• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book II
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• pp.50-59
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• 2003

BMB-CF has been constituted of purified fractions of Scutellaria baicalensis, which has medicinal effect such as anti-microbial. anti-inflammation. fever remedy. anti-oxidation. and anti-aging effect etc.. It has been used in traditional medicine formula from long time ago in the east Asia. It is constituted of the active flavone ingredients such as baicalin. baicalein. DTF(Di-methyl Tetra -hydroxy Flavone), wogonin. wogonoside. $\beta$- Sitosterol. etc.. General purified fractions of Scutellaria baicalensis has the high portion of the baicalin which has the problem of narrow antimicrobial spectrum and compatibility against cosmetic formula. Now. we has been develop the new purificaton process of Scutellaria baicalensis that has the high rate of DTF content, which is improved in antimicrobial activity and cosmetics compatibility. So. we have assure that it is the potent preservative against various cosmetic formula.

• 생약학회지
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• 제42권3호
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• pp.213-217
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• 2011

Platycodon grandiflorum (Campanulaceae) is listed in Shin-Nong-Bon-Cho-Kyung (神農本草經) as the remedy for ventilation the lung, resolving phlegm, promoting pus discharge and subduing carbuncles. The prescriptions of Gil-Gyung-Tang (桔梗湯) are also recorded in many other Chinese medicinal books. The identification of the cultivation year of P. grandiflorum is very important in commercial market as well as in research field. However, any reports about it have not been clearly established yet. To clarify the criterion, the morphological and anatomical characteristics of the roots of P. grandiflorum cultivated in Korea for various years were studied. The characteristics of the cork layer, latex tube, and vessels were shown to be useful keys to confirm the cultivation year of P. grandiflorm. As a result, it was clarified that Kilkyung from Korea was the two years root of Platycodon grandiflorm.

• Natural Product Sciences
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• 제25권3호
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• pp.181-199
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• 2019

Angelica decursiva Fr. et Sav. (Umbelliferae) has traditionally been used to treat different diseases due to its antitussive, analgesic, and antipyretic activities. It is also a remedy for thick phlegm, asthma, and upper respiratory infections. Recently, the leaf of A. decursiva has been consumed as salad without showing any toxicity. This plant is a rich in different types of coumarin derivatives, including dihydroxanthyletin, psoralen, dihydropsoralen, hydroxycoumarin, and dihydropyran. Its crude extracts and pure constituents possess anti-inflammatory, anti-diabetic, anti-Alzheimer disease, anti-hypertension, anti-cancer, antioxidant, anthelmintic, preventing cerebral stroke, and neuroprotective activities. This valuable herb needs to be further studied and developed not only to treat these human diseases, but also to improve human health. This review provides an overview of current knowledge of A. decursiva metabolites and their biological activities to prioritize future studies.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.382.2-382.2
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• 2002

Melanin biosynthesis inhibitors are useful not only for the materials used in cosmetics as skin-whitening agents but also for the remedy of hyperpigmentation. In order to find the new skin-whitening compounds from the natural products. screening of tyrosinase and melanin biosynthesis inhibitory activities in vitro has been carried out. The MeOH extracts and/or fractions of Polygoni multiflori Radix, Dalbergiae odoriferae Lignum. Solnani nigri Herba. Polygoni cuspidati Radix. POlygoni multiflori Ramulus. Salviae Radix showed tyrosinase inhibitory effects. Four methanolic extracts also showed melanin biosynthesis inhibitory effects in B-16 melanoma cell line.

• 동의생리병리학회지
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• 제17권4호
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• pp.969-979
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• 2003

Gamisoamsan is a prescription originated in Soamsan which is known as an anti-cancer remedy in the traditional Korean Medicine. To enhance the synergic effects of anti-cancer activity of Soamsan, this study reconstituted the original components of Soamsan with a slight modification and produced a novel herbal remedy, namely Gamisoamsan. To investigate the effects of Gamisoamsan on anti-cancer reaction, I studied the effects of Gamisoamsan on angiogenesis via chorioallantoic membrane (CAM) assay, corneal neovascularization assay and the effects on expression of growth factor which are VEGF, TGF-β, bFGF and IMUP-1. Anti-cancer effects of Gamisoamsan was also abserved through hematological parameters, tumor volume and survival rate in mice. Gamisoamsan inhibited embryonic angiogenesis of blood vessels in CAM assay and inhibited neovascularization of ral cornea. Gamisoamsan reduced cell proliferation in HT1080 cells and IC50 was 2.18 ㎎/㎖ Gamisoamsan reduced the expression of VEGF, TGF-β, bFGF and IMUP-1 which was known as vascular growth factor and this effects of Gamisoamsan was predominant than VP-16. The treatment of Gamisoamsan decreased the CT-26 cell inoculated-tumor volume in mice colon adenocarcinoma and increased mice survival which was inoculated CT-26 cells. The results of the present study suggest that Gamisoamsan extracts has a potential anti-tumor activity and may be an useful remedy to prevent and/or treat cancer.

• 대한건축학회논문집:구조계
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• 제35권12호
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• pp.149-156
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• 2019

Recently, skyscraper building and apartment fires, which were rapidly spread out from a low floor to a rooftop, have become a frequent occurrence in mass media. This fire problems have a fatal disadvantage that the exterior wall finish of the building emits toxic gas in case of fire by using dry bit method or organic insulating material. Therefore, in order to remedy these problems, many exterior wall finishing construction methods have been proposed, but the current trend is to use existing construction methods due to problems such as economy, weight, and durability. On the other hand, in countries such as Germany and Japan, ceramic sidings are used as exterior finishing material for buildings, which is environmentally friendly, excellent natural beauty, long life, easy maintenance and high-quality exterior materials. However, those ceramic sidings have still the problems such as manufacturing cost and weight problem because of boosting the sintering temperature up to 1,350℃ or more. Also, conventional CRC, MgO, FRP sidings which are composed of pulp, glass fiber and organic materials, have been reports of deformation due to ultraviolet rays, discoloration, corrosion and scattering, surface rupture, lifting and peeling. Therefore, in this study as an alternative to solve this problem, halosite nano kaolin produced in Sancheong in Korea and frit flux were used to satisfy the required properties as ceramic siding using low temperature sintering (below 1,000℃) and lightweight materials such as pearlite. This study aims to design the optimal formulation and process of materials and to study the characteristics of nano-coated ceramic siding material development and to present relevant basic data. The findings show that ceramic siding for nanocoated building materials is excellent as a natural ceramic siding building material. The fire resistance of natural minerals and nano particle refining technology satisfy the bending strength of 80kgf / cm2, the volume ratio of 2.0 and the absorption rate of less than 10.0%.

• Journal of Oral Medicine and Pain
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• 제30권1호
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• pp.1-14
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• 2005

성인의 양호한 구강위생상태 유지에 있어 주요 저해인자로 작용하며, 국소적으로 세균요인 측면에서 통상의 합성 항생제 또는 항균성을 가지는 화학물질에 낮은 감수성을 보이는 수종의 그람음성의 혐기성 세균들에 의해 유발되는 구취와 치주질환에 대한 세균요인 관리 측면에서의 효율적 치료를 위한 천연 항균성 구강함수제의 개발에 필요한 기초자료를 얻고자, 구취와 치주질환의 유발과 관련된 대표적 구강내 그람음성의 혐기성 세균들인 P. intermedia속, P. gingivalis속 및 F. nucleatum 속 가운데 수종의 균주들에, 천연물의 일종인 은으로부터 제조된 콜로이드상 은 용액을 농도(10 ppm, 30 ppm, 50 ppm, 80 ppm)를 달리 적용한 후, 혐기적 상태에서의 경과시간(24 시간, 48 시간, 72 시간)에 따른 증식억제율과 치사율을 측정하여, 최소증식억제농도(minimal inhibitory concentration), 최소세균치사농도(minimal bactericidal concentration) 및 항균효과의 양상을 분석, 평가하여 다음과 같은 결과를 얻었다. 1. 콜로이드상 은의 실험대상 세균에 대한 최소증식억제농도는 P. intermedia속의 경우 30 ppm, P. gingivalis속의 경우에는 실험 균주에 따라 10 ppm 또는 30 ppm, 그리고 F. nucleatum속의 경우에는 실험 균주에 따라 30 ppm, 50 ppm 또는 80 ppm이었다. 2. 콜로이드상 은의 실험대상 세균에 대한 최소세균치사농도는 P. intermedia속의 경우 30 ppm, P. gingivalis속의 경우에는 실험 균주에 따라 30 ppm 또는 50 ppm, 그리고 F. nucleatum속의 경우에는 실험 균주에 따라 30 ppm 또는 80 ppm이었다. 3. 콜로이드상 은의 실험대상 균주에 대한 항균효과는 동일한 농도에서도 실험대상 균주에 따라 정균효과나 살균효과, 또는 양자 모두에 기인하였다. 4. 콜로이드상 은이 농도별로 적용된 후 경과시간에 따른 실험대상 세균의 증식에 미치는 효과에 있어서 P. intermedia속 균주의 경우 콜로이드상 은이 30 ppm$\sim$50 ppm의 농도로 48 시간$\sim$72 시간, P. gingivalis속 균주의 경우 10 ppm$\sim$30 ppm의 농도로 24 시간$\sim$48 시간, 그리고 F. nucleatum속 균주의 경우에는 30 ppm의 농도로 24 시간 동안 적용된 경우 대조군에 비해 균주에 따라 현저하게 또는 보통수준으로 증식이 억제되었다.

• 한국자원식물학회지
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• 제21권1호
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• pp.96-102
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• 2008

Nelumbo nucifera Gaertn.(family Nymphaeaceae) has been used for summer heat syndrome as home remedy in Japan, China and Korea. Although whole plant parts are edible, root is commonly consumed. It has been reported that rhizome extract showed anti-diabetic and anti-inflammatory effects. However, in spite of usefulness for treatment of various diseases, the effect of Nelumbo nucifera rhizome(NNR) on proliferation, migration and matrix degrading enzymes-matrix metalloproteinsases(MMPs), the expression of which degrades extracellular matrix(ECM) leading to metastasis, has not been fully elucidated. We examined the effect of hot water extract of NNR on the proliferation, migration and secretion of MMP-2 and MMP-9 in rat smooth muscle cells(rSMC), epidermoid cancer cells(A431) and breast cancer cells(MDA-MB-231). The proliferation assay was carried out using MTT assay, the principle of which depends upon the conversion of MTT by mitochondrial dehydrogensases of viable cells to formazan crystals. The effect of NNR on migration of cells was examined using wound healing assay. Our results showed that there was inhibition in the proliferation, migration and expression of MMP-2 and MMP-9 in dose dependent fashion in all the cells used. Thus, we concluded that NNR could be used as traditional medicine in the treatment of various diseases where proliferation, migration and MMPs' expression plays a pathological role like in restenosis and metastasis.

• 동아시아식생활학회지
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• 제15권5
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• pp.542-548
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• 2005

In recent years, propolis has attracted much attention as an useful substance in medicine and functional food, even if it is known as a natural remedy in folk medicine since ancient times. propolis was registered as natural food since 1995 on Korean Food Act by Korean Food and Drug Administration(KFDA). The present study demonstrated the optimization of isolation of crude propolis by ethanol, and tumoricidal effect of pro polis. The optimal concentration of ethanol to separate a high quantity of propolis was $60\%$. The cytotoxic effect of ethanol extracted propolis against various cancer cell lines including murine lymphoma (Sarcoma-180), murine T-lymphoma (YAC-1), human breast carcinoma (MCF-7), human gastric carcinoma (KATOIII) and human hepatocellular carcinoma (Hep3B) and human lung adenocarcinoma (A-549) was observed using SRB and MIT assay. In order to investigate the curative activity by oral administration of propolis on tumor, ICR mice was subcutaneously implanted Sarcoma 180. In 300mg/kg and 600mg/kg propolis administered group, development of implanted tumors was inhibited by $40.9\%\;and\;67.9\%$ at 16th day, respectively. In the same dose of propolis administered group, development of implanted tumors was inhibited more strongly with dose dependent manner. Therefore, these data suggested propolis may show tumoricidal effects. In conclusion, these results indicate that propolis, one of the few natural remedies, can be used as functional food with tumoricidal effects.

• Applied Microscopy
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• 제38권1호
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• pp.1-10
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• 2008

본 연구는 급성 수은 독성에 대한 민들레의 효과를 알아보기 위하여 시도되었다. 30 g 내외의 생쥐를 대상으로 대조군, 수은(5 mg/kg) 투여군, 수은 투여 후 민들레(3 g/kg)를 구강투여 한 후 다시 24, 48, 72, 96시간, 1주일군으로 세분하여 간장 손상 억제효과를 알아보기 위하여 생화학적 및 조직학적 실험을 실시하였다. 혈액중 aspartate amiotransferase (AST)와 alanine aminotransferase (ALT)의 수치는 민들레 투여군이 수은 투여군보다 감소되었다. 또한 간조직의 SOD와 catalase활성도 역시 민들레 투여군이 수은 투여군에 비하여 감소하였으나 통계학적 유의성은 없었다. 간 조직의 광학현미경적 관찰에서 심한 조직괴사가 관찰되지만 민들레 투여군에서는 문맥주위의 약간의 괴사와 심한 호중구 침윤현상이 관찰되었다. 전자현미경적 관찰 결과, 간장에서 수은 투여군은 간세포의 핵이 함입되어 불규칙했으며 미토콘드리아와 조면소포체의 수조가 팽대되고, 리보솜의 탈락이 관찰되었다. 민들레 투여군은 핵이 정상적인 상태로 관찰되었고, 전자밀도가 높은 미토콘드리아가 분포되어 있었으며, 리보솜이 부착된 상태로 층판구조를 형성하는 조면소포체가 관찰되었다. 이상의 연구 결과로 보아 민들레가 수은으로 유발된 간손상을 보호하는 효과가 있는 것으로 사료되며 민들레에 대한 다양한 연구가 필요할 것으로 사료된다.