• Journal of Life Science
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• v.30 no.9
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• pp.772-782
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• 2020

Skeletal muscle differentiation or myogenesis is important to maintain muscle mass and metabolic homeostasis. Muscle-specific microRNAs (miRNAs) are known to play a critical role in skeletal myogenic differentiation. In this study, we examined the expression profiling of miRNAs during myogenic differentiation in rat L6 myoblasts using rat miRNA microarrays. We identified the upregulated expression of miR-128 as well as several well-known myogenic miRNAs, including miR-1, miR-133b, and miR-206. We additionally confirmed the increased expression of miR-128 observed on microarray through quantitative real-time PCR (qRT-PCR), which showed similarly upregulated expression of both primary miR-128 and mature miR-128, consistent with the microarray findings. Furthermore, transfection of miR-128 into rat L6 myoblasts induced gene expression of myogenic markers such as muscle creatine kinase (MCK), myogenin, and myosin heavy chain (MHC). Protein expression of MHC was increased as well. Inhibition of miR-128 by inhibitory peptide nucleic acids (PNAs) blocked the expression of those myogenic markers. In addition, the transfection of miR-128 into rat L6 myoblasts enhanced the phosphorylation of Erk and Akt proteins stimulated by insulin, while simultaneously reversing the inhibited phosphorylation of Erk and Akt due to insulin resistance. These findings suggest that miR-128 may play important roles in myogenic differentiation and insulin signaling.

• Journal of Periodontal and Implant Science
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• v.43 no.4
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• pp.147-152
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• 2013

Purpose: An animal periodontitis model is essential for research on the pathogenesis and treatment of periodontal disease. In this study, we have introduced a lipopolysaccharide (LPS) of a periodontal pathogen to the alveolar bone defect of experimental animals and investigated its suitability as a periodontitis model. Methods: Alveolar bone defects were made in both sides of the mandibular third premolar region of nine beagle dogs. Then, the animals were divided into the following groups: silk ligature tied on the cervical region of tooth group, Porphyromonas gingivalis LPS (P.g. LPS)-saturated collagen with silk ligature group, and no ligature or P.g. LPS application group as the control. The plaque index and gingival index were measured at 0 and 4 weeks postoperatively. The animals were then euthanized and prepared for histologic evaluation. Results: The silk ligature group and P.g. LPS with silk ligature group showed a significantly higher plaque index at 4 weeks compared to the control (P<0.05). No significant difference was found in the plaque index between the silk ligature group and P.g. LPS with silk ligature group. The P.g. LPS with silk ligature group showed a significantly higher gingival index compared to the silk ligature group or the control at 4 weeks (P<0.05). Histologic examination presented increased inflammatory cell infiltration in the gingival tissue and alveolar bone of the P.g. LPS with silk ligature group. Conclusions: An additional P.g. LPS-saturated collagen with silk ligature ensured periodontal inflammation at 4 weeks. Therefore, P.g. LPS with silk ligature application to surgically created alveolar bone defects may be a candidate model for experimental periodontitis.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.9
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• pp.6247-6253
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• 2015

This paper presents the transient-response improved LDO regulator based on parallel error amplifiers. The proposed LDO regulator consists of an error amplifier (E/A1) which has a high gain and narrow bandwidth and a second amplifier (E/A2) which has low gain and wide bandwidth. These amplifiers are in parallel structure. Also, to improve the transient-response properties and slew-rate, some circuit block is added. Using pole-splitting technique, an external capacitor is reduced in a small on-chip size which is suitable for mobile devices. The proposed LDO has been designed and simulated using a Megna/Hynix $0.18{\mu}m$ CMOS parameters. Chip layout size is $500{\mu}m{\times}150{\mu}m$. Simulation results show 2.5 V output voltage and 100 mA load current in an input condition of 2.7 V ~ 3.3 V. Regulation Characteristic presents voltage variation of 26.1 mV and settling time of 510 ns from 100mA to 0 mA. Also, the proposed circuit has been shown voltage variation of 42.8 mV and settling time of 408 ns from 0 mA to 100 mA.

• Journal of the Microelectronics and Packaging Society
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• v.26 no.1
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• pp.9-15
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• 2019

Here, we present a facile route to fabricate a vertically stacked 3D porous structure-based triboelectric nanogenerator (TENG) that can be used to harvest energy from the friction in a repetitive contact-separation mode. The unit component of TENG consists of thin Al foil electrodes integrated with microstructured 3D foams such as Ni, Cu, and polyurethane (PU), which provide advantageous tribo-surfaces specifically to increase the friction area to the elastomeric counter contact surfaces (i.e., polydimethylsiloxane, PDMS). The periodic contact/separation-induced triboelectric power generation from a single unit of the 3D porous structure-based TENG was up to $0.74mW/m^2$ under a mild condition. To demonstrate the potential applications of our approach, we applied our TENGs to small-scale devices, operating 48 LEDs and capacitors. We envision that this energy harvesting technology can be expanded to the applications of sustainably operating portable electronic devices in a simple and cost-effective manner by effectively harvesting wasted energy resources from the environment.

• Asian Journal of Innovation and Policy
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• v.1 no.2
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• pp.133-147
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• 2012

Asia is becoming a stronghold for innovation careers along with its resurgence in economic, political, and cultural arenas. This transformation happened on the backdrop of growing enrolments in higher education, increasing investments in scientific research & innovation, and innovation supportive policy measures by several Asian countries. Research and Development (R&D) and product customization centres of multinational corporations (MNCs) sited in emerging nations are also instrumental in this transformation.

• Bulletin of the Korean Chemical Society
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• v.32 no.11
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• pp.4001-4004
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• 2011

Various 5-substituted 1H-tetrazole derivatives were synthesized in a simple and environmentally benign method from the reaction of aryl and benzyl nitriles with sodium azide in solvent-free media using montmorillonite K-10 clay as solid recyclable heterogeneous acidic catalyst and microwave irradiation in good yields and short reaction times.

• Bulletin of the Korean Chemical Society
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• v.31 no.2
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• pp.271-272
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• 2010

• Journal of the KSME
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• v.32 no.5
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• pp.420-428
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• 1992

1980년대부터 새롭게 우리에게 다가온 nm의 세계는 그 동안 마이크로의 기술이 인류에게 가져다 준 성과 이상의 것을 약속하고 있다. Nanoscience와 Nanotechnology라는 용어가 차츰 일상적인 것이 되어가고 있으며 이들 기술을 응용한 제품들이 선을 보이고 있다. STM은, 개발된지 10년이 되는 현 시점에서 다른 분야들에 기술적으로 많은 파급효과를 끼쳤으며 STM자체의 성능도 크게 향상되었다. 앞으로도 성능 향상은 빠른 속도로 진행될 것이며 특히 단순한 측정장치를 넘어 가공과 제조장치로서 크게 기대가 된다. 다양한 형태로 결합된 개별 원자들의 성질을 측정함으 로써 거시적으로 나타나는 여러 복합적인 현상들을 근본적으로 이해할 수 있고 또 nm 수준에 서의 공정제어로 품질 좋은 무결점의 제품 생산을 가능하게 해 줄 것이다.

• 한국정보디스플레이학회:학술대회논문집
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• 2006.08a
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• pp.422-425
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• 2006

Recently, studies on orientation of carbon nanotubes (CNTs) dispersed in nematic liquid crystal (LC) and CNTs effects on electro-optic characteristics of the LC device have been performed. In this paper, we summarize interaction nature between CNT and LC, local distortion of the LC director field by motion of CNTs, and effects on electro-optic performances of LC device.

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 2012.11a
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• pp.60-60
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• 2012

본 발표에서는 물 또는 용매 속에서 어떤 물질의 표면도 개질할 수 있는 표면공학기법에 대해 발표하고자 한다. 본 기술은 홍합의 접착단백질의 성분에서 착안한 polydopamine 및 catecholamine으로 정의되는 일련의 chemical compounds에 의해 수행된다. 먼저 polydopamine의 형성 원리를 설명 하고 이를 이용하여, 에너지, 물, 나노바이오 등 다양한 분야의 응용예를 소개 할 예정이다.