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Metabolic Changes in Patients with Parkinson's Disease after Stereotactic Neurosurgery by Follow-up 1H MR Spectroscopy

  • Choe, Bo-Young;Baik, Hyun-Man;Chun, Shin-Soo;Son, Byung-Chul;Kim, Moon-Chan;Kim, Bum-Soo;Lee, Hyoung-Koo;Suh, Tae-Suk
    • Journal of the Korean Magnetic Resonance Society
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    • v.5 no.2
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    • pp.99-109
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    • 2001
  • Authors investigated neuronal changes of local cellular metabolism in the cerebral lesions of Parkinsonian symptomatic side between before and after stereotactic neurosurgery by follow-up 1H magnetic resonance spectroscopy (MRS). Patients with Parkinson's disease (PD) (n = 15) and age-matched normal controls (n = 15) underwen MRS examinations using a stimulated echo acquisition mode (STEAM) pulse sequence that provided 2${\times}$2${\times}$2 ㎤ (8ml) volume of interest in the regions of substantia nigra, thalamus, and lentiform nucleus. Spectral parameters were 20 ms TE, 2000 ms TR, 128 averages,2500 Hz spectral width, and 2048 data points. Raw data were processed by the SAGE data analysis package (GE Medical Systems). Peak areas of N-acetylaspartate (NAA), creatine (Cr), choline-containing compounds (Cho), inositols (Ins), and the sum (Glx) of glutamate and GABA were calculated by means of fitting the spectrum to a summation of Lorentzian curves using Marquardt algorithm. After blindly processed, we evaluated neuronal alterations of observable metabolite ratios between before and after stereotactic neurosurgery using Pearson product-moment analysis (SPSS, Ver. 6.0). A significant reduction of NAA/Cho ratio was observed in the cerebral lesion in substantia nigra of PD patient related to the symptomatic side after neurosurgery (P : 0.03). In thalamus, NAA/Cho ratio was also significantly decreased in the cerebral lesion including the electrode-surgical region (P : 0.03). A significant reduction of NAA/Cho ratio in lentiform nucleus was not oberved, but tended toward significant reduction after neurosurgery (P = 0.08). In particular, remarkable lactate signal was noted from the surgical thalamic lesions of 6 among 8 patients and internal segments of globus pallidus of 6 among 7 patients, respectively. Significant metabolic alterations of NAA/Cho ratio might reflect functional changes of neuropathological processes in the lesion of substantia nigra, thalamus, and lentiform nucleus, and could be a valuable finding fur evaluation of Parkinson's disease after neurosurgery. Increase of lactate signals, being remarkable in surgical lesions, could be consistent with a common consequence of neurosurgical necrosis. Thus, IH MRS could be a useful modality to evaluate the diagnostic and prognostic implications fur Parkinsons disease after functional neurosurgery.

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Neuronal Dysfunction in Patients with Chronic Alcoholism Evaluated by In Vivo $^1H$ Magnetic Resonance Spectroscopy (알콜중독환자의 신경기능 장애: 생체 양성자 자기공명분광 연구)

  • Bo-Young Choe;Euy-Neyng Kim;Chang-Wook Lee;In-Ho Baik;Kwang-Soo Lee;Byung-Chul Son;Heung-Jae Chun;Hyoung-Koo Lee;Tae-Suk Suh
    • Investigative Magnetic Resonance Imaging
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    • v.4 no.2
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    • pp.94-99
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    • 2000
  • Purpose : With the use of localized, water-suppressed in vivo $^1H$ magnetic resonance spectroscopy (MRS), we evaluated the proton metabolic alterations in patients with chronic alcoholism and healthy normal controls. Material and Methods : Patients with chronic alcoholism (N = 10) and normal control subjects (N = 10) underwent MRS examinations using a stimulated echo acquisition mode (STEAM) pulse sequence with $2{\times}2{\times}2{\;}\textrm{cm}^3$ volume of interest (VOI) in the left cerebellum and basal ganglia. Proton metabolite ratios relative to creative (Cr) were obtained using a Marquart algorithm. Results : The specific feature in patients with chronic alcoholism was a significant decrease of N-acetylaspartate (NAA)/Cr ratio in the left cerebellum, compared with normal controls. No clear correlation of other metabolite ratios such as choline (Cho)/Cr and inositols (Ins)/Cr was established. Conclusion : Our preliminary study suggests that the reduction of NAA/Cr ratio may indicate neuronal loss in patients with chronic alcoholism. Thus, in vivo 1H MRS may be a useful modality in the clinical evaluation of patients with chronic alcoholism based on the proton metabolite ratios.

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Structures and Variability of the T-S field and the Current across the Korea Strait (대한해협 횡단면 상의 수온-염분과 해류의 구조 및 변동)

  • RO, YOUNG JAE;PARK, MOON-JIN;LEE, SANG-RYONG;LEE, JAE CHUL
    • 한국해양학회지
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    • v.30 no.4
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    • pp.237-249
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    • 1995
  • To understand the cross-sectional structures of temperature, salinity and current across the Korea Strait, field measurements were carried out for the period of May 2 to 20, 1994. Using the R/V Tam Yang, detailed CTD profiles and ADCP records were obtained and used to examine the mean and variability field on two time scales (15 days and 25 hours). A sharp coastal front in the middle of the Korea Strait exists across which two different water masses, i.e., warm and saline water in the eastern side and cold and less saline water in the western side are neighboring. We observed highly variable field of T and S apparently caused by the westward movement of warm and saline water mass. Short-term fluctuations of T and S in the middle layer are remarkable and their importance was analysed as the first Eigen mode accounting for more than 50% of total variances. The currents in th Korea Strait are strongly influenced by tidal currents with spring and neap variation whose maximum speed ranges 80-90 and 60-70 cm/s respectively near the central portion of the channel. Strong southward tidal current could even mask the Tsushima Current completely. Results of harmonic analysis show that the magnitudes of semidiurnal, diurnal and mean components of currents are comparable to each other at spring and neap tide conditions. The volume transport across the western channel of the Korea Strait were estimated to be 2.1 Sv at neap tide condition and 3.4 Sv at spring tide condition.

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The Development and Application of Office Price Index for Benchmark in Seoul using Repeat Sales Model (반복매매모형을 활용한 서울시 오피스 벤치마크 가격지수 개발 및 시험적 적용 연구)

  • Ryu, Kang Min;Song, Ki Wook
    • Land and Housing Review
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    • v.11 no.2
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    • pp.33-46
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    • 2020
  • As the fastest growing office transaction volume in Korea, there's been a need for development of indicators to accurately diagnose the office capital market. The purpose of this paper is experimentally calculate to the office price index for effective benchmark indices in Seoul. The quantitative methodology used a Case-Shiller Repeat Sales Model (1991), based on actual multiple office transaction dataset with over minimum 1,653 ㎡ from Q3 1999 to 4Q 2019 in the case of 1,536 buildings within Seoul Metropolitan. In addition, the collected historical data and spatial statistical analysis tools were treated with the SAS 9.4 and ArcGIS 10.7 programs. The main empirical results of research are briefly summarized as follows; First, Seoul office price index was estimated to be 344.3 point (2001.1Q=100.0P) at the end of 2019, and has more than tripled over the past two decades. it means that the sales price of office per 3.3 ㎡ has consistently risen more than 12% every year since 2000, which is far above the indices for apartment housing index, announced by the MOLIT (2009). Second, between quarterly and annual office price index for the two-step estimation of the MIT Real Estate Research Center (MIT/CRE), T, L, AL variables have statistically significant coefficient (Beta) all of the mode l (p<0.01). Third, it was possible to produce a more stable office price index against the basic index by using the Moore-Penrose's pseoudo inverse technique at low transaction frequency. Fourth, as an lagging indicators, the office price index is closely related to key macroeconomic indicators, such as GDP(+), KOSPI(+), interest rates (5-year KTB, -). This facts indicate that long-term office investment tends to outperform other financial assets owing to high return and low risk pattern. In conclusion, these findings are practically meaningful to presenting an new office price index that increases accuracy and then attempting to preliminary applications for the case of Seoul. Moreover, it can provide sincerely useful benchmark about investing an office and predicting changes of the sales price among market participants (e.g. policy maker, investor, landlord, tenant, user) in the future.

Application of neural network for airship take-off and landing mode by buoyancy control (기낭 부력 제어에 의한 비행선 이착륙의 인공신경망 적용)

  • Chang, Yong-Jin;Woo, Gui-Ae;Kim, Jong-Kwon;Lee, Dae-Woo;Cho, Kyeum-Rae
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.33 no.2
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    • pp.84-91
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    • 2005
  • For long time, the takeoff and landing control of airship was worked by human handling. With the development of the autonomous control system, the exact controls during the takeoff and landing were required and lots of methods and algorithms were suggested. This paper presents the result of airship take-off and landing by buoyancy control using air ballonet volume change and performance control of pitch angle for stable flight within the desired altitude. For the complexity of airship's dynamics, firstly, simple PID controller was applied. Due to the various atmospheric conditions, this controller didn't give satisfactory results. Therefore, new control method was designed to reduce rapidly the error between designed trajectory and actual trajectory by learning algorithm using an artificial neural network. Generally, ANN has various weaknesses such as large training time, selection of neuron and hidden layer numbers required to deal with complex problem. To overcome these drawbacks, in this paper, the RBFN (radial basis function network) controller developed. The weight value of RBFN is acquired by learning which to reduce the error between desired input output through and airship dynamics to impress the disturbance. As a result of simulation, the controller using the RBFN is superior to PID controller which maximum error is 15M.

A Geochemical Study on Pyrophyllite Deposits and Andesitic Wall-Rocks in the Milyang Area, Kyeongnam Province (경남 밀양지역 납석광상과 안산암질 모암의 지구화학적 연구)

  • Oh, Dae-Gyun;Chon, Hyo-Taek;Min, Kyoung-Won
    • Economic and Environmental Geology
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    • v.25 no.1
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    • pp.27-39
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    • 1992
  • Several pyrophyllite deposits occur around the Milyang area where Cretaceous andesitic rocks and spatially related granitic rocks are widely distributed. Pyrophyllite ores consist mainly of pyrophyllite, and quartz with small amount of sericite, pyrite, dumortierite, and diaspore. The andesitic rocks and spatially related granitic rocks in this area suggest that they could be formed from the same series of a calc-alkaline magma series. The contents of $SiO_2$, $Al_2O_3$, LOI(loss on ignition) are enriched, and $K_2O$, $Na_2O$, CaO, MgO, $Fe_2O_3$ are depleted in altered andesitic rocks and ores. Enrichment of As, Cr, Sr, V, Sb and depletion of Ba, Cs, Ni, Rb, U, Y, Co, Sc, Zn are characteristic during mineralization. The pyrophyllite ores can be discriminated from the altered-and unaltered wall-rocks by an increasing of $(La/Lu)_{cn}$ from 4.18~22.13 to 8.98~55.05. In R-mode cluster analysis, Yb-Lu-Y, La-Ce-Hf-Th-U-Zr, $TiO_2-V-Al_2O_3$, Sm-Eu, $CaO-Na_2O-MnO$, Cu-Zn-Ag, $K_2O-Rb$ are closely correlated. In the discriminant analysis of multi-element data, $P_2O_5$, As, Cr and $Fe_2O_3$, Sr are helpful to identify the ores from the unaltered-and altered wall-rocks. In the factor analysis, the factors of alteration of andesitic rocks and ore mineralization were extracted. In the change of ions per unit volume, $SiO_2$, $Al^{3+}$ and LOI are enriched and $Na^+$, $K^+$, $Ca^{2+}$, $Mg^{2+}$, $Mn^{2+}$ and $Fe^{3+}$ are depleted during the alteration processes. The Milyang and the Sungjin pyrophyllite deposits could be mineralized by hydrothermal alteration in a geochemical condition of low activity ratio of alkaline ions to hydrogen ion with reference to spatially related granitic rocks.

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Frequency Reconfigurable Antenna for Multi Mode & Multi Band (MMMB) Communication Systems (셀룰러 및 커낵티비티 대역 통합용 동시동작모드 주파수 재구성 안테나)

  • Park, Se-Hyun;Yang, Chan-Woo;Jung, Chang-Won
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.10 no.6
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    • pp.1170-1174
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    • 2009
  • Two frequency-reconfigurable antennas have been designed and combined in a space with limited volume, i.e., 40mm ${\times}$ 20mm ${\times}$ 6mm. Each antenna can be reconfigured to operate at different frequency bands depending on the state of an embedded switch, which is implemented using a PIN diode. The first antenna can be switched between 0.82GHz ${\sim}$ 0.96GHz band (GSM/ CDMA) and 1.7GHz ${\sim}$ 2.17GHz band (DCS/ PCS/ WCDMA), which are cellular bands. The second antenna can be switched between 3.4GHz ${\sim}$ 3.6GHz band (mWiMax) and 2.3GHz ${\sim}$ 2.5GHz, 5.15GHz ${\sim}$ 5.35GHz bands (WiBro/ WLAN 11a/b/g/n), which are connectivity bands. The proposed combined antenna operates both over cellular bands and connectivity bands concurrently. The choice of the operation bands is made independently by the states of the two switches.

Mechanical Properties and Wear Behaviour of $Al/SiC/Al_{2}O_{3}$ Composite Materials ($Al/SiC/Al_{2}O_{3}$복합재료의 기계적 성질 및 마멸특성)

  • 임흥준;김영한;한경섭
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.17 no.10
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    • pp.2498-2508
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    • 1993
  • $Al/SiC/Al_{2}O_{3}$ hybrid composites are fabricated by squeeze infiltration method. From the misconstructive of $Al/SiC/Al_{2}O_{3}$ hybrid composites fabricated by squeeze infiltration method, uniform distribution of reinforcements and good bondings are found. Hardness value of $Al/SiC/Al_{2}O_{3}$ hybrid composites increases linearly with the volume fraction of reinforcement because SiC whisker and $Al_{2}$O$_{3}$ fiber have an outstanding hardness. Optimal aging conditions are obtained by examining the hardness of $Al/SiC/Al_{2}O_{3}$ hybrid composites with different aging time. Tensile properties such as Young's modulus and ultimate tensile strength are improved up to 30% and 40% by the addition of reinforcements, respectively. Failure mode of $Al/SiC/Al_{2}O_{3}$ hybrid composites is ductile on microstructural level. Through the abrasive wear test and wear surface analysis, wear behaviour and mechanism of 6061 aluminum and $Al/SiC/Al_{2}O_{3}$ hybrid composites are characterized under various testing conditions. The addition of SiC whisker to $Al/SiC/Al_{2}O_{3}$ composites gives rise to improvement of the wear resistance. The wear resistance of $Al/SiC/Al_{2}O_{3}$ hybrid composites is superior to that of Al/SiC composites. The wear mechanism of aluminum alloy is mainly abrasive wear at low speed range and adhesive and melt wear at high speed range. In contrast, that of $Al/SiC/Al_{2}O_{3}$ hybrid composites is abrasive wear at all speed range, but severe wear when counter material is stainless steel. As the testing temperature increases, wear loss of aluminum alloy decreases because the matrix is getting more ductile, but that of $Al/SiC/Al_{2}O_{3}$ hybrid composites is hardly varied. Oil lubricant is more effective to reduce the wear loss of aluminum alloy and $Al/SiC/Al_{2}O_{3}$ hybrid composites at high speed range.

The Hydrogenated Micro-crystalline Silicon(${\mu} c-Si:H$) Films Deposited by Hot Wire CVD Method (Hot Wire CVD법에 의한 수소화된 미세결정 실리콘(${\mu} c-Si:H$) 박막 증착)

  • Lee, Jeong-Cheol;Song, Jin-Su;Park, Lee-Jun
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.37 no.8
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    • pp.17-27
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    • 2000
  • This paper presents deposition and characterization of hydrogenated microcrystalline silicon (${\mu}c$ -Si:H) films on low cost glass substrate by Hot Wire CVD(HWCVD). The HWCVD ${\mu}c$ -Si:H films had deposition rates ranging from 2${\AA}$/sec to 35${\AA}$/sec with the variations of preparation conditions, which was 10 times higher than that of the films obtained from the conventional PECVD method. From the Raman spectroscopy, the prepared silicon films were found to be composed of the mixture of crystalline and amorphous phases. The crystalline volume fraction and average crystallite size, obtained from the Raman To mode peak near 520cm$^{-1}$, were 37-63% and 6-10 nm, respectively. The conductivity activation energy($E_a$) of the ${\mu}c$ -Si:H films, representing the difference of conduction band and Fermi level in an intrinsic semiconductors, increased from 0.22eV to 0.68eV with increasing pressure from 30mTorr to 300mTorr. The increase of $E_a$ with pressure indicates that the deposited films have properties close to intrinsic semiconductors, which is also proved with low dark conductivity of the ${\mu}c$ -Si:H deposited at 300mTorr. The tungsten concentration incorporated into films was about $6{\times}10^{16}atoms/cm^3$ in the samples prepared at wire temperature of 1800$^{\circ}C$.

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Shear Strength of Ultra-High Performance Fiber-Reinforced Concrete(UHPFRC) I-shaped Beams without Stirrup (강섬유 보강 초고성능 콘크리트(UHPFRC) I형 보의 전단 강도)

  • Lee, Ji-Hyung;Hong, Sung-Gul
    • Journal of the Korea Concrete Institute
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    • v.29 no.1
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    • pp.53-64
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    • 2017
  • Ultra-high performance fiber-reinforced concrete (UHPFRC) is characterized by a post-cracking residual tensile strength with a large tensile strain as well as a high compressive strength. To determine a material tensile strength of UHPFRC, three-point loading test on notched prism and direct tensile test on doubly notched plate were compared and then the design tensile strength is decided. Shear tests on nine I-shaped beams with varied types of fiber volume ratio, shear span ratio and size effect were conducted to investigate shear behavior in web. From the test results, the stress redistribution ability represented as diagonal cracked zone was quantified by inclination of principal stress in web. The test results shows that the specimens were capable of resistance to shear loading without stirrup in a range of large deformation and the strength increase with post-cracking behavior is stable. However at the ultimate state all test specimens failed as a crack localization in the damaged zone and the shear strength of specimens is affected by shear span ratio and effective depth. Strength predictions show that the existing recommendations should be modified considering shear span ratio and effective depth as design parameters.