• 대한구강악안면병리학회지
• /
• 제42권6호
• /
• pp.189-198
• /
• 2018

A 31 years old female had been suffered from a bony swelling in right premolar region of the mandible for 12 years, recently grown rapidly. A fistula tract developed on the right anterior mandibular border, but the lesion was relatively asymptomatic. In the radiological examination, the tumor mass was irregularly mixed with radiolucent and radiopaque areas, forming multiple cystic spaces. Under the diagnosis of calcifying odontogenic cyst, the mandibular mass was resected and examined pathologically. After decalcification, the dissected tumor mass showed multiple small cystic spaces and calcifying fibrous tissue, mimicking calcifying odontogenic cyst or ameloblastoma. Histological observation showed many calcifying cementoid materials and ossifying trabeculae. The cystic spaces were turned out to be dilated vascular channels lined by endothelial cells, containing plasma fluid. However, the main lesion was diagnosed as cemento-ossifying fibroma (COF), and the atypical vascular channels were greatly dilated and gradually expanded the whole tumor mass. The present COF was examined through immunohistochemical (IHC) array, and investigated for tumor cell characteristics, exhibiting abnormal ossification and aneurysmal cystic changes. IHC array disclosed that the tumor cells grew progressively in the lack of apoptosis, and that they showed lower expression of RUNX2 than BMP-2, RANKL, and OPG, and increases of protein expression in $HIF-1{\alpha}$, VEGF-A, and CMG2. These data suggested that the reduced expression of RUNX2, osteoblast differentiation factor, be relevant to abnormal ossification of COF, and that the consistent expressions of angiogenesis factors be relevant to de novo angiogenesis in COF, subsequently resulted in aneurysmal cystic changes.

• Journal of Korean Neurosurgical Society
• /
• 제41권1호
• /
• pp.57-60
• /
• 2007

The incidence of diastematomyelia associated with teratoma is extremely rare. We present a case of sacrococcygeal teratoma in a neonate with split spinal cord malformation[SSCM]. Magnetic resonance imaging[MRI] showed a heterogenous mass lesion with cyst in the sacrococcygeal region and multiple spinal anormalies [diastematomyelia, tethered cord, hydromyelia, and hemivertebrae]. The mature teratoma was confirmed on histopathological examination. In SSCMs, the potential for coexisting congenital anomalies at separate levels of the spinal cord must be considered in radiological investigations.

• Tuberculosis and Respiratory Diseases
• /
• 제74권3호
• /
• pp.97-103
• /
• 2013

A lung cyst is an air-filled lucent structure surrounded by a thin wall. The presence of multiple intrapulmonary cysts is defined as cystic lung disease. Although cystic lung disease is rare, incidental detection has increased significantly in recent years by screening using computed tomography. There are many conditions that can mimic lung cysts and cause cystic lung disease. Clinical, radiographic, and histologic findings are all necessary for a proper diagnosis, and multidisciplinary approaches are frequently required. The aim of this report is to review the causes and characteristics of cystic lung disease to better understand and improve treatment.

• Imaging Science in Dentistry
• /
• 제34권4호
• /
• pp.203-207
• /
• 2004

Basal cell nevus syndrome (BCNS) is principally characterized by cutaneous basal cell carcinomas, multiple odontogenic keratocysts and skeletal abnormalities. Our patient represented several characteristics of BCNS, such as, multiple odontogenic keratocysts, facial nevus, calcification of falx cerebri, parietal bossing and mental retardation. The cyst on posterior mandible showed recurrent and newly developing tendency.

• Imaging Science in Dentistry
• /
• 제43권4호
• /
• pp.303-308
• /
• 2013

This report describes a 31-year-old female patient with six impacted teeth. The crowns of the impacted teeth were surrounded with cyst-like lesions with a mixed internal structure and well-defined cortical borders. Microscopic examination of the specimen obtained from the follicle of the left mandibular third molar tooth revealed loose to moderately dense collagenous connective tissue with abundant calcified material and sparse epithelial islands. A diagnosis of multiple calcifying hyperplastic dental follicles was made.

• 대한소아치과학회지
• /
• 제36권2호
• /
• pp.270-274
• /
• 2009

함치성 낭종은 일반적으로 미맹출 치아의 치관을 포함하고 있는 형태로, 치아 법랑질과 이장 상피 사이에 액체가 축적되어 생긴 잔존 법랑 상피조직의 퇴행성 변화로 부터 생긴다. 치근단 낭 다음으로 가장 흔한 치성 낭종으로, 주로 단독으로 발생하고 하악 제 3대구치와 상악 소구치에 호발한다. 악골의 다발성 낭종은 주로 기저세포 모반 증후군과 관련된 치성 각화낭이 대부분이고, 점액다당류증 또는 쇄골두개 이형성증과도 관련이 있을 수 있다. 단발성의 함치성 낭종은 우리에게 친숙할 정도로 유병율에서 치료 및 예후까지 잘 알려져 있으나, 전신병력이 없는 다발성의 함치성 낭종은 드물며, 상악과 하악에 발생한 다발성 낭종은 특히 더 드물다. 본 증례는 편측성으로 양악에 함께 발생한 다발성의 함치성 낭종을 가진 11세 소년에 대한 치료 증례로 1년간의 관찰 후 양호할만한 결과를 얻었기에 보고하는 바이다. 1년이라는 관찰 기간이 짧기 때문에 향후 지속적인 임상적, 방사선적 관찰을 필요로 하리라 사료된다.

• Maxillofacial Plastic and Reconstructive Surgery
• /
• 제36권6호
• /
• pp.292-297
• /
• 2014

Nevoid basal cell carcinoma syndrome (NBCCS) is a rare autosomal genetic disease caused by a PTCH mutation. The disease is characterized by multiple basal cell carcinomas of the skin, multiple keratocystic odontogenic tumors (KCOTs) in the jaw, palmar and/or plantar pits, bifid ribs, ectopic calcification of the falx cerebri, and skeletal abnormalities. Early diagnosis is difficult in many cases because there may be a number of systemic symptoms. The purpose of this study is to report the case of a 12-year-old girl who was hospitalized with multiple KCOTs that occurred in the upper and lower jaws. Through characteristic clinical symptoms and radiologic findings, she was finally diagnosed as having NBCCS. This study also aims to organize the symptoms often observed in Korea using previously published case reports to provide useful information for the early diagnosis of NBCCS.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• 제44권3호
• /
• pp.107-111
• /
• 2018

Objectives: A keratocystic odontogenic tumor (KOT) is a type of odontogenic tumor that mainly occurs in the posterior mandible. Most KOTs appear as solitary lesions; however, they sometimes occur as multiple cysts. This study analyzed the clinical features of multiple KOTs. Materials and Methods: The participants were diagnosed with KOT by biopsy with multiple surgical sites, and were patients at the Pusan National University Hospital and the Pusan National University Dental Hospital from January 1, 2005 to March 31, 2016. Charts, records, images and other findings were reviewed. Results: A total of 31 operations were conducted in 17 patients. The mean patient age was $28.4{\pm}20.1years$. Multiple KOTs were found to occur at a young age (P<0.01). The predominant sites were in the posterior mandible (28.6%). Most cases of multiple lesions appeared in both the upper and lower jaw, and 40.3% of lesions were associated with unerupted and impacted teeth. The overall recurrence rate measured by operation site was 10.4% (8/77 sites). No patients were associated with nevoid basal cell carcinoma syndrome. Conclusion: The pure recurrence rate was lower than estimated, but there was a higher possibility of secondary lesions regardless of the previous operation site; therefore, long-term follow-up is necessary.

• 농촌의학ㆍ지역보건
• /
• 제43권4호
• /
• pp.224-233
• /
• 2018

이 연구는 제5기 국민건강영양조사 원시자료를 활용하여 우리나라 성인의 복합만성질환이 치주질환에 미치는 영향을 파악하고자 실시되었다. 건강설문 및 구강검진 조사를 완료한 만 35세 이상 대상자 중 무응답자를 제외한 4,142명을 최종 분석대상으로 하였다. 종속변수인 치주질환은 CPI 측정값이 3(4mm 이상의 치주낭 형성) 또는 4(6mm 이상의 치주낭 형성)인 경우로 정의하였다. 연구대상자의 성별은 남자 48.5%, 여자 51.5%였으며, 치주질환의 유병률은 30.1%였다. 연령이 증가할수록, 교육수준과 소득수준이 낮을수록, 지역이 농촌일 경우 유병률이 높았다(p<0.01). 만성질환 보유 개수에 따라서 치주질환 유병율은 만성질환이 없는 경우 27.8%, 1개인 경우 31.9%, 2개인 경우 33.1%, 3개 이상인 경우 35.2%로 통계학적으로 유의한 차이가 있었다(p<0.05). 치주질환을 종속변수로 한 로지스틱 회귀분석을 한 결과, 성별, 연령, 교육, 지역, 현재흡연, 구강위생용품 사용여부가 치주질환에 영향을 미치는 요인이었다. 이 연구에서는 신뢰성이 높은 국가자료를 활용하여 우리나라 성인의 치주질환 유병률 30.1%를 파악하였으며, 복합만성질환보다는 인구학적 특성과 구강건강관리행태가 치주질환에 유의한 영향 인자임을 확인하였다. 개인의 인구학적 특성에 맞는 구강건강행태 실천을 유도하여 적극적인 구강건강관리를 통한 치주질환의 예방이 중요하다고 할 수 있다.

• 대한영상의학회지
• /
• 제84권4호
• /
• pp.970-976
• /
• 2023

29세 남성에서의 미만성 연수막성 신경교종을 증례 보고한다. 이 질환은 드문 중추신경계 종양으로, 대부분 소아에서 발견되며 성인에서는 소수만 보고되어 있다. 본 환자는 만성 두통으로 내원하여 MRI를 시행하였다. 뇌 MRI에서 경도의 수두증과 다수의 테두리 조영증강을 보이는 병변이 안장위 수조에서 보였으며, FLAIR에서 신호가 억제되지 않는 다수의 비조영증강 낭종성 병변이 양측 기저핵, 시상 및 대뇌에서 관찰되었다. 척추 MRI에서는 요추 및 천추부위의 미만성 연수막 조영증강이 보였다. 생식세포종양의 연수막 파종을 의심하였고 경접형골 종양제거술을 시행 받았다. 병리학 검사에서 미만성 연수막성 신경교종으로 확진되었고, 차세대 염기서열 검사에서 FGFR1 유전자의 돌연변이가 발견되었다. 결론적으로 연수막 결절성 조영증강과 FLAIR에서 신호가 억제되지 않는 다수의 비조영증강 낭종성 뇌 병변이 함께 관찰될 경우 연수막 조영증강을 보이는 여러 다른 질환들과의 감별 진단에 도움이 된다.