• BMB Reports
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• 제49권4호
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• pp.199-200
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• 2016

Gene regulation in the brain is essential for long-term plasticity and memory formation. Despite this established notion, the quantitative translational map in the brain during memory formation has not been reported. To systematically probe the changes in protein synthesis during memory formation, our recent study exploited ribosome profiling using the mouse hippocampal tissues at multiple time points after a learning event. Analysis of the resulting database revealed novel types of gene regulation after learning. First, the translation of a group of genes was rapidly suppressed without change in mRNA levels. At later time points, the expression of another group of genes was downregulated through reduction in mRNA levels. This reduction was predicted to be downstream of inhibition of ESR1 (Estrogen Receptor 1) signaling. Overexpressing Nrsn1, one of the genes whose translation was suppressed, or activating ESR1 by injecting an agonist interfered with memory formation, suggesting the functional importance of these findings. Moreover, the translation of genes encoding the translational machineries was found to be suppressed, among other genes in the mouse hippocampus. Together, this unbiased approach has revealed previously unidentified characteristics of gene regulation in the brain and highlighted the importance of repressive controls.

• Journal of Information Display
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• 제3권3호
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• pp.1-11
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• 2002

Multi-view function is important to three-dimensional displays without dedicated glasses. It is the reason that the observers earnestly desire to change their positions freely. Multi-viewing is also principal to the reality of three-dimensional (3D) image displayed on the screen. The display of projection type has the advantage that the number of viewing points can be easily increased according to the number of projectors. The authors research on multi-view projection display with hologram screen. Powerful directionality of the diffracted beam from hologram screen is required unlike two-dimensional (2D) display. We developed a new method that all diffracted beams satisfied the same Bragg condition and became sufficiently bright to observe the 3D image under usual indoor light. The principle is based on the essential Bragg diffraction in the three-dimensional space. Owing to such three-dimensional Bragg diffraction we achieved an excellent hologram screen that could be multiple reconstructed in spite of single recording. This hologram screen is able to answer arbitrary numbers of viewing points within wide viewing zone. The distortion of 3D image becomes also sufficiently small with the method of dividing the cross angle between illumination and diffraction beam.

• 한국멀티미디어학회논문지
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• 제25권8호
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• pp.1069-1074
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• 2022

IP mobility can be handled in different layers of the protocol. Mobile IP has been proposed to handle the mobility of Internet hosts in the network layer. Recently, a new method based on the SIGMA mobility architecture has been proposed to support mobility management with reduced packet loss and latency. The location management structure is not suitable for frequent mobile handover due to the high mobility of the user with this transport layer solution. In this paper, we propose a location management optimization method in a mobile communication network by applying hierarchical location management using MMPs(Mobility Management Points) for transport layer mobility management. Therefore, we propose an efficient hierarchical mobility management structure even between heterogeneous wireless networks using MMPs for the probability that a mobile terminal can change multiple location areas between two messages and calls. The proposed method shows reduction in location update cost and data retrieval cost using MMPs, and as opposed to mobility appearing in time intervals with the minimum cost required to reach 90% of the stabilized cost, the mobility location update search, location It was found that the message processing cost per area was reduced.

• 한국농공학회논문집
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• 제61권4호
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• pp.33-42
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• 2019

In this study, the channel and floodplain widths are indirectly measured for three different watersheds using satellite images to reflect the shape of Korean channels in the Soil and Water Assessment Tool (SWAT) model. For measuring the channel and floodplain widths, multiple satellite images were referred to ensure the widest width of certain points. In the single channel, the widths at the multiple points were measured. Based on the measured data, the regression equations were derived to estimate the channel and floodplain widths according to watershed areas. Applying these developed equations, this study evaluated the effect of the change of channel and floodplain widths on the SWAT simulation by comparing to the measured streamflow data. The developed equations estimated larger channel width and smaller floodplain compared with those calculated in the current SWAT model. As shown in the results, there was no considerable changes in the predicted streamflow using the current and developed equations. However, the flow velocity and channel depth calculated from the developed equations were smaller than those of the current equations. The differences were caused by the effect of different channel geometries used for calculating the hydraulic characteristics. The channel geometries also affected the water quality simulation in channels because the hydraulic characteristics calculated by the channel geometries are directly related to the water quality simulation. Therefore, application of the river cross-sectional regression equation reflecting the domestic stream shape is necessary for accurate water quantity / quality and water ecosystem simulation using hydrological model.

• 한국멀티미디어학회논문지
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• 제7권7호
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• pp.877-885
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• 2004

본 논문은 여러 가지 장면 검출 방식들 중 강인한 특징 변수들의 선별과 신경망을 이용하여 향상된 장면 전환점 검출 기법을 제안한다. 기존의 장면 전환점 검출 방식에서는 인접한 프레임 간에 단일 특징과 고정된 임계값을 주로 사용하였다. 하지만, 비디오 시퀀스 내의 장면 전환점에서는 인접한 프레임 간의 내용(content)인 컬러, 모양, 배경 혹은 질감 등이 동시에 변화한다. 따라서 단일 특징보다는 상호 보완 관계를 갖는 강인한 특징을 이용하여 장면 전환점을 효율적으로 검출한다. 본 논문에서 강인한 특징 변수들을 선택하기 위해, 데이터 마이닝 기법 중 대표적인 CART(classification and regression tree)를 이용하고, 다차원 변수에 따른 임계값을 선정하기 위해 역전파 신경망(backpropagation neural net)을 이용한다. 제안한 방식과 대표적인 특징 추출인 PCA(principal component analysis)기법을 비교하여 특징 변수의 추출 성능을 평가한다. 실험 결과에 따라 제안된 방식이 PCA 기법과 비교하여 우수한 성능이 나타남을 확인한다.

• 대한치과교정학회지
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• 제38권4호
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• pp.252-264
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• 2008

본 연구는 안면비대칭 환자의 악교정수술 시 경조직 이동에 따른 연조직 변화를 정면에서 평가함으로써 정면 얼굴 이미지 시뮬레이션 프로그램 개발에 도움이 되고자 시행되었다. 안면비대칭이 동반된 하악골 수술 예정 환자 45명을 대상으로 정모 두부방사선규격사진과 얼굴사진(photo)을 술전 및 술후에 각각 같은 각도로 촬영한 후, 술전 및 술후의 방사선사진을 이용하여 경조직 계측점의 변화를, 얼굴사진을 이용하여 연조직 계측점의 변화를 수평 및 수직으로 구분하여 각각 측정한 후 경조직 변화에 따른 연조직 변화를 비교 분석하였다. 연조직 변화와 경조직 변화의 상관성을 살펴본 결과 수평 방향, 수직 방향 모두에서 전반적으로 낮은 상관성을 보였으며, 1 : 1 mean ratio 산출을 위하여 서로 상관성이 가장 높은 경조직 계측점을 연조직 계측점별로 선택한 결과 직하방에 있는 경조직보다는 다소 멀리 떨어져 있는 경조직 계측점이 선택되는 경우가 많이 나타났다. 경조직 변화를 이용하여 연조직 변화를 예측할 수 있는 회귀방정식을 연조직 계측점별로 산출한 결과 연조직 수평변화 예측에 경조직 수직변화도 사용되고 연조직 수직변화 예측에 경조직 수평변화도 사용되었으며, 수평과 수직변화 모두에서 가장 설명력이 높은 방정식은 연조직 menton에서 나타났다. 이상의 연구결과 하부 경조직 계측점과 상부 연조직 계측점의 비율을 이용하는 1 : 1 mean ratio 방법은 불가능한 것으로 나타난 반면 회귀분석을 이용한 연조직 변화 예측은 임상에 도움이 될 수 있는 것으로 나타나 정면 이미지의 경우 컴퓨터를 이용한 시뮬레이션 프로그램이 반드시 필요함을 시사하였다.

• ETRI Journal
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• 제36권1호
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• pp.1-11
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• 2014

In this paper, we propose a distributed synchronization algorithm for wireless mesh networks based on orthogonal frequency division multiple access. For time and frequency synchronization, a node requests its neighbor nodes for a change of fast Fourier transform starting points, transmission times, and carrier frequencies needed for synchronization. The node also updates its own time and frequency elements through simple formulas based on request messages received from neighbor nodes using a guard interval and a cyclic prefix. This process with the cooperation of neighbor nodes leads to a gradual synchronization of all nodes in the network. Through a performance comparison with a conventional scheme, we obtain simulation results indicating that the proposed scheme outperforms the conventional scheme in random topologies and a grid topology.

• 대한산업공학회지
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• 제31권2호
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• pp.106-119
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• 2005

Uncertainties inherent in customer demand patterns make it difficult for supply chains to achieve just-in-time inventory replenishment, resulting in loosing sales opportunity or keeping excessive chain wide inventories. In this paper, we propose two intelligent adaptive inventory control models for a supply chain consisting of one supplier and multiple retailers, with the assumption of information sharing. The inventory control parameters of the supplier and retailers are order placement time to an outside source and reorder points in terms of inventory position, respectively. Unlike most extant inventory control approaches, modeling the uncertainty of customer demand as a stationary statistical distribution is not necessary in these models. Instead, using a reinforcement learning technique, the control parameters are designed to adaptively change as customer demand patterns change. A simulation based experiment was performed to compare the performance of the inventory control models.

• Journal of Korean Neurosurgical Society
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• 제52권3호
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• pp.172-178
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• 2012

Objective : The aim of this study was to determine the role of intra-arterial (IA) nimodipine injections for cerebral vasospasm secondary to ruptured subarachnoid hemorrhage (SAH) and to investigate the factors that influence vasodilation and clinical outcomes. Methods : We enrolled 29 patients who underwent aneurysm clipping for ruptured cerebral aneurysms between 2009 and 2011, and who received IA nimodipine after subsequently presenting with symptomatic vasospasm. The degree of vasodilation shown in angiography was measured, and the correlation between the degree of vasodilation and both the interval from SAH to cerebral vasospasm and the interval from clipping to cerebral vasospasm was determined. The change in blood flow rate after IA injection was assessed by transcranial Doppler ultrasound. Multiple clinical parameters were completed before and after IA nimodipine injection to evaluate any improvements in clinical symptoms. Results : For eight patients, Glasgow Coma Scale (GCS) scores increased by two or more points. The regression analysis demonstrated a positive correlation between the change in GCS scores after IA nimodipine injection and the change in blood vessel diameter (p=0.025). A positive correlation was also observed between the interval from SAH to vasospasm and the change in diameter (p=0.040); and the interval from clipping to vasospasm and the change in diameter (p=0.022). Conclusion : IA nimodipine injection for SAH-induced vasospasm led to significant vasodilation in angiography and improvement in clinical symptoms without significant complications. Our findings suggest that IA nimodipine injection should be utilized when intractable vasospasm develops despite rigorous conservative management.

• 한국임상보건과학회지
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• 제6권2호
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• pp.1156-1170
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• 2018

Purpose. This study was conducted to analyze fatigue and subjective oral health status in the employees in educational institutions and provide basic data for the development of a program for the promotion of oral health. Methods. As for the subjects, this study conducted a survey with 468 educational personnel in elementary, middle, and high schools in the Daegu-Gyeongbuk area from March through June 2016 and utilized 407 copies finally. As for the items on the survey, this study conducted an investigation on their general characteristics, fatigue, and subjective oral health status(halitosis, xerostomia, temporomandibular disorder) with the self-administered method. With the data collected, this study conducted frequency analysis, t-test, ANOVA, and multiple regression analysis, using SPSS 20.0 statistical program, and the statistical significance level was .05. Results. As a result of this study, it turned out that by sex, fatigue was higher in women(4.59 points); by the place of work, those in 'elementary school' had higher fatigue(4.59 points); and by health condition and oral health status, most of them responded that they were 'not healthy'(4.81 and 4.84 points, respectively) and there was a statistically significant difference (p<.05). As for the correlation between fatigue and subjective oral health status, there were positive(+) impacts on halitosis(=.248, p<.001), xerostomia(=.097, p<.05), and temporomandibular disorder(=.148, p<.01), so it turned out that there was a correlation between fatigue and subjective oral health status. Conclusion. Based on the result of an analysis of the impacts of the fatigue level on subjective oral health status, it is judged that it would be necessary to continue to build up a program that can promote the oral health status of the educational personnel. In addition, it is necessary to conduct studies continuously for the development and application of a program for the change in lifestyle and behavior that can lower their fatigue.