되는 것으로, 들뢰즈의 시간-이미지 체제를 넘어서 미래의 시간성을 띤다. <블랙 스완>의 몰핑의 경우 니나의 신체가 흑조와 혼종화 되어서 계속적으로 변화하는 동안 신경-이미지적인 특성이 두드러지게 나타난다. 신경 이미지로서 이 영화의 디지털 몰핑은 주체가 겪는 현실의 충격을 조절하는 효과를 지닌다. 이 영화의 몰핑은 디지털 시대의 사회적 통제의 효과이자 그 통제를 조절하는 포스트 시네마의 역량을 보여주고 있다.

• 한국멀티미디어학회논문지
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• 제18권12호
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• pp.1445-1452
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• 2015

In these days, fluorescent materials such as ICG or 5-ALA is used for the brain surgery. The patients who underwent brain tumor surgery has been increased during last 30 years and the survivorship rate increased 22∼33% in 5 years. Recently, the Fluorescence induction surgery is developed for more safety and improved the resection rate for the glioma in the neurosurgery field. In this study, we proposed fluorescence area detection method for ICG and 5-ALA fluorescence induced surgery using acquired images from image processing. Accuracy was 99.21% from ICG images, and 99.51% from 5-ALA images. Matthews correlation coefficient was 88.67% from ICG images, and 90.49% from 5-ALA images.

• 대한핵의학회지
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• 제38권2호
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• pp.115-120
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• 2004

Molecular imaging is a rapidly growing field due to the advances in molecular biology and imaging technologies. With the introduction of imaging reporter genes into the cell, diverse cellular processes can be monitored, quantified and imaged non-invasively in vivo. These precesses include the gene expression, protein-protein interactions, signal transduction pathways, and monitoring of cells such as cancer cells, immune cells, and stem cells. In the near future, molecular imaging analysis will allow us to observe the incipience and progression of the disease. These will make us easier to give a diagnosis in the early stage of intractable diseases such as canter, neuro-degenerative disease, and immunological disorders. Additionally, molecular imaging method will be a valuable tool for the real-time evaluation of cells in molecular biology and the basic biological studies. As newer and more powerful molecular imaging tools become available, it will be necessary to corporate clinicians, molecular biologists and biochemists for the planning, interpretation, and application of these techniques to their fullest potential. in order for such a multidisciplinary team to be effective, it is essential that a common understanding of basic biochemical and molecular biologic techniques is achieved. Basic molecular techniques for molecular imaging methods are presented in this paper.