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Successful strategy of treatment used to rhBMP-2 and LFA-collagen scaffold for BRONJ  

Kwon, Kyung-Hwan (Department of oral and maxillofacial surgery, college of dentistry, Wonkwang university Wonkwang dental research institute)
Publication Information
The Journal of the Korean dental association / v.52, no.4, 2014 , pp. 218-233 More about this Journal
Abstract
Bispbosphonates are a class of pharmaceutic agents, which induce apoptosis of osteoclast as well as impair osteoclastic activity to suppress bone resorption. Thus, bisphophonates are effectively used to treat osteoporosis, multiple myeloma and to prevent bone metastases of malignant cancer. However, recently dental disease have been reported associated with Bisphosphonates. Thus, there are a number of discussions about proper prevention and treatment of bisphosphonate-related osteonecrosis of jaw(BRONJ). Marshall R. Urist in 1965 made the seminal discovery that a specific protein, BMP(bone morphogenetic protein), found in the extracellular matrix of demineralized bone could induce bone formation newly when implanted in extraosseous tissues in a host. BMPs are multi-functional growth factors which are members of the transforming growth factor-beta super family and their ability is that plays a pivotal roll in inducing bone. About 18 BMP family members have been identified and characterized. Among of them, BMP-2 and BMP-7 have significant importance in bone development. In this study, patients of BRONJ were recieved who visited Department of oral and maxillofacial surgery, school of dentistry, Wonkwang university for past 3 years from 2011 to 2013. We focused on the results of the surgical intervention. We suggest that new strategy of treatment used to rhBMP-2 and LFA(Lidocaine-Fibrinogen-Aprotinin)-collagen scaffold for patients of BRONJ. The purpose of this paper is to give a brief overview of BMPs and to critically review the clinical data currently available on rhBMP-2 and LFA collage scaffold.
Keywords
rhBMP-2; BRONJ; scaffold; collagen;
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1 Dehari H, Tomihara K, Ueda M, Shimanishi M, Ono M, Sasaki T, Igarashi T, Shiratori K, Abe M, Ogi K, Nakamori K, Miyazaki A, Nagai I, Hiratsuka H. Clinical investigation of bisphosphonate-related osteonecrosis of the jaws. Gan To Kagaku Ryoho. 2009 Dec;36(13):2587-92.
2 Vescovi P, Nammour S. Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ) therapy. A critical review. Minerva Stomatol. 2010 Apr;59(4):181-203, 204-13
3 Kwon YD, Lee DW, Choi BJ, Lee JW, Kim DY. Short-term teriparatide therapy as an adjunctive modality for bisphosphonate-related osteonecrosis of the jaws. Osteoporos Int. 2012 Nov;23(11):2721-5   DOI
4 Assael LA. Oral bisphosphonates as a cause of bisphosphonate-related osteonecrosis of the jaws: clinical findings, assessment of risks, and preventive strategies. J Oral Maxillofac Surg. 2009 May;67(5 Suppl):35-43.
5 Adornato MC1, Morcos I, Rozanski J. The treatment of bisphosphonate-associated osteonecrosis of the jaws with bone resection and autologous platelet-derived growth factors. J Am Dent Assoc. 2007 Jul;138(7):971-7.   DOI
6 Bocanegra-P럕ez S1, Vicente-Barrero M, Knezevic M, Castellano-Navarro JM, Rodr뭛uez-Bocanegra E, Rodr뭛uez-Millares J, P럕ez-Plasencia D, Ramos-Mac뭓s A. Use of platelet-rich plasma in the treatment of bisphosphonate-related osteonecrosis of the jaw. Int J Oral Maxillofac Surg. 2012 Nov;41(11):1410-5   DOI
7 Coleman RE. Bisohosphonate: clinical experience. Oncologist 2004;9(4):14-27
8 Migliorati CA, Siegel MA, Elting LS. Bisphosphonate-associated osteonecrosis: a long-term complication of bisphosphonate treatment. Lancet oncol 2006;7:508-14   DOI   ScienceOn
9 Scoletta M, Arduino PG, Dalmasso P, Broccoletti R, Mozzati M. Treatment outcomes in patients with bisphosphonate-related osteonecrosis of the jaw: a prospective study. Oral Surg Oral med Oral Pathol Oral Radiol Endod 2010;110:46-53   DOI
10 Molina-Minano F, Lopez-Jronet P, Camacho-Alonso F, Vicente-ortega V. Plasma rich in growth factors and bone formation: a radiological and histomorphometric study in New Zealand rabbits. Braz Oral Res 2009;23:275-80   DOI
11 Marx R. Oral and intravenous bisphosphonate-induced osteonecrosis of the jaws: history, etiology, prevention, and treatment. Hanover Park, I.L:Quintessence Publishing Co., Inc.; 2007
12 Graziani F, Cei S, La Ferla F, Cerri E, Itro A, Gabriele M. Association between osteonecrosis of the jaws and chronic high-dosage intravenous bisphosphonates therapy. J Craniofac Surg. 2006 Sep;17(5):876-9.   DOI
13 Hewitt C, Farah CS. Bisphosphonate-related osteonecrosis of the jaws: a comprehensive review. J Oral Pathol Med. 2007 Jul;36(6):319-28.   DOI
14 Magopoulos C1, Karakinaris G, Telioudis Z, Vahtsevanos K, Dimitrakopoulos I, Antoniadis K, Delaroudis S. Osteonecrosis of the jaws due to bisphosphonate use. A review of 60 cases and treatment proposals. Am J Otolaryngol. 2007 May-Jun;28(3):158-63.   DOI   ScienceOn
15 Urist M, Dowell T, Hay P, Strates B. Inductive substrates for bone formation. Clinical orthopaedics and related research 1968;59:59.
16 Wutzl A1, Biedermann E, Wanschitz F, Seemann R, Klug C, Baumann A, Watzinger F, Schicho K, Ewers R, Millesi G. Treatment results of bisphosphonate-related osteonecrosis of the jaws. Head Neck. 2008 Sep;30(9):1224-30. 3   DOI   ScienceOn
17 Goto H, Matsuyama T, Miyamoto M, Yonamine Y, Izumi Y. Platelet-rich plasma/osteoblasts complex induces bone formation via osteoblastic differentiation following subcutaneous transplanta tion. J Periodontal Res. 2006 Oct;41(5):455-62   DOI
18 Badr MS, Oliver RJ. Platelet-rich plasma: an adjunctive treatment modality for bisphosphonate osteonecrosis? J Oral Maxillofac Surg. 2009 Jun;67(6):1357.
19 Nystr쉙m E, Legrell P, Forssell, Kahnberg K. Combined use of bone grafts and implants in the severely resorbed maxilla Postoperative evaluation by computed tomography. International Journal of Oral & Maxillofacial Surgery 1995;24:20.   DOI   ScienceOn
20 Choi J, Shin H. Requirements of artificial materials for alveolar bone regeneration. Tissue Eng Regen Med 2007;4:478.
21 Yun S, Kim Y, Kwon O. Fabrication and characterization of biodegradable nanofiber containing gelatin. Tissue Eng Regen Med 2008;5:835.
22 Friedlaender G. Osteogenic protein-1 in treatment of tibial nonunions: current status. Surg technol int 2004;13:249-52
23 Bessa PC, Casal M, Reis RL. Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery). J Tissue Eng Regen Med 2008;2:81-96   DOI   ScienceOn
24 Kanakaris NK, Giannoudis PV. Clinical applications of bone morphogenetic proteins: current evidence. J Surg Orthop Adv 2008;17:133-46
25 Mont MA, Ragland PS, Biggins B, Friedlaender G, Patel T, Cook S, Etienne G, Shimmin A, Kildey R, Rueger DC. Use of bone morphogenetic proteins for musculoskeletal applications: an overview. J Bone Joint Surg Am 2004;86: 41-55   DOI
26 Burchardt H. The biology of bone graft repair. Clinical orthopaedics and related research 1983:28.
27 Takahashi Y, Yamamoto M, Tabata Y. Enhanced osteoinduction by controlled release of bone morphogenetic protein-2 from biodegradable sponge composed of gelatin and $\beta$-tricalcium phosphate. Biomaterials 2005;26:4856-65   DOI   ScienceOn
28 Carter TG, Brar PS, Tolas A, Beirne OR. Off-label use of recombinant human bone morphogenetic protein-2 (rhBMP-2) for reconstruction of mandibular bone defects in humans. J Oral Maxillofac Surg 2008;66:1417-25.   DOI   ScienceOn
29 Shields LB, Raque GH, Glassman SD, Campbell M, Vitaz T, Harpring J, Shields CB. Adverse effects associated with high-dose recombinant human bone morphogenetic protein-2 use in anterior cervical spine fusion. Spine 2006;31: 542-7.   DOI   ScienceOn
30 Jeon S, Chae J, Lee E. Recent research trends of bone graft. Tissue Eng Regen Med 2008;5:791.
31 Hoexter D. Bone regeneration graft materials. Journal of Oral Implantology. 2002;28:290.   DOI   ScienceOn
32 Patel ZS, Young S, Tabata Y, Jansen JA, Wong MEK, Mikos AG. Dual delivery of an angiogenic and an osteogenic growth factor for bone regeneration in a critical size defect model. Bone 2008;43:931-40.   DOI   ScienceOn
33 La WG, Kang SW, Yang HS, Bhang SH, Lee SH, Park JH, Kim BS. The efficacy of bone morphogenetic protein-2 depends on its mode of delivery. Artif Organs 2010;34: 1150-3.   DOI   ScienceOn
34 Uludag H, D'Augusta D, Palmer R, Timony G, Wozney J. Characterization of rhBMP 2 pharmacokinetics implanted with biomaterial carriers in the rat ectopic model. J Biomed Mater Res 1999;46:193-202.   DOI   ScienceOn
35 Haidar ZS, Hamdy RC, Tabrizian M. Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part A: current challenges in BMP delivery. Biotechnol Lett 2009;31:1817-24.   DOI   ScienceOn
36 Linde A, Thoren C, Dahlin C, Sandberg E. Creation of new bone by an osteopromotive membrane technique: an experimental study in rats. Journal of Oral and Maxillofacial Surgery 1993;51:892.   DOI   ScienceOn
37 Zhao B, Katagiri T, Toyoda H, Takada T, Yanai T, Fukuda T, Chung UI, Koike T, Takaoka K, Kamijo R. Heparin potentiates the in vivo ectopic bone formation induced by bone morphogenetic protein-2. J Biol Chem 2006;281:23246-53.   DOI   ScienceOn
38 Friberg O. Local collagen-entamicin for prevention of sternal wound infections: the LOGIP trial. Apmis. 2007;115:1016?1.
39 Jensen T, Rahbek O, Overgaard S, S?alle K. No effect of platelet-rich plasma with frozen or processed bone allograft around noncemented implants. International orthopaedics 2005;29:67.   DOI   ScienceOn
40 Byne EM, Farrel E, McMahon LA, Haugh MG, O'Brien FJ, Campbell VA, Prendergast PJ. & O'Connell, BC. Gene expression by marrow stromal cells in a porous collagen-glycosaminoglycan scaffold is affected by pore size and mechanical stimulation, J Mat Sci Mat Med 19:3455.   DOI
41 Boerckel JD, Kolambkar YM, Dupont KM, Uhrig BA, Phelps EA, Stevens HY, Garc?a AJ, Guldberg RE. Effects of protein dose and delivery vehicle on BMP-mediated bone regeneration. Biomaterials 2011;32:5241-51   DOI   ScienceOn
42 Fu YC, Nie H, Ho ML, Wang CK, Wang CH. Optimized bone regeneration based on sustained release from three dimensional fibrous PLGA/HAp composite scaffolds loaded with BMP-2. Biotechnol Bioeng 2008;99:996-1006   DOI   ScienceOn
43 Haidar ZS, Hamdy RC, Tabrizian M. Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part A: current challenges in BMP delivery. Biotechnol Lett 2009;31:1817-24   DOI   ScienceOn
44 Dayisoylu EH, senel Fc ungor C, Tosun E, cankaya M, Ersoz S, Taskesen F. The effects of adjunctive parathyroid hormone injection on bisphosphonate-related osteonecrosis of the jaws: an animal study. Int J Oral Maxillofac Surg 2013 Nov;42(11):1475-80   DOI
45 Dodson TB. Intravenous bisphosphonate therapy and bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg. 2009 May;67(5 Suppl):44-52.
46 Liu HW, Chen CH, Tsai CL, Hsiue GH. Targeted delivery vehicle for juxtacrine signaling growth factor based on rhBMP-2-mediated carrier-protein conjugation. Bone 2006; 39:825-36.   DOI   ScienceOn
47 Marco Mozzati, Giorgia Gallesio, Valentina Arata, Renato Pol, Matteo Scoletta. Platelet-rich therapies in the treatment of intraveonus bisphosphonate-related osteonecrosis of the jaw: A report of 32 cases. Oral oncology 48(2012):469-474   DOI   ScienceOn
48 Curi MM1, Cossolin GS, Koga DH, Ara쐉o SR, Feher O, dos Santos MO, Zardetto C. Treatment of avascular osteonecrosis of the mandible in cancer patients with a history of bisphosphonate therapy by combining bone resection and autologous platelet-rich plasma: Report of 3 cases. J Oral Maxillofac Surg. 2007 Feb;65(2):349-55.   DOI   ScienceOn
49 Lee CY, David T, Nishime M. Use of platelet-rich plasma in the management of oral biphosphonate-associated osteonecrosis of the jaw: a report of 2 cases. J Oral Implantol. 2007;33(6):371-82   DOI
50 Montebugnoli L, Felicetti L, Gissi DB, Pizzigallo A, Pelliccioni GA, Marchetti C. Biphosphonate-associated osteonecrosis can be controlled by nonsurgical management. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Oct;104(4):473-7.   DOI