• Title/Summary/Keyword: mucus

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A Case of Mucus Plug Impaction resulted in Bronchial Obstruction (광범위 기관지 폐쇄를 유발한 점액전 1례)

  • 고중화;전영명;김휘준
    • Korean Journal of Bronchoesophagology
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    • v.3 no.2
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    • pp.313-317
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    • 1997
  • Airway mucus provides the protective functions such as lubrication, barrier, disposal of trapped materials, and humidification. In the normal state, the mucus do not interfere with Bas transport and the other vital functions of lung. In diseases such as asthma, bronchitis, and cystic fibrosis, the mucus hypersecretion was physiologically developed in the response of multiple neurohumoral mechanism system. And regardless of the mechanism, many clinical sequelae result from mucus hypersecretion: atelectasis, infection, increased airway resistance, increased work of breathing, increased cough with its resultant complication. And the condensation of mucus tv mucus hypersecretion can make the mucus plug by which bronchial obstruction is developed. We have experienced a 7 Pear-old male patient with recurrent pneumonic symtom, which the bronchial obstruction was developed by the impacted mucus plug on the bronchoscopic finding. We report this case with the review of literature.

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Recent Advances in the Development of Novel Drug Candidates for Regulating the Secretion of Pulmonary Mucus

  • Li, Xin;Jin, Fengri;Lee, Hyun Jae;Lee, Choong Jae
    • Biomolecules & Therapeutics
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    • v.28 no.4
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    • pp.293-301
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    • 2020
  • Hypersecretion of pulmonary mucus is a major pathophysiological feature in allergic and inflammatory respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD). Overproduction and/or oversecretion of mucus cause the airway obstruction and the colonization of pathogenic microbes. Developing a novel pharmacological agent to regulate the production and/or secretion of pulmonary mucus can be a useful strategy for the effective management of pathologic hypersecretion of mucus observed in COPD and asthma. Thus, in the present review, we tried to give an overview of the conventional pharmacotherapy for mucus-hypersecretory diseases and recent research results on searching for the novel candidate agents for controlling of pulmonary mucus hypersecretion, aiming to shed light on the potential efficacious pharmacotherapy of mucus-hypersecretory diseases.

Physical Properties of Estrus Mucus in Relation to Conception Rates in Dairy Cattle

  • Lim, Hyun-Joo;Son, Jun-Kyu;Yoon, Ho-Beak;Baek, Kwang-Soo;Kim, Tae-Il;Jung, Yeon-Sub;Kwon, Eung-Gi
    • Journal of Embryo Transfer
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    • v.29 no.2
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    • pp.157-161
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    • 2014
  • The study aimed to determine the physical characteristics of estrus mucus and conception rates in dairy cattle. Samples of estrus mucus from the cervix were collected from 108 dairy cattle during heat and were examined for color and consistency. Samples were taken from bred animals at starting from day of breeding to the completion of one estrus cycle. The color of the cervical mucus was studied based on its transparency while the consistency was based on the thinness and thickness of the cervical mucus. The dairy cattle were bred and the pregnancy diagnosis was performed at the $60^{th}$ day post breeding. Findings showed that the estrus mucus of the dairy cattle was transparent in 58.3%, turbid in 31.5% and dirty in 10.2%. It was further observed that the mucus consistency of the dairy cattle was thin in 74.1% and thick in 25.9%. In the pregnant group, 67.3% mucus samples were found transparent, turbid in 23.6% and dirty in 9.1%. However, the corresponding figures for the non-pregnant group had 49.1%, 39.6% and 11.3%. The consistency of cervical mucus was found to be thin in 74.1% and thick in 25.9% of dairy cattle. The conception rates of dairy cattle with thin and thick consistency of cervical mucus were 81.8% and 18.2%, respectively. Pregnant was associated with consistency of cervical mucus (p<0.10). Findings indicated that dairy cattle with thin consistency of cervical mucus and had clear discharge were pregnant cows.

Airway Mucus: Its Components and Function

  • Lillehoj, Erik-P.;Kim, K.-Chul
    • Archives of Pharmacal Research
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    • v.25 no.6
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    • pp.770-780
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    • 2002
  • The airway surface liquid (ASL), often referred to as mucus, is a thin layer of fluid covering the luminal surface of the airway. The major function of mucus is to protect the lung through mucociliary clearance against foreign particles and chemicals entering the lung. The mucus is comprised of water, ions, and various kinds of macromolecules some of which possess the protective functions such as anti-microbial, anti-protease, and anti-oxidant activity. Mucus glycoproteins or mucins are mainly responsible for the viscoelastic property of mucus, which is crucial for the effective mucociliary clearance. There are at least eight mucin genes identified in the human airways, which will potentially generate various kinds of mucin molecules. At present, neither the exact structures of mucin proteins nor their regulation are understood although it seems likely that different types of mucins are involved in different functions and might also be associated with certain airway diseases. The fact that mucins are tightly associated with various macromolecules present in ASL seems to suggest that the defensive role of ASL is determined not only by these individual components but rather by a combination of these components. Collectively, mucins in ASL may be compared to aircraft carriers carrying various types of weapons in defense of airborne enemies.

Effect of an Improving Agent for the Intestinal Function, a Poly Herbal Formulation (KTG075) on Secretion of Mucus (장기능개선제(KTG075)의 대장관내 점액(Mucus)분비에 미치는 영향)

  • Baik, Soon-Ok;Lee, You-Hui;Kim, Hyun-Kyung
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.34 no.3
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    • pp.356-360
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    • 2005
  • The maintenance of intestinal health is complex and relies on a delicate balance between the diet, the normal microflora and mucosa, including the digestive epithelium and overlying mucus layer. The colorectal mucosa is protected by a visco-elastic mucus gel formed by high molecular mass glycoproteins referred to as mucins. Abnormality of mucin have been identified with colorectal disease. Constipation increases with age, and is more common among women than men in all age groups, e.g. 10% of men and 20% of women in the USA. The aim of the present study was conducted to investigate that the effects of formulation KTG075 from edible plants on intestinal function on mucus secretion, were examined by loperamide-induced constipation method using Sprague Dawley male rats. Epithelial cells of colonic crypt contained more mucus in the KTG075 group compared with those of the control group and the thickness of the mucus layer stained with alcian blue was significantly thicker in KTG075 treated rats compared with in control rats. Mucus production of epithelial cells of crypt and mucus contents at fecal and mucosa surfaces were reduced by loperamide-induced constipation. These results indicates that a poly herbal formulation KTG075 accelerates evacuation and activated intestines.

Seasonal Change of Skin Mucus Cells of Misgurnus mizolepis (Cobitidae) Dwelling in a Natural Stream in Korea (자연하천에 서식하는 미꾸라지 Misgurnus mizolepis 피부 점액세포의 계절변화)

  • Oh, Min-Ki;Park, Jong-Young
    • Korean Journal of Ichthyology
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    • v.22 no.4
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    • pp.230-237
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    • 2010
  • Histological observation on the seasonal variation of mucus cells of the mud loach Misgurnus mizolepis inhabiting a natural stream was carried out on three skin regions (dorsal, lateral and occiput) from March 2008 to February 2009. Our results showed no differences in general morphology by season, but the mucus cells of the epidermis showed significant seasonal change in their size and number as the water temperature changed. The ratio of surface area of the mucus cell layer and mucus cells, and the number of mucus cells in surface area of the epidermis were the greatest in the cold winter and the least in the hot summer in all regions of the epidermis. In particular, the occiput seemed to be a very sensitive region in response to environmental change, showing wide fluctuations in the size of mucus cells throughout the year and a great change in between seasons, especially from late autumn to early winter when the temperature decreased. As the temperature became colder, a small and spherical-shaped mucus cell was transformed into a large and elongated columnar form with a lot of secreted mucus material in a superficial layer of the epidermis. From our results, we can safely surmise that cold temperature is an important environmental factor having a close relationship with the modification of mucus cells of M. mizolepis in winter.

Temporal Variations of Skin Mucus Cells of Misgurnus mizolepis (Cobitidae) by a Change of Water Temperature (수온변화에 의한 미꾸라지, Misgurnus mizolepis 표피점액세포의 일시적 변화)

  • Oh, Min-Ki;Park, Jong-Young
    • Korean Journal of Ichthyology
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    • v.23 no.2
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    • pp.145-149
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    • 2011
  • We studied any variations of skin mucus cells of Misgurnus mizolepis caused by inducing a great change of water temperature including high temperature- and low temperature-adapted groups and then compared them with a control group of normal water condition. The high temperature-adapted group showed no significant different in size and number of the mucus cell (P>0.01), whereas in the low temperature-adapted group, the surface area of mucus cell layer and shape of its mucus cell, and the number of mucus cell remarkably increased in all the skin regions of dorsum, lateral region and occiput (P<0.01). Returned to the same condition as the control group, the low temperature-adapted groups showed the same features that appear in the normal water condition (P<0.01). Based on these results, the skin mucus cells of M. mizolepis seems to be very sensitive to cold water temperature and therefore they may play a key role in assessment of its environmental conditions.

Seasonal Change of the Skin Morphology of Muddy Loach, Misgurnus anguillicaudatus(Cobitidae) from Korea (계절변화에 따른 한국산 미꾸리, Misgurnus anguillicaudatus 피부의 조직학적 연구)

  • Oh, Min-Gi;Park, Jong-Young
    • Korean Journal of Ichthyology
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    • v.20 no.2
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    • pp.90-96
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    • 2008
  • The histological morphology on the skin of Misgurnus anguillicaudatus was described in the three regions such as dorsal, lateral, occiput and subsequently morphological variations of the skin were monthly observed for a year. The skin consisted of epidermis having epithelial cell, club cell and mucus cell, and dermis of mainly connective tissue fiber, embedded scale and blood capillary. Unicellular mucus cells situated at the epidermis underwent seasonal change in its size, as well as number and amounts of mucus-secreting materials, which they greatly increased in winter, but did not in summer. As it is getting cold, the mucus cells' shape changed from initial spherical to oval or elongated form. Such considerable changes in the mucus cell were particularly most evident in the occiput during winter. Moreover, the dermis largely thickened about 2~3 times in winter than in summer. Based on these results, we discussed function for the mucus on what it mainly acts in nature and information on whether mucus cells' seasonal variations affect on hibernation and cutaneous respiration.

Isolation and Characterization of Epidermal Mucus from Hirudo nipponia

  • Lee, Ju-Yun;Joe, Cheol-O;Kang, Ke-Won
    • BMB Reports
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    • v.29 no.3
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    • pp.248-252
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    • 1996
  • The epidermal organ of the leech contains a complex glycoprotein molecule of mucus. The mucus excreted from annelids plays Significant role in protection against desiccation and parasites. Mucus from the Korean native leech, H. nipponia, was investigated for biochemical characteristics for possible development of biomaterials of cosmetic and pharmaceutical agents. The leech skin mucus was heavily glycosylated mucin-like protein with a high molecular weight comprised 80% carbohydrate and 20% protein. Threonine, serine, and glycine were the major components of the isolated protein and these accounted for 50% of total amino acids. The carbohydrate portion contained glucosamine, galactosamine. galactose, glucose. mannose and sialic acid in oligosaccharide form linked with threonine and serine residues of the glycoprotein.

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EFFECTS OF ADMINISTRATION PYUNG YOE SAN TO THE SECRETING CELL IN THE GASTRIC MUCOSA OF THE RAT (평위산투여(平胃散投與)가 백서(白鼠)의 위장관상피점액분비세포(胃腸管上皮粘液分泌細胞)에 미치는 영향(影響))

  • Lee, Hack In;Yoo, Ki Won
    • The Journal of Internal Korean Medicine
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    • v.1 no.1
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    • pp.20-24
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    • 1976
  • In order to study the effects of administrated in the oral cavity pyung yue san to the mucus Secreting cell in the gastric of the Rat weight about 200g and P. A. S. Reaction observed results were as follows 1) Mucus secreting of superficial epithelium increased after 48 hours strongly P.A.S. positive 2) There is no different in the gastric foveola 3) Mucus secreting increased in the fundic gland between 24 hours and 48 hours 4) Mucus contents of mucus secreting cell, m the fundic. gland decreased 24 hours and 48 hours.

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