• Journal of Acupuncture Research
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• v.23 no.3
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• pp.117-127
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• 2006

Alzheimer's disease (AD) is the most prevalent form of neurodegenerative disease associated with aging in the human population. This disease is characterized by the following 4 structural changes : Atrophy of the Cortex, Parasympathetic, and other neural cells, the existence of Neurofibrillary tangles (NFTs), and the accumulation of Senile plaques. NFTs and Senile plaques is known to be the index of this disease. Senile plaques disturbs the neutro transmission and depletes of Acetylcholine. So, Recovery of Acetylcholine is the primal objective for treating Alzheimer's disease. So, Inhibiting the activity of Acetylcholine Esterase (AChE), which causes the hydrolysus of acetylcholine into choline and acetate, can be seen as a key role for treating Alzheimer's disease. Increasing body of evidence has been demonstrated that Bee Venom Acupuncture (BV) could compete with complex protein involving in multiple step of $NF-_{\kappa}B$ activation and exert the anti-inflammatory potential of combined inhibition of the prostanoid and nitric oxide synthesis systems by inhibition of IKK and $NF-_{\kappa}B$. BV dose-dependently attenuated Scopolamine-induced Acetylcholine esterase activities in cerebral cortex and hippocampus of the mice brain. This study therefore suggests that BV acupuncture method may be useful for prevention of development or progression of AD.

• Korean Journal of Oriental Medicine
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• v.16 no.2
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• pp.159-166
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• 2010

Objective : The purpose of this study is to compare the Effect of Acupuncture on Local Acupoints and Distal Acupoints for Patients with Whiplash Injury. Method : From January 1st 2009 to September 31th 2009, 10 patient were divided into 2 groups. One group was taken Local Acupoints, and the other group was taken Distal Acupoints. To check pain and treatment satisfaction, visual analog scale(VAS) and five-point likert scale were used before and after treatment. Result : Both acupuncture theraphy showed improvement in VAS and five-point likert scale. And Local Acupoints group showed more effective than Distal Acupoints group on five-point likert scale. Conclusion : This Study suggests that Acupuncture on Local Acupoints and Distal Acupoints can be applicable to improve symptom in Patients with Whiplash Injury.

• Journal of Pharmacopuncture
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• v.6 no.2
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• pp.91-104
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• 2003

Objective : This study was carried to make out the connection between cerebral artery blood flow velocity and ischemic theory that presumed the cause of Bell's palsy. Method : We measured cerebral artery blood flow velocity each external carotid artery, internal carotid artery, common carotid artery, siphon, superficial temporal artery by TCD to 20 patients who diagnosed as facial nerve palsy from march 2001 to July 2001 and all objectives devided two groups as palsy side. A group is right side facial nerve palsy and B group is left facial nerve palsy. Results : 1. There is no effective change of blood flow in external carotid artery either A, B group. 2. There is no effective change of blood flow in internal carotid artery either A, B group. 3. There is no effective change of blood flow in common carotid artery either A, B group. 4. There is no effective change of blood flow in siphon artery either A, B group. 5. There is no effective change of blood flow in superficial temporal artery either A, B group.

• Journal of Pharmacopuncture
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• v.10 no.1 s.22
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• pp.5-16
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• 2007

Objectives : The aim of this study was to verify anti-cancer and anti-oxidant efficacies of Korean wild ginseng and cultivated wild ginseng of Korea and China. Methods : For the measurement of anti-oxidation, SOD-like activity was evaluated using xanthine oxidase reduction method under in vitro environment. Subcutaneous and abdominal cancer were induced using CT-26 human colon cancer cells for the measurement of growth inhibition of cancer cells and differences in survival rate. Results : 1. Measurement of anti-oxidant activity of ginseng, Chinese and Korean cultivated wild ginseng, and natural wild ginseng samples showed concentration dependent anti-oxidant activity in HX/XOD system. Anti-oxidant activity showed drastic increase at 1mg/ml in all samples. 2. For the evaluation of growth inhibition of cancer cells after hypodermic implantation of CT-26 cancer cells in the peritoneal cavity of mice, Chinese and Korean cultivated wild ginseng and natural wild ginseng groups showed significant inhibition of tumor growth from the 12th day compared to the control group. Similar inhibitory effects were also shown on the 15th and 18th days. But there was no significant difference between the experiment groups. 3. For the observation of increase in survival rate of the natural wild ginseng group, CT-26 cancer cells were implanted in the peritoneal cavity of mice.

• Journal of Pharmacopuncture
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• v.14 no.4
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• pp.53-58
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• 2011

Objectives: There is no report on treatment of acute traumatic rotator cuff tear in Traditional Korean Medicine. We reported Traditional Korean Treatment for pain relief and better movement of acute traumatic rotator cuff tear. Methods: Shoulder MRI was used to confirm the diagnosis of tear of rotator cuff. The patient was treated with Traditional Korean Methods (Acupuncture, Herbal medicine, Pharmacopuncture) for 6 months. We evaluated the patient through VAS (Visual Analogue Scale), UCLA shoulder scale, ROM (Range of motion) and Shoulder MRI. Results: After 6 months of treatment, the patient's VAS was decreased whereas UCLA score and Shoulder ROM were increased. Rotator cuff tear was repaired on Shoulder MRI images. Conclusions: In acute traumatic rotator cuff tear, Korean Traditional Treatment is good method for pain relief and better movement.

• Journal of Physiology & Pathology in Korean Medicine
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• v.34 no.2
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• pp.97-101
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• 2020

Oral leukoplakia is the most common premalignant lesion of the oral mucosa. This case report presents the effect of acupuncture on Oral leukoplakia. The 67 years old male patient who has suffered for 2 years was treated with Right side Saam acupucture Damjeonggyeok(BL66, GB43, LI1, GB44) without other treatment. Acupuncture was performed for 15 minutes. The effect of acupuncture was evaluated as photographic change and visual analog scale(VAS) of subjective symptoms in oral cavity. After 87th acupunture treatment during 226 days, Leukoplakias were decreased at the right side of ventral tongue and the left border of the tongue and the lower lip. Furthermore, ulcer, erosion at the left border of the tongue were disappeared and VAS of Burning pain in the tongue decreased from 8 to 2. Although acupuncture is unusual treatment for Oral Leukoplakia, this case report suggested the effectiveness of using Damjeonggyeok on Oral Leukoplakia according to Saam acupuncture method.

• Journal of Acupuncture Research
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• v.34 no.1
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• pp.31-38
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• 2017

Objectives : The purpose of this study was to analyze the components of the clinically used bee venom (BV) pharmacopuncture. Methods : Two kinds of bee venom pharmacopuncture (BV-I and II), three kinds of separate purification BV (SPBV) pharmacopuncture (SPBV-I, II, and III), and apitoxin were investigated in this study. We performed a component analysis of melittin, apamin, and phospholipase $A_2$ using high-performance liquid chromatography (HPLC). Results :1. BV-I contained approximately 40% more melittin than BV-II did. 2. In the three separate purification BV pharmacopuncture, SPBV-I, SPBV-II, and SPBV-III, phospholipase $A_2$ content decreased remarkably. 3. The melittin content in SPBV-I increased by 5% compared to that in BV-I. 4. The amount of melittin in apitoxin was similar to that in SPBV-I. Conclusion : The compositions of the BV pharmacopuncture and separate purification BV pharmacopuncture changed depending on the collection method and concentration. Therefore, it is necessary to choose the most suitable BV for each specific medical treatment target. Furthermore, research into the composition of BV may be needed for its safe and effective use.

• Journal of Oriental Neuropsychiatry
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• v.14 no.2
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• pp.199-206
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• 2003

Objective : This is a case report of the patient diagnosed as the depressive episode mixed with organic depressive disorder. Method : We treat the patient with herbal medication and gave acupuncture treatment about 5 weeks, the symptom of the patient improved. The herbal medication and acupuncture treatment which we gave patient was based on Oriental medical diagnosis. Results : The patient had been taken the western medical treatment for 2 months, the symptom of the patient was not improved. But after the Oriental medical treatment, the patient is on the improving state. Conclusion : In the treatment of the depressive disorder which is mixed with organic depressive disorder, we found that the Herbal medication and Acupuncture based on correct 'Byonjung(辦證)' help the care of depressive episode which is mixed with organic depressive disorder.

• Journal of Haehwa Medicine
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• v.20 no.2
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• pp.117-124
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• 2012

Objective: This study was designed to evaluate the effect of Bee Venom Pharmacopuncture therapy in patients with Cervical Herniated Intervertebral Disc Methods: We investigated 30 cases of patients with Cervical Herniated Intervertebral Disc, who had been treated from October 2008 to December 2011. We divided patients into two groups: Group I was treated by Bee Venom Pharmacopuncture therapy and general acupuncture and Group II was treated by acupuncture therapy only. We measured the efficacy of treatments using the numerical rating scale(NRS). Results: 1. The treatment method for Group I was more effective than that of Group II in reducing the NRS on the tenth day after admission but there was no statistically significant difference between the results of two groups on the fifth day after admission and the tenth day after admission. Conclusion: The results of this study suggest that Bee Venom Pharmacopuncture therapy is effective in reducing pain for patients with Cervical Herniated Intervertebral Disc. Further clinical research is needed to verify these results and findings.

• Journal of Acupuncture Research
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• v.17 no.3
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• pp.151-167
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• 2000

Objective : The aim of this study is to determine the antimutagenic effect and genetic safety of Buthus martensi Karsch aqua-acupuncture solution(BMKAS) against various chemical carcinogens. Method : Ames(Salmonella typhimurium) test and Rec assay(Bacillus subtilis) were used as indicators for DNA damage and antimutagenesis. Furthermore, the levels of umu operon expression by measuring the ${\beta}$-galactosidase activity wete monitored with the SOS umu test using S. typhimurium 1535 containing plasmid pSK1002. And the host-mediated assay was used to investigate the mutagenicity and antimutagenicity of BMKAS inducing various chemical carcinogens after the activation with in vivo metabolic systems. Results : From the results, BMKAS did not atfect DNA of S. typhimurium and B. subtilis strains and showed no mutagenicity at the all concentrations of tested solution. Furthermore BMKAS dose-dependently protected the mutagenecity by AF-2, 2-AA and B[a]P. These phenomena was also similar to that after metabolic activation of BMKAS in in vivo system. Conclusion : These results suggested that BMKAS did not show the mutagenicity and protected the mutagenesis against various chemical carcinogens by four different methods used in this study.