• 제목/요약/키워드: minor salivary glands

검색결과 78건 처리시간 0.029초

후두에 발생한 선양낭성암종 1예 (A Case of Adenoid Cystic Carcinoma in Larynx)

  • 태경;이영석;김희옥;이용섭
    • 대한두경부종양학회지
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    • 제24권1호
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    • pp.76-79
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    • 2008
  • Adenoid cystic carcinoma(ACC) is one of the common malignant tumor of the major and minor salivary glands. ACC arising from the larynx is relatively rare(less than 1% of laryngeal malignant tumors) and only about eighty cases have been reported in the English literature. Definite diagnosis of these lesions is made only from a histological analysis, because findings and symptoms are non-specific. The diagnosis progresses very slowly, therefore it often presents at an advanced stage with regional and distant metastasis. Here, we present one case of ACC of the supraglottic region with a review of literature.

A radiolucent lesion of the jaw as a presentation form of a mucoepidermoid carcinoma of the oral cavity

  • Dominguez-Medina, David A.;Pena-Cardelles, Juan F.;Manzarbeitia-Arambarri, Felix
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • 제47권3호
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    • pp.229-232
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    • 2021
  • Cancer of the oral cavity and pharynx represents the 7th most diagnosed malignancy in Spain. Mucoepidermoid carcinomas are the most frequent malignancies of the minor salivary glands of oral cavities. The purpose of this report is to describe the very rare case of an alveolar ridge high-grade mucoepidermoid carcinoma presenting as an inside socket radiolucent lesion, simulating an apical cyst. The patient was diagnosed in our unit for oral and maxillofacial surgery and treated with surgery and adjuvant radiotherapy. The patient continues to be free of recurrent/persistent, local/regional disease after two years of follow up. Non-healed tooth related lesions present for more than one year are strongly recommended to be biopsied and evaluated histopathologically.

Cholinergic and Neurokinergic Agonist-induced $Ca^{2+}$ Responses in Rat von Ebner's Gland Acinar Cells

  • Chung, Ki-Myung;Kim, Sang-Hee;Cho, Young-Kyung;Roper, Stephen D.;Kim, Kyung-Nyun
    • International Journal of Oral Biology
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    • 제31권3호
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    • pp.99-105
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    • 2006
  • Von Ebner's glands (vEG) are minor salivary glands associated with circumvallate and foliate papilla. The secretions of vEG consist of microenvironment of the taste buds in the circumvallate and foliate papillae, and thus saliva from vEG plays a role in the perception of taste. The $Ca^{2+}$ signaling system in rat vEG acinar cell was examined using the $Ca^{2+}$-sensitive fluorescent indicator Fura-2. Agonist-induced increase in intracellular $Ca^{2+}\;([Ca^{2+}]_i)$ was stimulated by carbachol (CCh) and substance P (SP), but not by norepinephrine (NE), and recovered to control levels by their receptor antagonists dose-dependently. The effects were also observed in $Ca^{2+}$-free medium, suggesting mobilization from intracellular $Ca^{2+}$ store. These results in the vEG acinar cell indicate that 1) $[Ca^{2+}]_i$ is at least regulated by muscarinic and neurokininergic (NK1) receptors; 2) the increases in $[Ca^{2+}])i$ activated by CCh and SP are mainly mediated by discharge of cytosolic calcium pool.

이하선관에 발생한 MALT 림프종 1예 (A Case of MALT Lymphoma in Parotid Gland Duct)

  • 김기엽;양원용;권석민;강상윤
    • Archives of Plastic Surgery
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    • 제36권5호
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    • pp.663-666
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    • 2009
  • Purpose: Primary malignant lymphomas of the salivary glands are uncommon. The parotid gland was most frequently involved, followed by the submandibular gland, minor salivary gland and sublingual gland. The most common subtype is mucosa - associated lymphoid tissue(MALT) lymphoma. We experienced a case of salivary MALT lymphoma involving parotid gland duct, so report a case with a review of the literature. Methods: A 65 year old female presented with a palpable mass on the left side of her cheek. There was no clinical or laboratory evidence of pre - existing autoimmune disease. Preoperative facial and neck CT with contrast showed $2.1{\times}1.7cm$ sized, ill defined, homogeneous low density mass near left masseter muscle, and no evidence of other enlarged lymph nodes. Results: At operation, a yellowish oval shaped mass was found slightly adhered to middle portion of the parotid gland duct, meaduring $2{\times}1.5{\times}0.7cm$. Microscopic finding showed that centrocyte - like cells, monocyte B cells and plasma cells were diffusely infiltrated. Immunophenotyping was preformed on fixed section. The majority of the small cells were immunoreactive for the B cell marker CD20. Based on the typical histological findings supported by immunostaining, the mass was defined as MALT lymphoma. Conclusion: We report that very rare case of MALT lymphoma involving parotid gland duct in 65 year old female patient was experienced with clinical characteristics, histologic features and references.

타액선암에서 c-kit 유전자에 대한 분자생물학적 연구 (Molecular Biologic Analysis of c-kit Gene in Salivary Gland Carcinoma)

  • 서규환;정광윤;우정수;백승국;최성배;김상희;김인선;권순영
    • 대한두경부종양학회지
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    • 제19권2호
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    • pp.121-126
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    • 2003
  • Objectives: The c-kit gene encodes a transmembrane receptor-type tyrosine kinase, which is known to have a significant role in the normal migration and development of germ cells and melanocytes. In the previous studies of c-kit gene, c-kit expressions showed only in adenoid cystic carcinomas, lymphoepithelioma-like carcinomas and myoepithelial carcinomas, but not in others and mutation was not found in any types of salivary carcinoma. We investigate the c-kit expression which may be useful to differentiating adenoid cystic carcinomas from others, and mutation of the gene which may not be exist nor the mechanism of c-kit activation in salivary carcinomas. Material and Methods: The archival tissue samples from 42 salivary carcinomas of major and minor salivary glands were studied for c-kit expression by immunohistochemistry and gene mutation by polymerase chain reaction amplification and single strand conformational polymorphism. Results: The c-kit expressions were noted in 22/24 adenoid cystic carcinomas, 7/9 mucoepidermoid carcinomas, 2/3 acinic cell carcinomas, 3/4 malignant mixed tumors, and one undifferentiated carcinoma. The mutation of c-kit gene was found in 3/24 adenoid cystic carcinomas, 3/8 mucoepidermoid carcinomas, one acinic cell carcinoma, and 2/4 malignant mixed tumors. Conclusion: c-kit protein overexpression is seen in a variety of salivary gland carcinomas, and the mutation of the gene may be the mechanism of c-kit activation in these neoplasms.

주침샘의 병변 없이 경부림프절에 발생한 Warthin씨 종양 1예 (A Case of Solitary Warthin's Tumor from Cervical Lymph Node)

  • 이용수;박지수;나기상;구본석;장재원
    • 대한두경부종양학회지
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    • 제31권2호
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    • pp.39-42
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    • 2015
  • Warthin's tumor is the second most common salivary gland benign tumor, typically occurring in the fifth to seventh decades of life which shows an indolent feature. It is usually found in the parotid gland but occasionally in extra-parotid locations such as peri-parotid lymph node. However, Report of solitary Warthin's tumor in cervical lymph node is unusual. We here report a case of 72-year-old male with simultaneous malignant melanoma on eyelid and cervical lymph node enlargement in cervical level II area thus mimicking malignancy metastasis. After excisional biopsy under the local anesthesia, pathology was reported as papillary cystadenoma lymphomatosum, which is a histologically pathognomic finding of Warthin's tumor. However, there was no suspicious tumorous lesion in major or minor salivary glands. This case suggests that Warthin's tumor should be considered as a possible pathology in solitary lymph node lesion of neck.

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구개부에 발생한 다형성 저등급 선암종의 치험례 (Polymorphous low-grade adenocarcinoma on hard palate: case report)

  • 신영민;최소영;김진욱;변기정;김진수
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • 제37권1호
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    • pp.72-76
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    • 2011
  • Polymorphous low-grade adenocarcinomas (PLGA) are distinctive salivary gland neoplasms with a propensity to arise from the minor salivary glands. The most frequent location of PLGA is the palate, even though other locations have been described. Previously used terms for PLGA include lobular carcinoma and terminal duct carcinoma. Although the frequency of the tumor is unknown, the recognition of PLGA as an individual tumor has increased with the establishment of specific histopathological criteria characterizing the PLGA. The first choice of treatment is a wide surgical excision including the subjacent bone if necessary. The prognosis is generally good and the recurrence rate ranges from 17% and 22%. Distant metastases is unusual (9%) but occur mainly in the regional lymph nodes. This is a case report of a 67 year old female patient with PLGA who was treated with a wide excision by layers (2 stage) of the lesion including the surrounding bone. We present this case with a review of the relevant literature.

연구개에 발생한 근상피종 1예 -증례보고- (MYOEPITHELIOMA ON SOFT PALATE -A CASE REPORT-)

  • 최용석;김종국;김형준;서창호;차인호;윤중호
    • Maxillofacial Plastic and Reconstructive Surgery
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    • 제18권1호
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    • pp.115-119
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    • 1996
  • Myoepithelioma is composed exclusively of myoepithelial cells. Myoepithelial cells are ectodermally derived contractile cells that can be routinely identified in many normal tissues having secretory function such as major and minor salivary glands, lacrimal gland and sweat gland. Tumors composed exclusively of myoepithelial cells, so-called myoepitheliomas, are rare-less than 1% of all salivary gland tumors. Grossly, these tumors are well demarcated. The external surface is smooth and may be bosselated. The cut surface is white and homogenous. Microscopically, these tumors are surrounded by a thin fibrous capsule. They are composed of benign-appearing spindle- shaped and/or polygonal cells. Mitoses are rare. Frequently these tumors contain myxomatous stroma which is susceptible to alcial blue stain. Clinically, myoepitheliomas present as slow-glowing, painless masses and can not distinguished from pleomorphic adenomas. Treatment is the same as for pleomorphic adenoma, and the surgical excision should include a margin of normal tissue. Although the majority of myoepitheliomas have behaved in a beingn manner, pleomorphism and mitotic activity have been associated with local aggressiveness.

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Sialadenoma papilliferum: 증례보고 및 면역조직화학적 고찰 (Sialadenoma papilliferum: a case report and immunohistochemical study review)

  • 변준호;김동철;고경혁;박봉욱
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • 제36권6호
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    • pp.533-537
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    • 2010
  • Sialadenoma papilliferum (SP) is a rare benign neoplasm that normally arises from the minor salivary glands, particularly in the palate. SP is normally encountered in older men with an exophytic papillary surface growth. In the present study, an SP of the hard palate of a 69-year-old woman was examined immunohistochemically. Myoepithelial cell markers, such as S-100, smooth muscle actin and vimentin, were observed in the basal or luminal layer of tumor cells, indicating that myoepithelial cells participate in the pathogenesis of SP. In addition, cytokeratin 7 was also strongly detected in the tumor cells, suggesting that excretory ductal epithelial cells have a role in its histogenesis. A review of the literature of immunohistochemical studies on SP showed that the expression and co-expression of cytokeratins and myoepithelial cell markers have been reported in tumor cells. These results suggested that excretory duct cells and myoepithelial cells participate in the pathogenesis of SP.

연구개의 괴사성 타액선 화생 2예 (Two Cases of Necrotizing Sialometaplasia of the Soft Palate)

  • 정문상;이명철;모정아;조평산
    • 대한두경부종양학회지
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    • 제26권1호
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    • pp.24-26
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    • 2010
  • Necrotizing sialometaplasia was defined by Abrams et al. in 1973 as a reactive necrotizing inflammatory process involving minor salivary glands. Prior to recognition of necrotizing sialometaplasia as a benign, self-limited lesion, it was all too often diagnosed as either squamous cell carcinoma or mucoepidermoid carcinoma and had been improperly treated because of its clinical and histological resemblance to malignancy. We report two cases of necrotizing sialometaplasia. One case involved a 56-year-old female who developed a necrotizing sialometaplasia in association with palato-pharyngeal flap wound after excision of soft palate cancer and reconstruction. Another case involved a 55-year-old male who had a soft palate mass.