• 대한두경부종양학회지
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• 제31권1호
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• pp.14-17
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• 2015

Castleman's disease is an uncommon lymphoproliferative disorder. The disorder can be classified based on histological subtype, such as hyaline vascular type, plasma cell type, and mixed type, and can also be clinically divided into either unicentric or multicentric type. Its exact pathophysiology is not clearly identified. The unicentric type is able to be treated by surgical resection. However, there is no standard treatment modlity for the multicentric type. Treatment of multicentric type includes anti-cancer chemotherapy and radiation therapy. Recently, authors have experienced a rare case of unicentric type of Castleman's disease accompanying a mucoepidermoid carcinoma of parotid gland and report a case which is discussed with references.

• 한국식품위생안전성학회지
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• 제28권3호
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• pp.202-206
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• 2013

악성도가 높은 점액표피양 암종은 치료가 어렵고 5년 생존률이 매우 낮다. 따라서, 새로운 치료 물질과 분자표적을 찾는 것이 필요하다. Betulinic acid (BA)는 세계적으로 쉽게 얻을 수 있는 물질인 동시에 여러 종류의 종양에서 항암효과를 보인다. 또한 여러 정상 조직은 BA에 저항성을 보인다. 이 연구에서는 BA의 증식억제 효능과 MC-3 세포주에서의 분자 표적을 확인하고자 하였다. BA는 MC-3 세포주에서 세포 생존을 저해하였고 세포사멸을 유도하였다. BA는 Sp 1과 그의 하향 분자 표적인 survivin에 영향을 주었으나, 다른 하향 분자 표적인 Mcl-1에서는 유의한 변화를 일으키지 못하였다. 따라서, BA는 Sp1과 survivin을 조절하여 세포사멸을 일으키는 잠재적인 항암제 후보가 될 수 있을 것이라 사료된다.

• 대한두경부종양학회지
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• 제31권1호
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• pp.9-13
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• 2015

Fine needle aspiration cytology as a diagnostic workup of parotid gland tumor is a simple and useful method. Although fine needle aspiration cytology could not predict accurate diagnosis in all cases, it is usually helpful in differentiating malignancy and benign lesions. A 35-year-old female was found to have a parotid mass for 1 year. Preoperative evaluation including computed tomography and magnetic resonance imaging were non-diagnostic, but, fine needle aspiration cytology on parotid mass showed the suspicion of a low-grade mucoepidermoid carcinoma. Superficial parotidectomy and selective neck node dissection were done based on cytology. However, final pathological examination confirmed benign pleomorphic adenoma. Here, the diagnostic accuracy and cautions in interpretation of result of fine needle aspiration cytology is discussed with respect to the case.

• 대한두경부종양학회지
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• 제2권1호
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• pp.33-39
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• 1986

This is a clinical analysis of 24 cases of parotid gland tumor who were treated in the department of Surgery, Chonnam National University Medical School during the past 10years from January, 1976 to December, 1985. According to this analysis of total 24 cases, we concluded as follows; 1) 21 cases were benign tumors and 3 cases were malignant tumors. As the histopathological findings, benign tumor included 88%and malignant tumor 12%. Majority of benign tumor contained mixed tumor(86.7%), and the malignant tumor contained mucoepidermoid carcinoma (66.7%). 2) The peak age incidence was 40th in benign tumor and 50th in malignant tumor. 3) The chief complaints of patient was a painless mass and the duration of illness was average 5.2 years. 4) The mean size of mass was 4.5cm in diameter. 5) The surgical procedures were performed with excision 6 cases, superficial lobectomy 8 cases, wide excision with partial parotidectomy 4 cases, total parotidectomy 3 cases in benign tumors. In malignant tumors, total parotidectomy 2 cases and wide excision with partial parotidectomy 1 case were performed. 6) Major postoperative complications such as facial nerve palsy 7 cases (temporary ; 5 cases, permanent; 2 cases), Frey syndrome 1 case, seroma 1 case, hematoma 1 case, and wound infection 1 case were developed. The recurrence contained pleomorphic adenoma 1 case and mucoepidermoid carcinoma 1 case.

• 대한세포병리학회지
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• 제5권2호
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• pp.120-129
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• 1994

Fine needle aspiration biopsy cytology is a widely recognized and useful technique which can provide diagnosis in lesions of the head and neck, enabling appropriate management plans for individual patient to be made. Fifty one fine needle aspirates from salivary gland masses were examined. Four aspirates (8%) were inadequate for examination. Of the remaning 47 samples, 42 cases (82%) were benign lesions which consist of 30 pleomorphic adenoma(58%), 7 inflammatory lesion (14%), 4 Warthin's tumor(8%) and 1 benign lesion(2%). Two cases(4%) were atypical lesions. Three cases(6%) were malignant lesions consisting of 2 adenoid cystic carcinomas(4%) and 1 mucoepidermoid carcinoma (2%). The cytologic diagnoses were compared with the subsequent histologic diagnosis of surgical resected specimen in 24 cases. 19 cases of 21 aspirates from benign tumors were correctly diagnosed by fine needle aspiration cytology, with a specificity of 90%. All 3 aspirates from the 3 patients with malignant tumor were correctly diagnosed by fine needle aspiration cytology, with a sensitivity at 100%. Overall acurracy was 88%. Diagnostic error was encountered in adenoid cystic carcinoma, mucoepidermoid carcinoma and Warthin's tumor Correct histologic diagnosis was made in 86% of benign tumors(84% for pleomorphic adenoma and 100% for Warthin's tumor) and in 100% of malignant tumors.

• 대한두경부종양학회지
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• 제10권2호
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• pp.171-177
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• 1994

We reviewed retrospectively 152 patients' records with salivary gland tumors confirmed histologically at Hanyang University Hospital from Jan. 1984 to Dec. 1993. The results obtained were as follows: 1) Sites of tumors were parotid gland in 102 cases(67%), submandibular gland in 29 cases(19%) and minor salivary glands in 21 cases (14%). 2) 113 cases(74%) were benign. and 39 cases(26%) were malignant. 3) The incidence of benign and malignant tumors were 81% & 19%, 69% & 31% and 48% & 52% in the parotid gland, the submandibular gland and the minor salivary glands respectively. 4) The most frequent histologic types of benign and malignant tumors were pleomorphic adenoma (64%) and mucoepidermoid carcinoma (11%) respectively. 5) The surgical procedures include superficial parotidectomy. total parotidectomy. extended total parotidectomy & neck dissection in the parotid gland. wide excision & neck dissection in the submandibular gland and wide excision, partial maxillectomy & neck dissection in the minor salivary glands. 6) The postoperative recurrence rate were 4.4% in benign tumors and 27% in malignant tumors.

• Biomolecules & Therapeutics
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• 제31권3호
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• pp.306-311
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• 2023

The current study aimed to reveal the potential effect of meclofenamate, a nonsteroidal anti-inflammatory drug, on the gene expression of airway MUC5AC mucin. Human pulmonary mucoepidermoid NCI-H292 cells were pretreated with meclofenamate for 30 min and stimulated with phorbol 12-myristate 13-acetate (PMA) for 24 h. Thereafter, the effect of meclofenamate on the PMA-induced nuclear factor kappa B (NF-kB) signaling pathway was assessed. Meclofenamate inhibited glycoprotein production and mRNA expression of MUC5AC mucins induced by PMA by inhibiting the degradation of inhibitory kappa Bα (IkBα) and NF-kB p65 nuclear translocation. These results suggest meclofenamate suppresses mucin gene expression by regulating NF-kB signaling pathway in human pulmonary epithelial cells.

• Tuberculosis and Respiratory Diseases
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• 제45권2호
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• pp.311-321
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• 1998

연구배경: 기관지 점액상피암은 기관지의 점액선세포에서 기인한 악성 종양으로 세포들의 구성비와 mitosis정도에 따라 저등급 몇 고등급 종양으로 구분되며 저등급의 종양은 예후가 양호한 반면 고등급의 종양은 선종편평상피암과 조직학적으로 감별이 어렵고 악성 임상경과를 보인다. 기관지 점액상피암은 폐종양의 0.1~0.2%, 그리고 기관지선종의 1~5%를 차지한다고 알려져 있으나 국내에는 소수의 증례보고만 있었다. 저자들은 문헌으로 확인된 예를 포함하여 경북대학교 병원에서 기관 및 기관지 정액상피암으로 진단된 예에 대하여 임상고찰을 하였다. 방 법: 1990년 1월부터 1996년 12월까지 점액상피암으로 진단받았던 9예와 국내에 보고된 증례가운데 문헌으로 확인할 수 있었던 8예를 포함한 17예를 대상으로 임상상, 방사선 및 기관지내시경소견, 그리고 조직학적소견과 임상경과 등을 후향적으로 분석하였다. 결 과: 남자 12예와 여자 5예였으며, 평균나이는 42 세였다. 흡연력은 17예 가운데 5예에서 있었으며 평균 흡연력은 11인년이었다. 내원당시 주요 증상은 호흡곤란 9예, 기침 7예, 객혈 6예, 자각적 천명음 3예였으며, 증상이 없는 경우가 2 예였다. 단순 흉부 X-선 사진상 폐허탈소견이 8예, 종괴양 음영 5예, 폐렴양침윤소견이 2예, 다발성결절소견이 1예였으며. 1예는 정상이었다. 17예 가운데 16예는 중심형으로 발생부위는 좌주기관지가 5예, 우주기관지가 4예, 우중엽기관지가 2예였고, 그외 기관, 우중간간기관지, 우상엽기관지 및 좌상엽기관지가 각각 1예였으며, 1예는 양측 기관지에 병변이 있었다. 중심형 16예의 기관지 내시경소견은 외장형 종과 12예와 결절성 침윤소견 4 예였다. 우폐하야에 위치한 말초형 1예는 정상기관지 내시경소견이었다. 조직소견상 10예가 저등급이었고 7예는 고등급이었다. 10예의 저등급가운데 9예는 수술을 시행하였으며 종양이 상부기관에 있었던 l예는 레이저요법 및 방사선치료를 받았으나 사망하였다. 고등급암종 7예의 경우 2예는 전폐절제술을 시행하였고 종격동임파절, 심낭 및 흉막의 전이가 있었던 4 예와 폐결핵이 동반되어 전신상태가 불량하였던 1예는 항암화학요법과 방사선요법 또는 보존적치료를 하였다. 결 론: 점액상피암은 다양한 연령층에서 발생하고 대부분 중심기도에 위치하여 기도 자극증상과 함께 폐허탈, 종괴양음영 및 폐쇄성폐렴 등과 같은 방사선소견을 보인다. 병리조직학적인 등급과 주위장기로의 전이유무 등이 치료 및 예후판정에 있어 중요하다.

• 대한세포병리학회지
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• 제9권2호
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• pp.155-159
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• 1998

Fine needle aspiration cytology(FNAC) has become a popular method for the diagnosis of a wide variety of both superficial and deep-seated lesions. However, there are few reports about the potential of FNAC for the diagnosis of intraoral lesions. We experienced 44 FNACS from intraoral lesions at Asan Medical Center: 22 from the palate, 6 from the tongue, 5 from the parapharyngeal space, 5 from the lip, 2 from the floor of mouth, 1 from the buccal mucosa, and 3 from other intraoral sites. Histological confirmation was obtained in 32 cases and we analyzed 27 cases excluding 5 cases of inadequate aspirates. Diagnosis was specifically made in 19 of 27 cases(70%) including 1 mucoepidermoid carcinoma, 1 undifferentiated carcinoma, 1 chordoma, 9 pleomorphic adenomas, 1 neurofibroma, and 6 benign lesions. There were three false negative cases(sensitivity, 62.5%) and no false positive cases(specificity, 100%): Two cases diagnosed as "cystic lesion" were confirmed to be mucoepidermoid carcinomas and a case diagnosed as pleomorphic adenoma was proved to be adenoid cystic carcinoma. The results of our study suggest that FNAC is a useful technique in the diagnosis of intraoral lesion.

• 대한두경부종양학회지
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• 제1권1호
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• pp.21-34
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• 1985

The authors reviewed 114 cases of malignant major and minor salivary gland tumors at Presbyterian Medical Center seen from February, 1963 to December, 1983. The results were obtained as follows; 1) Overall male and female sex ratio was 2:1. The peak age of patients with major and minor salivary gland tumor were both 5 th decade. 2) The ratio of benign and malignant tumor was 83:114. The incidence of malignancy in each group was 52% in parotid (50 patients), 75% in minor salivary gland (45 patients), 49% in submaxillary gland(18 patients) and 25% in sublingual gland (1 patient). 3) The incidence according to the anatomic primary site for minor salivary cancers was 10 cases in the nasal cavity, each 8 in the palate and the maxillary antrum, 7 in the tongue, 5 in the gum, 3 in the larynx and 2 in the buccal mucosa. 4) Adenoid cystic carcinoma was the most common cancer of minor salivary gland and malignant mixed tumor was the most common in major salivary glands, each comprising 34 cases (76%) of minor and 19 cases (28%) of major salivary gland tumors. 5) The incidence of cervical lymph node metastasis was 50% in the submaxillary gland cancers, 44% in the parotid gland cancers and 21% in malignant tumors of minor salivary glands. The highest incidence of lymph node metastasis according to histopathological classification was formed in high grade of mucoepidermoid (67%). 6) Nerve invasion was common in mucoepidermoid carcinoma. According to anatomic site, nerve invasion occurred most often in adenoid cystic carcinoma of the submaxillary gland (44%). 7) The lung was the commonest site for distant metastasis comprising 12 cases among 26 cases in which distant spread occurred. 8) The recurrence rate was 50% for major salivary gland cancer and 52% in cancer of the minor salivary gland. In accordance with pathological classification, adenocarcinoma most frequently recurred after excision. This being seen in 88% of patients undergoing definitive therapy. 9) The determinate 5 year survival rate was 78% in major salivary gland tumors, but 69% in minor salivary gland tumors.