Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Enhancement of Angiogenesis by Sophorae Radix in Full-thickness Skin Wound of Rats

흰쥐의 피부상처 동물모델에서 고삼(苦蔘)이 신생혈관형성에 미치는 영향

  • Kim, Bum Hoi (Department of Anatomy, College of Korean Medicine, Dong-eui University) ;
  • Kang, Kyung-Hwa (Department of Physiology, College of Korean Medicine, Dong-eui University)
  • 김범회 (동의대학교 한의과대학 해부학교실) ;
  • 강경화 (동의대학교 한의과대학 생리학교실)
  • Received : 2017.11.22
  • Accepted : 2017.12.12
  • Published : 2017.12.25
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Abstract

Wound healing is the restoration in injured skin tissue and one of the most important therapeutic targets. The process consists of inflammation, proliferation, and remodeling. There have been reported multiple factors that accelerate and delay wound healing. In this study we tested the hypothesis that Sophorae Radix extract would improve the recovery of wound healing after full-thickness skin wound in rats. Twenty young male Sprague-Dawley rats were used for the studies. A full-thickness skin wound was made on the dorsal skin of the rats. Either Sophorae Radix water extract (SR) or saline (Control) was orally administrated every day. The wound area was measured and the percentages of wound contraction, wound healed and wound epithelization were evaluated. After 15 days, the skin tissues were excised and examined by histopathological and immunohistochemistrical method. In results, wound area in SR group was significantly decreased to compared with Control. SR group showed the significant enhancements in the percentages of wound contraction, wound healed and wound epithelization. Histopathological examination revealed that SR induces neo-vascularization potential in wound healing process. SR treatment in rats significantly accelerated cutaneous wound healing in the angiogenesis process by increasing VEGF and TGF-${\beta}1$ synthesis. These results suggest that Sophorae Radix enhance skin wound repair by increasing the angiogenic agents such as VEGF and TGF-${\beta}1$.

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