• BMB Reports
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• 제50권5호
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• pp.269-274
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• 2017

The biological activities of macrophage migration inhibitory factor (MIF) might be mediated through a classical receptor-mediated or non-classical endocytic pathway. JAB1 (C-Jun activation domain-binding protein-1) promotes the degradation of the tumor suppressor, p53, and the cyclin-dependent kinase inhibitor, p27. When MIF and JAB1 are bound to each other in various intracellular sites, MIF inhibits the positive regulatory effects of JAB1 on the activity of AP-1. The intestinal parasite, Anisakis simplex, has an immunomodulatory effect. The molecular mechanism of action of As-MIF and human JAB1 are poorly understood. In this study, As-MIF and hJAB1 were expressed and purified with high solubility. The structure of As-MIF and hJAB1 interaction was modeled by homology modeling based on the structure of Ace-MIF. This study provides evidence indicating that the MIF domain of As-MIF interacts directly with the MPN domain of hJAB1, and four structure-based mutants of As-MIF and hJAB1 disrupt the As-MIF-hJAB1 interaction.

• 제어로봇시스템학회논문지
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• 제7권12호
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• pp.973-979
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• 2001

Sliding mode control guarantees robustness in the presence of modeling uncertainties and external disturbances. However, this can be obtained at the cost of high control activity that may lead to chattering As one way to alleviate this problem a boundary layer around sliding surface is typically used. In this case the selection of controller gain, control ban width and boundary layer thickness is a crucial problem for the trade-off between tracking error and chattering. The parameter tuning is usually done by trail-and-error in practice causing significant effort and time. An auto tuning method based on fuzzy rules is proposed in the paper in this method tracking error and chattering are monitored by performance indices and the controller tunes the design parameters intelligently in order to compromise both indices. To demonstrate the efficiency of the propose method a mass-spring translation system and a roboic control system are simulated and tested It is shown that the proposed algorithm is effective to facilitae the parameter tuning for sliding mode controllers.

• 에너지공학
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• 제24권1호
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• pp.58-68
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• 2015

상향식 모형을 이용하여 국내 주거부문의 온실가스 배출특성과 감축 잠재량을 도출하고 이를 바탕으로 한계감축 비용 분석을 수행하였다. 이를 위하여 먼저 상향식 모형의 필수 입력요소인 주거부문의 최종수요, 기준에너지시스템 (Reference Energy System; RES) 등을 정의하고 국내 통계데이터를 분석하여 필요한 활동량 데이터를 도출하였다. 기준 시나리오에서의 연도별 에너지 사용량 및 온실가스 배출량을 구하고 감축수단의 도입에 따른 감축잠재량 및 관련 비용을 분석하였다. 한계감축비용 분석 결과는 중장기적으로 부문별 온실가스 감축목표 달성을 위한 감축정책의 수립에 기여할 것으로 기대된다.

• The Korean Journal of Physiology and Pharmacology
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• 제2권3호
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• pp.385-393
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• 1998

Human neutrophil elastase (HNElastase, EC 3.4.21.37), a causative factor of inflammatory diseases, was purified by Ultrogel AcA54 gel filtration and CM-Sephadex ion exchange chromatography. HNElastase was inhibited by phenylbutazone in a concentration dependent manner up to 0.4 mM, but as the concentration increased, the inhibitory effect gradually diminished. Binding of phenylbutazone to the human neutrophil elastase caused strong Raman shifts at 200, 440, and 1194 $cm^{-1}$. The peak at 1194 $cm^{-1}$ might be evidence of the presence $of\;-N=N-{\Phi}$ radical. The core area of the elastase, according to the visual molecular model of human neutrophil elastase, was structurally stable. A deeply situated active center was at the core area surrounded by hydrophobic amino acids. Directly neighboring the active site was one positively charged atom and two atoms carrying a negative charge, which enabled the enzyme and the drug to form a strong interaction. Phenylbutazone may form a binding, similar to a key & lock system to the atoms carrying opposite charges near the active site of the enzyme molecule. Furthermore, the hydrophobicity of the surrounding amino acid near the active site seemed to enhance the binding strength of phenylbutazone. Binding of phenylbutazone near the active site may cause masking of the active site, preventing the substrate from approaching the active site and inhibiting elastase activity.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1993년도 추계학술대회
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• pp.145-150
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• 1993

It is an important component of the diagnosis to research the morphological changes of EMG in pathological conditions. In order to provide an EMG signal resulting from a predetermined neuromuscular pathophysiology, we have initially developed a mathmatical model of electromyographic interference pattern(IP). It can be used to study the variation of the IP resulting from morphological and electrophysiological changes occurring in disease states, because the model computes the IP from the underlying fiber and muscle structure. We performed quantative analysis or the model output, focusing on IPs resulting from simulations of dystrophic fiber loss and the MU denervation and reinnervation typical of neuropathies. To discribe the characteristics of IPs associated with these pathologies, a set of frequency domain discriptors, activity, mobility, and complexity were used, as well as several measures of the spectral density function. These discriptors demonstrate distinct patterns of variation corresponding to morphological changes observed in disease states, and closely with results obtained from the classical method, turn/amp technique.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1996년도 추계학술대회
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• pp.217-220
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• 1996

In this paper, we compare three mehods to obtain PSD of HRV - FFT, AR modeling, and residual integration. Using these methods we speculate the balances of the LP and HF powers of HRV at $0^{\circ}$, $45^{\circ}$, $90^{\circ}$ tilt levels of head-up tilt table for young and healthy 24 men. R peaks are located at the highest point of QRS complex detected from modified spacial velocity algorithm. In general FFT is the most fast way to obtain PSD but PSD from FFT has too many peaks and valleies. AR PSD can show frequency of ANS activity effectively but LF component of PSD is often invisible due to interference of VLF power. The residual integration method that decomposes the AR PSD is very efficient way to extract LF component. Applying the above three methods to HRV we can visualize the trend of PSD variations along tilt levels.

• Nuclear Engineering and Technology
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• 제50권2호
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• pp.280-291
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• 2018

In the framework of OECD/NEA Working Group on Fuel Safety, a RIA fuel-rod-code Benchmark Phase I was organized in 2010-2013. It consisted of four experiments on highly irradiated fuel rodlets tested under different experimental conditions. This benchmark revealed the need to better understand the basic models incorporated in each code for realistic simulation of the complicated integral RIA tests with high burnup fuel rods. A second phase of the benchmark (Phase II) was thus launched early in 2014, which has been organized in two complementary activities: (1) comparison of the results of different simulations on simplified cases in order to provide additional bases for understanding the differences in modelling of the concerned phenomena; (2) assessment of the uncertainty of the results. The present paper provides a summary and conclusions of the second activity of the Benchmark Phase II, which is based on the input uncertainty propagation methodology. The main conclusion is that uncertainties cannot fully explain the difference between the code predictions. Finally, based on the RIA benchmark Phase-I and Phase-II conclusions, some recommendations are made.

• Earthquakes and Structures
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• 제9권2호
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• pp.281-303
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• 2015

The effects of infill panels on the response of r.c. frames subjected to seismic action are widely recognized. Numerous experimental investigations were effected and several analytical models were developed on this subject. This work, which is part of a larger project dealing with specific materials and structures commonly used in Italy, discusses experimental tests on masonry and samples of bare and infilled portals. The experimental activity includes tests on elemental materials, and 12 wall samples. Finally, three one-bay one-story reinforced concrete frames, designed according to the outdated Italian technical code D.M. 1996 without seismic details, were tested (bare and infilled) under constant vertical and cyclic lateral load. The first cracks observed on the framed walls occurred at a drift of about 0.3%, reaching its maximum capacity at a drift of 0.5% while retaining its capacity up to a drift of 0.6%. Infill contributed to both the stiffness and strength of the bare reinforced concrete frame at small drifts thus improving overall system behavior. In addition to the experimental activities, previously mentioned, the recalibration of a model proposed by Comberscue (1996) was evaluated. The accuracy of an OpenSees non linear fiber based model of the prototype tested, including a strut element was verified through a comparison with the final experimental results. This work has been partially supported by research grant DPC-ReLUIS 2014.

• 대한화장품학회지
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• 제46권1호
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• pp.43-47
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• 2020

안드로겐 수용체 길항제로서 N-아릴아미드의 신규한 아다만틸 유도체들을 합성하고 항안드로겐 활성을 평가 하였다. 아다만틸 유도체를 함유하는 N-아릴아미드는 아다만틸 치환체가 없는 유도체보다 더 높은 활성을 가졌다. 아다만틸의 공간부피 및 방향족 고리에 전자밀도 상승효과를 주는 pendant 작용기들이 강력한 길항작용에 결정적인 영향을 미쳤다. 리간드와 수용체 사이의 상호 작용을 설명하기 위해 분자 모델링 연구를 수행 하였다.

• International Journal of Computer Science & Network Security
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• 제21권8호
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• pp.105-110
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• 2021

The article presents the idea that in the conditions of modernization of higher professional education, there is an obvious contradiction between the practical need of higher education for a scientifically grounded theory and methodology of distance learning for students and the lack of the necessary didactic and content-methodological guidelines for its implementation. In theoretical research and applied development, as a rule, the technocratic approach prevails. The emphasis is on the technical capabilities of modern computers and telecommunications. Productively, from a pedagogical point of view, this contradiction can be resolved on the basis of modeling distance learning management for students, developing and implementing a corporate information educational environment in universities, increasing the effectiveness of the methodology of pedagogical interaction between students and teachers during the implementation of distance learning.