• Bulletin of the Korean Chemical Society
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• 제35권4호
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• pp.1154-1158
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• 2014

Hsp90 is an ubiquitous molecular chaperone protein, which plays an important role in regulating maturation and stabilization of many oncogenic proteins. Due to its potential to simultaneously disable multiple signaling pathways, Hsp90 represents great promise as a therapeutic target of cancer. In this study, we synthesized flavokawain analogues and evaluated their biological activities against drug-resistant cancer cells. The study indicated that compound 1i impaired the growth of gefitinib-resistant non-small cell lung cancer (H1975), down-regulated the expression of Hsp90 client proteins including EGFR, Her2, Met, Akt and Cdk4, and upregulated the expression of Hsp70. The result strongly suggested that compound 1i inhibited the proliferation of cancer cells through Hsp90 inhibition. Overall, compound 1i could serve as a potential lead compound to overcome the drug resistance in cancer chemotherapy.

• 한국농공학회논문집
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• 제46권1호
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• pp.35-40
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• 2004

This study is performed to examine the physical and mechanical properties of eco-concrete using soil, natural coarse aggregate, excellent soil compound and polypropylene fiber. The test result shows that mass loss ratio is decreased with increasing the content of coarse aggregate and excellent soil compound. The compressive and flexural strengths are increased with increasing the content of coarse aggregate, excellent soil compound and polypropylene fiber. The coefficient of permeability is decreased with increasing the content of coarse aggregate and excellent soil compound, but it is increased in 0.2% polypropylene fiber content. The lowest coefficient of permeability is showed in $5.066\times 10^{-9}$cm/s. These eco-concrete can be used for farm road.

• 한국태양에너지학회 논문집
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• 제32권spc3호
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• pp.199-206
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• 2012

The purpose of this study is to understand the change of impression by comparing the uniformity lighting with the compound lighting. In previous study, we proposed a light controlling method to harmonize daylight from a window and artificial lights from a ceiling and obtained the results to support our method. We referred this method as the Adjusted Compound-Lighting Model (AC Model). The experiment is carried out with the scaled-models and mock-up spaces that were supposed to be an office space. One is lit by the uniform lighting and the other by the compound lighting in each experimental space. In order to present varying illuminance distributions, the two variables were used in this study. Subjects were asked to evaluate the point of difference by semantic differential rating on their overall impression after comparing with two rooms. The results showed that the impressions of compound lighting were more positive score than that of uniformity lighting on the items of 'dim-bright', 'dislike-like', 'artificial-natural' and 'closed-open', and that there was no significant difference in impressions between two spaces on other items.

• Journal of the Korean Wood Science and Technology
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• 제25권1호
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• pp.1-7
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• 1997

Kraft oak lignin and ricestraw lignin from acetosolve pulping were dissolved in 50/50 mixture of tetralin/m-cresol solvent. The dissolved lignin was reacted in the pressurized autoclave which was operating at $350{\sim}500^{\circ}C$ of reaction temperature and 10~20 atms of reaction pressure respectively_Hydrogen pressure of 60~80kg/$cm^2$ was exercising into the pressurized autoclave reactor to create thermochemical hydrogenolysis reaction. It was identified by GLC, GC-MS and HPLC that the alkyl-aryl-${\beta}$-O-4 ether bond of lignin was cleaved and degraded into various smaller molecules of aromatic compound such as phenols and cresols under the reaction conditions around $300^{\circ}C$ and 10 atms of reaction temoerature and pressure. Hydrogenolysis reaction of lignin compound which was done above $500^{\circ}C$ of reaction temperature and 20 atms of reaction pressure showed that the amount of aromatic compound such as phenols and cresols degraded from reactant lignin was decreasing with newly present and increasing water out of product mixtures. It was supposed that new aliphatic compound of high molecular weight hydrocarbon is composed due to higher reaction temperature and pressure of hydrogenolysis reaction such as $500^{\circ}C$ and 20 atms, even though it was almost impossible, to identify what kind of degraded products it was by HPLC.

• Archives of Pharmacal Research
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• 제7권2호
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• pp.127-132
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• 1984

Systematic pharmacological astudies on pipeline have revealed that this compound elicited diverse pharmacological activities; CNS depressant activity characterized by antagonism against electo shock seizure and by muscle relaxant activity in mice; antipyretic activity in tyyhoid vaccinated rabbits; analgesic activity as evaluated by tail-clip pressure and writhing syndrome in mice; antiinflammatory activity in carrageenin-induced edema in rats.

• 생약학회지
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• 제18권2호
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• pp.89-93
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• 1987

Chemical investigation of the inhibitory compound on leucocyte migration from Melilotus officinalis has led to the isolation and characterization of azukisaponin V $(3-O-[{\alpha}-L-rhamonopyranosyl(1{\rightarrow}2)-{\beta}-D-glucopyransosyl(1{\rightarrow}2)-{\beta}-D-glucuronopyranosyl]-soyasapogenol B)$ as the carboxylate form, which exhibits potent leucocyte migration inhibitory activity at a dose of 6mg/rat.

• Archives of Pharmacal Research
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• 제20권1호
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• pp.91-92
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• 1997

In the course of continous work on tubers of Gastrodia elata, a new constituent, 4, 4$^{I}$-dihydroxybenzyl sulfoxide was isolated from the ethyl acetate soluble fraction prepared from the methanol extract. The structure of the compound was identified from the elemental analytical and spectroscopic data in comparison with those of non-substituted benzyl sulfoxide.e.

• 약학회지
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• 제19권1호
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• pp.9-15
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• 1975

The constitution of genin A-a new triterpenoid isolated from the roots of Phytolacca americana L. has been shown to be 3-oxo-30-carbomethoxy-24-norolean-12-en-28-oic acid. This compound is not a genuine spogenin but an artifact produced during hydrolysis of the Phyolacca saponins.

• 대한화학회지
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• 제48권2호
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• pp.220-224
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• 2004

• Natural Product Sciences
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• 제12권2호
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• pp.101-103
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• 2006

In the course of the continual work on the fresh tubers of Gastrodia elata, a fructoside constituent was isolated from the n-butanol soluble fraction prepared from the methanol extract. The structure of this compound was identified as $n-butyl-{\beta}-D-fructopyranoside$ from various spectroscopic data including $^1H-\;and\;^{13}C-NMR$, HMQC, HMBC, and FABMS.