• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.3991-3995
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• 2015

Background: Colorectal cancer (CRC) is the third most common cancer in Iranian women and fifth in men. The aims of this study were to investigate the relation of dietary factors and public health indicators to its development. Materials and Methods: The required information (2001-2006) about risk factors was obtained from the Non-Communicable Disease Surveillance Centre (NCDSC) of Iran. Risk factor data (RFD) from 89,404 individuals (15-64 years old) were gathered by questionnaire and laboratory examinations through a cross sectional study in all provinces by systematic clustering sampling method. CRC incidence segregated by age and gender was obtained from Cancer Registry Ministry of Health (CRMH) of Iran. First, correlation coefficients were used for data analysis and then multiple regression analysis was performed to control for confounding factors. Results: Colorectal cancer incidence showed a positive relationship with diabetes mellitus, hypertension, lacking or low physical activity, high education, high intake of dairy products, and non-consumption of vegetables and fruits. Conclusions: We concluded that many dietary factors and public health indicators have positive relationships with CRC and might therefore be targets of preliminary prevention. However, since this is an ecological study limited by potential ecological fallacy the results must be interpreted with caution.

• 한국지구물리탐사학회:학술대회논문집
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• 한국지구물리탐사학회 2006년도 공동학술대회 논문집
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• pp.281-284
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• 2006

저항성 V 다이폴(RVD)은 V 안테나의 각 암(arm)에 연속적인 Wu-King 저항 프로파일을 실은 것이다. RVD는 매우 짧은 펄스를 한 방향으로 복사할 수 있고, 복사된 펄스는 입력 펄스의 미분 등으로 간단하게 연관되는 등 지표 및 지하 탐사를 위해 매우 좋은 특성을 가지고 있다. 또한 레이더 단면적이 적어 지표와 안테나 사이의 다중 반사를 줄일 수 있다. 단점으로는 높은 입력저항과 제작의 어려움을 들 수 있다. 본 연구에서는 저주파에서의 성능과 제작상의 문제를 개선하면서도 저항성 V 다이폴의 특성을 유지하기 위한 방법을 제시한다. 제작된 V 다이폴을 이용하여 간단한 바이스태틱 레이더를 구성하고 지하 구조물에 대하여 스캔하여 이미지로 나타내었다.

• 동의생리병리학회지
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• 제31권6호
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• pp.334-340
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• 2017

Wound healing is the restoration in injured skin tissue and one of the most important therapeutic targets. The process consists of inflammation, proliferation, and remodeling. There have been reported multiple factors that accelerate and delay wound healing. In this study we tested the hypothesis that Sophorae Radix extract would improve the recovery of wound healing after full-thickness skin wound in rats. Twenty young male Sprague-Dawley rats were used for the studies. A full-thickness skin wound was made on the dorsal skin of the rats. Either Sophorae Radix water extract (SR) or saline (Control) was orally administrated every day. The wound area was measured and the percentages of wound contraction, wound healed and wound epithelization were evaluated. After 15 days, the skin tissues were excised and examined by histopathological and immunohistochemistrical method. In results, wound area in SR group was significantly decreased to compared with Control. SR group showed the significant enhancements in the percentages of wound contraction, wound healed and wound epithelization. Histopathological examination revealed that SR induces neo-vascularization potential in wound healing process. SR treatment in rats significantly accelerated cutaneous wound healing in the angiogenesis process by increasing VEGF and TGF-${\beta}1$ synthesis. These results suggest that Sophorae Radix enhance skin wound repair by increasing the angiogenic agents such as VEGF and TGF-${\beta}1$.

• 한국전기전자재료학회논문지
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• 제29권10호
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• pp.665-670
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• 2016

Prevailing dissemination of machine tools and cutting technology have caused drastic developments of high speed dry machining with work materials of high hardness, and demands on the high-hardness-materials with high efficiency have become increasingly important in terms of productivity, cost reduction, as well as environment-friendly issue. Addition of Si to TiAlN has been known to form nano-composite coating with higher hardness of over 30 GPa and oxidation temperature over $1,000^{\circ}C$. However, it is not easy to add Si to TiAlN by using conventional PVD technologies. Therefore, Ti-Al-Si-N have been prepared by hybrid process of PVD with multiple target sources or PVD combined with PECVD of Si source gas. In this study, a single composite target of Ti-Al-Si was prepared by powder metallurgy of MA (mechanical alloying) and SPS (spark plasma sintering). Properties of he resulting alloying targets were examined. They revealed a microstructure with micro-sized grain of about $1{\sim}5{\mu}m$, and all the elements were distributed homogeneously in the alloying target. Hardness of the Ti-Al-Si-N target was about 1,127 Hv. Thin films of Ti-Al-Si-N were prepared by unbalanced magnetron sputtering method by using the home-made Ti-Al-Si alloying target. Composition of the resulting thin film of Ti-Al-Si-N was almost the same with that of the target. The thin film of Ti-Al-Si-N showed a hardness of 35 GPa and friction coefficient of 0.66.

• Advances in Computational Design
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• 제5권2호
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• pp.195-207
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• 2020

The present study focuses on the application of artificial neural network (ANN) and Multiple linear Regression (MLR) analysis for developing a model to predict the unconfined compressive strength (UCS) and split tensile strength (STS) of the fiber reinforced clay stabilized with grass ash, fly ash and lime. Unconfined compressive strength and Split tensile strength are the nonlinear functions and becomes difficult for developing a predicting model. Artificial neural networks are the efficient tools for predicting models possessing non linearity and are used in the present study along with regression analysis for predicting both UCS and STS. The data required for the model was obtained by systematic experiments performed on only Kaolin clay, clay mixed with varying percentages of fly ash, grass ash, polypropylene fibers and lime as between 10-20%, 1-4%, 0-1.5% and 0-8% respectively. Further, the optimum values of the various stabilizing materials were determined from the experiments. The effect of stabilization is observed by performing compaction tests, split tensile tests and unconfined compression tests. ANN models are trained using the inputs and targets obtained from the experiments. Performance of ANN and Regression analysis is checked with statistical error of correlation coefficient (R) and both the methods predict the UCS and STS values quite well; but it is observed that ANN can predict both the values of UCS as well as STS simultaneously whereas MLR predicts the values separately. It is also observed that only STS values can be predicted efficiently by MLR.

• Asian Pacific Journal of Cancer Prevention
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• 제15권20호
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• pp.8539-8548
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• 2014

Mitogen-activated protein kinase (MAPK) is an important signaling pathway in living beings in response to extracellular stimuli. There are 5 main subgroups manipulating by a set of sequential actions: ERK(ERK1/ERK2), c-Jun N(JNK/SAPK), p38 MAPK($p38{\alpha}$, $p38{\beta}$, $p38{\gamma}$ and $p38{\delta}$), and ERK3/ERK4/ERK5. When stimulated, factors of upstream or downstream change, and by interacting with each other, these groups have long been recognized to be related to multiple biologic processes such as cell proliferation, differentiation, death, migration, invasion and inflammation. However, once abnormally activated, cancer may occur. Several components of the MAPK network have already been proposed as targets in cancer therapy, such as p38, JNK, ERK, MEK, RAF, RAS, and DUSP1. Among them, alteration of the RAS-RAF-MEK-ERK-MAPK(RAS-MAPK) pathway has frequently been reported in human cancer as a result of abnormal activation of receptor tyrosine kinases or gain-of-function mutations in genes. The reported roles of MAPK signaling in apoptotic cell death are controversial, so that further in-depth investigations are needed to address these controversies. Based on an extensive analysis of published data, the goal of this review is to provide an overview on recent studies about the mechanism of MAP kinases, and how it generates certain tumors, as well as related treatments.

• 대한한의학회지
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• 제24권2호
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• pp.148-158
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• 2003

Backgrounds & Objectives: In many recent studies, molecular biological methods have been used to investigate the role of cytokines in pathogenesis and new therapeutic targets of asthma. Recently, as a method of research on the gene expression, they are applying another method which assays multiple gene expressions at the same time by the microarray. In this study, the antioxidant effect, the inhibitory effect against interleukin-4 and the effect on the CD/cytokine gene expression in PBMC (peripheral blood mononuclear cells) was evaluated by using cDNA microarray chip of Chungsangboha-tang. Methods: Experimental studies were performed for the antioxidant effect of Chungsangboha-tang on DPPH (1, 1-diphenyl-2-picrylhydrazyl) solution, for the IL-4-inhibiting effect on BALB/c mouse spleen, and for the gene expression effect on PBMC (peripheral blood mononuclear cells) with microarray. Results: Chungsangboha-tang showed antioxidant effect dose-dependently. Chungsangboha-tang inhibited interleukin-4 dose-dependently and showed significant difference in 10ug/ml and 100ug/ml of test groups. There was no 2 more times upregulated genes than in the control group by using cDNA microarray chip of Chungsangbohn-tang, but there were 140%-200% upregulated genes. There was no 2 more times downregulated genes than in the control group by using cDNA microarray chip of Chungsangboha-Tang, but there was 50%-75% downregulated genes. Conclusions: This study showed that Chungsangboha-tang has an antioxidant effect and inhibition of Interleukin-4, but further studies are necessary with microarray.

• 생물정신의학
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• 제8권2호
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• pp.208-219
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• 2001

The pharmacotherapy of schizophrenia exhibits wide inter-individual variabilities in clinical efficacy and adverse effects. Recently, human genetic diversity has been known as one of the essential factors to the variation in human drug response. This suggests that drug therapy should be tailored to the genetic characteristics of the individual. Pharmacogenetics is the field of investigation that attempts to elucidate genetic basis of an individual's responses to pharmacotherapy, considering drug effects divided into two categories as pharmacokinetics and pharmacodynamics. The emerging field of pharmacogenomics, which focuses on genetic determinants of drug response at the level of the entire human genome, is important for development and prescription of safer and more effective individually tailored drugs and will aid in understanding how genetics influence drug response. In schizophrenia, pharmacogenetic studies have shown the role of genetic variants of the cytochrome P450 enzymes such as CYP2D6, CYP2C19, and CYP2A1 in the metabolism of antipsychotic drugs. At the level of drug targets, variants of the dopamine $D_2$, $D_3$ and $D_4$, and 5-$HT_{2A}$ and 5-$HT_{2C}$ receptors have been examined. The pharmacogenetic studies in schizophrenia presently shows controversial findings which may be related to the multiple involvement of genes with relatively small effects and to the lack of standardized phenotypes. For further development in the pharmacogenomics of schizophrenia, there would be required the extensive outcome measures and definitions, and the powerful new tools of genomics, proteomics and so on.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제3권7호
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• pp.285-292
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• 2014

개체명 인식은 정보검색 시스템, 질의응답 시스템, 기계번역 시스템 등의 성능을 향상시키기 위하여 사용된다. 개체명 인식은 일반적으로 PLOs(인명, 지명, 기관명)을 대상으로 하며, 주로 미등록어와 고유명사로 이루어져 있기 때문에 고유명사나 미등록어는 중요한 개체명 후보로 쓰일 수 있다. 하지만 도서명, 영화명, 음악명, TV프로그램명과 같은 제목 개체명은 PLO와는 달리 단어부터 문장까지 매우 다양한 형태를 지니고 있어서 개체명 인식이 쉽지 않다. 본 논문에서는 뉴스 기사문을 이용하여 제목 개체명을 빠르게 인식하고 자동으로 사전을 구축하는 방법을 제안한다. 먼저 특수기호로 묶인 어절을 추출하고, 주변 문맥 단어 및 단어 거리를 이용하여 SVM으로 제목 후보들을 추출하였다. 이렇게 추출된 제목 후보들은 상호 정보량을 가중치로 SVM을 이용해 제목 유형을 분류하였다.

• 항공우주기술
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• 제3권1호
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• pp.126-133
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• 2004

사진측량법(Photogrammetry)는 서로 다른 촬영각을 가지는 다수의 2차원 이미지로부터 대상물의 정밀한 3차원 형상을 얻어내는 기법이다. 본 연구에서는 사진측량법을 활용하여 다목적 실용위성 2호 비행모델 하부 탑재체 플랫폼(Low Payload Platform)의 고해상도 카메라 접합면에 대한 편평도(Flatness) 측정 작업을 수행하였으며, 정밀하게 교정된 2개의 스케일바(Scale Bar)를 사용하여 절대적인 길이 값을 3차원 모델에 부과함과 동시에 측정정확도를 계산하여 내었다. 또한 측정된 편평도 결과는 고해상도 카메라 납품 업체에서 제시한 편평도 요구조건과 비교되었다.