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Local radiotherapy for palliation in multiple myeloma patients with symptomatic bone lesions

  • Lee, Jeong Won;Lee, Jeong Eun
    • Radiation Oncology Journal
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    • v.34 no.1
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    • pp.59-63
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    • 2016
  • Purpose: To evaluate the clinical outcomes of symptomatic bone lesions in patients with multiple myeloma (MM) who received local radiotherapy (LRT). Materials and Methods: Fifty-one patients with 87 symptomatic bone lesions treated via LRT were analyzed. LRT was delivered at a median total dose of 21 Gy (range, 12 to 40 Gy) in a median of 7 fractions (range, 4 to 20 fractions). The clinical outcomes of LRT and the factors affecting treatment response were assessed. Results: After a median follow-up time of 66.7 weeks, symptom relief was achieved for 85 of 87 lesions (97.7%). The median time to symptom relief was 7 days from the start of LRT (range, 1 to 67 days). The duration of in-field failure-free survival ranged from 1.1 to 450.9 weeks (median, 66.7 weeks). The radiation dose or use of previous and concurrent chemotherapy was not significantly associated with in-field failure for LRT (p = 0.354, 0.758, and 0.758, respectively). Conclusion: Symptomatic bone lesions in patients with MM can be successfully treated with LRT. A higher radiation dose or the use of concurrent chemotherapy may not influence the in-field disease control. A relatively low radiation dose could achieve remission of symptoms in patients with MM.

TIME-DEPENDENT DEFORMATION OF POLYMER-BASED PROVISIONAL CROWN AND FIXED PARTIAL DENTURE MATERIALS

  • Pae Ahran;Jeong Mi-Sook;Kim Sung-Hun
    • The Journal of Korean Academy of Prosthodontics
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    • v.43 no.6
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    • pp.717-726
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    • 2005
  • Statement of problem. One of the common problems of provisional crown and fixed partial denture materials is that when they are subjected to constant loads for a long period of time, they exhibit a dimensional change (creep). Purpose. The aim of this study was to investigate the viscoelastic behaviour of polymer-based provisional crown and fixed partial denture materials with time at constant compressive load. Material and methods. Three dimethacrylate-based materials (Protemp 3 Garant, Temphase, Luxatemp) and one monomethacrylate-based material (Trim) were selected. Dimensional changes of the specimens were recorded by a LVDT to evaluate their viscoelastic behavior and creep strain. For all specimens, two loading procedures were used. At first, static compressive stress of 4 MPa was applied for 30 minutes and followed by 1 hour of strain recovery. Then, after 24 hours of water storage, the specimens were loaded again. The creep values between materials were statistically analyzed using one-way ANOVA and multiple comparison $Scheff\acute{e}$ test. Independent samples t-test was also used to identify the difference of creep strain between first and secondary loading conditions at the significance level of 0.05. Results. Following application of the first loading, Trim showed the highest maximum creep strain (32.7%) followed by Luxatemp, Protemp 3 Garant and Temphase, with values of 3.78%, 2.86% and 1.77%, respectively. Trim was significantly different from other materials (P<0.05), while there were no significant differences among Luxatemp, Protemp 3 Garant and Temphase (P>0.05). The highest recovery and permanent set of Trim, were significantly different from those of others (P<0.05). At the secondary loading of the dimethacrylate-based materials, creep deformation, recovery and permanent set decreased and the percentage of recovery increased, while in Trim, all values of the measurements increased. This result showed that the secondary loading at 24 hours produced a significant creep magnitude. Conclusion. The dimethacrylate-based provisional crown and fixed partial denture materials showed significantly higher creep resistance and lower deformation than the monomethacrylate-based material. Thus, monomethacrylate-based materials should not be used in long-term stress-bearing situations.

Recommendable Methods for Effective Improvement of Management System on Organic Materials based on the Analysis of Unintentional Contamination Investigation and Recognition Survey collected from Organic Farmer and so on (유기농업자재중 비의도적 오염원 조사분석 및 친환경농업인 등 인식조사에 근거한 유기농업자재 관리제도의 효율적 개선방안)

  • Ahn, In;Lee, In-Ae;Sim, Mi-Jin
    • Korean Journal of Organic Agriculture
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    • v.23 no.4
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    • pp.659-682
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    • 2015
  • This study was conducted to suggest ideal management system for organic materials. As the performing method of the study, surveyed results on understanding of related persons (organic farmer 846, organic materials manufacture 70 and Organic materials Auditors 7) with eco-friendly farming were used. And the opinion on unintentional pollution source contained in organic materials was surveyed additionally. The issues pointed out by organic farmers on product of organic materials were high price (60% to total), poor efficacy (16%), disorder on distribution system (13%) and containing chemicals as a pesticide (10%). And notification system for organic materials was accepted in general (positive and so so 76%) while most interviewees preferred (89%) unification of certification system dominantly. As unintentional contamination source, pollution on imported row material was indicated as major reason, and other causes were confirmed as insertion during manufacturing process, agricultural by-products using as product additive et al. Based on these surveyed results, authors suggest bellows as considerable methods for effective improvement of management system on organic material. First, establish new integrated certification system which contains standard of quality certification and notification system on organic material. Second, for evaluation of efficacy, apply relative evaluation system of significance such as Duncan's multiple test instead of existing absolute evaluation system. Third, constitute and operate selection of standard comparison subcommittee in organic Agro-materials committee in RDA.

Poisson's ratios of fabric materials in use for large-span membrane structures

  • Jianhui Hu;Wujun Chen;Chengjun Gao;Yibei Zhang;Yonglin Chen;Pujin Wang
    • Structural Engineering and Mechanics
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    • v.90 no.6
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    • pp.543-549
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    • 2024
  • The utilization of the fabric materials for lightweight building structures has attracted considerable attention due to the multiple functions and high strength-to-weight ratio. The mechanical properties of the fabric materials evolve with the loading cycle, especially for the Poisson's ratio that requires the full cyclic strain to determine the accurate values. The digital image correlation method has been justified but needs to meet the flexibility and complexity requirements of the fabric materials. This paper thus proposes a modified digital image correlation method to quantify the Poisson's ratio of fabric materials. To obtain the accurate Poisson's ratio of fabric materials in the cyclic experiments using non-contact measuring method, a speckle generation of the digital image correlation method is implemented to obtain the strain distribution and strain characteristics. The uniaxial cyclic experiments for the fabric materials are carried out in the warp, weft and 45° directions. The digital image correlation photos are taken when the material properties become stable in the cyclic loading. The results show that the strain distributions are non-uniform and dependent on the specimen directions. The reliable Poisson's ratios of the fabric materials in the warp, weft and 45° directions are 0.016, 1.2 and 2.6. The strain asymmetry at the maximum strain position is related with the weaving architecture. These observations and results are indispensable to understand the Poisson's ratios of fabric materials and to guide the proper analysis of the large-span membrane structures.

Combustion Modeling of a Solid Fuel Bed with Consideration of the Multiple Solid Phases (다중 고체상을 고려한 고체 연료층 연소 모델링)

  • Yang, Won;Ryu, Chang-Kook;Choi, Sang-Min
    • 한국연소학회:학술대회논문집
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    • 2003.05a
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    • pp.119-127
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    • 2003
  • In this study we propose an unsteady I-dimensional model of bed combustion with multiple solid phases, which confers a phase on each solid material. This model can be applied to a variety of bed combustion cases of various configurations and ignition methods. It contains fuel combustion, gaseous reaction, heat transfers between each phase, and geometric changes of the solid particles. An iron ore sintering pot is selected for verifying the model validity and simulation results are compared with the limited experimental data set of various coke contents and air supply rates. They predict the experimental results well and show applicabilities to the various system of the fuel bed with various solid materials.

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Computer Simulation of Multiple Reflection Waves for Thickness Measurement by Ultrasonic Spectroscopy (초음파 Spectroscopy에 의한 두께측정을 위한 다중반사파의 시뮬레이션)

  • Park, I.G.;Han, E.K.;Choi, M.Y.
    • Journal of the Korean Society for Nondestructive Testing
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    • v.12 no.1
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    • pp.9-15
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    • 1992
  • Ultrasonic spectroscopy is likely to become a very powerful NDE method for detection of microfects and thickness measurement of thin film below the limit of ultrasonic distance resolution in the opaque materials, provides a useful information that cannot be obtained by a conventional ultrasonic measuring system. In this paper, we considered a thin film below the limit of ultrasonic distance resolution sandwitched between two substances as acoustical analysis model, demonstrated the usefulness of ultrasonic spectroscopic analysis technique using information of ultrasonic frequency for measurements of thin film thickness, regardless of interference phenomenon and phase reversion of ultrasonic waveform. By using frequency intervals(${\triangle}f$) of periodic minima from the ratio of reference power spectrum of reflective waveform obtained a sample to power spectrum of multiple reflective waves obtained interference phenomenon caused by ultrasonic waves reflected at the upper and lower surfaces of a thin layer, can measured even dimensions of interest are smaller than the ultrasonic wave length with simplicity and accuracy.

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Robust Design Methodology under Design Constraints (기술적 설계제약을 고려한 강건설계법)

  • Kim, Kyung-Mo
    • Journal of Korean Society for Quality Management
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    • v.35 no.4
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    • pp.52-60
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    • 2007
  • A multi-attribute robust design methodology is presented. This method can be applied where there are various technical constraints in design variables, multiple potentially conflicting design attributes, and uncontrollable noise variables. Two forms of technical constraints, soft and hard constraints, are considered in robust design settings. Specifically, this work presents procedures for integrating two types of design constraints seamlessly on the multiple design attributes, which is achieved through a development of multi-attribute utility formulation. The effectiveness of the overall procedures is tested with the aid of an I-Beam design problem, and results of sensitivity analysis are discussed.

A Consideration on the Characteristics of Electron Beam Dose Distributions for Clinical Applications (임상적용을 위한 전자선의 선량분포 특성에 대한 고찰)

  • Cha, Dong-Soo
    • Korean Journal of Digital Imaging in Medicine
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    • v.12 no.1
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    • pp.65-69
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    • 2010
  • High energy electron beams were to concentrically dose inside a tumor and more energy is a shape decreased of dose. Therefore, it is useful to radiation therapy of a tumor. Also high energy electron beams ionized into collision with a atom in structure material of tissue and it has big changes to dose distribution by multiple scattering. The study had to establish characteristic of electron beams from interaction of electron beams and materials. Experiment method was to measure dependence of electron beam central axis for depth dose curve, field flatness and symmetry and field size dependence. The results were able to evaluate data for a datum pint of electron beam. Also radiotherapy has to be considered for not only energy pencil of lines but characteristic, electron guide and isodose curves distribution.

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A Study on the Mechanical Properties of Hybrid HPFRCs Using Micro and Macro Fibers (마이크로 및 매크로 섬유를 사용한 하이브리드 HPFRCC의 역학적 특성에 관한 연구)

  • Kim Jae Hwan;Lee Eui Bae;Kim Yong Sun;Kim Yong Duk;Joo Ji Hyun;Kim Moo Han
    • Proceedings of the Korea Concrete Institute Conference
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    • 2004.05a
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    • pp.276-279
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    • 2004
  • Concrete is one of the principal materials for the structure and it is widely used all over the world. but it shows extremely brittle failure under bending and tensile load. Recently to improve such a poor property. High Performance Fiber Reinforced Cementitious Composites (HPFRCC) have been developed. and it are defined by an ultimate strength higher than their first cracking strength and the formation of multiple cracking during the inelastic deformation process. This study is to develop the hybrid HPFRCC with high ductility and strain capacity in bending and tensile load. and the three-point bending test on hybrid HPRFCC reinforced with micro and macro fibers is carried out in this paper. As the results of the bending tests. hybrid HPFRCCs reinforced with PVA40+SF and PVA100+PVA660 showed the high ultimate bending stress, multiple cracks and displacement hardening under bending load.

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A Study on the Development of Progressive Die for Multi-Stage Forming

  • Sim, Sung-Bo;Jang, Chan-Ho;Sung, Yul-Min;Lee, Sung-Taeg
    • Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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    • 2002.05a
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    • pp.86-91
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    • 2002
  • The production part requiring multiple processes such as piecing, blanking and notching, are performed with a high production rates in progressive die. In order to prevent the dejects of process result, the optimum of strip process layout design, die design, die making, and tryout with inspection etc. are needed. According to these factors of die development process, they required theory and practice of metal working process and its phenomena, die structure, machining conditions for die making, die materials, heat treatment of die camponents, know-how and so on. In this study, we designed and analyzed die camponents also simulated the strip process layout of multiple stage drawing by DEFORM. Especially the result of tryout and its analysis become to the feature of this study.

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