• 한국정보시스템학회지:정보시스템연구
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• 제30권4호
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• pp.43-69
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• 2021

Purpose Although companies occupied the network market take the advantageous position first and can be successful in securing users over a certain size, it is important to satisfy the customers' demand and prevent the outflow of users toward a new alternative SNS. What is more, there are frequent changes in the flow of users toward new SNSs. Despite these dynamic market circumstances, there is a lack of research to explain the switching behaviors of SNS users. Design/methodology/approach The objective of this study is to explain and verify a specified migration theory(Push-Pull-Mooring model) focused on SNS fatigue in the psychological point of view, as well as reviewing previous studies on functional and technical characteristics of SNSs themselves. Moreover, this study tried to highlight factors affecting users actual SNS switch rather than their switching intention. Findings According to the statistical analysis, the most influenced pull factor to switch SNS was the alternative attractiveness. On the other hand, undesired relationship burden, service innovation and important mooring factors to prevent users' SNS switch. This study has a significant contribution to the theory, which analyzed users' actual SNS switch, and examined SNS users' psychological factors(SNS fatigue), reviewing the characteristics of existing services. To secure more users and to keep them, companies providing social network service need to develop differentiated strategies by analyzing psychological characteristics of various users.

• 한국환경과학회:학술대회논문집
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• 한국환경과학회 2020년도 정기학술대회 발표논문집
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• pp.221-221
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• 2020

Curcumin, a hydrophobic polyphenol derived from turmeric, has been used a food additive and as a herbal medicine for the treatment of various diseases. In the present study, we found the functional role of a nanosphere loaded with curcumin (CN) in the promotion of the motility of human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) during the wound closure. We found that the efficacy of hUCB-MSCs migration induced by CN was 1000-fold higher than that of curcumin powder. CN significantly increased the motility of hUCB-MSCs by activating c-Src, which is responsible for the phosphorylation of protein kinase C (PKC) and extracellular signal-regulated kinase (ERK). CN induced the expression levels of α-actinin-1, profilin-1 and filamentous-actin, as regulated by the phosphorylation of nuclear factor-kappa B during its promotion of cell migration. In a mouse skin excisional wound model, we found that transplantation of UCB-MSCs pre-treated with CN enhances wound closure, granulation, and re-epithelialization at mouse skin wound sites. These results indicate that CN is a functional agent that promotes the mobilization of UCB-MSCs for cutaneous wound repair.

• 대한약침학회지
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• 제26권4호
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• pp.357-365
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• 2023

Objectives: Since stroke is a serious health issue, novel therapeutic strategies are required. In a mouse model of ischemic stroke, this study analyzed the potential of electroacupuncture (EA) and tenuigenin (TE) to improve the efficacy of human mesenchymal stem cell (hMSC) transplantation. Methods: Middle cerebral artery occlusion (MCAO) with reperfusion was used to generate ischemic stroke. Forty-eight male C57BL/6 mice were randomly divided into five groups: control, MCAO-operated, MCAO-EA, MCAO-TE, or MCAO + EA + TE. Subsequently, hMSCs were transplanted into the ischemic region and EA, TE, or the combination was administered. Behavior assessments and immunohistochemistry were conducted to evaluate motor and cognitive recovery and hMSCs survival, migration, and differentiation. Results: The combined treatment of EA and TE exhibited enhanced hMSCs survival, migration and differentiation into neural cell lineages while suppressing astrocyte formation. Immunohistochemistry demonstrated increased neurogenesis through hMSCs transplantation in the ischemic brain. Immediate behavioral improvements were not significantly different between groups, but there was a gradual recovery in motor and cognitive function over time. Conclusion: These findings highlight the potential of EA and TE co-treatment as a therapeutic strategy for ischemic stroke, opening avenues for further research to optimize treatment protocols and elucidate underlying mechanisms.

• 지구물리와물리탐사
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• 제5권3호
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• pp.178-184
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• 2002

탄성파굴절법 탐사는 절차가 단순하고 경제적이기 때문에 대형 구조물 건설을 위한 지반조사나 지질조사에 널리 이용되고 있다. 본 연구에서는 굴절법 탐사자료에 Kirchhoff 구조보정 방법을 적용하여 다양한 모형자료의 반응을 알아보고, 이에 대한 결과를 고찰하여 굴절법 탐사 자료를 이용한 지하 경계면 영상화 기법의 적용성을 파악해보고자 하였다. 모형반응 계산에 필요한 인공주시곡선의 작성에는 Vidale(1988)이 제시한 알고리즘을 사용하였고, 모형에 따른 반응을 살펴보기 위해 2층, 3층 모형 및 불규칙한 지표면을 가지는 모형 등에 대해 다양하게 살펴보았다. 구조보정을 위한 초기 속도 모형으로는 실제 구조와 같은 모형, 토모그래피에 의한 역산 단면, 실제 구조를 평활화한 모형 등을 사용해 초기 속도 모형이 달라질 때 결과에 어떤 영향을 미치는가 살펴보았다. 각각의 모형에 본 연구에 사용된 기법을 적용해 본 결과 반사법 구조보정에 비해 초기 속도 모형에 더욱 민감하다는 것을 확인할 수 있었으며, 현장 자료에 적용되기 위해서는 적절한 초기속도모형을 결정해야 할 것임을 알 수 있었다.

• 한국수자원학회논문집
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• 제50권5호
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• pp.315-324
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• 2017

2014년 8월 25일 집중호우시 효암천 상류지역의 도심과 농경지 등에 큰 침수피해가 발생하였다. 이 지역은 고리원전 부지조성을 위해 하구부의 하천이설과 주변지역에 대한 성토 등 대규모 개발사업이 이루어진 곳이다. 본 연구에서는 이러한 개발이 홍수시 침수피해의 원인이 되었는지를 알아보기 위해 HEC-GeoRAS 모형을 이용하여 개발사업 전 후에 대한 효암천 유역의 침수심과 침수면적의 변화를 조사하였다. 분석결과, HEC-GeoRAS 모형은 농경지 등 지형변화 및 표고차가 작은 하천유역에 대해서도 홍수시 침수심과 침수면적의 변화를 비교적 정확하게 산정할 수 있는 것으로 확인되었다. 침수심은 개발사업의 영향으로 2014년 8월 집중호우시 0.99 m가 상승하였고, 100년빈도 홍수시에는 0.39 m가 상승하는 것으로 나타났다. 침수면적은 100년빈도 훙수시 침수심 1.5 m 이하에서는 감소하였으나 침수심 4.5 m 이상에서는 오히려 증가하는 것으로 나타났다. 결론적으로, 하천이설과 개발사업으로 인해 하구부의 농경지와 저지대의 자연저유기능이 상실된 것이 2014년 8월 집중호우시 홍수발생의 주된 원인이 되었으며, 하천이설에 따라 신설된 하천단면의 총 하폭은 크게 증가하였으나 실질적인 유효하폭은 오히려 축소되어 통수단면적이 감소되었던 것이 침수피해를 가중시킨 것으로 나타났다. 추후 하천이설이나 주변지역에 대한 성토 등 개발행위시에는 기존의 저유기능이 충분히 고려된 하천개수계획이 필요한 것으로 판단된다.

• Nutritional Sciences
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• 제7권3호
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• pp.144-150
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• 2004

We have investigated the effect of calcium spirulan(Ca-SP) isolated from a blue-green alga Spirulina platensis, which is a sulfated polysaccharide chelating calcium and mainly composed of rhamnose and fructose, on invasion of both B16- BL6 melanoma cells, Colon 26 carcinoma and HT-1080 fibrosarcoma cells through reconstituted basement membrane (Matrigel). Ca-SP significantly inhibited the invasion of these tumor cells through Matrigel/fibronectin-coated filters in a concentration-dependent manner. Ca-SP also inhibited the haptotactic migration of tumor cells to laminin, but it had no inhibitory effect on tumor cell migration to fibronectin-coated filters. Ca-SP prevented the adhesion of B16-BL6 cells to Matrigel- and laminin-substrates but did not affect the adhesion to fibronectin. The pretreatment of tumor cells with Ca-SP inhibited the adhesion to laminin in a concentration-dependent fashion, while the pretreatment of laminin-substrates did not. Ca-SP had no effect on the production and activation of type IV collagenase in gelatin zymography. In contraset, Ca-SP significantly inhibited degradation of heparan sulfate by purified heparanase. The experimental lung metastasis was significantly reduced by co-injection of B16-BL6 cells with Ca-SP in a dose-dependent manner. Seven intermittent ⅰ.ⅴ. injection of 100$\mu\textrm{g}$ of Ca-SP caused a marked decrease of lung tumor colonization of B16-BL6 cells in a spontaneous lung metastasis model. These results suggest that Ca-SP, a novel sulfated polysaccharide, could reduce the lung colonization of B16-BL6 melanoma cells in experimental metastasis model, by inhibiting the tumor invasion of basement membrane Matrigel, probably through the prevention of the adhesion and migration of tumor cells to laminin-substrate and of the heparanase activity.

• Journal of Ginseng Research
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• 제47권1호
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• pp.133-143
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• 2023

Background: Past studies suggested that ginseng extracts and ginseng-derived molecules exerted significant regulatory effects on skin. However, no reports have described the effects of ginseng-derived nanoparticles (GDNPs) on skin cell proliferation and wound healing. In this study, we investigated whether GDNPs regulate the proliferation of skin cells and promote wound healing in a mouse model. Methods: GDNPs were separated and purified via differential centrifugation and sucrose/D2O gradient ultracentrifugation. GDNP uptake, cell proliferation and cell cycle progression were measured by confocal microscopy, CCK-8 assay and flow cytometry, respectively. Cell migration and angiogenic effects were assessed by the wound scratch assay and tube formation assay, respectively. ELISA was used to detect extracellular matrix secretion. The relevant signaling pathway was confirmed by western blotting. The effects of GDNPs on skin wound healing were assessed by wound observation, HE staining, and western blotting. Results: GDNPs possessed the essential features of exosomes, and they were accumulated by skin cells. Treatment with GDNPs notably enhanced the proliferation of HaCaT, BJ and HUVECs. GDNPs also enhanced the migration in HaCaT cells and HUVECs and angiogenesis in HUVECs. GDNPs increased the secretion of MMP-1, fibronectin-1, elastin-1, and COL1A1 in all three cell lines. GDNPs regulated cell proliferation through the ERK and AKT/ mTOR pathways. Furthermore, GDNPs facilitated skin wound healing and decreased inflammation in a mouse skin wound model. Conclusion: GDNPs can promote skin wound healing through the ERK and AKT/mTOR pathways. GDNPs thus represent an alternative treatment for chronic skin wounds.

• 한국지역지리학회지
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• 제11권4호
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• pp.523-535
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• 2005

이 연구는 학습자들의 일상적인 생활 속에서 얻는 지리적 경험에 기초한 생활중심 교수학습의 모형 설계와 적용 가능성을 살펴보려고 한다. 생활중심 교수학습 모형의 효과를 실증적으로 검증하기 위하여 실험집단과 비교집단을 비교하여 수행하였다. 교수학습의 실제사례로 고등학교 2학년의 '인구이동과 인구변화'의 단원을 선정하였다. 실험 수업대상으로는 강원도 춘천시 C고등학교 2학년을 대상으로 하며 생활중심 교수학습 모형을 적용한 실험집단 2개 반과 적용하지 않은 비교집단 2개 반 모두 4개반의 122명이 선정되었다. 연구 결과는 다음과 같다. 첫째, 교사가 교수할 개념들을 체계화된 지식 구조로 교수하지 않을 경우 이에 대한 학습자의 인지구조 재구성은 보다 활발하게 이루어 질 수 없기 때문에, 고등학교 한국지리의 '인구이동과 인구변화' 단원의 지리개념은 상위개념인 이동에서, 기본개념인 이주, 하위개념인 이주 요인으로 위계화하고 학생들이 경험할 수 있는 일상적 지리경험을 알아보았다. 둘째, 지리과 생활 중심 교수학습 내용의 실제 사례로 학생 자신의 가족 이주사 및 가족수의 변화를 조사하는 과제학습지를 기초적 자료로 활용하였다. 셋째, 이 연구에서 개발한 수업모형은 암기식 수업보다 학업성취도 측면에서 효과가 더 높게 나타났다. 수업반응도 검사를 분석한 결과, 정의적인 측면에서는 수업의 흥미도, 만족도 수업내용의 활용성에서는 긍정적인 효과가 나타났다. 특히 이러한 수업모형에 의한 학습이 학생들의 흥미를 유발시킬 수 있다는 것을 알 수 있다. 그러나 지리적 탐구력 신장에는 도움이 되지 않았다.

• 한국지하수토양환경학회지:지하수토양환경
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• 제27권spc호
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• pp.75-91
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• 2022

Differences in subsurface migration of LNAPL/DNAPL contaminants caused by a selection of 3-phase (aqueous, NAPL, and gas) relative permeability function (RPF) models in numerical modeling were investigated. Several types of RPF models developed from both experimental and theoretical backgrounds were introduced prior to conducting numerical modeling. Among the RPF models, two representative models (Stone I and Parker model) were employed to simulate subsurface LNAPLs/DNAPLs migration through numerical calculation. For each model, the spatiotemporal distribution of individual phases and the mole fractions of 6 NAPL components (4 LNAPL and 2 DNAPL components) were calculated through a multi-phase and multi-component numerical simulator. The simulation results indicated that both spilled LNAPLs and DNAPLs in the unsaturated zone migrated faster and reached the groundwater table sooner for Stone I model than Parker model while LNAPLs migrated faster on the groundwater table under Parker model. This results signified the crucial effect of 3-phase relative permeability on the prediction of NAPL contamination and suggested that RPF models should be carefully selected based on adequate verification processes for proper implementation of numerical models.

• Archives of Plastic Surgery
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• 제51권2호
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• pp.163-168
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• 2024

Background The study determined to compare the clinical outcomes of traditional gold weight implantation for the correction of paralytic lagophthalmos with those of a newly designed model. Methods In this retrospective cohort study, we enrolled 30 patients (76% females; average age 60.8 ± 12 years) with facial palsy who underwent implantation of either the traditional pretarsal gold weight (PT group; n = 15) or a new supratarsal model (ST group; n = 15) from May 2014 to April 2019. The main outcome measures were the 12-month postoperative weight prominence, weight migration, improvement of lagophthalmos, upper eyelid contour, and upper eyelid ptosis. The secondary outcome was long-term (24 months) reoperative rate. Results The new model group had significantly better eyelid contour (risk ratio [RR] 3.16, 95% confidence interval [CI] 1.62-6.15, p = 0.001), less weight prominence (RR 1.74, 95% CI 1.13-2.70, p = 0.013), less weight migration (RR 1.31, 95% CI 1.12-1.54, p = 0.001), and less eyelid ptosis (RR 2.36, 95% CI 1.21-4.59, p = 0.011) than the traditional model group. Improvement of lagophthalmos was not statistically significant between the two groups (RR 1.44, 95% CI 0.72-2.91, p = 0.303). The 24-month reoperative rate was 53.3% in the PT group versus 13.3% in the ST group (RR 2.00, 95% CI 1.15-3.49, p = 0.015). Conclusion The newly designed supratarsal gold weight showed superior postoperative outcomes than the standard traditional model.