• 제목/요약/키워드: migraine

검색결과 179건 처리시간 0.024초

The Effects of Coenzyme Q10 Supplementation on Oxidative Status and Lipid Profile in Migraine Patients: A Randomized Double-Blinded Controlled Clinical Trial

  • Monireh Dahri;Atefeh Sarafan Sadeghi;Naseh Pahlavani;Elyas Nattagh-Eshtivani;Mazyar Hashemilar;Mohammad Asghari-Jafarabadi;Hanieh Barghchi;Ali Tarighat-Esfanjani
    • Clinical Nutrition Research
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    • 제12권4호
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    • pp.257-268
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    • 2023
  • Migraine is a common neurological disease correlated with oxidative stress and lipid profile disorders. The present study was designed to determine the effects of Coenzyme Q10 (Co-Q10) supplementation on oxidative status and lipid profile in migraine individuals. This clinical trial was conducted on 84 females aged 18-50 years, diagnosed for episodic migraine according to the International Headache Society. Subjects were randomized to receive either Co-Q10 supplement (400 mg/day) or placebo for 12 weeks. Lipid profile and oxidative stress indices including malondialdehyde (MDA) and total antioxidant capacity (TAC) were measured before and after intervention in both groups. Also, anthropometric indices, dietary intakes, and clinical features were collected. Data analysis was conducted using SPSS version 16. Seventy-seven of the participants, with mean age of 33.70 ± 7.75 years, completed the study. After 12-week intervention, Co-Q10 led to a significant decrease in MDA levels compared to placebo (p = 0.009), with no effect on TAC levels (p = 0.106). A significant increase in serum Co-Q10 concentration and high-density lipoprotein cholesterol (HDL-C) level in Co-Q10 group was observed, but no significant differences were found in other lipid profile variables (low-density lipoprotein cholesterol, triglycerides and total cholesterol). Among anthropometric variables, Co-Q10 only caused a significant reduction in body fat percentage (BFP), but we did not find any significant changes in others. A 12-week Co-Q10 supplementation led to significant improvement in clinical features, BFP, and HDL-C level among migraine individuals.

Intravenous caffeine citrate vs. magnesium sulfate for reducing pain in patients with acute migraine headache; a prospective quasi-experimental study

  • Baratloo, Alireza;Mirbaha, Sahar;Kasmaei, Hossein Delavar;Payandemehr, Pooya;Elmaraezy, Ahmed;Negida, Ahmed
    • The Korean Journal of Pain
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    • 제30권3호
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    • pp.176-182
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    • 2017
  • Background: Current evidence suggests that intravenous magnesium sulfate might be effective for reducing migraine pain. In a recent pilot study, we showed that intravenous caffeine citrate could reduce the severity of migraine headache. The objective of this study is to investigate the efficacy of intravenous caffeine citrate vs. magnesium sulfate for management of acute migraine headache. Methods: We conducted a prospective quasi-experimental study from January until May 2016 in two educational medical centers of Shahid Beheshti University of Medical Sciences (Shoahadaye Tajrish Hospital and Imam Hossein Hospital), Tehran, Iran. The study included patients who were referred to the emergency department and met the migraine diagnosis criteria of the International Headache Society. Patients were allocated into 2 groups receiving either 60 mg intravenous caffeine or 2 g intravenous magnesium sulfate. The pain scores, based on the visual analog scale, were recorded on admission, as well as one and two hours after receiving the drug. A Chi-Square test and student t-test were used for analysis of baseline characteristics. A Mann-Whitney U test and Wilcoxon singed rank test were used to analyze differences in the visual analogue scale (VAS) score between and within the groups respectively. Results: In total, 70 patients (35 patients in each group) with the mean age of $33.1{\pm}11.3years$ were included (64.3% female). For the Caffeine citrate group, the median pain score decreased from 9.0 (2.0) to 5.0 (4.0) after one hour and to 3.0 (4.0) after two hours. For the magnesium sulfate group, the pain score decreased from 8.0 (2.0) to 2.0 (2.0) after one hour and to 0.0 (1.0) after two hours. Both intravenous caffeine citrate and intravenous magnesium sulfate reduced pain scores significantly but the magnesium sulfate group showed more improvement than the Caffeine citrate group after one hour (P < 0.001) and after two hours (P < 0.001). Conclusions: It is likely that both intravenous caffeine and intravenous magnesium sulfate can reduce the severity of migraine headache. Moreover, intravenous magnesium sulfate at a dose of 2 g might be superior to intravenous caffeine citrate 60 mg for the short term management of migraine headache in emergency departments.

두풍(頭風)과 편두통(Migraine)에 대(對)한 동서의학적(東西醫學的) 문헌고찰(文獻考察) (The biblographical study on $T{\acute{o}}u\;f{\bar{e}}ng$ and Migraine -(Comparative study between Oriental and Western Medicine)-)

  • 오소조;정지천;이원철
    • 대한한방내과학회지
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    • 제14권1호
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    • pp.129-138
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    • 1993
  • This report on the $T{\acute{o}}u\;f{\bar{e}}ng$ and Migraine comes to conclude, through the study of the Oriental- Western medical references, as follow; 1. First, $T{\acute{o}}u\;f{\bar{e}}ng$ and Migraine had some concurrencies that both the two symptoms have appeared severe and recurrent headache and more often to the female. 2 Many of them e.g. Sensory disturbance, Vertigo, Nausea, Vomiting, Tinnitus etc. in the prodrome and main symptom of $T{\acute{o}}u\;f{\bar{e}}ng$ and Migraine were identical, especially the symptom of the $f{\bar{e}}ng\;t{\acute{a}}n\;t{\acute{o}}u\;t{\grave{o}}ng$ was similar to the prodrome of the Migraine. We could find out the semilarity of the symptoms through that Migraine is proximately set in unilateral, and $Pi{\bar{a}}nT{\acute{o}}u\;f{\bar{e}}ng$ is so called alias $B{\grave{a}}n\;bi{\bar{a}}n\;t{\acute{o}}u\;t{\grave{o}}ng$. 3. The pathogeny of $T{\acute{o}}u\;f{\bar{e}}ng$ include the case of ‘$f{\bar{e}}ng\;xi{\acute{e}}\;r{\grave{u}}\;n{\bar{a}}o$’, the patient feeling weak condition, $T{\acute{a}}n,\;T{\acute{a}}nshi,\;T{\acute{a}}nhu{\breve{o}},\;Y{\grave{u}}q{\grave{i}}$, etc. and, ‘$t{\acute{a}}n\;zhu{\grave{o}}\;sh{\grave{a}}ng\;y{\acute{a}}o$’, ‘$G{\bar{a}}n\;y{\acute{a}}ng\;hu{\grave{a}}\;f{\bar{e}}ng$’. There were variable that $F{\bar{e}}ng,\;Xu{\grave{e}},\;F{\bar{e}}ngr{\grave{a}},\;F{\bar{e}}ngx{\bar{u}},\;Xu{\grave{e}}x{\bar{u}},\;Hu{\check{o}}$ in the left, and $t{\acute{a}}n,\;R{\grave{e}},\;t{\acute{a}}nr{\grave{e}},\;Qir{\acute{a}}$ in the right partial pathogeny. It was referred $Sh{\grave{a}}o\;y{\acute{a}}ng\;j{\bar{i}}ng$, $Ju{\acute{e}}\;y{\bar{i}}n\;j{\bar{i}}ng$, $Y{\acute{a}}ng\;m{\acute{i}}ng\;j{\bar{i}}ng$, $T{\grave{a}}i\;y{\acute{a}}ng\;j{\bar{i}}ng$ in connection with the Meridian system. And otherwise the primary cause of Migraine is still unknown to us. Heredity is probably important, but the mode of transmission is uncertain. Recently, the important assumption is the vasomotor change caused by vasoconstrictors like that norepinephrine, epinephrine, and serotonin etc.

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경부 경막외 블록에 의한 편두통의 완화 경험 -증례 보고- (Improvement of Migraine by Cervical Epidural Block -A case report-)

  • 김기석;이우용;우승훈;홍기혁
    • The Korean Journal of Pain
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    • 제18권1호
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    • pp.64-68
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    • 2005
  • Migraine is a disabling headache that can occur with or without aura. We present here a case of migraine that was effectively managed by a series of cervical epidural blocks. A 41-year-old woman who had suffered from severe headache on her left temporal area for 12 years visited our pain clinic. Her 11-point numeric pain rating scale was 10 out of 10 at the first visit and the symptoms were associated with homonymous visual disturbances, paresthesia on the left face, shoulder and arm, and general weakness. For the first 5 years after the headaches began, her headache was relatively well controlled by acetaminophen; after then, the acetaminophen wasn't effective. After wandering from this hospital to the next one in search of relief, she managed to visit our pain clinic. We tried several blocks including cervical epidural block, and she was continuously medicated with sumatriptan. Her headache was gradually relieved. Now, her 11-point numeric rating scale is 1-2 out of 10 at the most during her headache attacks.

변형편두통을 호소하는 환자 치험 1례 (A Case of Headache Patient Diagnosed as Transformed Migraine)

  • 손정화;박민정;우지명;조기호;문상관;정우상
    • 대한중풍순환신경학회지
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    • 제17권1호
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    • pp.39-44
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    • 2016
  • ■ Objectives A case of a 44 years old Korean female with left side headache due to Transformed migraine is presented. ■ Methods He was treated with electroacupuncture around eyes and dry cupping on shoulder, moxibustion, acupuncture and herbal medicine, Chai Ling Tang. Then we evaluated the improvement by Pain area comparison and Numerical Rating Scale(NRS). ■ Results Headache was improved after the administration of Korean medical treatments. ■ Conclusion Korean medical treatment may be effective in treating headache due to Transformed migraine.

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긴장성두통과 편두통의 바이오피드백 치료 (Biofeedback Treatment for Tension-Type Headache and Migraine)

  • 박주언;이계성;신상은
    • 정신신체의학
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    • 제14권1호
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    • pp.25-32
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    • 2006
  • 연구목적 : 두통은 일생 동안 90% 이상의 사람들이 경험하게 되는 임상 증후군이다. 이 논문은 긴장성두통과 편두통의 현재의 개념과 바이오피드백 치료 및 이완요법에 대해 요약하였다. 방법: Pubmed/Medline 검색에 포함된 용어는 바이오피드백(biofeedback), 이완(relaxation), 생리적(physiological), 행동적 (behavioral), 비약물의 (nonpharmacological), 두통(headache), 긴장성두통(tension-type headache), 그리고 편두통(migraine)이었다. 검색되지 않은 저술 중 적절한 논문과 바이오피드백을 수행하는 전문가의 의견도 포함시켰다. 결과 : 두통은 바이오피드백 및 이완요법을 포함한 행동치료적 개입에 의해 치료될 수 있는 정신생리장애(psycho-physiological disorder)로 볼 수 있다. 두통에서 이러한 치료들을 통해 임상적 호전을 보인다는 보고들이 지속되고 있다. 또한, 환자에게 실제 적용 시 고려할 점도 제시하였다. 결론: 바이오피드백 치료와 이완요법은 단독 또는 약물치료와 함께 두통 환자에게 제공될 수 있는 효과적인 치료법으로 제안된다.

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주기성 구토증(cyclic vomiting syndrome)의 장기 추적 관찰 -이형 편두통(migraine variant)으로의 이행 과정인가?- (Long Term Follow-Up of Cyclic Vomiting Syndrome)

  • 황진복;오희종;최광해
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • 제3권1호
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    • pp.75-83
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    • 2000
  • 저자들은 주기성 구토증으로 진단된 3명의 소아에서 6년 이상의 장기 추적관찰을 통하여 임상양상의 다양한 변화과정을 관찰하여 보고, 뇌파검사의 이상소견을 근거로 이형 편두통의 형태로 진행하여 가는 과정을 관찰하였다. 시간의 경과에 따라 구토 발병 주기, 기간의 변화와 함께 위배출능 저하, 두통의 발현, 뇌파의 이상 등 다양한 임상 양상의 변화를 보여주며, 2례에서는 증상의 소실이 관찰되었다. 특히, 뇌파 검사상 증상 발현시 발생하는 서파는 편두통의 발생 직전에 뇌혈류의 감소로 발생하는 양상과 매우 유사하며, 주기성 구토증과 편두통의 관련성을 시사하여 주는 소견으로, 진단 및 치료적 접근시 반드시 고려하여야 한다. 주기성 구통증은 이형 편두통으로의 이행 과정인가?

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무전조성 편두통 환자에서 온열과 마사지 동시 치료의 효과: 증례보고 (Simultaneous Heat-Massage Therapy for Migraine Without Aura : A Case Report)

  • 이광재;윤용순
    • 디지털융복합연구
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    • 제18권8호
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    • pp.505-509
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    • 2020
  • 편두통은 중등도 내지 중증의 두통이 재발하는 것을 특징으로 하는 두통 장애이다. 진단은 임상 징후 및 증상을 기반으로 하며, 약물 치료, 물리 치료, 신경 차단 및 신경 자극이 치료에 적용될 수 있다. 이 보고서는 59세 여성의 심각한 무전조성 편두통 사례에 대한 것이다. 환자는 정기적으로 두통이 14년 이상 지속되었으며, 약과 신경 차단제를 복용했지만 심한 통증 (VAS 7)이 지속되어 왔다. 우리는 척주 온열 마사지 기기(CGM MB-1401)를 편두통 환자에게 6주간 주 3회씩 40분간 처치하였다. 최초 4주간의 자동모드에서는 통증척도에 변화가 없었다. 이후 경추부 반자동 모드를 2주간 처치하여 통증척도가 완화되었으며, 두 달 동안 통증이 없는 상태로 유지되었음을 확인하였다. 본 사례는 무전조성 편두통을 관리하기 위해 척주 온열 마사지기 적용을 고려할 수 있음을 강조한다.

전침을 활용한 안검하수와 안구운동마비를 동반한 편두통환자의 치험 1례 (A Clinical Study on the Case of Ophthalmoplegic Migraine Treated with Electroacupuncture)

  • 유윤선;노동진;박장호;이고은;박인숙;강형원;류영수
    • 동의신경정신과학회지
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    • 제22권4호
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    • pp.135-142
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    • 2011
  • Objectives : The purpose of this case was to investigate the effectiveness of electroacupuncture for ophthamoplegic migraine. Methods : We provided electroacupuncture therapy and prescribed oriental medicine, Joganiknoe-tang daily. We measured patient's pain by VAS(Visual Analogue Scale) and eye movement with a ruler every five days. Results & Conclusions : Any patient who has a headache with paresis of the extraocular muscle should be considered for ophthalmoplegic migraine. To diagnose ophthalmoplegic migraine, family history, past medical history, associated symptoms and signs, neurologic examinations and neuroimaging tests are needed. The symptoms of patient improved gradually within 26days from the first day of admission, and we can see her complete recovery.

Giant Arachnoid Granulations in Headache Mimicking Migraine with Aura

  • Park, Jung E;Lee, Eun-ja
    • Investigative Magnetic Resonance Imaging
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    • 제21권3호
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    • pp.192-194
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    • 2017
  • Giant arachnoid granulations have been reported to be associated with headaches, which can be acute or chronic in presentation. In some cases, idiopathic intracranial hypertension, previously called pseudotumor cerebri, may occur. The pathophysiology of these enlarged structures seen as filling defects on imaging is not clearly defined, although they are presumed to cause symptoms such as headache via pressure resulting from secondary venous sinus obstruction. We present a unique presentation of secondary headache in a 39-year-old man with no prior history of headaches found to have giant arachnoid granulations, presenting as migraine with aura.