• Earthquakes and Structures
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• v.17 no.1
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• pp.49-61
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• 2019

A novel asymmetrical resistance friction damper (ARFD) was proposed in this study to be applied on a rocking column base. The damper comprises multiple steel plates and was fastened using high-strength bolts. The sliding surfaces can be switched into one another and can cause strength to be higher in the loading direction than in the unloading direction. By combining the asymmetrical resistance with the restoring resistance that is generated due to an axial load on the column, the rocking column base can develop a self-centering behavior and achieve high connection strength. Cyclic tests on the ARFD proved that the damper performs a stable asymmetrical hysteretic loop. The desired hysteretic behavior was achieved by tuning the bolt pretension force and the diameter of the round bolt hole. In this study, full-scale, flexural tests were conducted to evaluate the performance of the column base and to verify the analytical model. The results indicated that the column base exhibits a stable self-centering behavior up to a drift angle of 4%. The decompression moment and maximum strength reached 42% and 88% of the full plastic moment of the section, respectively, under a column axial force ratio of approximately 0.2. The strengths and self-centering capacity can be obtained by determining the bolt pretension force. The analytical model results revealed good agreement with the experimental results.

• Parasites, Hosts and Diseases
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• v.60 no.2
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• pp.109-116
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• 2022

Drug resistance is an important problem hindering malaria elimination in tropical areas. Point mutations in Plasmodium falciparum dihydrofolate reductase (Pfdhfr) and dihydropteroate synthase (Pfdhps) genes confer resistance to antifolate drug, sulfadoxine-pyrimethamine (SP) while P. falciparum chloroquine-resistant transporter (Pfcrt) genes caused resistance to chloroquine (CQ). Decline in Pfdhfr/Pfdhps and Pfcrt mutations after withdrawal of SP and CQ has been reported. The aim of present study was to investigate the prevalence of Pfdhfr, Pfdhps, and Pfcrt mutation from 2 endemic areas of Thailand. All of 200 blood samples collected from western area (Thai-Myanmar) and southern area (Thai-Malaysian) contained multiple mutations in Pfdhfr and Pfdhps genes. The most prevalent haplotypes for Pfdhfr and Pfdhps were quadruple and double mutations, respectively. The quadruple and triple mutations of Pfdhfr and Pfdhps were common in western samples, whereas low frequency of triple and double mutations was found in southern samples, respectively. The Pfcrt 76T mutation was present in all samples examined. Malaria isolated from 2 different endemic regions of Thailand had high mutation rates in the Pfdhfr, Pfdhps, and Pfcrt genes. These findings highlighted the fixation of mutant alleles causing resistance of SP and CQ in this area. It is necessary to monitor the re-emergence of SP and CQ sensitive parasites in this area.

• Smart Structures and Systems
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• v.28 no.6
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• pp.737-744
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• 2021

In this study, structural health monitoring (SHM) methods of carbon fiber reinforced plastics (CFRPs) were investigated using electrical resistance. The developed sensing technique monitored electrical resistance in accordance with the impact damage of a CFRP. The changes in electrical resistances with multiple electrode sets enabled SHM without extra sensors so that this technique can be called self-sensing. Moreover, this study proposed electrodes only at peripheral side of a structure to minimize the number of electrodes compared to those in an array which has square number of sensors as the sensing area increases. For the intensive investigation, electromechanical sensitivity in terms of electrode distance was analyzed and optimized under drop weight impact testing. Then, SHM methods with electrodes in an array and electrodes in peripheral edges were comparatively investigated. The developed methods successfully localized impact damages into 2D coordinates. Furthermore, damage severity can be shown with a damage map by calculating electrical resistance change ratio. Therefore, structural health self-sensing system using electrical resistance was successfully developed with the minimum number of electrodes.

• Steel and Composite Structures
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• v.44 no.6
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• pp.769-788
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• 2022

In this paper a mathematical model for the prediction of the fire resistance of slim-floor steel beams based on an Artificial Neural Network modeling procedure is presented. The artificial neural network models are trained and tested using an analytical database compiled for this purpose from analytical results based on FEM. The proposed model was selected as the optimum from a plethora of alternatives, employing different activation functions in the context of Artificial Neural Network technique. The performance of the developed model was compared against analytical results, employing several performance indices. It was found that the proposed model achieves remarkably improved predictions of the fire resistance of slim-floor steel beams. Moreover, based on the optimum developed AN model a closed-form equation for the estimation of fire resistance is derived, which can prove a useful tool for researchers and engineers, while at the same time can effectively support the teaching of this subject at an academic level.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2023.05a
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• pp.145-146
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• 2023

In this study, the effect of hybrid fiber reinforcement on the residual strength and impact resistance of high-strength cementitious composites exposed to high temperatures was investigated. A cementitious composites was manufactured in which 0.15 vol% of polypropylene fiber (PP) and 1.0 vol% of smooth steel fiber (SSF) were double-mixed, and a residual strength test was conducted while thermal stress was applied by heating test, and then a high-velocity impact test was performed. In the case of general cementitious composites, the rear surface is damaged due to explosion and low tensile strength during high temperature or impact, while hybrid fiber reinforced cementitious composites can repeatedly absorb and distribute stress until multiple fibers are damaged to suppress the propagation of impact and resistance to explosion. Therefore, this study analyzed the residual strength of cementitious composites exposed to high temperatures depending on whether hybrid fibers were mixed or not, and collected research data on fracture behavior through high-speed impact tests to evaluate impact resistance and mechanical properties.

• Journal of Ecology and Environment
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• v.29 no.5
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• pp.479-484
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• 2006

Ecophysiological parameters of non-transgenic sweetpotato (NT) and transgenic sweetpotato (SSA) plants were compared to evaluate their resistance to multiple environmental stresses. Stomatal conductance and transpiration rate in NT plants decreased markedly from Day 6 after water was withheld, whereas those values in SSA plants showed relatively higher level during this period. Osmotic potential in SSA plants was reduced more negatively as leaf water potential decreased from Day 8 after dehydration treatment, while such reduction was not shown in NT plants under water stressed condition. SSA plants showed less membrane damage than in NT plants. As water stress and high light stress, were synchronously applied to NT and SSA plants maximal photochemical efficiency of PS II ($F_v/F_m$) in NT plants markedly decreased, while that in SSA plants was maintained relatively higher level. This trend of changes in $F_v/F_m$ between SSA plants and NT plants was more conspicuous as simultaneously treated with water stress, high light and high temperature stress. These results indicate that SSA plants are more resistive than NT plants to multiple environmental stresses and the enhanced resistive characteristics in SSA plants are based on osmotic adjustment under water stress condition and tolerance of membrane.

• Korean Journal of Veterinary Research
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• v.48 no.3
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• pp.275-285
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• 2008

Antimicrobial drugs are widely used in poultry industry as growth promoters or to control infectious diseases. However, this practice is reported to have caused high resistance to antimicrobial drugs in normal chicken flora and pathogens. Antimicrobial resistance to Escherichia coli (E. coli) from chicken has been mainly reported in normal flora, but rare in pathogenic organism in Korea, recently. Therefore, this study was conducted to investigate prevalence of antimicrobials resistance, transfer of R plasmid, and association between antimicrobial drug resistance and O serotype of 203 pathogenic E. coli from poultry in Korea during the period from April 2003 to December 2005. These isolates showed a high resistance to tetracycline (Tc, 93.6%), nalidixic acid (Na, 92.6%), streptomycin (Sm, 81.8%), ampicillin (Ap, 77.3%), ciprofloxacin (Ci, 70.9%), sulfisoxazole (Su, 66.5%), and trimethoprim (Tp, 58.1%). Two hundred-one (99.0%) of the isolates were resistant to one or more drugs. They showed 57 different resistant patterns, and the most prevalent resistant pattern among them was Tc, Sin, Su, Ap, Tp, Ci, Na. Sixty-eight (33.8%) of the isolates transferred all or a part of their antimicrobial resistant pattern to the recipient strain by R plasmid. The most common antimicrobial resistant pattern was Tc, Sm, Su, Ap, Tp, Ci, Na in serotype O78, O88 and O15, respectively. These results exhibit high individual and multiple resistance to antimicrobials of pathogenic E. coli from poultry in Korea. They also suggest the needs for surveillance to monitor antimicrobial resistance in pathogenic bacteria that can be potentially transmitted to humans from food animals and to regulate the abuse of antimicrobials on food-producing animals in Korea.

• Korean Journal of Breeding Science
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• v.51 no.4
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• pp.504-514
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• 2019

'Yechan' is a high grain quality mid-late maturing rice cultivar with lodging tolerance and multiple disease resistance. It was a derived from a cross between 'Hopum' and 'Iksan537' (cultivar name 'Haepum'). 'Hopum' is a high grain quality mid-late maturing rice cultivar with strong lodging tolerance and 'Haepum' is a high grain quality medium maturing rice cultivar with multiple disease resistance. To shorten the breeding period, another culture method was applied to the F₁ plants. 'Yechan' was selected through the pedigree method, yield trials, and local adaptability tests, with a high selection pressure for grain quality, lodging, and disease resistance. The heading date of 'Yechan' was August 14, one day later than that of 'Nampyeong'. 'Yechan' is a cultivar tolerant to lodging and it has short culms. It has multiple disease resistance against rice blast, rice stripe virus, and bacterial blight, including the K3a race, the most virulent race in Korea. The yield of 'Yechan' was similar to that of 'Nampyeong'. 'Yechan' showed excellent grain appearance, superior taste when cooked, and enhanced milling performance; thus, we concluded that it could contribute to the improvement of Korean japonica rice cultivar quality. 'Yechan', a high grain quality mid-late maturing rice cultivar with lodging tolerance and multiple disease resistance, would be suitable for cultivation in the southern plain area in Korea and has been utilized in the breeding programs aimed at enhancing the grain quality and stability for the cultivation of Korean japonica rice (Registration No. 7647).

• Journal of Microbiology and Biotechnology
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• v.8 no.5
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• pp.497-500
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• 1998

A new strain of Bacillus capable of growing upto pH 11 was isolated from a local pond polluted with detergents. This strain elicited unimpaired growth in media supplemented with heavy metals such as As, Cu, Cd, Hg, Ni and Zn. A MIC value of 200, 3, 1.60, 2.25, 7.50 and 3.70 mM was noticed for As, Cu, Cd, Hg, Ni and Zn respectively. Analysis of total DNA revealed the presence of a plasmid of 26 kb. This plasmid was lost by acriflavine treatment to the cultures. Such cured strains were found sensitive to heavy metals. Our findings suggest that incidence of heavy metal resistance is widely distributed and resistant strains could be isolated from heavy metal unpolluted sites.

• Biomolecules & Therapeutics
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• v.5 no.3
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• pp.265-271
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• 1997

Since the advent of chemotherapy, certain types of cancer have been particularly resistant to chemotherapeutic treatment. One of the most well-studied types of resistance is resistance to multiple struc-turally dissimialr hydrophobic chemotherapeutic agents, or multidrug resistance (MDR). We found that MDR cells (KBV20C, KB7D) being highly resistant to colchicine, etoposide, and vincristine were found to have very low level of putrescine and low level of spermidine than the drug sensitive parental cells (KB) but they had almost same level of spermine as the drug sensitive cells. Although both MDR and drug sensitive cells had almost same rate of polyamine uptake, MDR cells were much more sensitive to an inhibitor of polyamine synthesis, methylglyoxal-bis guanylhydrazone (MGBG), suggesting that MDR cells might be defective in polyamine synthesis. These results also suggest that HGBG can be used for treatment of MDR in vivo.