• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제54권9호
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• pp.427-432
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• 2005

Ion migration characteristics of a rotary spark airgap of high voltage Pulse generator had been investigated. It was considered that the ion migration speed and the ions of the gases(atmosphere gases, $O_2,\;N_2,,\;and\;H_{2}O,\;etc$.) and the charged very fine particles(about $10\~100nm$ size) migrated through the upper stator ball and bottom stator ball of the rotary spark airgap would determined the rise and fall times of the output high voltage pulse. In this paper, a basic study on the ion migration characteristics of the rotary spark airgap between the spark stator ball and the ion-sensing electrode of the proposed high voltage pulse generator have been investigated experimentally. As a result, the three kinds of ion speeds were detected by the ion-sensing electrode installed at the position of the bottom stator ball of the ball type sparkgap high voltage pulse generator. The migration velocities, diameters, masses, charges, numbers of the ions and particles were obtained by experiments and calculations, which, however, would determine the rise and fall times of the output high voltage pulse.

• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6349-6352
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• 2014

The present study was undertaken to determine the roles of insulin in the growth of transplanted breast cancer in nude mice, and the proliferation and migration of MCF-7 human breast cancer cells and assess its influence on downstream signaling pathways. In a xenograft mouse model with injection of MCF-7 human breast cancer cells, tumor size was measured every other day. The insulin level and insulin receptor (IR) were increased in the breast cancer patient tissues. Insulin injected subcutaneously around the tumor site in mice caused increase in the size and weight of tumor masses, and promoted proliferation and migration of MCF-7 cells. The effects of insulin on the increase in the proliferation and migration of MCF-7 human breast cancer cells were abolished by pretreatment with the extracellular regulated kinase (ERK) inhibitor PD98059. Insulin increased the phosphorylation of ERK in the MCF-7 cells. These results indicate that insulin promotes the growth of breast cancer in nude mice, and increases the proliferation and migration of MCF-7 human breast cancer cells via the ERK pathway.

• Journal of Microbiology and Biotechnology
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• 제14권2호
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• pp.379-384
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• 2004

Fibroblast growth factor-2 (FGF-2) is known to modulate numerous cellular functions in various cell types, including cell proliferation, differentiation, survival, adhesion, migration, and motility, and also in processes such as wound healing, angiogenesis, and vasculogenesis. FGF-2 regulates the expression of several molecules thought to mediate critical steps during angiogenesis. This study examines the mechanisms underlying FGF-2-induced cell migration, using human umbilical vein endothelial cells (HUVECs). FGF-2 induced the nondirectional and directional migration of endothelial cells, which are inhibited by MMPs and plasmin inhibitors, and induced the secretion of matrix metalloproteinase-3 (MMP3) and MMP-9, but not MMP-l and MMP-2. FGF-2 also induced the secretion of the tissue inhibitor of metalloproteinase-l (TIMP-I), but not of TIMP- 2. Also, the pan-PKC inhibitor inhibited FGF-2-induced MMP-9 secretion. It is, therefore, suggested that FGF-2 induces the migration of cultured endothelial cells by means of increased MMPs and plasmin secretion. Furthermore, FGF-2 may increase MMP-9 secretion by activating the PKC pathway.

• 한국농공학회논문집
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• 제46권2호
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• pp.3-14
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• 2004

This study was conducted to assess the possibility of the field application of the iceharbor-type precast fishway. When overflow depth of weir is 4.0 cm in model fishway, upper part velocities appear appropriate for upstream migration of fish and the lowest overflow wall (right line) in lower part has shown velocity distribution more or less inadequate for upstream migration. Except that right line, left and middle line revealed that velocities are appropriate for upstream migration of fish. Therefore, we concluded that this fishway owing to be not broad growth width of overflow velocities according to increasing discharges can correspond to variation of water level. Also We consider that various velocities in fishway were effective, because slow velocity line can guide flow for upstream migration. For low flow, the arrangement of different crest level or each overflow part (higher left, middle and lower right, or lower left, middle and higher right) was more effactive than unform crert level. Hole plays an important role as migration pass during drought and flood flow. Therefore, We concluded that this fishway can cope with water depth variation by various overflow wall height change and raise the field applicability with better performance hydraulically and structurally.

• Biomolecules & Therapeutics
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• 제22권6호
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• pp.540-546
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• 2014

The high mortality rates associated with cancer reflect the metastatic spread of tumor cells from the site of their origin. Metastasis, in fact, is the cause of 90% of cancer deaths. Therefore, considerable effort is being made to inhibit metastasis. In the present study, we screened ketotifen for anti-migratory and anti-invasive activities against MDA-MB-231 breast cancer and HT-1080 fibrosarcoma cancer cells. Cancer cell migration and invasion were measured using multi-well chambers. Additionally, western blots were used to examine the effects of ketotifen on the expressions of CDC42, Rho, Rac, and matrix metalloproteinase 9 (MMP-9). The results showed that ketotifen dose-dependently suppressed the migration and invasion of MDA-MB-231 and HT-1080 cells. Ketotifen also suppressed the expressions of CDC42, Rac, and Rho, which, significantly, are involved in MDA-MB-231 and HT-1080 cancer cell migration. Moreover, ketotifen suppressed the expression and activity of MMP-9, which is involved in degradation of the extracellular matrix leading to invasion. The overall data suggested that ketotifen suppresses the migration and invasion of MDA-MB-231 and HT-1080 cancer cells via inhibition of CDC42, Rac, Rho, and MMP-9 expression.

• The Journal of Asian Finance, Economics and Business
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• 제9권1호
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• pp.63-71
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• 2022

To investigate the short-run effects of social capital on migration decisions of individuals in the rural areas of Vietnam, we conducted dataset mining and performed regression model analysis in the form of panel data. As control variables, we employed the variable of social capital, which is measured by an individual's network, as well as demographic characteristics of individuals and households. We discovered that when a household is in financial distress, social networks such as linkages or asking for aid from others often enhance individual capacity. Individuals with a large social network outside of their immediate area are more inclined to relocate to the location where their connectors live. Individual participation and degree of participation in the organizational community, on the other hand, have little bearing on the likelihood of migration. In addition, this research examines theories and empirical research on the relationship between social capital and migration. Based on our research findings, we have recommended some measures to boost the efficiency of social capital and migration in rural areas of Vietnam through local government solutions.

• 대한지리학회지
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• 제43권6호
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• pp.894-913
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• 2008

본 연구는 페미니스트 이주연구의 화두인 '이주의 여성화' 에 내포된 스케일 이슈를 각종 문헌을 통해 분석하였다. 젠더선별적인 접근을 필요로 하는 페미니스트 이주연구는 거시적 스케일에서 뿐만 아니라 미시적 스케일에서 형성되는 젠더관계와 다양한 스케일에서의 과정이 상호 접목되는 양상을 분석할 것을 요구한다. 기존의 이주연구가 국가별 수준에서, 젠더요인에 대한 피상적 고려에 그친 것을 비판하면서, 페미니스트 접근은 지구적인 노동의 성별분업, 초국가적 가족연계망, 이주여성의 몸과 가정을 통해 이루어지는 재생산을 통해 역동적으로 재구성되는 젠더관계를 주요 연구주제로 상정한다. 최근 국제거 주요 주체로 부상하고 있는 이주여성은 국경과 공적 사적 영역을 넘나들며 근대적 젠더관계와 그 경계를 교란하고 있다. 이들의 경계넘기의 젠더정치학은 다양한 스케일의 창출을 수반하는 스케일의 정치로 이해될 수 있다. 특히 개인의 증대된 에이전시와 가족관계망의 초국가적 확장을 통한 국제이주의 증가는 이주여성들에 의한 초국가적 스케일의 생성인 동시에 아래로부터의 세계화의 전형을 보여준다. 본 연구는 페미니스트 이주 문헌에서 나타나는 스케일에 대한 오해를 시정하고 페미니스트 지리학의 연구 성과를 접목하여 양 학문분야의 의사소통을 증진하고자 한다.

• 국제지역연구
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• 제21권4호
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• pp.125-139
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• 2017

본 연구는 미얀마의 지역 간 인구이동의 결정요인과 패턴을 분석한다. 인구이동은 경제적 요인과 사회적 요인뿐만 아니라 지역적 특성 등 다양한 요인에 의해 영향을 받는다. 소득과 취업 그리고 사회간접자본과 같은 요소에 의해 영향을 받는다. 따라서 본 연구는 다음의 두 가지 연구문제를 분석하려고 한다. 첫째로, 미얀마의 개혁과 개방으로 농촌에서 도시로의 인구이동이 일어나고 있는 지 분석하려고 한다. 미얀마에서도 다른 개도국들이 경험했던 인구이동의 패턴이 발생하는 지를 검증하려고 한다. 둘째로, 미얀마의 인구이동에 사회간접자본이 미치는 영향을 분석한다. 도로, 전기, 수도 등 기본적 사회간접자본이 인구이동에 미치는 영향을 분석한다. 이는 지역 균형 발전을 위한 사회간접자본의 투자 정책 결정에 시사점을 줄 것이다. 분석결과 첫째로, 미얀마의 인구이동 패턴은 다른 개도국이 경험한 것과 같이 농촌에서 도시지역으로의 인구이동이 일어나고 있다. 미얀마의 도시지역인 양곤과 만달레이 지역으로 인구이동이 이루어지고 있는 것으로 분석되었다. 둘째로 도로를 비롯한 사회간접자본은 인구를 흡입하는 능력이 있는 것으로 분석되었다. 셋째로, 취업기회는 미얀마 인구이동에 가장 큰 영향을 미치는 것으로 분석되었다. 경제개발 초기 단계이지만 해외 자본이 들어오고 있는 상황에서 취업의 기회가 높은 지역으로 인구가 이동하는 것으로 분석되었다. 이는 해외자본을 통해서 경제개발이 이루어지고 있는 상황에서 해외자본의 유입의 방향과 지역의 발전의 불균형 정도가 결정될 것으로 분석된다.

• International Journal of Stem Cells
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• 제16권2호
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• pp.180-190
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• 2023

Background and Objectives: Regenerative endodontic procedures (REPs) are a research hotspot in the endodontic field. One of the biggest problems of REPs is that it is difficult to realize regeneration of pulp-dentin complex and functional reconstruction. The reason is still not clear. We hypothesize that the migration may be different in different dental stem cells. Periodontal ligament stem cells (PDLSCs) may migrate faster than stem cells of apical papilla (SCAPs), differentiating into cementum-like tissue, bone-like tissue and periodontal ligament-like tissue and, finally affecting the outcomes of REPs. Hence, this study aimed to explore the mechanism that regulates the migration of PDLSCs. Methods and Results: After isolating and culturing PDLSCs and SCAPs from human third molars, we compared the migration of PDLSCs and SCAPs. Then we investigated the role of SDF-1𝛼-CXCR4/CXCR7 axis in PDLSC migration. We further investigated the impact of Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide (LPS) on PDLSC migration and the potential mechanism. PDLSCs showed better migration under both noninflammatory and inflammatory conditions than SCAPs. SDF-1𝛼 can promote the migration of PDLSCs by elevating the expression of CXCR4 and CXCR7, increasing the interaction between them, promoting expression of 𝛽-arrestin1 and activating the ERK signaling pathway. P. gingivalis LPS can promote the migration of PDLSCs toward SDF-1𝛼 through increasing the expression of CXCR4 via the NF-𝜅B signaling pathway, promoting the expression of 𝛽-arrestin1, and activating the ERK signaling pathway. Conclusions: This study helped elucidate the potential reason for the difficulty in forming pulp-dentin complex.

• 인터넷정보학회논문지
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• 제21권4호
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• pp.1-8
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• 2020

5G 목표 중 하나인 초신뢰성 저지연 통신에 도달하기 위해 멀티액세스 엣지 컴퓨팅 패러다임이 탄생했다. 이 패러다임은 클라우드 컴퓨팅 기술을 네트워크 엣지에 더 가깝게 하며 서비스 지연 시간을 줄이기 위해서는 네트워크 엣지에 있는 여러 Edge Cloud에서 서비스 호스팅된다. 모바일 사용자의 경우 서비스 품질 유지를 위해 서비스를 가장 적합한 Edge Cloud로 마이그레이션하는 것은 중요하고 고이동성 시나리오에서는 서비스 마이그레이션 문제가 더욱 복잡해진다. 고정 이동 경로에서 사용자 이동성과 Edge Cloud 선택에 대한 어떤 영향을 미치는 건지 관찰하는 것이 이 연구의 목표다. Mobility-Aware Service Migration (MASM)은 고이동성 시나리오 동안 라우팅 비용과 서비스 마이그레이션 비용이라는 두 가지 주요 매개변수를 기반으로 서비스 마이그레이션을 최적화하기 위해 제안된다. 제안된 알고리즘을 기존의 그리디 알고리즘과 비교하여 평가한다.