Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Isolation of Azukisaponin V Possessing Leucocyte Migration Inhibitory Activity from Melilotus officinalis

  • Kang, Sam-Sik (Natural Products Research Institute, Seoul National University) ;
  • Lee, Young-Soon (Natural Products Research Institute, Seoul National University) ;
  • Lee, Eun-Bang (Natural Products Research Institute, Seoul National University)
  • Published : 1987.06.30
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Abstract

Chemical investigation of the inhibitory compound on leucocyte migration from Melilotus officinalis has led to the isolation and characterization of azukisaponin V $(3-O-[{\alpha}-L-rhamonopyranosyl(1{\rightarrow}2)-{\beta}-D-glucopyransosyl(1{\rightarrow}2)-{\beta}-D-glucuronopyranosyl]-soyasapogenol B)$ as the carboxylate form, which exhibits potent leucocyte migration inhibitory activity at a dose of 6mg/rat.

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