• Journal of Marine Life Science
• /
• v.4 no.2
• /
• pp.45-52
• /
• 2019

Polycyclic aromatic hydrocarbons (PAHs) are persistent and commonly detected in marine ecosystem. They coexist with a various contaminants including heavy metals in real environment, but most studies have been still focused on single effects of these contaminants to aquatic organisms. In this study, the single and combined effects of benzy[a]pyrene (B[a]P) and HgCl₂ were investigated in the brackish water flea, Diaphanosoma celebensis. For combined effect study, three mixtures A (3:7), B (5:5), and C (7:3) of benzy[a]pyrene (B[a]P) and HgCl₂ were determined by 48 h - LC₅₀ values of single exposure. Combined effects of both chemicals were estimated by concentration addition (CA) model and independent action (IA) model. As results, 48 h - LC₅₀ values of benzy[a]pyrene (B[a]P) and HgCl₂ was 25.75 ㎍ l^-1 and 3.6 ㎍ l^-1, respectively. TU values of mixture A, B, and C were 1.06, 0.83, and 0.96, respectively, indicating additive effects of mixtures using CA model. This study will be helpful as basic data for understanding the combined effects of contaminants in marine environment.

• Journal of Chest Surgery
• /
• v.50 no.3
• /
• pp.144-152
• /
• 2017

Background: The ubiquitin-proteasome system (UPS) is an important pathway of proteolysis in pathologic hypertrophic cardiomyocytes. We hypothesize that MG132, a proteasome inhibitor, might prevent hypertrophic cardiomyopathy (CMP) by blocking the UPS. Nuclear factor kappa-light-chain-enhancer of activated B cells ($NF-{\kappa}B$) and androgen receptor (AR) have been reported to be mediators of CMP and heart failure. This study drew upon pathophysiologic studies and the analysis of $NF-{\kappa}B$ and AR to assess the cardioprotective effects of MG132 in a left ventricular hypertrophy (LVH) rat model. Methods: We constructed a transverse aortic constriction (TAC)-induced LVH rat model with 3 groups: sham (TAC-sham, n=10), control (TAC-cont, n=10), and MG132 administration (TAC-MG132, n=10). MG-132 (0.1 mg/kg) was injected for 4 weeks in the TAC-MG132 group. Pathophysiologic evaluations were performed and the expression of AR and $NF-{\kappa}B$ was measured in the left ventricle. Results: Fibrosis was prevalent in the pathologic examination of the TAC-cont model, and it was reduced in the TAC-MG132 group, although not significantly. Less expression of AR, but not $NF-{\kappa}B$, was found in the TAC-MG132 group than in the TAC-cont group (p<0.05). Conclusion: MG-132 was found to suppress AR in the TAC-CMP model by blocking the UPS, which reduced fibrosis. However, $NF-{\kappa}B$ expression levels were not related to UPS function.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.27 no.4C
• /
• pp.371-379
• /
• 2002

In this paper, the MMIC SPST switches operating from DC to 3GHz were designed and implemented. Prior to the design of switches, the small and large-signal switch models were needed to predict switch performance accurately. The newly proposed small-signal switch model parameters were extracted from measured S-parameters using optimization technique with estimated initial values and boundary limits. In the extraction of large-signal switch model parameters, the current source was modeled by fitting empirical equations to measured DC data and the charge model was derived from extracted channel capacitances from measured S-parameters varying the drain-source voltage. To design basic series-shunt SPST switches and isolation-improved SPST switches, we applied this model to commercial microwave circuit simulator. The improved SPST switches exhibited 0.302dB insertion loss, 35.762dB isolation, 1.249 input VSWR, 1.254 output VSWR, and about 15.7dBm PldB with 0/-3V control voltages at 3GHz.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.14 no.7
• /
• pp.692-698
• /
• 2003

This paper presents IM model which is produced in 3 port RF passive component. We calculated forward and reflect PIM of 3 port component by using the model. And they are reasonable agreement with measurement result like below. In the case of forward IM, calculated result is -122 dBc(at 43 dBm), which differ 2.5 dB with measurement result. And reflected IM, the average calculated result is -130 dBc(at 43 dBm), which differ 3 dB with measurement result. The results which are calculated and measured under various condition(IM source level, frequency sweep, contour length, etc.) show that forward method gets more fixed result than that of reflect. Consequently, PIM of 3 port component is predicted and analyzed for desensitizing by the proposed model.

• Earthquakes and Structures
• /
• v.10 no.3
• /
• pp.629-643
• /
• 2016

Among all the natural disasters, earthquakes are the most destructive calamities since they cause a plenty of injuries and economic losses leaving behind a series of signs of panic. The present study highlights the moment-curvature relationships for the structural elements such as beam and column elements and Non-Linear Static Pushover Analysis of RC frame structures since it is a very simplified procedure of non-linear static analysis. The highly popular model namely Mander's model and Kent and Park model are considered and then, seismic risk evaluation of RC building has been conducted using SAP 2000 version 17 treating uncertainty in strength as a parameter. From the obtained capacity and demand curves, the performance level of the structure has been defined. The seismic fragility curves were developed for the variations in the material strength and damage state threshold are calculated. Also the comparison of experimental and analytical results has been conducted.

• The Journal of Korean Academy of Prosthodontics
• /
• v.29 no.1
• /
• pp.233-248
• /
• 1991

The purpose of this study was to qunatatively analyze the stress patterns induced in the abutment, superstructure, supporting bone and to determine the deflection of abutment and superstructure by appling occlusal force to natural teeth supported fixed prostheses and implant-supported fixed prostheses. The analysis has been conducted by using the two dimensional finite element method. The implant and natural tooth-supported bridge has a first molar pontic supported by mandibular second bicuspid and implant posterior retainer, which were rigidly(Model A) or flexible(Model B). The natural teeth-supported bridge has a first molar pontic supported by mandibular second bicuspid and second molar, which were rigidly splinted together(Model C). 63.5kg(Load P1) of localized load on central fossa of first molar pontic and 24kg(Load P2) of distributed load on each occlusal surface were applied respectively. 1. The coronal portion of premolar pontic and posterior abutment in fixed partial denture deflected inferiorly in order of Model B, Model C and Model A under Load P1 and Load P2. 2. Mesial displacement of the coronal portion of premolar showed in Model A, Model B and Model C under Load P1, but mesial displacement of that in Model B and distal displacement of that in Model A and Model C showed under Load P2. 3. Mesial displacement of the coronal portion of the pontic and distal displacement of the coronal portion of posterior abutment showed in Model A, Model B and Model C under Load P1 and Load P2. Displacement in the case of Model B was greater than that of Model A and Model C. 4. In the case Model A under Load P1 and Load P2, high stress apically was concentrated in the mesiocervical portion of the posterior abutment than in the disto-cervical portion of the premolar. 5. In the case of Model B under Load P1 and Load P2 high stress was concentrated in the case of the premolar than in that of posterior abutment and high stress especially was concentrated in the connected portion of pontic and posterior abutment. 6. In the case of Model C under Load P1 and Load P2, high stress was concentrated in the distal area of the cornal portion of premolar and the mesial area of the coronal portion of posterior abutment, and stress pattern was anteroposterially symmetric around the pontic. 7. Load P1 and Load P2 compared, stress magnitude was different but stress pattern was similar in Model A, Model B and Model C. 8. Under Load P1 and P2, stress magnitude in the mesial distal portion and the portion of root apex of the posterior abutment was in order of Model B, Model A and Model C.

• Spatial Information Research
• /
• v.19 no.1
• /
• pp.93-105
• /
• 2011

In recent years, large and complex three-dimensional building has been constructed by the development of building technology and advanced IT skills, and people have lived there and spent a considerable time so far. Accordingly. in this sophisticatcd three-dimensional space, emergencies services or convenient information services have been in demand. In order to provide these services efficiently, understanding of topological relationships among the complex space should be supported naturally. Not on1y each method of understanding the topological relationships but also its efficiency can be different depending on different topological data models. B-rep based data model is the most widely used for storaging and representing of topological relationships. And from early 2000s, many researches on a network based topological data model have been conducted. The purpose of this study is to verify the efficiency of performance on spatial queries. As a result, Network-based topological data model is more efficient than B-rep based data model for determining the spatial relationship.

• The Journal of Korean Academy of Prosthodontics
• /
• v.29 no.2
• /
• pp.147-160
• /
• 1991

The purpose of this study was to examine, by the method of finite element analysis, how implant geometry with or without connection between natural tooth and osseointegrated abutments affected the stress distribution in surrounding bone and osseointegrated prosthesis. The mandibular first and second molars were removed and the two osseointegrated implants were placed in the first and second molar sites. Stress analysis induced by prostheses with connection(Model A)or without connection(Model B) between natural tooth(second bicuspid) and two osseointegrated abutments(first molar and second molar) was performed under vertical point load(Load P1) or distributed point load(Load P2). The results were as follows; 1. Under vertical point load, mesial tilting was shown in both Model A and Model B and inferior displacement of Model A was greater than that of Model B in the second bicuspid. 2. Under vortical point load, the first and second molars showed mesial tilting in both Model A and Model B, and inferior displacement of them was similar in Model A and Model B and was less than that of the second bicuspid. 3. Under distributed point load, mesial displacement was shown in Model A and Model B and inferior displacement of Model A was less than that of Model B in the second bicuspid. 4. Under distributed point load, mesial tilting was shown and inferior displacement of Model A was similar to that of Model B in the first and second molars. 5. In Model A under vertical point load, high stress was concentrated in the corneal portion of first molar and distributed throughout the second molar and the second bicuspid, and the stress distribution of the second molar was greater than that of the second bicuspid. 6. In Model B under vertical point load, high stress was concentrated in the coronal and mesio-cervical portion of the first molar. 7. In Model A under distributed point load, high stress was concentrated in the mesio-cervical portion of the first molar and evenly distributed throughout the second molar and the second bicuspid. 8. In Model B under distributed point load, high stress was concentrated in the disto-cervical portion of the second bicuspid and evenly distributed throughout the first and second molars.

• Journal of Korean Institute of Industrial Engineers
• /
• v.28 no.3
• /
• pp.274-282
• /
• 2002

This paper discusses a multi-dimensional analysis for Customer Relationship Management (CRM). For this, We propose a decision-making methodology which employs three analysis models. The first model is a three-dimension positioning map to derive a strategy which achieves the Process Value Line (PVL). The second model is the web-shape analysis model to visibly understand the individual based on the customer CSI (Customer Satisfactory Index) data. The third model which supports the web-shape analysis model, is the relative satisfactory analysis model. It considers a satisfaction level after purchasing against before purchasing. Then we perform overall analysis based on the three analysis models to provide marketing strategies to decision makers.

• The Journal of the Korea institute of electronic communication sciences
• /
• v.17 no.2
• /
• pp.237-244
• /
• 2022

We measured the clutter loss (CL) and building entry loss (BEL) of signals in a low-rise high-density suburban environment. Three propagation models for BEL, CL, and a combination of BEL and CL were measured in the selected environment. We then derived the figures when the BEL was combined with the CL. At the two frequencies, the measured value of combination of BEL and CL is 27.55 dB and 26.12dB, respectively, and the differences between the measured value and the sum were -4.19 dB and 5.82 dB. Considering that the measurement was performed inside a building, such a difference seems to be small. Therefore, when BEL and CL were measured separately and summed, and then combined and summed, differences of -4.19 dB and 5.82 dB were apparent. This this result can be referenced when similar case of a propagation model was analyzed.