• BMB Reports
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• 제55권7호
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• pp.323-335
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• 2022

Together with neuronal loss, the existence of insoluble inclusions of alpha-synuclein (α-syn) in the brain is widely accepted as a hallmark of synucleinopathies including Parkinson's disease (PD), multiple system atrophy, and dementia with Lewy body. Because the α-syn aggregates are deeply involved in the pathogenesis, there have been many attempts to demonstrate the mechanism of the aggregation and its potential causative factors including post-translational modifications (PTMs). Although no concrete conclusions have been made based on the previous study results, growing evidence suggests that modifications such as phosphorylation and ubiquitination can alter α-syn characteristics to have certain effects on the aggregation process in PD; either facilitating or inhibiting fibrillization. In the present work, we reviewed studies showing the significant impacts of PTMs on α-syn aggregation. Furthermore, the PTMs modulating α-syn aggregation-induced cell death have been discussed.

• 한국해양공학회지
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• 제36권1호
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• pp.61-81
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• 2022

The available underwater acoustic spectrum is limited. Therefore, it is imperative to avoid frequency interference from overlapping frequencies of underwater acoustic equipment (UAE) for the co-existence of the UAE. Cognitive technology that senses idle spectrum and actively avoids frequency interference is an efficient method to facilitate the collision-free operation of multiple UAE with overlapping frequencies. Cognitive technology is adopted to identify the frequency usage of UAE to apply cognitive technology. To this end, we investigated two principle underwater acoustic sources: UAE and marine animals. The UAE is classified into five types: underwater acoustic modem, acoustic positioning system, multi-beam echo-sounder, side-scan sonar, and sub-bottom profiler. We analyzed the parameters of the frequency band, directivity, range, and depth, which play a critical role in the design of underwater acoustic cognitive technology. Moreover, the frequency band of several marine species was also examined. The mid-frequency band from 10 - 40 kHz was found to be the busiest. Lastly, this study provides useful insights into the design of underwater acoustic cognitive technologies, where it is essential to avoid interference among the UAE in this mid-frequency band.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2023년도 학술발표회
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• pp.180-180
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• 2023

To improve global risk management, understanding the characteristics and distribution of precipitation is crucial. However, obtaining spatially and temporally resolved climatic data remains challenging due to sparse gauge observations and limited data availability, despite the use of satellite and reanalysis products. To address this challenge, merging available precipitation products has been introduced to generate spatially and temporally reliable data by taking advantage of the strength of the individual products. However, most of the existing studies utilize all the available products without considering the varying performances of each dataset in different regions. Comprehensively considering the relative contributions of each parent dataset is necessary since their contributions may vary significantly and utilizing all the available datasets for data merging may lead to significant data redundancy issues. Hence, for this study, we introduce a site-specific precipitation merging method that utilizes the Quadruple Collocation (QC) approach, which acknowledges the existence of error-cross correlation between the parent datasets, to create a high-resolution global daily precipitation data from 2001-2020. The performance of multiple gridded precipitation products are first evaluated per region to determine the best combination of quadruplets to be utilized in estimating the error variances through the QC approach and computation of merging weights. The merged precipitation is then computed by adding the precipitation from each dataset in the quadruplet multiplied by each respective merging weight. Our results show that our approach holds promise for generating reliable global precipitation data for data-scarce regions lacking spatially and temporally resolved precipitation data.

• International Journal of Advanced Culture Technology
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• 제11권2호
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• pp.415-420
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• 2023

Since 2017, the application of VR technology in the game field has become more and more extensive, and more and more scholars have conducted research on VR games, especially VR horror games. This article will conduct research on VR horror games and scrolling scroll games through comparative analysis, and believes that VR horror games are much stronger than side scrolling scrolling games in terms of immersion. However, due to its unique flat third-person perspective, completely different operation methods and the existence of 'the fourth wall in side-scrolling horror games, Players can clearly realize that they are in an absolutely safe environment, and that they are just manipulators of game characters, not experiencers of terrorist events, so players will not receive excessive fright. Therefore, this article believes that the number of players who like side-scrolling horror games with certain horror elements is greater than the number of players who like pure VR horror games.Many traditional games in this paper have their own advantages in many aspects. For example, many traditional games such as horizontal games also have good development prospects in the future. We should promote the research on games in the academic community from multiple angles, not limited to popular VR games.

• Archives of Plastic Surgery
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• 제51권1호
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• pp.110-117
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• 2024

Percutaneous first annular pulley (A1 pulley) release, which has been increasingly used to treat trigger fingers, has been widely established as a safe and simple procedure. Multiple studies have reported positive results of percutaneous A1 pulley release. In this study, however, we report cases of patients who developed complications after undergoing percutaneous A1 pulley release at local clinics. A total of six patients visited our hospital for infectious complications after percutaneous A1 pulley release. Various sequelae such as damage to normal structures, insufficient procedure, and tissue necrosis were observed during the exploration. A retrospective study was conducted to identify the cause and trend of the observed complications by instruments (HAKI knife or needle). In the HAKI knife group, there was a tendency for damage to normal structures, while in the needle group, an insufficient release or serious soft tissue necrosis was observed. Based on these cases, our findings confirm the existence and characteristics of infectious complications following the percutaneous A1 pulley release. We further identify that the type of instrument used predicts the nature of complications. Thus, reliable and skilled performance of the procedure by experts is essential for safe treatment.

• Journal of Korean Neurosurgical Society
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• 제29권10호
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• pp.1316-1321
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• 2000

Objectives : The authors analyzed the surgical series of Cushing's disease to evaluate the proper treatment policy and to verify the possible prognostic factors. Material and Methods : Of 50 patients diagnosed as Cushing's disease and operated at Department of Neurosurgery of our institute between 1988 and 1999, 48 patients with available medical records were analyzed retrospectively. Mean follow-up period was 48 months(3 to 109 months). Preoperative diagnosis was made after evaluating the patients with multiple-stage endocrinological studies and 31 selective patients were evaluated with inferior petrosal sinus sampling(IPSS). Magnetic resonance imaging(MRI) and/or high resolution computerized tomography(CT) was done in all patients. A total of 51 transsphenoidal adenomectomy(TSA) were performed including 3 revision for initial surgical failure cases. Remission was decided on the basis of both endocrinological criteria and clinical status. Radiation and/or ketoconazole therapy were applied to failed cases. For the verification of prognostic factors, the authors evaluated the statistical significance of multiple variables over remission rate by chi-square test. Result : Sensitivity of IPSS for central localization was 93.5% which was better than that of MRI(87.5%). But for lateralization, it was 72.4% for IPSS versus MRI 90.5%. Success rate of TSA was 82%(42/51) and recurrence rate was 9%(4/48). When including adjuvant treatments for surgically failed cases, overall success rate was 89.6% and all of 3 reoperated cases(TSA) due to recurrence were successful. Significant complication occurred in 7.8%(4/51) after TSA including hypopituitarism, diabetes insipidus, and visual loss. Non-existence of tumor in MRI and prolonged symptom duration(>3 years) were significant prognostic factors. Conclusion : TSA can be considered as initial treatment for Cushing's disease. In surgically failed cases, multiple treatment modality may improve the overall outcome and repeated TSA for recurrent cases seem to provide similar success.

• 한국과학교육학회지
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• 제40권1호
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• pp.61-75
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• 2020

이 연구에서는 2015 개정 교육과정 7학년 과학의 물질 영역인 '기체의 성질'과 '물질의 상태 변화' 단원에 제시된 외적 표상을 분석하여 표상을 활용한 과학교육을 위한 시사점을 도출하고자 하였다. 표상의 유형, 표면적 특성의 해석, 본문과의 관련성, 캡션의 존재와 특성, 복합적 표상에서 표상 간 관련성, 표상의 기능의 여섯 가지 범주로 구성된 분석틀을 이용하여 다섯 종의 교과서에 나타난 표상의 특성을 분석하였다. 또한, '기체의 성질'과 '물질의 상태 변화' 단원의 성취기준을 설명하는 각 교과서에 제시된 대표적인 표상의 특징을 분석하였다. 연구의 결과는 다음과 같다. 먼저 표상의 유형에서는 거시적 표상이 가장 높은 빈도로 나타났으며, 표면적 특성의 해석 범주에서는 명시적 특성을 가진 표상의 빈도가 가장 높았다. 본문과의 관련성 범주의 분석 결과, 대부분의 표상이 완전한 연관성과 연결 또는 완전한 연관성과 비연결에 해당하여 표상과 본문 내용은 일관성 있게 연관되어 있는 것으로 나타났다. 캡션의 존재와 특성 범주에서는 적절한 캡션이 존재하는 표상의 빈도가 가장 높았고, 복합적 표상에서 표상 간의 관련성은 충분히 연결된 표상이 대부분이었다. 표상의 기능 범주에서는 완성형이 가장 높은 빈도를 보였으나 탐구 활동에 제시된 표상에서는 미완성형이 높은 빈도를 나타냈다. 성취기준과 관련된 대표적인 표상을 분석한 결과, 표상의 유형, 표상에 제시된 정보및 기호의 사용 등에서 교과서별로 차이를 나타냈다. 연구의 결과로부터 7학년 물질 영역의 표상 활용과 관련된 교육적 시사점을 논의하였다.

• 수산해양기술연구
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• 제57권3호
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• pp.236-245
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• 2021

In this study, a drifting test using a experimental vessel (2,966 tons) in the northern waters of Jeju was carried out for the first time in order to obtain the fundamental data for drift. During the test, it was shown that the average leeway speed and direction by GPS position were 0.362 m/s and 155.54° respectively and the leeway rate for wind speed was 8.80%. The analysis of linear regression modes about leeway speed and direction of the experimental vessel indicated that wind or current (i.e. explanatory variable) had a greater influence upon response variable (e.g. leeway speed or direction) with the speed of the wind and current rather than their directions. On the other hand, the result of multiple regression model analysis was able to predict that the direction was negative, and it was demonstrated that predicted values of leeway speed and direction using an experimental vessel is to be more influential by current than wind while the leeway speed through variance and covariance was positive. In terms of the leeway direction of the experimental vessel, the same result of the leeway speed appeared except for a possibility of the existence of multi-collinearity. Then, it can be interpreted that the explanatory variables were less descriptive in the predicted values of the leeway direction. As a result, the prediction of leeway speed and direction can be demonstrated as following equations. Ŷ₁= 0.4031-0.0032X₁+0.0631X₂-0.0010X₃+0.4110X₄ Ŷ₂= 0.4031-0.6662X₁+27.1955X₂-0.6787X₃-420.4833X₄ However, many drift tests using actual vessels and various drifting objects will provide reasonable estimations, so that they can help search and rescue fishing gears as well.

• 대한간호학회지
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• 제25권4호
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• pp.729-740
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• 1995

The purpose of this study is to provide basic data for school health computerization by investigating the nurse teacher's attitudes toward school health computerization. For this study, the questionnaires were given to 559 nurse teachers from 3. March to 17. March, 1995. Among them, 338 were returned and included for the analysis. The results of the study were as follows : 1. In general characteristics, the results showed average of 38.6 years in age ; and average of 11.1 years in education experience. In distribution of school, the result showed 47.0% in elementary school, 30.5% in middle school and 22.5% in high school ; 75.4% national and public school vs 26.4% private school. 2. In attitudes of computerization, the score was varied from 19 to 76 point. The attitudes was generally positive with the average of 60.23±7.63(SD) score. The respondents are willing to participate in computer education(the highest score, 3.69), they worry about electromagnetic waves by computer (the lowest score : 2.30). 3. 92.6％ of the respondents want to participate in computer education. The major reason the respondents have not yet learned computer is that they had little chance to learn. While 58.0% of them answered that they had an experience of computer use in school health works, few schools had computer in dispensary. In computer use, nurse teachers in public school have more experience than ones in private school. Word processing was the major function that the most respondents can do(62.7%). They answered that they have little knowledge of computer (84.0%). 4. Computer can be utilized in school health works as follows in order : message from school to home, reports, annual plan and statistics. 65.4% of them answered that computer can be used in 10 items of 13 items. 5. The attitudes of computerization showed differences in the following variables career, age, existence of computer in school health clinic, experience of computer use, intention to participate in computer education, computer knowledge, frequent computer use, ability of computer use, school health computerization areas, experience of computer education. Among there variables, age, existence of computer in school health clinic, intention to participate in computer education, ability of computer use, school health computerization areas showed significant explanation(28.3%) for the attitudes of computerization in multiple regression analysis The younger. the higher degree of intention, the more functions they can perform, the more school health computerization areas, and the more computers in school health clinic, the more positive attitude on school health computerization. In conclusion, to achieve the successful computerization of school health works, the positive attitudes of nurse teachers should be encourged for school health computerization. For this purpose, the chance of computer education should be given as many times as possible. And administerial as well as financial support are essential for enlarging the knowledge and ability of computer.

• 가정과삶의질연구
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• 제27권1호
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• pp.73-88
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• 2009

The purpose of this study was to investigate the influence of the factors such as self-esteem, social supports, socio-economic status of parents, degree of disability in child, stress coping, religion, and sports.exercise on the qualities of lives in mothers with disabled children. Data were collect from 45 institutions(schools from kindergarten to senior-high, special education institutes, and social welfare institutions) by self-report questionnaire, and the subjects of the study were 386 mothers in Seoul whose children were attending the schools or institutions. Findings according to socio-demographic variables are as follows: 1. Mothers with disabled children in this study thought their quality of life as average degree. 2. The younger the mothers and children, the higher the quality of life was. 3. The higher the educational level and monthly income, the higher the quality of life was. 4. There was no statistically significant difference between the existence and nonexistence of spouse, and between the existence and nonexistence of religion as well. Findings analyzed by multiple regression are as follows: 1. Among 7 independent variables 'self-esteem'(${\beta}$=.49, p<.001), 'social supports'(${\beta}$=.15, p<.01), and 'socio-economic status'(${\beta}$=.11, p<.05) were found to be statistically significant in quality of life in mothers, while the rests were found not significant. 2. 'Self-esteem' was found to be the most influencing variable, meaning that the psychological factor such as self-esteem is more important than environmental factors in qualities of lives in mothers. 3. The total amount of explanation of the model was Adjusted R square=.301, so that it can be said about 30% can be explained among total variance of the qualities of lives in mothers with disabled children. Conclusions and recommendations based on the results above are: First, it is strongly recommended to conduct programs promoting self-esteem in mothers with disabled children, and to include 'self-esteem' hereafter in the studies related to qualities of lives in mothers with disabled children. Second, comprehensive and practical countermeasures should to be formulated to back up expenses for education and medical care, purchasing relative tools and equipments, plus helping to find jobs.