• 한국엔터테인먼트산업학회논문지
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• 제15권7호
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• pp.215-223
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• 2021

본 연구의 목적은 지역사회에 거주하고 있는 경도인지장애를 보이는 노인을 대상으로 한 컴퓨터 기반의 인지재활프로그램의 적용이 인지기능과 도구적 일상생활수행능력에 미치는 영향을 알아보고는 것이다. MCI 노인 22명을 실험군 11명, 대조군 11명으로 무작위 할당하여 진행하였으며, 총 10주간, 주 3회, 회기당 30분씩 실험군은 CoTras, 대조군은 전통적 인지 재활을 받았다. 중재 전후로 인지기능과 수단적 일상생활활동의 수행 능력애 대한 변화를 알아보기 위해 NCSE와 K-IADL을 사용하였다. 연구 결과, 실험군은 집중력과 기억력을 포함한 전반적인 인지기능과 수단적 일상생활활동의 수행능력의 향상을 보였다. 지역사회 경도인지장애 노인들을 대상으로 인지기능과 수단적 일상생활활동의 수행능력 증진을 위해 CoTras의 적용을 고려해 볼 수 있을 것이다.

• 성인간호학회지
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• 제27권6호
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• pp.707-717
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• 2015

Purpose: This study was to develop and verify the effects of the exercise-cognitive combined dual-task training program on cognitive function and depression of the elderly with mild cognitive impairment (MCI). Methods: A non-equivalent control group pretest-posttest design was used. The participants were assigned into two groups: an experimental group receiving an exercise-cognitive combined dual-task (n=20) and a control group receiving a simple-task (n=18). After 8 weeks of intervention (2 days per week), the change in depression and cognitive functions were compared between the groups. Results: General cognitive function (t=-2.81, p=.011), frontal cognitive function (Z=-3.50, p<.001), attention/working memory function (U=-2.91, p=.004), depression (t=4.96, p<.001) of the experimental group were significantly increased than those of the control group. Conclusion: The findings of the study showed that an exercise-cognitive combined dual-task program for MCI was effective in improving general cognitive function, frontal and executive function, attention/working memory function, and reducing depression.

• 동의신경정신과학회지
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• 제24권1호
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• pp.63-74
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• 2013

Objectives : The purpose of this study is to examine the effects of 3 day Forests healing programs for cognitive improvement, which consists of helpful contents of Korean medicine. Methods : This study examined the effects of forests healing for mild cognitive impairment patients, who visited a Korean medicine hospital neuropsychiatry clinic for outpatients. The Forests healing programs for cognitive improvement was run with 24 participants, in which 9 of them quit in the middle of the program, so excluded in data analysis. The Forests healing programs for cognitive improvement was consisted of 3 day helpful Korean medicine contents. The primary outcome measurement was a Computerized Neurocognitive Test (CNT), which measured the cognitive functions with computer programs. Results : The results of this study showed that CNT scores were not significantly changed after 3 day forests healing. General psychological states, including depression, anxiety, and anger, were also checked. Among them, depressive mood significantly improved. Quality of life (QOL) was also enhanced after 3 day program. These results indicate that the 3 day Forests healing programs for cognitive improvement was effective for depressive mood and QOL of mild cognitive impairment patients, but not enough for cognitive functions directly. Conclusions : The 3 day Forests healing programs for cognitive improvement were shown to be an effective intervention in improving some aspects of mild cognitive impairment patients, including depressive mood, and QOL. We suggest that repeated participation of this program can enhance cognitive function of mild cognitive impairment patients.

• 성인간호학회지
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• 제24권2호
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• pp.171-182
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• 2012

Purpose: This study aimed to identify depression and its predictors among Korean community-dwelling elderly with mild cognitive impairment. Methods: Secondary data analyses of the data collected by the "Study on tailored integration program for reinforcing cognitive and physical function of the frail elderly. The study used data from one-to-one interviews using structured questionnaires. The subjects were 346 community-dwelling elderly who visited a healthcare center in Seoul, Korea. A descriptive correlational study design was utilized to explore depression and its predictors including physical factors and psychosocial factors among the elderly with mild cognitive impairment. Data were analyzed using t-test, Pearson's correlation, and hierarchical regression. Results: Mean score of depression was within normal limit $11.61{\pm}6.69$. Somatic symptoms, negative life events (severity), social support were shown as significant predictors of depression. The most influential predictor for depression was somatic symptoms (${\beta}$=.340, $p$ <.001). Conclusion: To prevent and relieve depression in the elderly with mild cognitive impairment, nursing intervention strategies which consider well-balanced physical and psychosocial aspects are needed. In particular, a specific nursing intervention strategy is required to improve physical health of the elderly with mild cognitive impairment.

• 대한한방내과학회지
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• 제42권5호
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• pp.1082-1093
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• 2021

Objective: Alzheimer's disease is characterized by progressive, irreversible brain damage and cognitive decline. Although the diagnosis and treatment of the prodromal symptoms of dementia are important, no treatment for mild cognitive impairment has been currently established. Herein, we report the case of an 80-year-old female patient with memory complaints treated with Gugijihwang-tang, a traditional Korean medicine herbal formula, as an add-on medication. Case Presentation: The patient was diagnosed with mild cognitive impairment based on clinical examinations using the Mini-Mental State Examination (MMSE), the Consortium to Establish a Registry for Alzheimer's Disease (CERAD), Activities of Daily Living (ADL) Scale, Global Deterioration (GDR) Scale, and Clinical Dementia Rating (CDR) Scale. She was treated with Gugijihwang-tang bis in die for 12 months while continuing her original medications, including 5-mg donepezil and 590-mg acetyl-l-carnitine. The MMSE score in the Korean Version of the CERAD Assessment Packet increased from 21 to 27 during the 12-month treatment period, and the CERAD 2 score increased from 33 to 62. The instrumental ADL scale score improved from 11 to 5. Other clinical examination results also showed improvement. The patient was satisfied and experienced no significant adverse events related to the Gugijihwang-tang treatment. Conclusion: This case suggests that Gugijihwang-tang could be considered as a treatment method for patients with mild cognitive impairment.

• Journal of Acupuncture Research
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• 제36권2호
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• pp.72-79
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• 2019

Background: The aim of this study was to review clinical efficacy of acupuncture treatment of mild cognitive impairment. Methods: Randomized controlled trials that performed acupuncture treatment for mild cognitive impairment were retrieved from 6 online databases (PubMed, Cochrane Library, EMBASE, CNKI, NDSL, OASIS) on September $30^{th}$, 2018. Studies were selected according to inclusion and exclusion criteria, and were reviewed by Risk of Bias assessment. Results: In total, 21 studies were included in this review. All studies were Chinese (19 studies published in Chinese and 2 in English). The sample size, 50 to 100, and the number of treatment times, 20 to 30, were the largest range in all studies. The most treatments performed was 30. The longest treatment period was 56 days, which accounted for 33% of the studies. The most frequently used evaluation index was the Mini Mental State Examination followed by the Montreal Cognitive Assessment, each used 17 times and 15 times, respectively. The most frequently used acupoints were GV20, EX-HN1, GB20, and GV24, which accounted for 47% of total number of acupoints used. In 48% of the studies, needle retention time was 30 minutes. Western medicine treatment was the most common control group. Most studies reported that the intervention group was statistically significantly different to the control group. Conclusion: These results suggest that acupuncture for mild cognitive impairment was effective. However, it is difficult to confirm this conclusion because the quality of most of these studies were of low quality.

• 인간식물환경학회지
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• 제23권1호
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• pp.35-46
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• 2020

The purpose of this study was to investigate the effects of the horticultural therapy program on patients with mild cognitive impairment and mild dementia depending on the frequency and duration of the interventions. We developed the same 15-session program to improve cognitive functions and life satisfaction and alleviate depression of the elderly women with mild cognitive impairment or mild dementia. Subjects in Longer Treatment group participated in the program once a week for 15 weeks and subjects in Shorter Tratmet group participated twice a week for 7½ weeks. This study conducted pretest-posttest verification of both groups using quasi-experimental design involving 21 subjects. Elderly life satisfaction, Geriatric Depression Scale (short form), and the Korean Version of Consortium to Establish a Registry of Alzheimer's Disease (CERAD-K) were used in the evaluation. As a result, both groups showed an increase in life satisfaction, and a decrease in depression. However, there was a significant difference in the changes of the CERAD-K scores between the two groups (p < .05). In Longer Treatment group, life satisfaction increased significantly (p < .001), and depression decreased at a marginally significant level (p = .068), but no statistically significant change was observed in neurocognitive function. In Shorter Treatment group, life satisfaction increased at a marginally significant level (p = .059), and depression and CERAD-K scores decreased significantly (p < .05). However, in the case of Mini-Mental State Examination (MMSE-K), there was no significant change in both groups. According to these results, when planning a horticultural therapy program for persons with mild cognitive impairment or mild dementia, it is effective to organize and execute the program by determining the duration of intervention as 3 to 4 months or longer, even if this reduces the number of interventions per week.

• Physical Therapy Rehabilitation Science
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• 제10권4호
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• pp.493-502
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• 2021

Objective: Older adults with mild cognitive impairment (MCI) are more likely to progress to dementia. Motor-cognitive training is applied as a dual-task to improve the cognitive and physical functions of older adults with MCI. The purpose of the study was to know the recent trends in motor training types and outcome measures used for motor-cognitive training in older adults with MCI. Design: Aliterature review Methods: This literature review was conducted in Pubmed, MEDLINE® and Google Scholar with the following key words: older adults, mild cognitive impairment, motor-cognitive training, cognition, and dual-task. The 7 studies were found with the search tool and all studies were randomized controlled trials. Results: In motor-cognitive training in older adults with MCI, 6 studies applied aerobic exercise. And 3 out of 6 studies also applied strengthening exercises. One study applied dual tasks without aerobic exercise. In the 6 studies, overall cognitive and executive function were used as outcome measures, and physical function was evaluated as gait performance. Memory and physical frailty were also used as measurement tools. As a result of all studies, when motor-cognitive training was applied, cognition and physical performance showed significant results. Conclusions: A recent five-year study applied mainly aerobic exercise and strength training to older adults with MCI and found it to improve cognitive and physical performance.

• 지역사회간호학회지
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• 제30권2호
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• pp.119-129
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• 2019

Purpose: The purpose of this study is to develop and evaluate the effects of a multifaceted cognitive training program on cognitive function, depression, and instrumental activities of daily living (IADL) in community dwelling elders with mild cognitive impairment. Methods: A non-equivalent control group pretest-posttest design was used. The subjects were recruited from a community health center in D metropolitan city and were assigned to the experimental or control group. Weekly 50-minute session intervention was delivered to the experimental group over 12 weeks. 8 weeks and 12weeks after intervention, the changes in cognitive function, depression, and IADL in the groups were measured and compared. Data were analyzed with Mann-Whitney U test, Wilcoxon Signed Rank test, and post-hoc test with Bonferroni correction using SPSS/WIN 23.0. Results: When compared with their counterparts (n=15), the elders in the experimental group (n=12) showed significant improvement in cognitive function and depression at week 12. The mean scores of IADL at week 12 were not significantly different between the groups. Conclusion: The results indicate that this multifaceted cognitive training program is effective in improving cognitive function, depression, and avoiding deterioration of IADL among elders with mild cognitive impairment.

• 한국방사선학회논문지
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• 제8권4호
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• pp.163-170
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• 2014

본 연구는 경도인지장애가 동반된 환자를 대상으로 뇌 자기공명영상에서 인지 영역에 대한 대뇌 피질 두께를 측정하고 신경심리검사 결과와 비교하여 신경해부학적 상관관계를 규명하고자 하였다. 이를 위하여 파킨슨병으로 최초 진단 받고 신경심리검사를 시행한 78명(경도인지장애군: 39명; 비인지장애군: 39명)과 정상인 그룹 32명을 선정하였다. 신경심리검사에서 경도인지장애군과 비인지장애군의 상관관계와 신경심리검사와 뇌 자기공명영상에서 대뇌 피질 두께의 상관관계는 독립표본 T 검증 또는 피어슨 상관분석을 실시하였으며 수집된 자료의 유의 수준은 p<0.05에서 검증하였다. 결론적으로 경도인지장애를 동반한 파킨슨병 환자는 뇌 자기공명영상에서 양측 쐐기압소엽과 우하측두엽의 대뇌 피질 두께가 통계적으로 유의하게 감소하였으며 인지 기능 평가를 위한 신경심리검사에서 시공간 기능, 언어 및 시각 기억력 기능이 저하되었다. 특히 언어 및 시각 기억력 영역에 대한 신경심리검사와 신경해부학적으로 좌측 쐐기앞소엽에서 상관관계가 있었다.