• Journal of Biomedical Engineering Research
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• v.43 no.1
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• pp.19-26
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• 2022

The Comprehensive in vitro Proarrhythmic Assay(CiPA) project was launched for solving the hERG assay problem of being classified as high-risk groups even though they are low-risk drugs due to their high sensitivity. CiPA presented a protocol to predict drug toxicity using physiological data calculated based on the in-silico model. in this study, features calculated through the in-silico model are analyzed for correlation of changing action potential in the near future, and features are verified through predictive performance according to drug datasets. Using the O'Hara Rudy model modified by Dutta et al., Pearson correlation analysis was performed between 13 features(dVm/dtmax, APpeak, APresting, APD90, APD50, APDtri, Ca_peak, Ca_resting, CaD90, CaD50, CaDtri, qNet, qInward) calculated at 100 pacing, and between dVm/d_{tmax_repol} calculated at 1,000 pacing, and linear regression analysis was performed on each of the 12 training drugs, 16 verification drugs, and 28 drugs. Indicators showing high coefficient of determination(R²) in the training drug dataset were qNet 0.93, AP resting 0.83, APDtri 0.78, Ca resting 0.76, dVm/dt_max 0.63, and APD90 0.61. The indicators showing high determinants in the validated drug dataset were APDtri 0.94, APD90 0.92, APD50 0.85, CaD50 0.84, qNet 0.76, and CaD90 0.64. Indicators with high coefficients of determination for all 28 drugs are qNet 0.78, APD90 0.74, and qInward 0.59. The indicators vary in predictive performance depending on the drug dataset, and qNet showed the same high performance of 0.7 or more on the training drug dataset, the verified drug dataset, and the entire drug dataset.

• Journal of Forest and Environmental Science
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• v.24 no.1
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• pp.15-25
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• 2008

Social and scientific changes, i.e., global warming, desertification, pollution, biodiversity, bioenergy, plant variety protection, biotechnology, timber demand, reforestation in North Korea, and etc., were reviewed for new strategy of forest tree breeding in Korea. Diversified breeding goals, globalization of breeding target species, multidisciplinary research approaches, manpower networking, establishment of new administrative and research units in KFS and KFRI were proposed. Principles suggested for new tree breeding strategy are: 1) multi-disciplinary approach in settlement of objectives, breeding methods, and etc., 2) expansion of target trees including foreign species, 3) fulfillment of both domestic and international demands for forest tree breeding, 4) establishment of breeding program well-grounded on genetic resources conservation, 5) acknowledgement of breeding products (i.e., variety, technique, gene, and etc.) as goods, and 6) provision of more research opportunities for young scientists. Lastly, ongoing tree breeding project in Indonesia and NTFP R&D Center at the College of Forest and Environmental Sciences, Kangwon National University were introduced as examples of desirable breeding projects based on target species diversification, multidisciplinary approach, and manpower networking.

• The Journal of Korea Robotics Society
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• v.7 no.4
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• pp.284-291
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• 2012

Recently, development of underwater robot has actively been in progress in the world as ROV(Remotely Operator Vehicle) and AUV(Autonomous Unmmanded Vehicle) style. But KIOST(Korea Institute of Ocean Science and Technology), beginning in 2010, launched the R&D project to develop the robot, dubbed CRABSTER(Crab + (Lob)ster) in a bid to enhance the safety and efficiency of resource exploration. CRABSTER has been designed to be able to walk and swim with its own legs without screws. Among many research subjects regarding CRABSTER, optimal swimming patterns are handled in this paper. In previous studies, drag forces during one period with different values for angle of each joint were derived. However kinematics of real-robot and fluid-dynamics are not considered. We conducted simulations with an optimization algorithm for swimming by considering simplified fluid dynamics in this paper. Drag-coefficients applied to the simulation were approximated values calculated by CFD(Computational Fluid Dynamics : Tecplot 360, ANSYS). In addition, optimized swimming patterns were applied to a real robot. The experiments with the real robot were conducted in circumstances in the water. As a result, when the experiments were carried out in the water, a regular pattern of drag force output came out depending on the movement of the robot. We confirmed the fact that the drag forces from the simulation and the experiment has a high similarity.

• Journal of Korea Society of Digital Industry and Information Management
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• v.8 no.4
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• pp.217-230
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• 2012

To look at Korea trade environment, as increasing the quantity of goods transported in North-East Asia and deepening national competitive, information-oriented logistics environment is needed. That means it is automated work process and can provide value-added service. To do this, logistics business can be efficiently handled through "Electronic Means for the Clearance of Ships" and electronically data processing. Also, by increasing the risk of international terrorism, regulation regarding to logistics security has strengthened around the advanced country, such as USA and EU, etc. or international organization, such as IMO, ISO, etc.. Furthermore, because trade and logistics environment is changing and security becomes more important in logistics area, movement or status information of goods within the port or in entry in/out becomes more and more be needed in real time. In case cross-border logistics activities, international cooperation or agreement between countries is very important. However, different opinions much happened on defining the interface. If to follow one format or type using at a specific country or organization, it was occurred to difficulty in respect of interoperability as well as additional costs or time. Therefore, this paper proposes common interface model to exchange information for the efficient global SCM for using by the output of Korea R&D project, "National Logistics Standardization System Development".

• Journal of the Korean Society for Railway
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• v.18 no.5
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• pp.471-480
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• 2015

Reliance on road transport in domestic logistics can lead to intensified congestion and greenhouse gas emissions due to the rise in oil prices, any increase in logistics costs can have a high social cost. The government policy on Low Carbon Green Growth is seeking to take advantage of the railway system. However, existing railway transport logistics systems, for reasons such as low speed, low track capacity constraints, and the impossibility of implementing a Door to Door system, make it difficult to activate a railway logistics program. As a result of this study, a national R&D project to develop a High-Speed Passenger/Baggage Mixed Train(Hy-SoBex) utilizing the rail capacity constraints to overcome the difficulties of linking an air cargo and freight railway logistics system, we propose a variety of service models and select the optimal service model.

• Journal of Korea Technology Innovation Society
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• v.20 no.4
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• pp.989-1014
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• 2017

Major advanced countries pursuing accountability for research and development are carrying out gendered innovations by recognizing the importance of sex and gender analysis in science research and technology development. Korea needs to actively promote gendered innovations as a strategy moving from Fast Follower to First Mover. In order to promote gendered innovations in the science, technology and ICT fields, policies of integrating the gender dimension in the process of research from research design to the analysis of research outcomes should be declared and research support measures should be introduced from the proposal evaluation for the gendered innovations. In particular, in order to support the new gendered innovations research systematically in Korea's R & D system, a legal basis must precede. In this study, we propose an amendment to the law related to gender innovation by analyzing the cases in foreign countries.

• Journal of the Economic Geographical Society of Korea
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• v.15 no.4
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• pp.550-569
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• 2012

This paper studies the R&D network of the Zhongguancun Cluster, the most representative innovative cluster of the high-tech industry in China at present. For this study, Zhongguancun Cluster was the first high-tech cluster to have been created in China, the current Zhongguancun Cluster has played a leading role in the development of the high-tech industry in China. In addition, the Zhongguancun Cluster has at helped elevate China as a key region in terms of research development in relation to the high-tech industry. In particular, companies evaluate the research development network culture of Zhongguancun cluster positively and this increases their tendency to approach the research development network with an open mind. The main contents in research development network are as follows; (1) joint or consigned research development and technology transfer in the case of research development network between companies, (2) joint or consigned research development, human resource support and employment, technical advice and consultant and technology transfer in the case of industrial-educational relationships (3) joint or consigned research development, technical advice and consultant and technology transfer in the case of industrial-research relationships, (4) financial support and participation in joint research development project held by government in the case of industrial and governmental relationships (5) financing for research development, utilization of research human resources, purchase of research development and use of research development equipment for mediators. The main difficulties in creating a research development network are 'lack of mutual trust', 'financial problems of companies' and 'lack of information'. Especially, the main key obstacles for the most important research development network between industry and government in the case of the Zhongguancun Cluster are 'complicated and strict procedures. Therefore, more accurate and detailed understanding of the conditions and the following institutional measures from government are required for research development among companies.

• The Journal of Engineering Geology
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• v.28 no.2
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• pp.133-160
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• 2018

$CO_2$ storage is a very important technology for reduction of greenhouse gas emissions and has been considered as almost the only viable and effective option for immediate large-scale $CO_2$ sequestration. Small-scale demonstration project for offshore $CO_2$ storage in the Pohang Basin is the transitional stage R&D program for technological preparation of large-scale $CO_2$ storage project in Korea. Through the extensive exploration research for prospective $CO_2$ storage sites, the offshore strata in the Pohang Basin was recommended for the storage formation of the small-scale demonstration project. The Pohang Offshore Storage Project launched at 2013, and has accomplished the technical demonstration and technological independence in a wide range of $CO_2$ storage technology, such as geophysical exploration, storage site characterization, storage design, offshore platform construction, injection-well drilling and completion, deployment of injection facility, operation of $CO_2$ injection, and $CO_2$ monitoring. The project successfully carried out $CO_2$ test injection in early 2017, and achieved its final goal for technical development and demonstration of $CO_2$ storage in Korea. The realization of $CO_2$ injection in this project is the measurable result and has been recorded as the first success in Korea. The Pohang Offshore Storage Project has a future plan for the continuous operation of $CO_2$ injection and completion of $CO_2$ monitoring system. The project has provided in-house technical and practical expertises, which will be a solid foundation for the commercial-scale $CO_2$ storage business in Korea. Additionally, the project will help to secure national technical competitiveness in growing international technology market for $CO_2$ storage.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.10
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• pp.72-76
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• 2020

The central government operates a Balanced National Development Special Account, and wants more regional development. Many local governments try various ways to establish a foothold for independent governments. Establishing a regional base center is one of the major plans for economic development, and Chungnam is proceeding with "establishing a platform for Chungnam high-tech metal materials." This paper analyzes the effects on the regional economy based on the expense that goes into a regional base center in Chungnam. For the analysis, an input/output table is used, and we present the effects of the annual input cost in detail. This study specifically analyzes the production-inducing effects, the value-added inducing effects, and employment-inducing effects using a demand-drive model. Furthermore, we suggest the effectiveness of this same business. The analyzed results give 32,230,000,000 in production-inducing effects, 13,820,000,000 in value-added inducing effects, and 101 in employment-inducing effects. These results can be used as reasonable evidence to promote the project, since the production-inducing effects and value-added inducing effects show high results, compared to input. The employment-inducing effects can also be used to create new jobs and figure out the number of people employed through this project.

• Journal of Information Management
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• v.31 no.1
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• pp.12-42
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• 2000

Digital library research has attracted much attention. While many research projects are funded by government agencies and national and international bodies, some are run by specific academic and research institutions and libraries. While some digital library projects, such as the ELINOR project in the UK, the first two phases of the eLib(Electronic Libraries) programme in the UK, and the first phase of the DLI(Digital Library Initiative) in the USA, are now over, a number of other projects are currently under-way in different parts of the world. Beginning with the definitions and characteristics of digital libraries proposed by various researchers, this paper provides brief accounts of some major digital library projects that are currently in progress, or are just completed, in different parts of the world. There follows a review of digital library research under 16 major headings. Literature for this review has been identified through a search on the LISA CD-ROM database and a Dialog search on library and information science databases, and the resulting output has been supplemented by a scan of the various issues of D-Lib Magazine and Ariadne, and the Web sites of various organizations and institutions engaged in digital library research. The review indicates that we have learned a lot through digital library research within a short span of time. However, a number of issues are yet to be resolved. The paper ends with an indication of the research issues that need to be addressed and resolved in the near future in order to bring the digital library from the researcher's laboratory to the real life environment.