• Title/Summary/Keyword: multi-class system

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CNVDAT: A Copy Number Variation Detection and Analysis Tool for Next-generation Sequencing Data (CNVDAT : 차세대 시퀀싱 데이터를 위한 유전체 단위 반복 변이 검출 및 분석 도구)

  • Kang, Inho;Kong, Jinhwa;Shin, JaeMoon;Lee, UnJoo;Yoon, Jeehee
    • Journal of KIISE:Databases
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    • v.41 no.4
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    • pp.249-255
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    • 2014
  • Copy number variations(CNVs) are a recently recognized class of human structural variations and are associated with a variety of human diseases, including cancer. To find important cancer genes, researchers identify novel CNVs in patients with a particular cancer and analyze large amounts of genomic and clinical data. We present a tool called CNVDAT which is able to detect CNVs from NGS data and systematically analyze the genomic and clinical data associated with variations. CNVDAT consists of two modules, CNV Detection Engine and Sequence Analyser. CNV Detection Engine extracts CNVs by using the multi-resolution system of scale-space filtering, enabling the detection of the types and the exact locations of CNVs of all sizes even when the coverage level of read data is low. Sequence Analyser is a user-friendly program to view and compare variation regions between tumor and matched normal samples. It also provides a complete analysis function of refGene and OMIM data and makes it possible to discover CNV-gene-phenotype relationships. CNVDAT source code is freely available from http://dblab.hallym.ac.kr/CNVDAT/.

Analysis of River Channel Morphology and Riparian Land Use Changes using Multi-temporal Aerial Photographs and Topographic Maps of the Early 20th Century in Gyeongan-cheon Watershed (시계열 항공사진과 20세기 초 지형도를 이용한 경안천유역의 하천형태 및 하천부지 변화추세 분석)

  • Park, Geun-Ae;Lee, Mi-Seon;Kim, Hyeon-Jun;Kim, Seong-Joon
    • Journal of Korea Water Resources Association
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    • v.38 no.5 s.154
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    • pp.379-390
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    • 2005
  • This study is to trace the change of stream shape using the past series of aortal photographs and topographic maps, and to compare the land use changes of inland along the stream. For the Gyeongan first & second class of local stream, aerial photographs of 1966, 1981 and 2000 were selected and ortho photographs were made with interior orientation and exterior orientation, respectively. In addition, topographic maps of 1914 - 1915 were used to compare with stream of 1966, 1981 and 2000. As apparent changes of the stream, the consolidated reaches of stream with levee construction were straightened and their stream width widened. Especially the stream width of inlet part of Paldang lake was widened almost twice because of the rise of water level by dam construction in 1974. The land use maps (1966, 1981, 2000) of riparian areas were also made, respectively and classified into 6 categories (water, forest, agricultural land, urban area, road, sandbar) by digitizing, The main changes of land use were agricultural land, urban area, road and sandbar.

Directions and Assignments of Educational Welfare in Korea (우리나라 교육복지의 방향과 과제)

  • Hong, Bong-Sun
    • Korean Journal of Social Welfare
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    • v.56 no.1
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    • pp.253-282
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    • 2004
  • The study is to examine the actual conditions and problems of educational welfare which is a part of social welfare and to offer its future directions and things to do. First of all, education has been considered to be part of social welfare in developed countries for a long time and it has been used the same as school educational welfare. These days Korea is confronted with increasing needs of educational welfare caused by emphasis of manpower, appearance of new poor class after IMF, handing down poverty to their children, absence of public education and educational fever, stress of life long learning and extending needs of students' social welfare service. In advanced countries compared to Korea, people perceive education as an equal opportunity. To reach this thesis, various efforts have been making in terms of manpower development such as reform of related laws, financial and official support, offering of parental skills and protecting children for the disadvantaged, dispatching school social workers and overall life improvement. The subjects and age of educational welfare are also diverse ranging from poor families and pre school children to general public and adults. On the other hand, Korea lacks related laws and financial support that are supposed to enforce educational welfare systematically. Also integrated and professional services are not often available due to the lack of cooperation between related agencies. Therefore, government's role and responsibility should be defined clearly in the future directions of educational welfare in Korea. For this, it is needed to establish related laws and build a concrete financial and executive interrelationship. Also every person should be a target of educational welfare putting priorities on the disadvantaged. A lot of efforts should be made to achieve things mentioned above. Multi-dimensional approach intertwined with education, welfare and labour, establishment of cooperation system between related agencies, reinforcement of life long learning, extension of free education including infants and toddlers, and offering financial support to the poor are a few among these efforts. Finally, institutionalization of school social welfare and improvement school facilities are strongly recommended to get to the right track of educational welfare.

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How sun spot activity affects on positioning accuracy?: Case study of solar storm (태양 흑점활동이 측위오차에 미치는 영향: 태양폭풍 사례연구)

  • Yoo, Yun-Ja;Cho, Deuk-Jae;Park, Sang-Hyun
    • Proceedings of the Korean Institute of Navigation and Port Research Conference
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    • 2011.06a
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    • pp.27-28
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    • 2011
  • A solar flares have the 11-year cycle and release a large energy which may produce coronal mass ejections (CME). The NOAA (National Oceanic and Atmospheric Administration) predicted that the sun spot activity will be maximized in 2013-2014. A strong solar flare can cause the disturbance of global positioning system including various communication of TV, radio broadcasting. The actual solar storm in 1989 caused power outages in Canada during 9 hours and about 600 million people had experienced a blackout. Such a solar storm can shorten the GPS satellite's life span about 5 to 10 years which can be resulted in economic loss considering the amount of multi-billion won. This paper analyzed the recent solar storm of X-class occurred on 15th of February about 10:45 this year that was reached Korea (Bohyun observatory) on 18th of February about 10:30 (local time), and compared with the data of before and after a week. The proton data of 18th of February considered that the solar strom reached on earth showed a fluctuation compared to the data of before and after a week. The positioning results at Daejeon also showed higher positioning error compared to the data of before and after a week results.

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REAL-TIME MEASUREMENT OF DENTINAL TUBULAR FLUID FLOW DURING AND AFTER AMALGAM AND COMPOSITE RESTORATIONS (아말감과 복합레진의 수복 과정과 수복 후 발생하는 상아세관액 흐름의 실시간 측정)

  • Kim, Sun-Young;Cho, Byeong-Hoon;Baek, Seung-Ho;Lim, Bum-Sun;Lee, In-Bog
    • Restorative Dentistry and Endodontics
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    • v.34 no.6
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    • pp.467-476
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    • 2009
  • The aim of this study was to measure the dentinal tubular fluid flow (DFF) during and after amalgam and composite restorations. A newly designed fluid flow measurement instrument was made. A third molar cut at 3 mm apical from the CEJ was connected to the flow measuring device under a hydrostatic pressure of 15 $cmH_2O$. Class I cavity was prepared and restored with either amalgam (Copalite varnish and Bestaloy) or composite (Z-250 with ScotchBond MultiPurpose: MP, Single Bond 2: SB, Clearfil SE Bond: CE and Easy Bond: EB as bonding systems). The DFF was measured from the intact tooth state through restoration procedures to 30 minutes after restoration, and re-measured at 3 and 7days after restoration. Inward fluid flow (IF) during cavity preparation was followed by outward flow (OF) after preparation, In amalgam restoration, the OF changed to IF during amalgam filling and slight OF followed after finishing. In composite restoration, application CE and EB showed a continuous OF and air-dry increased rapidly the OF until light-curing, whereas in MP and SB, rinse and dry caused IF and OF, respectively. Application of hydrophobic bonding resin in MP and CE caused a decrease in flow rate or even slight IF. Light-curing of adhesive and composite showed an abrupt IF. There was no statistically significant difference in the reduction of DFF among the materials at 30 min. 3 and 7 days after restoration (p > 0.05).

How sun spot activity affects on positioning accuracy?: Case study of solar storm (태양 흑점활동이 측위오차에 미치는 영향: 태양폭풍 사례연구)

  • Yoo, Yun-Ja;Cho, Deuk-Jae;Park, Sang-Hyun
    • Journal of Navigation and Port Research
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    • v.35 no.6
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    • pp.477-482
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    • 2011
  • Solar flares have the 11-year cycle and release a large energy which may produce coronal mass ejections (CME). The NOAA (National Oceanic and Atmospheric Administration) predicted that the sun spot activity will be maximized in 2013-2014. A strong solar flare can cause the disturbance of global positioning system including various communication of TV, radio broadcasting. The actual solar storm in 1989 caused power outages in Canada during 9 hours and about 600 million people had experienced a blackout. Such a solar storm can shorten the GPS satellite's life span about 5 to 10 years which can resulted in economic loss considering the amount of multi-billion won. This paper analyzed the influence of recent X-class solar storm occurred on 15th of February about 10:45 this year that was reached Korea (Bohyun observatory) on 18th of February about 10:30 (01:30 - UTC), and compared with the data before and after a week. The proton data of 18th of February considered that the solar storm reached on earth showed a fluctuation compared to the data before and after a week. The positioning results at Daejeon and Seoul of Korea also showed higher positioning error compared to the data before and after a week results.

A Comparative Study on the Paid Work Time and Work-Leisure Balance by Household Income (가구소득별 유급노동 시간과 일-여가 균형에 관한 국가비교)

  • Noh, Hye Jin;Hwang, Eunjung
    • Korean Journal of Social Welfare Studies
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    • v.49 no.1
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    • pp.51-83
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    • 2018
  • This study examines whether the widening gap between income groups is worsening in the distribution of time use, similar to the worsening of income distribution after the IMF. To do this, we conducted multilevel analysis (HLM) on six countries including France, the Netherlands, Spain, the United Kingdom, the United States and Korea. The results of the analysis are as follows. First, in all countries, low income groups have a longer paid working time and shorter leisure time. Second, the low income groups in Korea have the longest paid work time and the shortest leisure time, the lowest level of work-leisure balance, and this aspect has not recovered since the IMF. Third, as the result of multilevel analysis, the lower the household income, the more time paid labor increased and the work-leisure balance decreased. Fourth, while average annual working hours increase paid working time, the expansion of family policy expenditure, redistribution policy and income maintenance policy has reduced it. Fifth, the annual average working hours decreased the work-leisure balance, but the family policy expenditure, the redistribution policy and the income guarantee policy increased the work-leisure balance. The significance of this study is that after the IMF, not only the income distribution but also the inequality among the income class in time use has deepened. Based on the results of the research this study suggests the reinforcement of labor time regulation, the activation of parental leave system, the realization of the income replacement rate, the expansion of the policy related to income redistribution, and the complementary development of the income guarantee and the time guarantee policy as the policy intervention strategy that restructures time.

A STUDY ON THE MICROLEAKAGE OF DENTIN BONDING SYSTEMS (상아질 접착제의 미세누출에 관한 연구)

  • Son, Jeong-Min;Choi, Nam-Ki;Kim, Seon-Mi;Yang, Kyu-Ho;Park, Yang, Ji-il
    • Journal of the korean academy of Pediatric Dentistry
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    • v.35 no.4
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    • pp.619-627
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    • 2008
  • The objective of this study was to compare the microleakage of five adhesive systems in the enamel and dentin of permanent teeth. Class V cavity preparations with occlusal margins in enamel and gingival margins in dentin were prepared on both buccal and lingual surfaces of 25 extracted human molar teeth. The tested adhesives were: Adper Scotchbond Multi-purpose Plus Adhesive (SM), Adper Single bond 2 (SB), Clearfil SE Bond (SE), Adper Prompt L-Pop (PL) and G-Bond (GB). The results were as follows: 1. At the enamel margins, PL showed the highest leakage value(0.85), and others showed values of SB(0.55), GB(0.50), SM(0.35) and SE(0.25) in decreasing order. There were statistically significant differences in PL vs. SM and PL vs. SE(p<0.05). 2. At the dentin margins, GB showed the highest leakage value(2.10), and others showed values of SE(1.45), PL(1.40), SB(1.05), SM(0.70) in decreasing order. There were statistically significant differences in GB vs. SB and GB vs. SM(p<0.05). 3. Dentin margins showed high dye penetration rate than enamel margins in all material tested groups and there were statistically significant differences for SE, PL and GB.

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INFLUENCE OF REBONDING PROCEDURES ON MICROLEAKAGE OF COMPOSITE RESIN RESTORATIONS (복합레진 수복 시 재접착 술식이 미세누출에 미치는 영향)

  • Lee, Mi-Ae;Seo, Duck-Kyu;Son, Ho-Hyun;Cho, Byeong-Hoon
    • Restorative Dentistry and Endodontics
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    • v.35 no.3
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    • pp.164-172
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    • 2010
  • During a composite resin restoration, an anticipating contraction gap is usually tried to seal with low-viscosity resin after successive polishing, etching, rinsing and drying steps, which as a whole is called rebonding procedure. However, the gap might already have been filled with water or debris before applying the sealing resin. We hypothesized that microleakage would decrease if the rebonding agent was applied before the polishing step, i.e., immediately after curing composite resin. On the buccal and lingual surfaces of 35 extracted human molar teeth, class V cavities were prepared with the occlusal margin in enamel and the gingival margin in dentin. They were restored with a hybrid composite resin Z250 (3M ESPE, USA) using an adhesive AdperTM Single Bond 2 (3M ESPE). As rebonding agents, BisCover LV (Bisco, USA), ScotchBond Multi-Purpose adhesive (3M ESPE) and an experimental adhesive were applied on the restoration margins before polishing step or after successive polishing and etching steps. The infiltration depth of 2% methylene blue into the margin was measured using an optical stereomicroscope. The correlation between viscosity of rebonding agents and mciroleakage was also evaluated. There were no statistically significant differences in the microleakage within the rebonding procedures, within the rebonding agents, and within the margins. However, when the restorations were not rebonded, the microleakage at gingival margin was significantly higher than those groups rebonded with 3 agents (p < 0.05). The difference was not observed at the occlusal margin. No significant correlation was found between viscosity of rebonding agents and microleakage, except very weak correlation in case of rebonding after polishing and etching at gingival margin.

A Study on the Prediction Model of Stock Price Index Trend based on GA-MSVM that Simultaneously Optimizes Feature and Instance Selection (입력변수 및 학습사례 선정을 동시에 최적화하는 GA-MSVM 기반 주가지수 추세 예측 모형에 관한 연구)

  • Lee, Jong-sik;Ahn, Hyunchul
    • Journal of Intelligence and Information Systems
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    • v.23 no.4
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    • pp.147-168
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    • 2017
  • There have been many studies on accurate stock market forecasting in academia for a long time, and now there are also various forecasting models using various techniques. Recently, many attempts have been made to predict the stock index using various machine learning methods including Deep Learning. Although the fundamental analysis and the technical analysis method are used for the analysis of the traditional stock investment transaction, the technical analysis method is more useful for the application of the short-term transaction prediction or statistical and mathematical techniques. Most of the studies that have been conducted using these technical indicators have studied the model of predicting stock prices by binary classification - rising or falling - of stock market fluctuations in the future market (usually next trading day). However, it is also true that this binary classification has many unfavorable aspects in predicting trends, identifying trading signals, or signaling portfolio rebalancing. In this study, we try to predict the stock index by expanding the stock index trend (upward trend, boxed, downward trend) to the multiple classification system in the existing binary index method. In order to solve this multi-classification problem, a technique such as Multinomial Logistic Regression Analysis (MLOGIT), Multiple Discriminant Analysis (MDA) or Artificial Neural Networks (ANN) we propose an optimization model using Genetic Algorithm as a wrapper for improving the performance of this model using Multi-classification Support Vector Machines (MSVM), which has proved to be superior in prediction performance. In particular, the proposed model named GA-MSVM is designed to maximize model performance by optimizing not only the kernel function parameters of MSVM, but also the optimal selection of input variables (feature selection) as well as instance selection. In order to verify the performance of the proposed model, we applied the proposed method to the real data. The results show that the proposed method is more effective than the conventional multivariate SVM, which has been known to show the best prediction performance up to now, as well as existing artificial intelligence / data mining techniques such as MDA, MLOGIT, CBR, and it is confirmed that the prediction performance is better than this. Especially, it has been confirmed that the 'instance selection' plays a very important role in predicting the stock index trend, and it is confirmed that the improvement effect of the model is more important than other factors. To verify the usefulness of GA-MSVM, we applied it to Korea's real KOSPI200 stock index trend forecast. Our research is primarily aimed at predicting trend segments to capture signal acquisition or short-term trend transition points. The experimental data set includes technical indicators such as the price and volatility index (2004 ~ 2017) and macroeconomic data (interest rate, exchange rate, S&P 500, etc.) of KOSPI200 stock index in Korea. Using a variety of statistical methods including one-way ANOVA and stepwise MDA, 15 indicators were selected as candidate independent variables. The dependent variable, trend classification, was classified into three states: 1 (upward trend), 0 (boxed), and -1 (downward trend). 70% of the total data for each class was used for training and the remaining 30% was used for verifying. To verify the performance of the proposed model, several comparative model experiments such as MDA, MLOGIT, CBR, ANN and MSVM were conducted. MSVM has adopted the One-Against-One (OAO) approach, which is known as the most accurate approach among the various MSVM approaches. Although there are some limitations, the final experimental results demonstrate that the proposed model, GA-MSVM, performs at a significantly higher level than all comparative models.