• Information Systems Review
• /
• v.4 no.2
• /
• pp.223-236
• /
• 2002

In an agent-based system, each agent has its own decision making capability and competes, cooperates, and communicates each other with an agent interface. Virtual manufacturing has characteristics as a typical application area of agent-based system: complex and time-bound decision making and negotiation. The time-boundness influences the choice of decision making models and design of protocols for internal and external negotiation. In this paper, we provide a case study which suggests a time-bound framework for external and internal negotiation between the agents for virtual manufacturing environment. We illustrate decision making model selection strategy and the system architecture of the agent-based system for the complex and time-bound environment.

• Proceedings of the Korean Society of Applied Pharmacology
• /
• 1993.04a
• /
• pp.130-130
• /
• 1993

실험목적: KR 53170 및 KR 53234 는 천연물에서 분리 추출한 화합물로 terpene lacton ring을 가진 약산성 물질이다. in vitro 항종양 실험에서 종양억제효과가 있었고 in vivo 항종양 실험에서도 유의성 있는 효과가 있었으며 급성 경구독성시험에서도 독성이 낮은 것으로 평가 되었다. 이에 따라 KR 53170 등의 약물동태학적인 성질을 연구하여 독성실험과 임상실험을 위한 용법용량을 결정하고 나아가 본약물의 제제개발에 도움이 되도록 본 연구를 시행하였다. 방법: KR 53170 및 53234은 경구시 20mg/kg, 정맥투여시는 10mg/kg로 투여하였다. Rat의 혈장 sample 채취는 ether로 흡입마취 시킨 후 heart puncture 하였다. 뇨시료는 대사 cage를 이용하여 채취하였으며 얻어진 모든 시료는 HPLC로 분석 하였다. 분석결과는 computer program 'Multi-free'를 이용하여 주요 pqarameter를 산출하였다. 인체혈액에 대한 혈청단백결합율 측정은 ultrafiltration법을 이용하였다. 즉 YMT membrane을 이용하여주요 parameter를 산출하였다. 인체혈액에 대한 혈청단백결합율 측정은 ultrafiltration법을 이용하였다. 즉 YMT membrane을 이용하여 유리약물을 분리하여 HPLC로 정량하였다. 결과 및 고찰: 1. KR 53170 10mg/kg 정맥투여시 최고혈중농도는 0.55ug/ml, 반감기는 0.51hr, 분포용적은 4.5L이었다. 20mg/kg를 경구 투여시 최고 혈중농도는 0.18ug/ml, 반감기는 3.5기산이고 AUC는 0.91ug.ml, 분포용적 28Lm, Ka 3.49$hr^{－1}$ 그리고 Cl는 5.5L/hr/kg이었다. 이는 투여용량에 비해 매우 적은량이 흡수되고 배설 된 것으로 약물이 혈액에 대한 용해도 문제에 기인하는 것으로 간주된다. 2. KR 53234 10mg/kg 정맥투여후의 최고혈중농도는 1.14ug/ml, 반감기는 0.50hr, 분포용적은 2.2L이었다. 20mg/kg 경구 투여시의 최소 혈중 농도는 0.33 ug/ml, 소실반감기는 1.5시간, AUC는 0.942ug.hr/ml, 분포용적 11L, Ka는 3.05 $hr^{－1}$ 그리고 Cl는 5.3L/hr/kg이었다. 이는 KR 53170에서와 같이 매우 적은량이 흡수되고 배설되었다. 3. KR 53170의 혈청단백 결합율은 5-500 ug/ml 범위에서 78.7-86.2%이었고 KR 53234의 혈청단백결합율은 5-100 ug/ml 범위에서 79.6-71.2%이었다.이었다.

• Journal of Internet Computing and Services
• /
• v.2 no.4
• /
• pp.41-53
• /
• 2001

Multi-distributed web cluster model built for high availability E-Business model exposes internal system nodes on its structural characteristics and has a potential that normal job performance is impossible due to the intentional prevention and attack by an illegal third party. Therefore, the security system which protects the structured system nodes and can correspond to the outflow of information from illegal users and unfair service requirements effectively is needed. Therefore the suggested distributed invasion detection system is the technology which detects the illegal requirement or resource access of system node distributed on open network through organic control between SC-Agents based on the shared memory of SC-Server. Distributed invasion detection system performs the examination of job requirement packet using Detection Agent primarily for detecting illegal invasion, observes the job process through monitoring agent when job is progressed and then judges the invasion through close cooperative works with other system nodes when there is access or demand of resource not permitted.

• Journal of the Computational Structural Engineering Institute of Korea
• /
• v.21 no.6
• /
• pp.555-561
• /
• 2008

This paper describes an e-Engineering framework to support collaborative design of automotive suspension systems developed at KIMM(Korea Institute of Machinery and Materials). The e-Engineering framework is proposed and developed on the base of the multi-layered software agents including engineering task agent which is generated from the domain knowledge of experts. The developed framework is aim to widely spread application to the small and medium enterprises by adopting open source technologies such as JADE (Java Agent Development Framework) and by using the independent characteristics related with applicant H/W and 81W system. This framework can provide an integrated design environment to support distributed personnel, design activities and engineering resources during product development process. For the validation of the system's applicability and efficiency, the several practical design processes for automotive suspension systems of RR/FR lower arms and RR cross member are applied and discussed.

• YAKHAK HOEJI
• /
• v.52 no.6
• /
• pp.434-440
• /
• 2008

The purpose of this research was to investigate the microbiological quality and antimicrobial susceptibilities of the ready-to-eat side dishes, which are were collected from the grocery stores, big markets, and department stores in Seoul throughout November, 2007. Of total 124 samples, presence of staphylococci and enteric bacilli was observed in 38 samples (31%) and 53 samples (43%), respectively. And 30 samples (24%) were shown to be of unsatisfactory quality for total bacterial count (>$10^5$). Antimicrobial susceptibilities of the staphylococci isolated from the side dishes were tested for six different antimicrobial agents, which are in widespread clinical use in Korea, as well as four new antimicrobials, daptomycin, linezolid, quinupristin/dalfopristin and tigecycline. As a result, the staphylococcal isolates were found to be resistant to oxacillin (${MIC}_{90}$, >128 ${\mu}g$/ml), teicoplanin (${MIC}_{90}$, >128 ${\mu}g$/ml), mupirocin (${MIC}_{90}$, >128 ${\mu}g$/ml), linezolid (${MIC}_{90}$, 128 ${\mu}g$/ ml) and quinupristin/dalfopristin (${MIC}_{90}$, 32 ${\mu}g$/ml). Especially, some of the staphylococcal isolates exhibited high level and multi-drug resistance. Moreover, these bacteria were also resistant to new antimicrobials, except tigecycline.

• YAKHAK HOEJI
• /
• v.52 no.5
• /
• pp.323-330
• /
• 2008

This study was conducted to investigate the actual conditions of vitamin supplement usage, the importance of their agents for health management, and the distribution of basic data for their correct consumption. For a period of one month 2003, the study was conducted based on questionnaires to the parents of students in both a middle school and a high school, and the personnel of K Company at random. The material used the survey sheets by setting up the previous investigation. The collected data analyzed the frequency and percentage of the following items: General demographic characteristics of consumers; the supplements taking; the reasons for taking them; the kinds of supplements taken; the media used for distributing data on their use; the potential use in the future, etc. According to the survey, the number of people who were taking supplements was higher than the number of people who weren’t taking them. Multi-vitamins were mostly consumed. The rate of supplements consume was high in people of a higher income bracket, had the time to exercise and to enjoy physical recreation. Most of the consumers who were taking the supplements said they did it to maintain their health and to recover from the fatigue. Those who weren’t taking them said they had enough vitamins from eating the appropriate food, and they were also concerned about the effectiveness of taking the supplements. The majority of useful information or advice for purchasing vitamins came from doctors, medical experts, relatives, and various media sources such as TV, newspapers, and magazines.

• The Journal of Engineering Research
• /
• v.7 no.1
• /
• pp.17-28
• /
• 2005

A distributed constraint satisfaction problem (distributed CSP) is a constraint satisfaction problem (CSP) in which variables and constraints are distributed among multiple automated agents. A CSP is a problem to find a consistent assignment of values to variables. Even though the definition of a CSP is very simple, a surprisingly wide variety of AI problems can be formalized as CSPs. Similarly, various application problems in DAI (Distributed AI) that are concerned with finding a consistent combination of agent actions can be formalized as distributed CPSs. The experimental results on example problems show that this algorithm is by far more efficient than the backtracking algorithm, in which the priority order is static. The priority order represents a hierarchy of agent authority, i.e., the priority of decision-marking. Therefore, these results imply that a flexible agent organization, in which the hierarchical order is changed dynamically, actually performs better than an organization in which the hierarchical order is static and rigid. Furthermore, we describe that the agent can be available to hold multiple variables in the searching scheme.

• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.43 no.4
• /
• pp.321-327
• /
• 2017

This study was carried out to develop a stable plant-derived natural sunscreen (BHC-S) that replaces the artificially synthesized organic sunscreen agents. The natural sunscreen (BHC-S), which is composed of peanut extract, Centella asiatica extract, and Ecklonia stolonifera extract, has the same level of ultraviolet shielding effect as PARSOL MCX-XR (OMC), which is a synthetic sunscreen. and has safety against skin. MultiFunctional effect such as and anti-wrinkle improvement. Thus, it can be used as raw material for natural cosmetics for ultraviolet ray blocking, and anti-aging.

• Journal of KIBIM
• /
• v.6 no.3
• /
• pp.34-41
• /
• 2016

The previous studies argue that using the semantic properties of BIM objects is efficient for simulating the behaviors of autonomous, computer agents, called virtual-users, but such assumption is not proven via evidence-based research approaches. Hence, this present study aims to investigate the empirical effects of a human behavior simulation model equipped the semantics of spaces on the architecture-major students' operation and understanding of the simulation system, compared to a typical path-finding model. To achieve the aim, this study analyzed the survey and interview data, collected in the authentic design projects. The analysis indicates that (1) using a simulation model equipped the semantics of spaces helps the students' operation of the simulation, and (2) it also aids understanding the relationship between the variables of spaces and virtual-users (${\alpha}=0.74$). In addition, the qualitative data inform that the advantages of the simulation model that computes the semantics of spaces stem in the automatic behavioral changes of massive numbers of virtual-users, and efficient detection and activation on the what-if situations. The analysis also reveals that the simulation model has shortcomings in orchestrating the complex data structure between the semantics properties of spaces and virtual-users under multi-sequential scenarios. The results of this study contribute to develop a future design system combining BIM with human behavior simulation.

• The Journal of the Korean dental association
• /
• v.52 no.4
• /
• pp.218-233
• /
• 2014

Bispbosphonates are a class of pharmaceutic agents, which induce apoptosis of osteoclast as well as impair osteoclastic activity to suppress bone resorption. Thus, bisphophonates are effectively used to treat osteoporosis, multiple myeloma and to prevent bone metastases of malignant cancer. However, recently dental disease have been reported associated with Bisphosphonates. Thus, there are a number of discussions about proper prevention and treatment of bisphosphonate-related osteonecrosis of jaw(BRONJ). Marshall R. Urist in 1965 made the seminal discovery that a specific protein, BMP(bone morphogenetic protein), found in the extracellular matrix of demineralized bone could induce bone formation newly when implanted in extraosseous tissues in a host. BMPs are multi-functional growth factors which are members of the transforming growth factor-beta super family and their ability is that plays a pivotal roll in inducing bone. About 18 BMP family members have been identified and characterized. Among of them, BMP-2 and BMP-7 have significant importance in bone development. In this study, patients of BRONJ were recieved who visited Department of oral and maxillofacial surgery, school of dentistry, Wonkwang university for past 3 years from 2011 to 2013. We focused on the results of the surgical intervention. We suggest that new strategy of treatment used to rhBMP-2 and LFA(Lidocaine-Fibrinogen-Aprotinin)-collagen scaffold for patients of BRONJ. The purpose of this paper is to give a brief overview of BMPs and to critically review the clinical data currently available on rhBMP-2 and LFA collage scaffold.