Isolation of Azukisaponin V Possessing Leucocyte Migration Inhibitory Activity from Melilotus officinalis

  • Kang, Sam-Sik (Natural Products Research Institute, Seoul National University) ;
  • Lee, Young-Soon (Natural Products Research Institute, Seoul National University) ;
  • Lee, Eun-Bang (Natural Products Research Institute, Seoul National University)
  • 발행 : 1987.06.30

초록

Chemical investigation of the inhibitory compound on leucocyte migration from Melilotus officinalis has led to the isolation and characterization of azukisaponin V $(3-O-[{\alpha}-L-rhamonopyranosyl(1{\rightarrow}2)-{\beta}-D-glucopyransosyl(1{\rightarrow}2)-{\beta}-D-glucuronopyranosyl]-soyasapogenol B)$ as the carboxylate form, which exhibits potent leucocyte migration inhibitory activity at a dose of 6mg/rat.

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