• Journal of Periodontal and Implant Science
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• v.53 no.6
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• pp.429-443
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• 2023

Purpose: The aim of this study was to determine 1) the bone-regenerative effect of porcine bone block materials with or without collagen matrix incorporation, 2) the effect of a collagen barrier, and 3) the effect of adding recombinant human bone morphogenetic protein-2 (rhBMP-2) to the experimental groups. Methods: Four treatment modalities were applied to rabbit calvaria: 1) deproteinized bovine bone mineral blocks (DBBM), 2) porcine bone blocks with collagen matrix incorporation (PBC), 3) porcine bone blocks alone without collagen matrix incorporation (PB), and 4) PBC blocks covered by a collagen membrane (PBC+M). The experiments were repeated with the addition of rhBMP-2. The animals were sacrificed after either 2 or 12 weeks of healing. Micro-computed tomography (micro-CT), histologic, and histomorphometric analyses were performed. Results: Micro-CT indicated adequate volume stability in all block materials. Histologically, the addition of rhBMP-2 increased the amount of newly formed bone (NB) in all the blocks. At 2 weeks, minimal differences were noted among the NB of groups with or without rhBMP-2. At 12 weeks, the PBC+M group with rhBMP-2 presented the greatest NB (P<0.05 vs. the DBBM group with rhBMP-2), and the PBC and PB groups had greater NB than the DBBM group (P>0.05 without rhBMP-2, P<0.05 with rhBMP-2). Conclusions: The addition of rhBMP-2 enhanced NB formation in vertical augmentation using bone blocks, and a collagen barrier may augment the effect of rhBMP-2.

• Korean Journal of Microbiology
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• v.43 no.4
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• pp.273-278
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• 2007

As a model compound of PAHs (polycyclic aromatic hydrocarbons) phenanthrene has been regarded as a toxic material, mutagen and carcinogen in various animals. Biodegradation conditions of phenanthrene such as pH, temperature, shaking speed, stabilizer and cofactor of degrading enzymes were investigated with Trametes versicolor and its transformant T. versicolor MrP1 in YMG medium, minimal medium and soil microcosm. T. versicolor MrP1 can overexpress mrp gene encoding Mn-repressed peroxidase that is involved in fungal degradation. Biodegradations of phenanthrene by T. versicolor and T. versicolor MrP1 were optimally performed in conditions of weak-acid (pH 6.0), $30^{\circ}C$, shaken culture and medium containing 5 mM veratryl alcohol or tryptophan. In these optimal conditions, biodegradation of phenanthrene by T. versicolor MrP1 is 31% higher than that of wild type strain in a minimal medium for 20 days. Biodegradation of phenanthrene by T. versicolor MrP1 was also higher than that of wild type in soil microcosm. T. versicolor MrP1 can be a excellent candidate for the bioremediation of PAHs contaminated environments.

• Korean journal of communication and information
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• v.26
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• pp.7-44
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• 2004

This paper proposed semiotic model to explain representation process of time in cinema. Limitations of cinematic narratology which explain representation process of time in cinema were indicated, then alternative explanations of Deleuzian philosophy of cinema were proposed. After discussion about articulations of cinematic code, Deleuzian concept of movement-image was suggested as semiotic minimal unit of cinema. In cinema, Movement-image is divided two different aspects ; "normal movement-image" and "abnormal movement-image". Therefore, two different semiotic representation process of time was reconstructed in accordance with Peircean semiosis theory. In this two different semiotic process, modern cinema emphasize the direct representation process of time with "abnormal movement-image". As Deleuze indicated, The "time-image" is presented in this semiotic process. The "time-image" makes it possible to consider "time itself" as philosophical fact which is laid between reality and cinema, This semiotic process more emphasizes pure expressionality than representationality. Deleuzian philosophical journey through cinema was started in this point.

• Journal of Life Science
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• v.12 no.5
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• pp.610-621
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• 2002

Conserved genes are importantly used to understand the major function in survival and replication of living organism. This study was focused on identification of conserved genes in microbial species and measuring the degree of conservation. For this purpose, in silico analysis was performed to search conserved genes based on the conservation level within microbial species. The ortholog list of COGs (Clusters of Orthologous Groups of proteins) in NCBI was used and whole genomes of 43 microbial species were included in that list. The distance value, derived from CLUSTALW multiple alignment program, was used as a descriptor of the conservation level of orthologs. It was revealed that 43 microbial genomes hold 72 conserved orthologs in common. The majority(72.2%) of the conserved genes was related to "translation, ribosomal structure and biogenesis" functional category. A GTPase-translation elogation factor(COG0050) was the best conserved gene from the distance value analysis. The 72 conserved genes, found in this research, would be useful not only to study minimal function genes but also new drug target among pathogens and to make a model of the virtual cell.tual cell.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.36 no.2
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• pp.231-243
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• 2016

This study presents the applicability of two-dimensional (2D) flood inundation model by applying to real irrigation reservoir failure with limited available data. The study area is Sandae Reservoir placed in Gyeongju and downstream area of it and the reservoir was failured by piping in 2013. The breach hydrograph was estimated from one-dimensional (1D) hydrodynamic model and the discharge was employed for upstream boundary of 2D flood inundation model. Topography of study area was generated by integrating digital contour map and satellite data, and Cartesian grids with 3m resolution to consider geometry of building, road and public stadium were used for 2D flood inundation analysis. The model validation was carried out by comparing predictions with field survey data including reservoir breach outflow, flood extent, flood height and arrival time, and identifying rational ranges with allowed error. In addition, the applicability of 2D model is examined using different simulation conditions involving grid size, building and roughness coefficient. This study is expected to contributed to analysis of irrigation reservoirs were at risk of a failure and setting up Emergency Action Plan (EAP) against irrigation reservoir failure.

• The Journal of Korean Medicine
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• v.23 no.2
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• pp.39-56
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• 2002

Objective : The aim of this study is to investigate the inhibitory effect of lnjinchunggantang-derivative on acute and sub-acute hepatic fibrosis induced by $CCl_4$, and to compare the efficiency of lnjinchunggantang-derivative, Salviae Radix and Scirpi Tuber.Zeloariae Rhizoma on acute and sub-acute hepatic fibrosis induced by $CCl_4$. Method : Western blotting for collagen type N, quantitative RT-PCR and gross & histological findings on liver tissue (Hematoxylin & Eosin stain, Reticulin stain, Masson-Trichrome stain) were studied. Results : In the study on collagen type N expression, lnjinchunggantangcderivative, Scirpi Tuber.Zeloariae Rhizoma and Salviae Radix showed inhibitory effect in western blotting. In quantitative RT-PCR assay, lnjinchunggantang-derivative showed inhibitory effect on collagen type N expression in acute hepatic fibrosis model, whereas lnjinchunggantang-derivative, Scirpi Tuber.Zeloariae Rhizoma and Salviae Radix showed inhibitory effect on collagen type N expression in sub-acute hepatic fibrosis model. In the gross findings of acute and sub-acute hepatic fibrosis models,lnjinchunggantang-derivative, Salviae Radix and Scirpi Tuber. Zeloariae Rhizoma showed inhibitory effect on hepatic fibrosis in the order. In the histological findings of acute and sub-acute hepatic fibrosis models in Hematoxylin & Eosin, Reticulin and Masson-Trichrome staining, the liver of $CCl_4$-only group showed atrophy and necrotic change with white nodules whereas that of $CCl_4$+ Injinchunggantang-derivative showed no significant histological change with well preservation of the tone of the tissue, and Scirpi Tuber. Zeloariae Rhizoma and Salviae Radix group showed minimal fibrotic changes. In the scoring system of the extent of the inhibition of the hepatic fibrosis, lnjinchunggantang-derivative group showed statistically significant inhibitory effect(p<0.05) whereas Scirpi Tuber.Zeloariae Rhizoma and Salviae Radix group showed no statistically significant effect in the acute hepatic fibrosis model. In the sub-acute hepatic fibrosis model, lnjinchunggantang-derivative, Scirpi Tuber.Zeloariae Rhizoma and Salviae Radix group showed statistically significant effect (p<0.01). Conclusion : These results show that lnjinchunggantang-derivative, Salviae Radix and Scirpi Tuber.Zeloariae Rhizoma have inhibitory effect in the order on hepatic fibrosis induced by $CCl_4$ by suppressing the expression of collagen type N, ultimately preventing liver cirrhosis. To obtain more credible results in this experiment, developement of a new experimental model more similar to human hepatic fibrosis is still needed.

• Environmental and Resource Economics Review
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• v.23 no.2
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• pp.187-224
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• 2014

We present key issues to consider in estimating damages from price-fixing cases and then apply the procedure addressing those issues to a transportation fuel market. Among the five methods of overcharge calculation, the regression analysis incorporating the yardstick method is the best. If the price equation relates the domestic price to the foreign price and the exchange rate as in the transportation fuel market, the functional form satisfying both logical consistency and modeling flexibility is the log-log functional form. If the data under analysis is of time series in nature, then the ARDL model should be the base model for each market and the regression analysis incorporating the yardstick method combines these ARDL equations to account for inter-market correlation and arrange constant terms and collusion-period dummies across component equations appropriately so as to identify the overcharge parameter. We propose a two-step test for the benchmarked market: (a) conduct market-by-market Spearman or Kendall test for randomness of the individual market price series first and (b) then conduct across-market Friedman test for homogeneity of the market price series. Statistical significance is the minimal requirement to establish the alleged proposition in the world of uncertainty. Between the sensitivity analysis and the model selection process for the best fitting model, the latter is far more important in the economic analysis of damage in price-fixing litigation. We applied our framework to a transportation fuel market and could not reject the null hypothesis of no overcharge.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.42 no.5 s.305
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• pp.123-136
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• 2005

We propose a recognition system for superimposed patterns based on selective attention model and SVM which produces better performance than artificial neural network. The proposed selective attention model includes attention layer prior to SVM which affects SVM's input parameters. It also behaves as selective filter. The philosophy behind selective attention model is to find the stopping criteria to stop training and also defines the confidence measure of the selective attention's outcome. Support vector represents the other surrounding sample vectors. The support vector closest to the initial input vector in consideration is chosen. Minimal euclidean distance between the modified input vector based on selective attention and the chosen support vector defines the stopping criteria. It is difficult to define the confidence measure of selective attention if we apply common selective attention model, A new way of doffing the confidence measure can be set under the constraint that each modified input pixel does not cross over the boundary of original input pixel, thus the range of applicable information get increased. This method uses the following information; the Euclidean distance between an input pattern and modified pattern, the output of SVM, the support vector output of hidden neuron that is the closest to the initial input pattern. For the recognition experiment, 45 different combinations of USPS digit data are used. Better recognition performance is seen when selective attention is applied along with SVM than SVM only. Also, the proposed selective attention shows better performance than common selective attention.

• Geophysics and Geophysical Exploration
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• v.14 no.1
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• pp.88-97
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• 2011

We present a method for modelling the terrain response of gravity gradiometry surveys utilising an adaptive quadtree mesh discretization. The data- and terrain-dependent method is tailored to provide rapid and accurate terrain corrections for draped and barometric airborne surveys. The surface used in the modelling of the terrain effect for each datum is discretized automatically to the largest cell size that will yield the desired accuracy, resulting in much faster modelling than full-resolution calculations. The largest cell sizes within the model occur in areas of minimal terrain variation and at large distances away from the datum location. We show synthetic and field examples for proof of concept. In the presented field example, the adaptive quadtree method reduces the computational cost by performing 351 times fewer calculations than the full model would require while retaining an accuracy of one E$\"{o}$tv$\"{o}$s for the gradient data. The method is also used for the terrain correction of the gravity field and performed 310 times faster compared with a calculation of the full digital elevation model.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.3
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• pp.584-593
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• 2018

The highly efficient operation of induction motors has been studied in the past years. Among the many attempts made to obtain highly efficient operation, Maximum Torque Per Amp (MTPA) controls in induction motor drives were proposed. This method enables induction motor drives to operate very efficiently since it achieves the desired torque with the minimal stator current. This is because the alternate qd induction motor model (AQDM) is a highly accurate mathematical model to represent the dynamic characteristics of induction motors. However, it has been shown that the variation of the rotor resistance degrades the performance of the MTPA control significantly, thus leading to its failure to satisfy the maximum torque per amp condition. To take into consideration the mismatch between the actual value of the rotor resistance and its parameter value in the design of the control strategy, an adaptive MTPA control was proposed. In this work, this adaptive MTPA control is investigated in order to achieve the desired torque with the minimum stator current at multiple operating points. The experimental study showed that (i) the desired torque was accurately achieved even though there was a deviation of the order of 5% from the commanded torque value at a torque reference of 25 Nm (tracking performance), and (ii) the minimum stator current for the desired torque (maximum torque per amp condition) was consistently satisfied at multiple operating points, as the rotor temperature increased.