• 대한기계학회:학술대회논문집
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• 대한기계학회 2000년도 춘계학술대회논문집A
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• pp.562-565
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• 2000

For solving problems of manpower and improving working environment, Robot System have been introduced. In the past, Robot System was adopted mass production, indoor factory condition, but present Robot System is applied to many other fields. This applied field is Robot System was adopted fruit harvest, maintenance, and so on. The developed Multi-Linked Lifter is applied to eminant multi-purpose working. The purpose of this study is to develop control algorithm for this equipment composed of multi-linked manipulator.

• 한국해양공학회지
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• 제37권6호
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• pp.273-281
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• 2023

Recently, offshore structures for eco-friendly energy, such as wind and solar power, have been developed to address the problem of insufficient land space; in the case of energy generation, they are designed on a considerable scale. Therefore, the scalability of offshore structures is crucial. The Korea Research Institute of Ships & Ocean Engineering (KRISO) developed multi-linked floating offshore structures composed of floating bodies and connection beams for floating photovoltaic systems. Large-scale floating photovoltaic systems are mainly designed in a manner that expands through the connection between modules and demonstrates a difference in structural response with connection conditions. A fluid-structure coupled analysis was performed for the multi-linked floating offshore structures. First, the wave load acting on the multi-linked offshore floating structures was calculated through wave load analysis for various wave load conditions. The response amplitude operators (RAOs) for the motions and structural response of the unit structure were calculated by performing finite element analysis. The effects of connection conditions were analyzed through comparative studies of RAOs and the response's maximum magnitude and occurrence location. Hence, comparing the cases of a hinge connection affecting heave and pitch motions and a fixed connection, the maximum bending stress of the structure decreased by approximately 2.5 times, while the mooring tension increased by approximately 20%, confirmed to be the largest change in bending stress and mooring tension compared to fixed connection. Therefore, the change in structural response according to connection condition makes it possible to design a higher structural safety of the structural member through the hinge connection in the construction of a large-scale multi-linked floating offshore structure for large-scale photovoltaic systems in which some unit structures are connected. However, considering the tension of the mooring line increases, a safety evaluation of the mooring line must be performed.

• 융합보안논문지
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• 제14권2호
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• pp.11-16
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• 2014

최근 스마트폰이나 태블릿 등을 통해서 사용자가 IPTV를 사용해 집에서 시청하던 멀티미디어 서비스를 지속적으로 이용할 수 있는 멀티-스크린 서비스가 급격하게 발전하고 있다. 특별히 IPTV와 스마트폰을 연동하여 멀티-스크린 서비스를 이용하고자 하는 사용자 요구는 날로 급증하고 있는 실정이다. 하지만, IPTV에 대한 보안서비스는 다소 제공되고 있지만, 스마트폰에 대한 보안서비스는 매우 부족하고, 더욱이 스마트폰과 IPTV를 연동하기 위한 보안 서비스는 전무한 실정이다. 이에 본 연구에서 사용자가 소지한 스마트폰과 집에서 시청하는 IPTV를 연동해 멀티-디바이스 연동형 사용자 인증시스템을 제안하고자 한다. 우리가 제안한 멀티-스크린 환경을 위한 사용자 인증시스템은 커베로스를 기반으로 쉽고 빠른 사용자 인증서비스를 제공할 수 있다. 우리가 제안한 멀티-스크린 서비스에 사용자 인증 서비스를 제공할 수 있는 시스템은 기존의 PKI 인증시스템 보다 처리 절차가 가볍고 보안성이 높은 것으로 판단된다. 뿐만 아니라 향후 발생할 수도 있는 보안 위협들에 대해서도 안전한 멀티-스크린 환경을 제공할 수 있을 것으로 예상된다.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2009년도 추계학술대회 논문집
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• pp.143-144
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• 2009

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2011년도 춘계학술대회 논문집
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• pp.327-328
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• 2011

• Asian Pacific Journal of Cancer Prevention
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• 제13권11호
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• pp.5619-5625
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• 2012

Gastric carcinoma is a leading cause of cancer death in the world and multi-drug resistance (MDR) is an essential aspect of gastric carcinoma chemotherapy failure. Recent studies have shown that integrin-linked kinase (ILK) is involved in metastasis of human tumors, expression silencing of ILK inhibiting the metastasis of several types of cultured human cancer cells. However, the role and potential mechanism of ILK to reverse the multi-drug resistance in human gastric carcinoma is not fully clear. In this report, we focused on roles of expression silencing of ILK in multi-drug resistance reversal of human gastric carcinoma SGC7901/DDP cells, including increased drug sensitivity to cisplatin, cell apoptosis rates, and intracellular accumulation of Rhodamine-123, and decreased mRNA and protein expression of multi-drug resistance gene (MDR1), multi-drug resistance-associated protein (MRP1), excision repair cross-complementing gene 1 (ERCC1), glutathione S-transferase -${\pi}$ (GST-${\pi}$) and RhoE, and transcriptional activation of AP-1 and NF-${\kappa}B$ in ILK silenced SGC7901/DDP cells. We also found that there was a decreased level of p-Akt and p-ERK. The results indicated that ILK might be used as a potential therapeutic strategy to combat multi-drug resistance through blocking PI3K-Akt and MAPK-ERK pathways in human gastric carcinoma.

• Journal of Genetic Medicine
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• 제15권1호
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• pp.24-27
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• 2018

Cornelia de Lange syndrome (CdLS) is a rare, clinically and genetically heterogeneous, multi-system developmental disorder caused by mutations in genes that encode components of the cohesin complex. X-linked CdLS caused by an SMC1A mutation is an extremely rare disease characterized by phenotypes milder than those of classic CdLS. In the Republic of Korea, based on a literature review, one family with SMC1A-related CdLS with mild phenotypes has been genetically confirmed to date. In this study, we describe the clinical features of a Korean boy with a hemizygous novel missense mutation and his mother with a heterozygous mutation, i.e., c.2447G>A (p.Arg816His) in SMC1A, identified by multi-gene panel sequencing. The proband had a mild phenotype with typical facial features and his mother exhibited a mild, subclinical phenotype. This study expands the clinical spectrum of patients with X-linked CdLS caused by SMC1A variants. Moreover, these findings reinforce the notion that a dominant negative effect in a carrier female with a heterozygous mutation in SMC1A results in a phenotype milder than that in a male patient with the same mutation.

• Animal cells and systems
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• 제12권4호
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• pp.261-267
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• 2008

The human chromosomes 2, 7, 12 and 17 show genomic homology around Hox gene clusters, is taken as evidence that these paralogous gene families might have arisen from a ancestral chromosomal segment through genome duplication events. We have examined protein data from vertebrate and invertebrate genomes to analyze the phylogenetic history of multi-gene families with three or more of their representatives linked to human Hox clusters. Topology comparison based upon statistical significance and information of chromosome location for these genes examined have revealed many of linked genes coduplicated with Hox gene clusters. Most linked genes to Hox clusters share the same evolutionary history and are duplicated in concert with each other. We conclude that gene families linked to Hox clusters may be suggestion of ancient genome duplications.

• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 1996년도 춘계공동학술대회논문집; 공군사관학교, 청주; 26-27 Apr. 1996
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• pp.442-442
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• 1996

• Macromolecular Research
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• 제16권4호
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• pp.293-302
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• 2008

In our previous publication, the problem of particle deformation and coagulation at the nucleation stage in the presence of cross-linker was intensely studied by seeded batch dispersion polymerization of methyl methacrylate (MMA). In the present work, highly cross-linked, monodisperse PMMA particles were prepared under various reaction conditions by seeded semi-continuous process. Monodisperse, $6.5{\mu}m$-diameter PMMA particles containing up to 8 wt% of DVB or EGDMA were successfully made by seeded semi-continuous process and multi-semi-continuous addition process, respectively. Therefore, this study shows that seeded semi-continuous process is more effective and efficient to prepare highly cross-linked, monodisperse particles than non-seeded and seeded batch processes.