• Title/Summary/Keyword: n'-site

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A Study on the User for Activation of University Community Site (대학 커뮤니티 사이트 활성화를 위한 사용자 연구)

  • Chae Duck-Yeop;Park Su-Jin
    • Proceedings of the Korea Contents Association Conference
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    • 2005.05a
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    • pp.268-272
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    • 2005
  • The university community site can be used as a potential element to improve the recognition of the university through the satisfaction of the members of the university with using it as well as an important means for communication on the line among the members. In spite that the community site is used by the users in the twenties at university, it consists of the contents with only basic functions. Consequently it is necessary to find out the different traits of the users to make the university community site active. Therefore, this study aims at analyzing the reality of the university community site and finding out the characteristics of the university students characterized as N-generations

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Distinct $[^3H]$MK-801 Binding Profiles with the Agonist, Partial Agonist, and Antagonist Acting at the Glycine Binding Site of the N-Methyl-D-Aspartate Receptor

  • Cho, Jung-sook;Park, No-Sang;Kong, Jae-Yang
    • Biomolecules & Therapeutics
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    • v.4 no.2
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    • pp.196-201
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    • 1996
  • The N-methyl-D-aspartate (NMDA) receptor-ion channel complex is activated by the simultaneous presence of L-glutamate and glycine, allowing the binding of MK-801 to the phencyclidine (PCP) site of the receptor. The $[^3H]$MK-801 binding assay system was established for determination of pharmacological functions of test compounds acting at the glycine site of the receptor. The binding in the presence of 0.1 $\mu$M L-glutamate was increased by an agonist (glycine) in a dose-dependent fashion, while decreased by either partial agonist (R-(+)-HA-966) or antagonist (5,7-dichlorokynurenic acid: 5,7-DCKA). To distinguish partial agonism from antagonism, various concentrations of 7-chlorokynurenic acid (7-CKA) were added in the assay to eliminate the interference of the endogenous glycine present in the membrane preparations. The bindings in the presence of L-glutamate (0.1$\muM$) and 7-CKA (1, 5, or 10$\muM$) were increased by R-(+)-HA-966. Being a weak partial agonist, the extent of potentiation was much less than that by the agonist. These binding profiles were clearly distinguishable from those by the antagonist, 5,7-DCKA, which exhibited no intrinsic activity. The binding assays established in the present study are a useful system to classify ligands acting at the glycine site of the NMDA receptor by their pharmacological functions.

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DentalVibe reduces pain during the administration of local anesthetic injection in comparison to 2% lignocaine gel: results from a clinical study

  • Joshi, Sagar;Bhate, Kalyani;Kshirsagar, Kapil;Pawar, Vivek;Kakodkar, Pradnya
    • Journal of Dental Anesthesia and Pain Medicine
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    • v.21 no.1
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    • pp.41-47
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    • 2021
  • Background: This study was designed to compare the efficacy of DentalVibe against 2% lidocaine gel in reducing pain during the administration of local anesthetic injection in the adult population. Methods: This was a split-mouth open-label, randomized, controlled clinical study conducted in the Department of Oral and Maxillofacial Surgery of a dental institute. Fifty patients who were scheduled for bilateral dental extractions requiring an inferior alveolar nerve block were enrolled in the study. Site A (n = 50) was coated with 2% lidocaine gel followed by a local anesthetic injection, and DentalVibe with local anesthetic injection was used for Site B (n = 50). The primary outcome was pain, which was recorded immediately after the administration of anesthetic injection using the Visual Analogue Scale [VAS 0 - 10]. Results: The VAS pain scores ranged from 4 to 10 for site A and 0 to 6 for site B. Comparison between the two sites showed a statistically significant difference [Mann-Whitney U test value = 51.50, P < 0.001] favoring site B. Conclusion: This study showed that DentalVibe reduces pain during injection of local anesthesia compared to topical anesthetic gel.

Effects of Multi-site and Single-site Functional Massage and Stretching on Pain, Tenderness Threshold and Grip Strength in Patients with Lateral Epicondylalgia (가쪽위관절융기 통증 환자에서 복합 부위와 단일 부위에 기능적 마사지와 스트레칭을 적용할 때 통증, 압통 역치와 악력에 미치는 영향)

  • Min-keun Jung;Jae-guk Jeon;Eui-joo Shin
    • The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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    • v.29 no.3
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    • pp.13-22
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    • 2023
  • Background: The purpose of this study was to investigate the effects of functional massage and stretching, applied to the elbow and shoulder joints, on pain, tenderness threshold, and grip strength. Methods: A total of 29 individuals were assigned to a single site (n=15) or multiple sites (n=14). Pain measured through the visual analogue scale (VAS), tenderness threshold (TTH), and grip strength (GI) were measured before and four weeks after the intervention. Results: After four weeks of treatment, visual analogue scale significantly decreased in both groups (p<.05), and the tenderness threshold and grip strength significantly increased in both groups (p<.05). There was also a significant difference between the two groups (p<.05). Conclusion: The reduction of visual analogue scale and the increase in the tenderness threshold and grip strength were more significant in the multi-site treatment group than in the single-site treatment group.

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Water Quality and Sediment Contamination in the Iksan Stream (익산천 수질시료와 저질토의 오염도 평가)

  • Seo, Young-Seok;Cho, Min;Oh, Byung-Taek
    • Journal of Soil and Groundwater Environment
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    • v.18 no.1
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    • pp.123-128
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    • 2013
  • Water quality and contamination of sediment is a growing concern in the Iksan stream of Korea. Heavy metal contamination and changes in the physicochemical properties of the stream were evaluated. Water and sediment samples were collected from six sites during the dry and rainy seasons; pH, DO, EC, ORP, turbidity, $PO_4$-P, $NO_3$-N and selected heavy metals (Cu, Pb, Ni, As, Zn, Cd, Hg) were measured. Results showed almost no change in pH between seasons. DO was highest at site 2 (~2.63 mg/L) in the dry season; EC (1,540 ms/m) was greatest at site 1 in both seasons. The ORP gradually increased from the dry to rainy season at most of the sites and was highest at site 5. Turbidity was highest at site 1 and gradually decreased from the dry to rainy season at all sites except site 3. $PO_4$-P ranged from a high of 1,193mg/L at site 1 to in the dry season to a low of ~1.2 mg/L at site 4. In contrast, $NO_3$-N was highest at site 3 in the rainy season (12,531 mg/L). Among the heavy metals measured, Cu and Zn concentrations were highest at all sediment sites. Cu and Zn are added to livestock feed to improve reproductive rates and can be carried to the stream with manure. Transport of sediment and heavy metals during the rainy season is the major source of stream contamination and it is important to continue monitoring and take necessary action in these areas.

Synthesis and Characterization of Palladium (IV) Complexes with Guanine, Adenine, and Uracil Base (Guanine, Adenine 및 Uracil 염기를 갖는 팔라듐 (IV) 착물의 합성과 그 성질)

  • Oh Sang Oh;Chung Duck Young;Kim Hee Seon
    • Journal of the Korean Chemical Society
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    • v.36 no.5
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    • pp.679-684
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    • 1992
  • New Pd(IV) complexes have been prepared through the reactions of $trans-[Pd(en)_2Cl_2](ClO_4)_2 $(en = ethylenediamine) with Guanine, Adenine, or Uracil anion as purine and pyrimidine base. We identified the ratio of central metal versus ligands by $C{\cdot}H{\cdot}N$ elemental analysis and proposed the coordinating site of the base by infrared spectrum, $^1H-NMR,\; and\; ^{13}C$-NMR spectrum. Guanine or Adenine ligand coordinated at N7 site and an en ligand exchanged for $ClO_4^-$ counter ions of the starting material . As these results, the complexes showed the formula $[Pd(en)L_2(ClO_4)_2](ClO_4)_2{\cdot}(en)$, (L = Guanine, Adenine). But in the Uracil complex no exchange of the en ligand and $ClO_4^-$ occured and Uracil anion preferred the N1 to N3 as coordinating site, the complex $[Pd(en)_2(Urac)_2](ClO_4)_2(Urac = Uracil anion).$

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Effects of forest fire on physical and chemical properties of soil (산불이 토양의 물리ㆍ화학적 특성에 미치는 영향)

  • 박관수
    • Journal of Korea Soil Environment Society
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    • v.4 no.1
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    • pp.119-126
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    • 1999
  • This study was carried out to estimate the effect of forest fire on physical and chemical properties of soil The forest fire was in April 1995 at Kongju of Chungnam. Soil samples were collected at 0~5cm, 5~10cm, and 10~20cm soil depths in September 1998 from the burned and unburned sites. Soil organic matter concentrations at 0~5cm and 5~10cm soil depths were significantly greater in unburned site than in burned site. Soil concentrations were greater in unburned site than in burned site at all soil depths. Cation exchange capacity was significantly higher in unburned site than in burned site at 0~5cm soil depth. There were no differences in available soil P, exchangeable soil K, Ca, and Mg, and pH of soil between burned and unburned sites. Soil water content at 0~5cm soil depth was significantly greater in unburned site than in burned site. Bulk density at 0~5cm soil depth was significantly higher in burned site than in unburned site. Forest fire had an adverse effect on physical and chemical properties of soil in this study, Burning of vegetation and forest 리oor organic matter in burned site may reduce organic matter supply to soil and increase soil erosion. Consequently, forest fire may have adverse influence on long-term site productivity.

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Influences of Clearcutting of Timber Harvesting on Stream Water Quality (개벌에 의한 수확벌채가 계류수질에 미치는 영향)

  • Park, Jae-Hyeon
    • Korean Journal of Ecology and Environment
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    • v.35 no.1 s.97
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    • pp.45-51
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    • 2002
  • This study was investigated to tile influences of clearcutting of timber harvesting on stream water quality at a natural deciduous forest catchment within the Seoul National University Research Forests in Mt. Baegun, Chunnam province during the periods of 1993 to 2001. Soil chemical ingredients and stream water qualities were monitored at 13 ha clearcutting site, non-treatment site and included in these catchment nearby. After the harvesting first and End years, the levels of total- N, and exchangeable ions ($K^+,\;Na^+,\;Ca^{2+},\;Mg^{2+}$) were decreased the values of before harvesting, and after the harvesting 111th years and eighth years, respectively. But the chemical characteristics of soil were not changed at all. pH of water in the harvesting area was 6.5 in stream water. Among the nutrient, Cd, Pb, Cu, and phosphate were not found, and the level of BOD reached at the level of the domestic use for drinking. Turbidity, odor, taste, $NH_4\;^+-N,\;NO_3\;^--N$, standard plate count, and coliform were also low enough to be used as the domestic use for drinking in the near villagers. Total amount of cation, total amount of anion and total amount of ion in clearcutting site, non- treatment site and included in these catchment nearby were higher than clearcutting site and non- treatment site. But, there was no great difference.

The Radiological Findings of the Catheters Inserted 10cm Cephaladly in Epidural Space (경막외강내 두측으로 10cm 삽입한 카테터의 X-선상 소견)

  • Chung, So-Young;Lee, Hyo-Keun;Chae, Jin-Ho;Lee, Chul-Seung;Lee, Chul;Kim, Chan;Kim, Soon-Yul
    • The Korean Journal of Pain
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    • v.8 no.2
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    • pp.298-303
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    • 1995
  • We have inserted epidural catheter for single or continuous injection of a drug for epidural analgesia. It is important to localize the tip of epidural catheter in appropriate site to acquire the most effective analgesia. In epidural block, we observed course and location of the tip of epidural catheter. Subject: 70 patients were divided into group I(non-injection of saline group during catheter insertion) and group II(injection group during catheter insertion). Group I included cervical(n=20), thoracic(n=10), and lumbar(n=20) epidural group. Group II, cervical(n=10), and lumbar(n=10) epidural group. Method: 19G FlexTip $Plus^{TM}$ Epidural Catheter ($Arrow^{(R)}$) was inserted 10cm cephaladly in epidural space with(group II) or without(group I) saline flushing. We observed course and location of the tip of epidural catheter by C-arm image intensifier during injection of contrast media ($Omnipaque^{(R)}$). Result: In group I, the number of tips of epidural catheters located within 2 cm from inserted site were: cervical 14/20(70%), thoracic 2/10(20%). lumbar 16/20(80%). In thoracic epidural blocks, tips of epidural catheters were more cephaladly located than with cervical and lumbar epidural blocks. With cervical epidural blocks, the number of tips of epidural catheters located within 2 cm from insertion site were less in group II than group I (20% vs. 70%). But no significant differences were noted between group I and group II with lumbar epidural block(90% vs. 80%). The number of tips of epidural catheters located around a predicted site were: cervical 2/20(10%), thoracic 4/10(40%), lumbar 0/20(0%) in group I, and cervical 2/10(20%), lumbar 1/10(10%) in group II. Conclusion: It was impossible to predict the exact location of tips of epidural catheters by measuring the inserted length without epidurogram. With many cases, tips of epidural catheters were located around the insertion site in lumbar epidural blocks, and in some cases around the predicted site in thoracic epidural blocks. The results suggests that epidural block should be done at a point near the required band of analgesia.

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Transient Phenomena in the Temperature rise of p-n Junctions (p-n Junction에서의 온도상승의 과도현상)

  • Lee, U-Il;Son, Byeong-Gi;Lee, Geon-Il
    • Journal of the Korean Institute of Telematics and Electronics
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    • v.7 no.4
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    • pp.14-19
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    • 1970
  • Transient phenomena in the p-n junction due to the selfheating effect of microplasma current have been investigated for the cases of small current and of large current. For the small current case, the temperature rise of the microplasma site is proportional to the current decrease and a unique time constant could be defined. However, the situation was complicated for the case of large current, and the time constant was not uniquely defined.

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