• Korean Journal of Veterinary Service
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• v.40 no.2
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• pp.139-142
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• 2017

A six-year-old male captive nutria (Myocastor coypus) maintained in a closed space with a small vent was found dead in his cage. Gross findings showed multifocal nodules in varying sizes, small 0.5 to large 5 cm in diameter, intermixed with normal parenchyma were scattered all over the surface of the lungs and a kidney, which the cut surface was smooth, compact and whitish in color. Microscopically, small round to oval neoplastic cells with modest to slight amounts of cytoplasm formed acinar and gland-like structures. Immunohistochemically, cells were strongly positive for E-cadherin and slightly reactive for thyroid transcription factor-1 (TTF-1). Based on those diagnostic features, the neoplasia was diagnosed as primary pulmonary adenocarcinoma (small cell type) and metastasized into the kidney. This is the first case report of malignant pulmonary tumor and its metastasis in the nutria.

• Journal of Plant Biology
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• v.33 no.3
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• pp.211-215
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• 1990

There is a family of homologous proteins known to small GTP-inding proteins which have a GTP binding domains and GTPase activity with molecular weight of about 20000 in mammalian tissues. Recently at least 20 different small GTP-binding proteins including three rasproto-oncogene, smg25, rho, and ral gene products were identified. These proteins play a central role in cellular prolifration, neoplasia, signal transduction, terminal differentiation, and secretory process of the cells. In this review, I have briefly compiled current information on the different areas of research in the small GTP-binding proteins in an attempt to convey an overall view of the fundamental role that this family of protein in normal cellular processes. Moreover, furture goals of research in the small GTP-binding proteins as well as the possible existence of this family of proteins in plant cells were discussed.

• Journal of Veterinary Clinics
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• v.19 no.3
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• pp.353-356
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• 2002

A 9-year-old male Yorkshire terrior with recurrent chronic otitis externa and otitis interna was referred to the Veterinary Medical Teaching Hospital of Seoul National University. Radiographic findings indicated mineralization around the right ear canal. A tan nodular mats, 1 cm in diameter. was noted near the tympanum after total ear canal ablation. Cytologically. the imprint smear of the cut surface of the mass produced clusters of cells with abundant and weakly basophilic cytoplasm, one small round nucleus and one or two nucleoli, mixed with both degenerate and non degenerate neutrophils. The location of the nuclei was eccentric, and some cells contained somewhat coarse black granules in their cytoplasms, on which the mass was diagnoted as ceruminous gland adenoma or hyperplasia associated with inflammation. Histopathologic examination of the tumor was compatible with a diagnosit of ceruminous gland adenoma. The patient is responding well to sugery and antimicrobial treatment.

• Journal of Veterinary Clinics
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• v.20 no.4
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• pp.474-477
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• 2003

This study comprised 13 cases having canine perianal adenoma at Veterinary Medical T~aching Hospital, Seoul National University from January 2000 to October 2003. All referred dogs were intact male and mean age of dogs was 11.5 years (ranged from 7 to 15 years). The most prevalent breed was Shih Tzu. The clinical signs were presence of 1 to 5 cm in diameter firm mass, perianal swelling, hemorrhage, pain and dyschezia. The masses were located either in the perineum (12 cases) or tail (5 cases). Five dogs had masses with ulceration. Concurrent prostatomegaly and seminoma was found in 5 and 1, respectively. Castration was performed in 5 cases. In 8 cases, surgical excision of the tumor was performed with castration. There was no recurrence in all cases after removal. In all cases with castration, perianal adenomas were regressed within 1-2 months. In one case among them, excision of the tumor was also performed because of persistent ulceration. According to these clinical results, perianal adenoma excellently responded to castration with or without surgical excision of the tumor.

• Preventive Nutrition and Food Science
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• v.2 no.2
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• pp.180-190
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• 1997

Garlic (Alium sativum L.), originated in the Kirghiz region of Central Asia, is oneof the oldest cultivated plants. It has reached Europe via Egypt in the days of Pharaohs. Since then, the legendary medicinal properties attributed to garlic have attracted human interests for thousands of years. However, the research on the medicinal effect of garlic, mostly on this anticarcinogenic actions has been systematically performed only for the last tow or three decades. Many researches have proven that garlic inhibits neoplasia elicited by chemical carcinogens using in vitro or in vivo experimental systems. Attention has recently been focused on assessing the therapeutic or chemopreventive measures of garlic compounds against carcinogenesis in animals. The active principles of he garlic extract, mainly the sulfur compounds and their derivatives have been deeply scrutinized into their chemical, functional and medicinal properties.

• Korean Journal of Veterinary Research
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• v.59 no.1
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• pp.47-49
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• 2019

A renal oncocytoma was diagnosed in an 8-year-old female Maltese dog with a history of renal cysts. Tumor cells were not detected until six months after observation of renal cysts. Nephrectomy was performed to treat the neoplasia. Tumor-like masses with numerous nodules were observed in the inner surface of cysts present in the caudal part of the left kidney. Histologically, the tumor consisted of cells with abundant eosinophilic cytoplasm. The diagnosis was based on histological features, periodic acid-Schiff reaction, and immunohistochemical cytokeratin staining. Based on a literature review, this is the first canine renal oncocytoma case reported in Korea.

• Kosin Medical Journal
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• v.33 no.3
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• pp.446-453
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• 2018

Pheochromocytomas might be sporadic or genetic. Genetic pheochromocytoma is associated with multiple endocrine neoplasia (MEN) type 2A, MEN type 2B, and von Hippel-Lindau (VHL) disease. RET mutations are identified in more than 90% of index cases of MEN2 and familial medullary thyroid cancer and in about 4-12% of apparent sporadic cases. Here, we report a 54-year-old man presenting with pheochromocytoma and renal cell carcinoma, who was identified as having a novel missense RET mutation.

• Journal of Digestive Cancer Reports
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• v.8 no.2
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• pp.77-80
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• 2020

Gastric cancer is one of the leading causes of cancer-related deaths worldwide. The increased expression of cyclooxygenase (COX)-2 has been implicated in the development and progression of gastric cancers. A number of recent studies have been published evaluating the chemopreventive effect of aspirin and non steroidal anti inflammatory drungs (NSAIDs) against gastric cancer. Aspirin and NSAIDs use may reduce the risk of gastric cancer incidence and death, whereas other studies have reported contradictory results. Therefore, further study should be needed to clarify the role of aspirin and NSAIDs in the chemoprevention of gastric cancer.

• Journal of Veterinary Science
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• v.21 no.1
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• pp.3.1-3.8
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• 2020

A 12-year-old Warmblood mare was presented with an acute onset left hindlimb lameness associated with generalised soft tissue swelling of the entire limb and medial saphenous vein (MSV) thrombophlebitis. A presumptive diagnosis of extremity compartment syndrome (ECS) was made. Due to the clinical deterioration, emergency fasciotomy of the crural fascia and biopsy was performed. Histological and immunohistochemical examination of the samples confirmed a diagnosis of leiomyosarcoma likely originating from the tunica media of the MSV. This report is the first to describe an unique combination of ECS and thrombophlebitis associated with a leiomyosarcoma in a horse.

• Journal of the Korean Burn Society
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• v.24 no.1
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• pp.18-20
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• 2021

TCA is widely used in cosmetic treatments such as chemical peels, tattoo removal, and also in gynecological procedures for managing cervical intraepithelial neoplasia. However, storage of high concentration of TCA in a gynecology office is a potential hazard, as it may accidentally cause severe chemical burns. We report a case of deep dermal TCA chemical burn on genital area, which occured accidentally and resulted from misuse of high concentration (90%) of TCA coated vaginal gauze packing dressing during gynecological procedures.