• Nutrition Research and Practice
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• 제14권4호
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• pp.352-364
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• 2020

BACKGROUND/OBJECTIVES: Given the increasing proportion of the Korean population that is aged 65 years and older, the present study analyzed the relationship between diet quality and sarcopenia in elderly persons by using data from the 2008-2011 Korea National Health and Nutrition Examination Survey (KNHANES). SUBJECTS/METHODS: Data for 3,373 persons aged 65 years and over (men: 1,455, 43.1%) were selected from the 2008-2011 KNHANES. Sarcopenia assessments are based on a formula that divides a subject's appendicular skeletal muscle mass (ASM) by their weight (wt) and multiplies that result by 100 ([ASM/wt] × 100). Sarcopenia is present if the subject's result was less than one standard deviation (SD) below the sex-specific mean for a young reference group. For evaluation of diet quality, data obtained via the 24-hour recall method were used to calculate the Diet Quality Index for Koreans (DQI-K). A general linear model was applied in order to analyze general information and nutritional intake according to sarcopenia status. For analysis of the relationship between diet quality and sarcopenia, a binominal logistic regression analysis was undertaken. RESULTS: The sarcopenia prevalence rate among the study subjects aged 65 years and over was 37.6%. The DQI-K of those without sarcopenia was 3.33 ± 0.04 points, while that of those with sarcopenia was 3.45 ± 0.04 points (P < 0.05). The relationship between diet quality and sarcopenia revealed that subjects aged 75 and older had a poor diet quality, and their odds ratio (OR) of sarcopenia presence was significantly higher (OR: 1.807, 95% confidence interval: 1.003-3.254, P < 0.05). CONCLUSIONS: This study revealed that poor diet quality was related to sarcopenia presence in Koreans aged 75 and older. In order to improve the diet quality of the elderly (aged 75 and older), it is necessary to develop dietary improvement guidelines.

• 한국산학기술학회논문지
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• 제13권6호
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• pp.2664-2671
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• 2012

본 연구는 노인들의 신체적 특성이 보행 속도에 어떠한 영향을 미치는지 알아보기 위하여 시행되었다. 연구대상자는 보조도구의 사용에 관계없이 독립보행이 가능한 노인 77명(남 38명, 여자 39명)을 대상으로 하였다. 상관분석과 단계적 다중 선형 회귀분석을 사용하여 신체적 특성(연령, 성별, 신장, 체중, 신체질량지수, 근육량, 허리/엉덩이둘레비, 심박수, 폐활량, 유연성, 최대산소섭취량, 눈감고 한발 서기)과 하지 근력(슬관절 신전근, 슬관절 굴곡근)이 보행 속도와 어떠한 관련성이 있는지 분석하였다. 보행 속도는 연령, 신장, 폐활량, 눈감고 한발 서기 시간, 슬관절 굴곡근 및 신전근의 근력과 상관관계가 있었다. 또한 슬관절 굴곡근에 의해 보행 속도는 27%로 설명력을 가지고 있었으며, 슬관절 신전근 변수가 추가되었을 때 설명력은 32%로 높아졌다. 이러한 결과는 노인의 보행 속도가 하지의 근력과 다양한 신체적 특성에 영향을 받는다는 것을 의미한다.

• 한국수산과학회지
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• 제46권1호
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• pp.70-76
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• 2013

Some fish live in aquatic environments with low or temporally changing $O_2$ availability. Variation in dissolved oxygen (DO) levels requires behavioral, physiological, and biochemical adaptations to ensure the uptake of sufficient $O_2$. Several species are relatively well adapted to tolerate low $O_2$ partial pressures (hypoxia). The medaka (Oryzias dancena ) is an important model organism for biomedical research that shows remarkable tolerance to hypoxia. We investigated the regulation and role of hypoxia-inducible factor-1 (HIF-$1{\alpha}$) as a general hypoxia-response gene and stanniocalcin-2 (STC2), which is one of the genes regulated by HIF-$1{\alpha}$ in mammals under hypoxia. We subjected adult male medaka to the following three acute hypoxia regimes: 1, 24, and 72 h at DO = $1.8{\pm}0.5$ ppm. The changes in STC2 and HIF-$1{\alpha}$ mRNA were monitored using quantitative real-time reverse-transcription PCR. We found strong upregulation of HIF-$1{\alpha}$ mRNA in the livers of fish exposed to hypoxia. Hypoxia rapidly upregulated STC-2 mRNA expression in muscle, but not in the brain, gills, liver, or intestine. Therefore, unlike in mammals, hypoxia might regulate O. dancena STC-2 expression in an HIF-$1{\alpha}$-independent manner.

• 대한약리학회지
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• 제19권2호
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• pp.1-8
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• 1983

Prostaglandin(PG) is ubiquitously distributed in most mammalian tissue and their actions are complicated. Especially in autonomic nervous system, there are evidences indicating that PGs act as neuromodulators i.e., PGs, which are released in the vicinity of autonomic neuroeffector junctions, influence the release and the response of the neurotransmitter. Present study was undertaken to elucidate the interrelationship between $PGF_{2\alpha}$ and adrenergic ${\alpha}_2-receptor$ function in electrical field stimulation induced contractile response of vas deferens in rat. Male rat, weighing 150{\sim}200\;g, was sacrificed and vas deferens was obtained. The isolated vas deferens strip was placed between two platinum electrodes in temperature controlled $(37^{\circ}C)$ muscle chamber containing Tyrode's solution and the electrical field stimulation(EFS) induced contraction was recorded with Grass Polygraph(Model 7) via force displacement transducer (FT .03, Grass). The results are summarized as follows: 1) Electrical field stimulation for 1sec( 1 msec, 40 cps) induced contraction of vas deferens was completely blocked by tetrodotoxin. 2) Bretylium caused marked inhibition of the EFS-induced contraction, hut tyramine and cocaine augmented the contraction. 3) EFS-induced contraction was inhibited or little affected in distal portion of vas deferens by norepinephrine or methoxamine, but the contraction was rather augmented by the ${\alpha}-agonists$ in proximal portion. 4) Clonidine inhibited the EFS-induced contraction proportionally to the concentration in distal portion, which was blocked by yohimbine pretreatment, but in the presence of $PGF_{2\alpha}$ the blockade by yohimbine was reversed. 5) Indomethacin pretreatment reduced the effect of clonidine, but addition of $PGF_{2\alpha}$ after washing-out the indomethacin caused the contraction to the control level. From these results it is suggested that PG synthesis is a necessary step and the PG itself has a permissive role in ${\alpha}_2-adrenoceptor$ action in rat vas deferens.

• 전기전자학회논문지
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• 제22권2호
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• pp.362-368
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• 2018

본 논문은 학습으로 공감각 현상을 지각할 수 있는 의도적인 공감각을 기반으로 신체의 움직임에서 시각과 청각정보로의 변환 및 역변환 시스템을 구현하였다. 신체의 움직임은 웨어러블 암밴드인 Myo의 출력인 오일러 각을 사용하였고, 근감각 정보로서 롤(Roll), 피치(Pitch), 요(Yaw) 신호를 사용하였다. 또한, 시각과 청각 정보로서 미디(MIDI, Musical Instrument Digital Interface)신호와 HSI 컬러 모델을 사용하였다. 근감각 신호와 시 청각 신호 사이의 상호변환 방법은 일대일 대응 관계를 적용함으로써 직관적으로 쉽게 유추할 수 있도록 하였다. 시뮬레이션 결과에서 신체의 움직임 정보와 시 청각 정보의 상호변환이 가능함을 ROS(Root Operation System)와 3D 시뮬레이션 툴인 Gazebo를 사용하여 입력과 출력을 비교하였고 변환 오차가 작음을 확인하였다.

• 대한한의학회지
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• 제39권2호
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• pp.92-105
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• 2018

Objectives: This aim of this study is to compare the reflux esophagitis improvement effects of Sepiae Os, Arcae Concha, Ostreae Concha, and Proton Pump Inhibitor(esomeprazole) through rat experiments. Methods: NO production inhibitory effect was measured by NO production amount and iNOS mRNA expression level in cell lines. iNOS, $TNF-{\alpha}$ and $p-I{\kappa}B$, and serotonin were compared using immunohistochemistry at the rat reflux esophagitis. Reflux esophagitis connection external form, lower esophageal sphincter, and gap were observed and an esophageal inflammatory indicator, IL-6 activity was also evaluated by immunohistochemistry. Results: NO production and iNOS mRNA expression was showed concentration dependent decrease in cell lines treated with Sepiae OS, Arcae Concha, and Ostreae Concha at the experiments of cell lines. In the suppression of iNOS and $p-I{\kappa}B$ at the rat reflux esophagitis, Sepiae Os treat group(SOT) and Ostreae Concha treat group(OCT) were more effective. In the increase of serotonin at the rat reflux esophagitis, ACT, MT and OCT were more effective. Damage of lower esophageal sphincter, and gap between esophageal keratin and mucosa were observed less at the SOT, ACT, OCT. In the suppression of IL-6 at the rat reflux esophagitis, SOT and OCT were more effective than GE and, SOT was more effective than MT significantly. Conclusions: The anti-inflammatory effect was the best in the SOT and lower esophageal sphincter muscle contraction was the best in the ACT at the rat reflux esophagitis. Sepiae OS was more effective than esomeprazole in the suppression of iNOS, $TNF-{\alpha}$, and IL-6.

• Asian-Australasian Journal of Animal Sciences
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• 제19권10호
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• pp.1379-1383
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• 2006

A total of 6,804 records for Duroc breed were collected from three farms registered at the Korean Animal Improvement Association (KAIA) from 1998 to 2004 of which both records from two ultrasound modes (A and B) were analyzed to estimate the variance components of carcass traits. Three carcass traits backfat thickness (bf), loin eye muscle area (lma) and lean meat percentage (lmp) were measured. These traits were analyzed separately as bf1, lma1 and lmp1 for ultrasound mode A and bf2, lma2 and lmp2 for ultrasound mode B with multiple trait animal model by using MTDFREML (Boldman et al., 1993). All the traits revealed medium heritability values. Estimated heritabilities for bf1, bf2, lma1, lma2, lmp1 and lmp2 were 0.45, 0.39, 0.32, 0.25, 0.28 and 0.39, respectively. Estimated genetic correlations for traits bf1 and bf2, lma1 and lma2, lmp1 and lmp2 were positive but low. Specifically, genetic correlations between bf1 and bf2 was 0.30 while the estimates for lean traits between lma1 and lma2 and between lmp1 and lmp2 were 0.15 and 0.18, respectively. Conversely, high negative genetic correlations existed between bf1 and the lean traits lma2, lmp2. Likewise, the estimated genetic correlations between lma1 and lma2 and lmp1 and lmp2 were low.

• 생약학회지
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• 제44권1호
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• pp.75-82
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• 2013

Previous studies have shown that Aloe QDM complex, which is consisted of chromium (Cr), aloesin (ALS) and processed Aloe vera gel (PAG), exert antidiabetic activity in a high fat diet-induced mouse model of type 2 diabetes. In this study we examined the mechanism of the antidiabetic activity of the Aloe QDM complex. Rat myoblast cell line L6 cells were cultured in the presence of Cr, ALS, and PAG alone and in combinations, and then the capability of the cells to uptake glucose was examined using radiolabeled glucose. All of the 3 agents, Cr, ALS and PAG, exerted glucose uptake-enhancing activity in L6 cells. The most potent capability to uptake glucose was observed when L6 cells were cultured with the Aloe QDM complex. The activity of the Aloe QDM complex to enhance glucose uptake was prominent in conditions where existing insulin concentrations are low. We also examined the effects of the Aloe QDM complex on the plasma membrane expression of GLUT4 in L6 cells. The Aloe QDM complex increased the content of GLUT4 in the plasma membrane, while decreasing the content of GLUT4 in the light microsome. Taken together, these results show that the antidiabetic activity of the Aloe QDM complex is at least in part due to the stimulation of glucose uptake into the muscle cells, and this activity of the Aloe QDM complex is mediated through the enhancement of the translocation of GLUT4 into the plasma membrane.

• 구강회복응용과학지
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• 제25권4호
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• pp.319-328
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• 2009

측두하악장애(TMD)는 측두하악관절, 저작근 및 주변 구조물과 관련된 많은 임상적 문제들을 포괄하는 집합적인 용어로 정의되어 왔다. 1934년 이비인후과의사인 Costen이 턱 내측과 주변부의 통증 및 관련된 귀 증상이 교합의 변화로 개선되었다고 주장하는 논문을 발간한 이후, 턱관절장애의 진단과 치료는 교합이라는 개념 안에 속해 있었으나, 이에 대한 대부분의 최근 저서들은 교합장애를 더 이상 그 범주에 포함시키지 않고 있다. 측두하악장애 영역에서 교합장애를 배제시키려는 이러한 경향에도 불구하고 측두하악장애와 교합치료와의 유대는 여전히 강력하다. 현재 측두하악장애의 병인에 관한 가장 대중적인 이론들은 사회심리생물학적 모형에 기반을 두고 있으며 따라서, 향후의 치료방식들은 관절 및 근육 통증의 병태생리학적 과정뿐만 아니라, 만성 통증의 사회심리적 측면들까지도 그 대상으로 해야 할 것이다.

• Asian-Australasian Journal of Animal Sciences
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• 제27권10호
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• pp.1387-1393
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• 2014

This study aimed to estimate genetic correlation between carcass grading and retail productivity traits and to estimate the correlated response on retail productivity traits through selection for carcass grading traits in order to assess the efficacy of indirect selection. Genetic parameters were estimated with the data from 4240 Hanwoo steers using mixed models, and phenotypes included carcass weight (CWT), back fat thickness (BFT), eye muscle area (EMA), marbling (MAR), and estimated lean yield percentage (ELP) as the carcass grading traits, and weight and portion of retail cuts (RCW and RCP), trimmed fats (TFW and TFP) and trimmed bones (TBW and TBP) as the lean productivity traits. The CWT had positive genetic correlations with RCW (0.95) and TFW (0.73), but its genetic correlation with RCP was negligible (0.02). The BFT was negatively correlated with RCP (-0.63), but positively correlated with TFW and TFP (0.77 and 0.70). Genetic correlations of MAR with TFW and TFP were low. Among the carcass grading traits, only EMA was positively correlated with both RCW (0.60) and RCP (0.72). The EMA had a relatively strong negative genetic correlation with TFW (-0.64). The genetic correlation coefficients of ELP with RCP, TFW, and TFP were 0.76, -0.90, and -0.82, respectively. These correlation coefficients suggested that the ELP and EMA might be favorable traits in regulating lean productivity of carcass.