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Upregulation and Clinicopathological Significance of Long Non-coding NEAT1 RNA in NSCLC Tissues

  • Pan, Lin-Jiang;Zhong, Teng-Fei;Tang, Rui-Xue;Li, Ping;Dang, Yi-Wu;Huang, Su-Ning;Chen, Gang
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.7
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    • pp.2851-2855
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    • 2015
  • Background: Recent reports have shown that nuclear enriched abundant transcript 1 (NEAT1), a long noncoding RNA (lncRNA), contributes to the precise control of gene expression and is related to several human malignancies. However, limited data are available on the expression and function of NEAT1 in lung cancer. The major objective of the current study was to profile the expression and clinicopathological significance of NEAT1 in non-small cell lung cancers (NSCLCs). Materials and Methods: NEAT1 expression in 125 NSCLC cases and paired adjacent non-cancer tissues was assessed by real-time quantitative reverse transcription-PCR (qRT-PCR). Relationships between NEAT1 and clinicopathological factors were also investigated. Results: The relative level of NEAT1 was $6.98{\pm}3.74$ in NSCLC tissues, significantly elevated as compared to that of the adjacent non-cancer lung tissues ($4.83{\pm}2.98$, p<0.001). The area under curve (AUC) of high expression of NEAT1 to diagnose NSCLC was 0.684 (95% CI: 0.619~0.750, p<0.001). NEAT1 expression was positively correlated with patient age (r=-2.007, p=0.047), lymphatic metastasis (r=-2.731, p=0.007), vascular invasion (r=-3.617, p=0.001) and clinical TNM stage (r=-4.134, p<0.001). Conclusions: This study indicates that NEAT1 might be associated with oncogenesis and progression in NSCLC, and suggests application in molecular targeted therapy.

Prediction of non-exercise activity thermogenesis (NEAT) using multiple linear regression in healthy Korean adults: a preliminary study

  • Jung, Won-Sang;Park, Hun-Young;Kim, Sung-Woo;Kim, Jisu;Hwang, Hyejung;Lim, Kiwon
    • Korean Journal of Exercise Nutrition
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    • v.25 no.1
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    • pp.23-29
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    • 2021
  • [Purpose] This preliminary study aimed to develop a regression model to estimate the non-exercise activity thermogenesis (NEAT) of Korean adults using various easy-to-measure dependent variables. [Methods] NEAT was measured in 71 healthy adults (male n = 29; female n = 42). Statistical analysis was performed to develop a NEAT estimation regression model using the stepwise regression method. [Results] We confirmed that ageA, weightB, heart rate (HR)_averageC, weight × HR_averageD, weight × HR_sumE, systolic blood pressure (SBP) × HR_restF, fat mass ÷ height2G, gender × HR_averageH, and gender × weight × HR_sumI were important variables in various NEAT activity regression models. There was no significant difference between the measured NEAT values obtained using a metabolic gas analyzer and the predicted NEAT. [Conclusion] This preliminary study developed a regression model to estimate the NEAT in healthy Korean adults. The regression model was as follows: sitting = 1.431 - 0.013 × (A) + 0.00014 × (D) - 0.00005 × (F) + 0.006 × (H); leg jiggling = 1.102 - 0.011 × (A) + 0.013 × (B) + 0.005 × (H); standing = 1.713 - 0.013 × (A) + 0.0000017 × (I); 4.5 km/h walking = 0.864 + 0.035 × (B) + 0.0000041 × (E); 6.0 km/h walking = 4.029 - 0.024 × (C) + 0.00071 × (D); climbing up 1 stair = 1.308 - 0.016 × (A) + 0.00035 × (D) - 0.000085 × (F) - 0.098 × (G); and climbing up 2 stairs = 1.442 - 0.023 × (A) - 0.000093 × (F) - 0.121 × (G) + 0.0000624 × (E).

Isoconversional Cure Kinetics of Modified Urea-Formaldehyde Resins with Additives

  • Park, Byung-Dae
    • Current Research on Agriculture and Life Sciences
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    • v.30 no.1
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    • pp.41-50
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    • 2012
  • As a part of abating formaldehyde emission of urea-formaldehyde resin, this study was conducted to investigate the rmalcure kinetics of both neat and modified urea-formaldehyde resins using differential scanning calorimetry. Neat urea-formaldehyde resins with three different formaldehyde/urea mol ratios (1.4, 1.2 and 1.0) were modified by adding three different additives (sodium bisulfite, sodium hydrosulfite and acrylamide) at two different levels (1 and 3wt%). An isoconversional method at four different heating rates was employed to characterize thermal cure kinetics of these urea-formaldehyde resins to obtain activation energy ($E{\alpha}$) dependent on the degree of conversion (${\alpha}$). The $E{\alpha}$ values of neat urea-formaldehyde resins (formaldehyde/urea = 1.4 and 1.2) consistently changed as the ${\alpha}$ increased. Neat and modified urea-formaldehyde resins of these two F/U mol ratios did show a decrease of the $E{\alpha}$ at the final stage of the conversion while the $E{\alpha}$ of neat urea-formaldehyde resin (formaldehyde/urea = 1.0) increased as the ${\alpha}$ increased, indicating the presence of incomplete cure. However, the change of the $E{\alpha}$ values of all urea-formaldehyde resins was consistent to that of the Ea values. The isoconversional method indicated that thermal cure kinetics of neat and modified urea-formaldehyde resins showed a strong dependence on the resin viscosity as well as diffusion control reaction at the final stage of the conversion.

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A blueprint for designing and developing the listening and the reading test of National English Ability Test (NEAT): Item-types decision-making model (국가영어능력평가시험(NEAT)의 검사지 구성의 원칙과 절차: 문항 유형 확정 모델)

  • Kim, Yong-Myeong
    • English Language & Literature Teaching
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    • v.16 no.4
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    • pp.153-184
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    • 2010
  • On the bases of the 5 principles and the 4 criteria for designing and developing of the listening and the reading test of National English Ability Test (NEAT), this study presents Item-Types Decision-Making Model as a blueprint for designing and constructing the two tests. It sets up the criteria for validating item types, designs a modular type of test specifications, constructs an item-types bank, and specifies a complementary type of test specifications of the two tests. To gather all these threads up, it constructs Item-Types Decision-Making Model which consists of such components as the item-type pool, the validity criteria and the procedures of testing item types, the item-types bank, the modular and the complementary type test specification. Thus, it shows how the Model works in developing and constructing the two level-differentiated listening and reading tests (the 2nd and the 3rd rank) of NEAT. Finally, it discusses some implications and applications of the Model to the two level-differentiated tests (the A and the B type) of 2014 CSAT (College Scholastic Ability Test) systems, National Assessment of Educational Achievement (NAEA), and classroom testing. In conclusion, Item-Types Decision-Making Model functions as a testing template in an item development system and as a matrix in an item-types bank system.

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Synchrotron X-Ray Diffraction Studies on Crystalline Domains in Urea-Formaldehyde Resins at Low Molar Ratio

  • WIBOWO, Eko Setio;PARK, Byung-Dae;CAUSIN, Valerio;HAHN, Dongyup
    • Journal of the Korean Wood Science and Technology
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    • v.50 no.5
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    • pp.353-364
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    • 2022
  • The crystalline domain of thermosetting urea-formaldehyde (UF) resins at low formaldehyde-to-urea (F/U) molar ratios (≤ 1.0) is known to be responsible for their poor performance as wood adhesives. Crystallization has been observed in 1.0 F/U UF resins during the addition reaction stage and at the end of the synthesis process (neat UF resins). The crystallinity and X-ray diffraction (XRD) spectra of the uncured neat UF resins, on the other hand, differed significantly from those of the cured neat UF resins, raising the possibility that their crystal structures were also different. This study demonstrates for the first time that the crystalline domains in 1.0 F/U UF resins generated from uncured and cured samples are identical. Despite having a lower crystallinity value, the synchrotron XRD patterns of purified neat UF resins were equivalent to the XRD patterns of cured neat UF resins. Transmission electron microscope images of the cured UF resins showed that the crystals were lamellar structures. This finding suggests that the crystal at low molar ratio UF resins are isotropic polycrystals with random orientation.

Frequency Analysis of Adaptive Behavior of NEAT based Control for Snake Modular Robot (뱀형 모듈라 로봇을 위한 NEAT 기반 제어의 적응성에 대한 주파수 분석)

  • Lee, Jaemin;Seo, Kisung
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.64 no.9
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    • pp.1356-1362
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    • 2015
  • Modular snake-like robots are robust for failure and have flexible locomotions for obstacle environment than of walking robot. This requires an adaptation capability which is obtained from a learning approach, but has not been analysed as well. In order to investigate the property of adaptation of locomotion for different terrains, NEAT controllers are trained for a flat terrain and tested for obstacle terrains. The input and output characteristics of the adaptation for the neural network controller are analyzed for different terrains in frequency domain.

The visual Effect by physical and clothes design of the mid-aged Korean and American women(II) -Focusing on the psychological visual effects- (한국과 미국 중년 여성의 체형과 의복디자인에 따른 시각효과(II) - 심리적 시각효과를 중심으로 -)

  • Park, Soon-Chun;O'rourke-Kaplan, Marian
    • Fashion & Textile Research Journal
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    • v.11 no.3
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    • pp.371-382
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    • 2009
  • In this study, I examined the psychological visual effect and clothes preference by clothes designs for the mid-aged Korean and American women's somatotypes. The psychological visual effects of each somatotypes' clothes are like these. First, the primary factors for psychological visual effect were analyzed into 5, neat, feminine, polished, modern and active. Second, in thin somatotype, Korean evaluated that china collar and V-neckline are the least feminine, and stand collar is the most polished and the modernest. American evaluated that V-neckline is the most feminine, and tailored collar is the modernest. It shows that there's the difference of culture. In standard somatotype, Korean thought stand collar with pants is the neatest, but tailored collar and china collar with pants are not neat. Contrary, they thought tailored collar with skirt is the neatest and stand collar with skirt is not neat. American thought tailored collar with skirt is the neatest and modernest. The neat visual effects are evaluated differently according to the clothes' styles of bottom. In obesity, Korean evaluated that tailored collar with skirt is the neatest and modernest, but stand collar with skirt is not modern. Stand collar with pants is the modernest, but tailored collar with pants is the least modern and active. American evaluated that round neckline with pants is not neat, modern and active, and round neckline with skirt is the modernest and the most active. So neckline's visual effects are differently showed by culture and the clothes' styles of bottom.

Non-energy Use and $CO_2$ Emissions: NEAT Results for Korea

  • Park, Hi-chun
    • Journal of Energy Engineering
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    • v.11 no.1
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    • pp.34-46
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    • 2002
  • Carbon accounting is a key issue in the discussions on global warming/CO$_2$mitigation. This paper applies both the IPCC Approach and the NEAT (Non-Energy use Emission Accounting Tables) model, a bottom-up approach, to estimate the potential CO$_2$ emissions (carbon storage) originating from the non-energy use as to assess the actual CO$_2$ emissions (carbon release) from the use of fossil fuels in Korea. The current Korean carbon accounting seems to overestimate the potential CO$_2$ emissions and with it to underestimate the actual CO$_2$ emissions. The estimation shows that the potential CO$_2$ emissions calculated according to the IPCC Approach are lower than those calculated using the NEAT model. This is because the IPCC default storage fraction for naphtha seems to be low for the Korean petrochemical production structure, on the one hand and because the IPCC Approach does not consider the trade with short life petrochemical products, on the other hand. This paper shows that a bottom-up approach like the NEAT model can contribute to overcome some of limitations of the IPCC guidelines, especially by considering the international trade with short life petrochemical products and by estimating the storage fractions of fossil fuels used as feedstocks for the country in consideration. This paper emphasizes the importance of accurate energy statistics for carbon accounting.

Locomotion Control of 4 Legged Robot Using HyperNEAT (HyperNEAT를 이용한 4족 보행 로봇의 이동 제어)

  • Jang, Jae-Young;Hyun, Soo-Hwan;Seo, Ki-Sung
    • Journal of the Korean Institute of Intelligent Systems
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    • v.21 no.1
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    • pp.132-137
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    • 2011
  • The walking mobility with stability of 4 legged robots is the distinguished skills for many application areas. Planning gaits of efficient walking for quadruped robots is an important and challenging task. Especially, autonomous generation of locomotion is required to manage various robot models and environments. In this paper, we propose an adaptive locomotion control of 4 legged robot for irregular terrain using HyperNEAT. Generated locomotion is executed and analysed using ODE based Webots simulation for the 4 legged robot which is built by Bioloid.

The performance and emissions of methanol-LPG fueled spark ignition engine (Methanol-LPG연료 전기점화기관의 성능 및 배출물농도)

  • 김응서;조경국
    • Journal of the korean Society of Automotive Engineers
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    • v.7 no.2
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    • pp.64-79
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    • 1985
  • Engine performances and emission characteristics were investigated, using a experimental single cylinder engine with methanol-LPG(butane) fuel blend. The results were compared with the case of neat methanol and gasoline. The blending ratio of methanol to LPG was reasonable at 90 : 10(M90) and in using M90, the engine performances including output, brake specific fuel consumption and brake thermal efficiency, were better than those of neat methanol and gasoline. CO emission of M90 was lower than that of meat methanol by 15% and lower than that of gasoline by 35%. HC emission of M90 was also lower than that of gasoline by 46-85% in the whole range of .phi. The concentration of NOx emission of M90 was lower than that of gasoline and higher than that of neat methanol.

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