• 콘크리트학회지
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• 제24권1호
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• pp.33-35
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• 2012

• 생명과학회지
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• 제28권12호
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• pp.1536-1544
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• 2018

우울증은 심각하며 재발하는 흔한 정신질환이다. 우울증은 환경 요인과 유전 요인, 그리고 신경생물학적 체계의 구조 및 기능의 변화로 발병한다. 후성유전학적 변화가 우울증과 관련 된다는 여러 연구들이 보고되었다. 후성 유전은 환경 요인이 크로마틴 구조를 변화시켜 DNA 염기 서열 변화 없이 유전자 발현을 조절하는 기전으로 설명된다. DNA 메틸화와 히스톤 아세틸화 및 메틸화를 포함하고 있는 히스톤 변형이 주요 후성유전기전으로 알려져 있다. 우울증 동물모델연구에서는 생애 초기 스트레스 같은 스트레스 환경이 게놈에 지속적으로 후성유전표지를 남기게 되고 이로 인해 유전자 발현이 변화되고 결국 성체가 되었을 때 신경 기능이나 행동 기능에 영향을 미치게 된다고 설명하고 있다. BDNF는 우울증과 관련된 대표적인 유전자로 알려져 있다. 설치류가 출생 전, 후, 그리고 성체 기간에 스트레스에 노출되면 해마에서 BDNF 유전자의 히스톤 변형과 DNA 메틸화 패턴이 변화되고 이로 인해 BDNF 발현이 변화된다. 이러한 과정은 불안과 우울 행동에도 영향을 미치게 된다. 본 종설에서는 BDNF 유전자의 히스톤 변형 및 DNA 메틸화와 같은 우울증 발병에 관여하는 후성유전기전의 최신 지견에 대해 논의하여 우울증 치료의 새로운 타겟 개발에 도움이 되고자 한다.

• 한국실내디자인학회논문집
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• 제26권1호
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• pp.25-32
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• 2017

As the elderly population increases rapidly, existing houses many elderly reside are under poor conditions that they work as a factor to impede on the independent living of elderly people. Thus, improving existing housing environment to suit the needs of elderly life has been required. Academics has been continuously researched on the field considering the importance of elderly housing modification and the importance on the research of this field is projected to be greater with the coming of aging society. Hence, this study has a purpose on analyzing trends of previous studies related to housing modification for the elderly published in Korean academic journals in depth. This study is a content analysis study and analyzed the trend of previous studies with academic journal field, purpose of study, research subject, research area, research method, research content as analysis categories. As a result, previous studies was published the most in natural science academic journals and main stream of research was to suggest direction of housing modification by conducting surveys on actual conditions and needs of single elderly families and to suggest improving the directions of policies related to modification. On the other hand, empirical studies needed to execute housing modification such as standard and method of housing modification and supporting tools are still at minimal level that researches on this field should be conducted additionally. This study is expected to be used as basis to examine the current state of previous studies on housing modification for the elderly and to seek further research directions.

• 한국소음진동공학회논문집
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• 제15권3호
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• pp.341-345
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• 2005

Structural Dynamics Modification (SDM) is a very effective technique to improve structure's dynamic characteristics by adding or removing auxiliary structures, changing material properties and shape of structure. Among those of SDM technique, the method to change shape of structure has been mostly relied on engineer's experience and trial-and-error process which are very time consuming. In order to develop a systematic method to change structure shape, surface grooving technique is studied. In this work, the shape of base structure was modified to improve its dynamic characteristics such as natural frequencies via surface grooving technique. Grooving shape was formed by mergingthe neighboring small embossing elements after analyzing frequency increment sensitivities of all the neighboring emboss elements. For this process, Criterion Factor was introduced and the initial grooving was started from the element having highest strain energy and the grooving is expanded into neighboring element. The range of targeting grooving area to check its frequency variations restricted to their neighboring area to reduce the computation effort. This surface grooving technique was successfully applied to a hard disk drives (HDD) cover model to raise its natural frequency by giving some groove on its surface.

• Steel and Composite Structures
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• 제14권6호
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• pp.523-545
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• 2013

In this study, the effect of presence and distribution of masonry infill walls on the mid-rise steel frame structures having soft ground storey was evaluated by implementing finite element (FE) methods. Masonry infill walls were distributed randomly in the upper storey keeping the ground storey open without any infill walls, thus generating the worst case scenario for seismic events. It was observed from the analysis that there was an increase in the seismic design forces, moments and base shear in presence of randomly distributed masonry infill walls which underlines that these design values need to be amplified when designing a mid-rise soft ground storey steel frame with randomly distributed masonry infill. In addition, it was found that the overstrength related force modification factor increased and the ductility related force modification factor decreased with the increase in the amount of masonry infilled bays and panels. These must be accounted for in the design of mid-rise steel frames. Based on the FE analysis results on two mid-rise steel frames, design equations were proposed for determining the over strength and the ductility related force modification factors. However, it was recommended that these equations to be generalized for other steel frame structure systems based on an extensive analysis.

• Steel and Composite Structures
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• 제42권1호
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• pp.59-74
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• 2022

This study introduces a general reliability-based, performance-based design framework to design frames regarding their uncertainties and user-defined design goals. The Iterative-R method extracted from the main framework can designate a proper R (i.e., response modification factor) satisfying the design goal regarding target reliability index and pre-defined probability of collapse. The proposed methodology is based on FEMA P-695 and can be used for all systems that FEMA P-695 applies. To exemplify the method, multiple three-dimensional, four-story steel special moment-resisting frames are considered. Closed-form relationships are fitted between frames' responses and the modeling parameters. Those fits are used to construct limit state functions to apply reliability analysis methods for design safety assessment and the selection of proper R. The frameworks' unique feature is to consider arbitrarily defined probability density functions of frames' modeling parameters with an insignificant analysis burden. This characteristic enables the alteration in those parameters' distributions to meet the design goal. Furthermore, with sensitivity analysis, the most impactful parameters are identifiable for possible improvements to meet the design goal. In the studied examples, it is revealed that a proper R for frames with different levels of uncertainties could be significantly different from suggested values in design codes, alarming the importance of considering the stochastic behavior of elements' nonlinear behavior.

• 한국지진공학회논문집
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• 제5권6호
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• pp.11-19
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• 2001

일정한 축하중과 반복적인 횡하중을 받는 콘크리트충전 강합성 기둥의 내진성능에 관한 실험적인 연구가 수행되었다. 강합성 기둥은 충전콘크리트가 강판의 국부좌굴로 인한 내측방향의 변형을 억제하고, 강판의 콘크리트 측압에 대한 구속효과와 같은 상호작용에 의해서 콘크리트와 강재의 단순누가강도 이상의 강도증진효과를 가지며, 강재 및 콘크리트기둥에 비해 우수한 연성 및 에너지 흡수능력을 나타내었다. 단면분할법을 이용하여 콘크리트충전 강합성 기둥의 비선형 모멘트-곡률 관계를 예측해 보았으며, 이는 실험결과와 비교적 잘 일치하는 것으로 나타났다. 또한, 구조물의 내진설계의 중요한 요소인 강합성 기둥의 연성 및 응답수정계수를 평가해 보았다. 실험결과 강합성 기둥은 효과적인 내진구조 부재로 판단되었다.

• 한국정밀공학회지
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• 제33권2호
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• pp.109-114
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• 2016

Nowadays, lower gear vibration and noise are necessary for drivers in automotive gearbox, which means that transmission gearbox should be optimized to avoid noise annoyance and fatigue before quantity production. Transmission error (T.E.) is the excitation factor that affects the noise level known as gear whine, and is also the dominant source of noise in the gear transmission system. In this paper, the research background, the definition of T.E. and gear micro-modification were firstly presented, and then different transmission errors of loaded torques for the spur gear pair were studied and compared by a commercial software. It was determined that the optimum gear micro-modification could be applied to optimize the transmission error of the loaded gear pair. In the future, a transmission test rig which is introduced in this paper is about to be used to study the T.E. after gear micro-geometry modification. And finally, the optimized modification can be verified by B&K testing equipment in the semi-anechoic room later.

• 한국응용과학기술학회지
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• 제27권3호
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• pp.282-289
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• 2010

In preparation of silica aerogel-based hybrid coating materials, the combination of hydrophobic aerogel with organic polar binder material is shown to be very limited due to dissimilar surface property between two materials. Accordingly, the surface modification of the aerogel would be required to obtain compatibilized hybrid coating sols with homogeneous dispersion. In this study, the surface of silica aerogel particles was modified by using both surfactant adsorption and heat treatment methods. Four types of surfactants with different molecular weights and HLB values were used to examine the effect of chain length and hydrophilicity. The surface property of the modified aerogel was evaluated in terms of visible observation for aerogel dispersion in water, water contact angle measurement, and FT-IR analysis. In surface modification using surfactants, the effects of surfactant type and content, and mixing time as process parameter on the degree of hydrophilicity for the modified aerogel. In addition, the temperature condition in modification process via heat treatment was revealed to be significant factor to prepare aerogel with highly hydrophilic property.

• Earthquakes and Structures
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• 제16권2호
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• pp.185-196
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• 2019

One of the shortcomings of seismic bridge design codes is the lack of clarity in defining the role of different seismic isolation systems with linear or nonlinear behavior in terms of R-factor. For example, based on AASHTO guide specifications for seismic isolation design, R-factor for all substructure elements of isolated bridges should be half of those expressed in the AASHTO standard specifications for highway bridges (i.e., R=3 for single columns and R=5 for multiple column bent) but not less than 1.50. However, no distinction is made between two commonly used types of seismic isolation devices, i.e., elastomeric rubber bearing (ERB) with linear behavior, and lead rubber bearing (LRB) with nonlinear behavior. In this paper, five existing bridges located in Iran with two types of deck-pier connection including ERB and LRB isolators, and two bridge models with monolithic deck-pier connection are developed and their R-factor values are assessed based on the Uang's method. The average R-factors for the bridges with ERB isolators are calculated as 3.89 and 4.91 in the longitudinal and transverse directions, respectively, which are not in consonance with the AASHTO guide specifications for seismic isolation design (i.e., R=3/2=1.5 for the longitudinal direction and R=5/2=2.5 for the transverse direction). This is a clear indicator that the code-prescribed R-factors are conservative for typical bridges with ERB isolators. Also for the bridges with LRB isolators, the average computed R-factors equal 1.652 and 2.232 in the longitudinal and transverse directions, respectively, which are in a good agreement with the code-specified R-factor values. Moreover, in the bridges with monolithic deck-pier connection, the average R-factor in the longitudinal direction is obtained as 2.92 which is close to the specified R-factor in the bridge design codes (i.e., 3), and in the transverse direction is obtained as 2.41 which is about half of the corresponding R-factor value in the specifications (i.e., 5).