• Archives of Pharmacal Research
• /
• v.22 no.6
• /
• pp.549-553
• /
• 1999

The antipruritic effect of DA-5018m a capsaicin derivative, was examined in mice. Male ICR mice were topically pretreated with Zostrix-HP (0.075% capsaicin cream), 0.1%, 0.3% DA-5018 cream or cream base (control) twice daily for 4 days. One hour after the last application, itch was induced either by compound 48/80 ($50{\mu}g$, s.c.) or leukotriene B4 (0.03 nmol, i.d.) injection into the rostral back of the animals, and the number of scratches made by the animals at the injection site was counted for 60 min post-injection. DA-5018 cream (both 0.1 and 0.3%) significantly inhibited compound 48/80-induced scratching when compared with the cream base control (p<0.01), which Zostrix-HP showed minimal inhibition of the scratching behavior. In leukotriene B4-induced itch model, Zostrix-HP and 0.3% DA-5018 cram significantly inhibited the scratching during the first 10-min period (p<0.01). The results suggest that DA-5018 cream can be used as an antipruritic agent and warrant clinical evaluation.

• Restorative Dentistry and Endodontics
• /
• v.45 no.3
• /
• pp.27.1-27.9
• /
• 2020

Apical surgery for a mandibular molar is still challenging for many reasons. This report describes the applications of computer-guided cortical 'bone-window technique' using piezoelectric saws that prevented any nerve damage in performing endodontic microsurgery of a mandibular molar. A 49-year-old woman presented with gumboil on tooth #36 (previously endodontically treated tooth) and was diagnosed with chronic apical abscess. Periapical lesions were confirmed using cone-beam computed tomography (CBCT). Endodontic microsurgery for the mesial and distal roots of tooth #36 was planned. Following the transfer of data of the CBCT images and the scanned cast to an implant surgical planning program, data from both devices were merged. A surgical stent was designed, on the superimposed three-dimensional model, to guide the preparation of a cortical window on the buccal side of tooth #36. Endodontic microsurgery was performed with a printed surgical template. Minimal osteotomy was required and preservation of the buccal cortical plate rendered this endodontic surgery less traumatic. No postoperative complications such as mental nerve damage were reported. Window technique guided by a computer-aided design/computer-aided manufacture based surgical template can be considerably useful in endodontic microsurgery in complicated cases.

• Journal of the Korean Society of Safety
• /
• v.26 no.4
• /
• pp.87-95
• /
• 2011

The urgent VAI(Vital Area Identification) method development is required since 'The Act of Physical Protection and Radiological Emergency' that is established in 2003 requires an evaluation of physical threats in nuclear facilities and an establishment of physical protection in Korea. The KAERI(Korea Atomic Energy Research Institute) has developed the VAI methodology and VAI software called as VIPEX(Vital area Identification Package EXpert) for identifying the vital areas. This study is to demonstrate the applicability of KAERI's VAI methodology to a hypothetical facility, and to identify the importance of information of cable and piping runs when identifying the vital areas. It is necessarily needed to consider cable and piping runs to determine the accurate and realistic TEPS(Top Event Prevention Set). If the information of cable and piping runs of a nuclear power plant is not considered when determining the TEPSs, it is absolutely impossible to acquire the complete TEPSs, and the results could be distorted by missing it. The VIPEX and FTREX(Fault Tree Reliability Evaluation eXpert) properly calculate MCSs and TEPSs using the fault tree model, and provide the most cost-effective method to save the VAI and physical protection costs.

• Proceedings of the KIEE Conference
• /
• 1993.07b
• /
• pp.929-931
• /
• 1993

The design sensitivity analysis based on the finite element method is presented for the eddy current problem with a voltage source. Since, in this problem, the complex variable is used as the state variable, new approach to the sensitivity calculation for the complex variable system is required. Its result is applied to the design of the rotor slot shape of squirrel cage induction motor. As a analysis model, only one slot pitch of rotor is analyzed by using a Periodic boundary condition. The use of this minimal modelling method leads to much saving of calculation time. The design objective is to obtain the desired slip-torque characteristic. Because the shape of rotor slot has much influence on the slip torque characteristic, the design variables are taken on the interface shape between rotor core and rotor bar. The initial shape of rotor slot is the trapezoidal type with rounding corners. The obtained final shape is quite similar to the double squirrel cage type.

• Journal of Korean Society on Water Environment
• /
• v.29 no.6
• /
• pp.730-738
• /
• 2013

In recent years, low impact development (LID) has emerged as an effective approach to control stormwater in an urban area, and watershed and stormwater managers need modeling tools to evaluate alternative plans for controlling stormwater. This study illustrates how to design and evaluate the effect of non-point pollutant management using SUSTAIN which is developed by USEPA. SUSTAIN can provide evaluating, selecting, and placing LID facilities in an urban catchment based on user-defined cost-effectiveness criteria. Also, this paper suggests a minimal methodology for estimating model parameters for modeling an ungauged urban catchment to reflect the situation of typical Korean urban interested catchments which are usually ungauged. In addition, the optimal length of various LID facilities and the optimal number of units in our test catchment are estimated.

• Transactions of the Korean Society for Noise and Vibration Engineering
• /
• v.21 no.7
• /
• pp.622-628
• /
• 2011

The purpose of this study was to analyze the vibro-acoustic characteristics of a stiffened rectangular plate at high frequencies. The stiffeners attached along the plate surface were assumed to have rotational and translational stiffness and inertia. The harmonic response of the stiffened plate were predicted and compared using the Rayleigh-Ritz method with two different trial functions - polynomial and beam functions. The variation of the spatially averaged mean square velocity and the modal characteristics with the number of stiffeners were obtained. The use of the beam function ensured fast convergence which was essential for analyzing the high frequency vibration responses. Using the calculated modal characteristics and the Rayleigh-integral, the radiated sound power was predicted, and the effects of stiffeners were investigated. The proposed model can be applied to study optimal layout of stiffeners for minimal noise generation of the stiffened structures.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
• /
• 2013.10a
• /
• pp.543-548
• /
• 2013

This paper presents a design of magnetorheological (MR) damper for control vibration of washing machine. This design is based on the requirements such as small dimensions with high damping force, and minimal consumed energy. The MR damper is designed using the shear mode of MR fluid, and Bingham plastic model is used for optimization process. In this design, a multi-coil design is adopted for damper to enhance damping force and reduce optimally structural parts. In optimization process, ADPL (Ansys Parametric Design Language) program is applied. Base on the optimal parameters, MR damper is manufactured and tested. In evaluation of MR damper, a modified sliding mode control is formulated and applied in both simulation and experiment. Results of experiment show that the MR damper satisfy the requirement of damping force for vibration control of washing machine.

• Information Systems Review
• /
• v.5 no.2
• /
• pp.151-168
• /
• 2003

A knowledge portal is an integrated gateway for accessing relevant knowledge, collaborating and communicating with other users, and also linking internal applications which is becoming crucial in the age of information abundance. Research and development is a typical knowledge-intensive activity. However, knowledge management support in R&D has been minimal in most research organizations. In this paper, a knowledge portal is designed to support team-based researches in science and technology for searching and browsing knowledge, and also communicating with other team members, coordinating research project and collaborating with other researchers. Automating knowledge acquisition from various knowledge sources, knowledge categorization by applying text categorization method, and knowledge recommendation can help to relieve management effort and increase the efficiency of knowledge management processes. A prototype system based on the suggested model is also presented.

• Journal of KIISE:Computing Practices and Letters
• /
• v.6 no.1
• /
• pp.36-44
• /
• 2000

In this paper, we describe the developing of a tool which supports both multimedia presentation with user's participation through a high speed network and authoring of various media using a single authoring tool. To support real-time synchronous multimedia presentation, we adopt dynamic synchronization method and adaptive transmission algorithm for synchronizing data transfer rate between sender and receiver using buffer management algorithm based on QoS parameters. And we also allow user's participation in the presentation using TRSG(Temporal Relationship Specification Graph) model. Finally, the proposed tool supports the minimal level of QoS and its continuous play-out using event auditing threads which control the current state of a multimedia presentation continuously by monitoring of negative factors effecting on QoS, and synchronization.

• Steel and Composite Structures
• /
• v.33 no.1
• /
• pp.1-18
• /
• 2019

In the present study, the behavior of steel plate shear walls (SPSW) with variable column flexural stiffness is experimentally and numerically investigated. Altogether six one-bay one-story specimens, three moment resisting frames (MRFs) and three SPSWs, were designed, fabricated and tested. Column flexural stiffness of the first specimen pair (one MRF and one SPSW) corresponded to the value required by the design codes, while for the second and third pair it was reduced by 18% and 36%, respectively. The quasi-static cyclic test result indicate that SPSW with reduced column flexural stiffness have satisfactory performance up to 4% story drift ratio, allow development of the tension field over the entire infill panel, and cause negligible column "pull-in" deformation which indicates that prescribed minimal column flexural stiffness value, according to AISC 341-10, might be conservative. In addition, finite element (FE) pushover simulations using shell elements were developed. Such FE models can predict SPSW cyclic behavior reasonably well and can be used to conduct numerical parametric analyses. It should be mentioned that these FE models were not able to reproduce column "pull-in" deformation indicating the need for further development of FE simulations with cyclic load introduction which will be part of another paper.