• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2003년도 생물공학의 동향(XIII)
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• pp.717-720
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• 2003

A chromogenic biosensor employing microfluidics on a chip has been developed for the determination of high-density lipoprotein (HDL) cholesterol (HDL-C) in human serum. We have investigated a plain and effective method to immobilize enzymes within the microchip without chemically modifying micro-channel or technically micro-fabricating column reactor and fluid channel network. In assessing risk factors of coronary heart disease, a micro-chip system would minimize requirements of instrument and reagent handling.

• 한국정밀공학회지
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• 제23권1호
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• pp.32-40
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• 2006

• 대한화학회지
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• 제59권1호
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• pp.88-92
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• 2015

• 한국지반신소재학회논문집
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• 제14권1호
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• pp.23-32
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• 2015

본 연구에서는 지반 내 오염원제거와 저투수성 지반의 개량이 동시에 이루어 질 수 있는 연직배수시스템의 최적화 기술을 마련하기 위하여, 중금속 오염물질을 대상으로 미세유체 흐름실험을 수행하였으며, 그 결과를 바탕으로 pH조건에 따른 흐름특성을 분석하였다. 중금속 오염물에 대한 미세유체 흐름실험 결과, 소수성 성질이 반영되는 위치가 오염물의 흐름속도에 큰 영향을 미치는 것으로 분석되었으며, pH 조건이 흐름속도 변화에 영향인자로 작용하였다. 또한 복합 중금속 오염물인 경우에 pH가 염기성일수록 납의 흐름속도가 다소 증가하는 경향으로 나타났는데, 이는 납 오염물이 구리에 비하여 소수성 표면특성을 감소시킬 수 있음을 의미하는 결과라 할 수 있다.

• Nuclear Engineering and Technology
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• 제51권1호
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• pp.257-262
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• 2019

The control of microstructure is critical for the porous fuel particles used for infiltrating actinide nuclides. This study concerns the effect of heating processes on properties and microstructure of the fuel particles. The uniform gel precursor beads were synthesized by a microfluidic sol-gel process and then the porous $CeO_2$ microspheres, as a surrogate for the ceramic nuclear fuel particles, were obtained by heating treatment of the gel precursors. The fabricated $CeO_2$ microspheres have a narrow size distribution and good sphericity due to the feature of microfluidics. The effects of heating processes parameters, such as heating mode and peak temperatures on the properties of microspheres were studied in detail. An optimized heating mode and the peak temperature of $650^{\circ}C$ were selected to produce porous $CeO_2$ microspheres. The optimized heating mode can avoid the appearance of broken or crack microspheres in the heating process, and as-prepared porous microspheres were of suitable pore size distribution and pore volume for loading minor actinide (MA) solution by an infiltration method that is used for fabrication of MA-bearing nuclear fuel beads. After the infiltration process, $1000^{\circ}C$ was selected as the final temperature to improve the compressive strength of microspheres.

• 마이크로전자및패키징학회지
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• 제29권4호
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• pp.55-61
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• 2022

다중 암의 동시 진단 기술에 대한 관심이 전 세계적으로 증가하는 추세이며, 진단 난이도를 낮추기 위해 혈액과 같은 미량의 바이오 유체를 이용하여 질병을 진단하는 미세 유체 소자 기반의 액체 생검 기술이 연구되고 있다. 바이오 유체를 이용하여 형광 영상 등을 통해 분석물질의 농도를 측정하는 광학적 바이오 센싱에 있어 민감도를 향상시키기 위한 기술개발이 필요하다. 본 논문에서는 모세관력에 의한 자가구동 기반의 마이크로 채널의 기하학적 구조와 미세 유체 현상만으로 수동적 자기 혈장 분리 기술과 유체 혼합을 통한 분자 인식 활성화 기능을 구현하는 형광 다중 암 진단 센서 플랫폼 구조를 제안하고 설계하였다. 설계된 센서의 혈장 분리부의 성능에 영향을 미치는 파라미터를 확인하기 위해 채널의 수력학적 직경과 종횡비, 유체의 점도를 변수로 설정하여 딘 와류 형성 여부를 시뮬레이션을 통해 확인하였고 최적의 센서 플랫폼 구조를 제시하였다.

• Journal of Veterinary Science
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• 제25권3호
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• pp.40.1-40.19
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• 2024

Importance: The creation of robust maternal-embryonic interactions and implantation models is important for comprehending the early stages of embryonic development and reproductive disorders. Traditional two-dimensional (2D) cell culture systems often fail to accurately mimic the highly complex in vivo conditions. The employment of three-dimensional (3D) organoids has emerged as a promising strategy to overcome these limitations in recent years. The advancements in the field of organoid technology have opened new avenues for studying the physiology and diseases affecting female reproductive tract. Observations: This review summarizes the current strategies and advancements in the field of 3D organoids to establish maternal-embryonic interaction and implantation models for use in research and personalized medicine in assisted reproductive technology. The concepts of endometrial organoids, menstrual blood flow organoids, placental trophoblast organoids, stem cell-derived blastoids, and in vitro-generated embryo models are discussed in detail. We show the incorportaion of organoid systems and microfluidic technology to enhance tissue performance and precise management of the cellular surroundings. Conclusions and Relevance: This review provides insights into the future direction of modeling maternal-embryonic interaction research and its combination with other powerful technologies to interfere with this dialogue either by promoting or hindering it for improving fertility or methods for contraception, respectively. The merging of organoid systems with microfluidics facilitates the creation of sophisticated and functional organoid models, enhancing insights into organ development, disease mechanisms, and personalized medical investigations.

• KIEE International Transactions on Electrophysics and Applications
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• 제4C권4호
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• pp.155-159
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• 2004

This work reports the theoretical and experimental investigations of capillary bust valves to regulate liquid flow in microchannels. The theoretical analysis uses the Young-Laplace equation and geometrical considerations to predict the pressure at the edge of the valve opening. Numerical simulations are employed to calculate the meniscus shape evolution while the interface is pinned at the valve edge. Microchannels and valves are fabricated using soft lithography. A wafer-rotating system, which can adjust the driving pressure by rotational speed, induces a liquid flow. Experimentally measured valve-bursting pressure agrees with theoretical predictions.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2007년도 춘계학술대회B
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• pp.2811-2816
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• 2007

We conducted a numerical study of AC-electroosmotic (alternating current) effect on the fluid flow and mixing in a 3-D microchannel. The microchannel used as an efficient micro-mixer is composed of a channel and a series of pairs of electrodes attached in zigzag pattern on the bottom wall. The AC electric field is applied to the electrodes so that a steady flow current takes place around the electrodes. This current is flowing across the channel and thus contributing to the mixing of the fluid within the channel. We performed numerical simulations by using a commercial code to obtain a steady flow field. This steady flow is then used in evaluation of the mixing performance via the concept of mixing index. It was found that good combination of two kinds of electrode, which gave us a good mixing, is not simple harmonic. And when the length ratio of these two kinds of electrode is 2:1, we can get the best mixing effect.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2009년 추계학술대회논문집
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• pp.84-87
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• 2009

Electrowetting is a versatile tool to handle tiny droplets and forms a backbone of digital microfluidics. Numerical analysis is necessary to fully understand the dynamics of electrowetting, especially in designing electrowetting-based devices, such as liquid lenses and reflective displays. We developed a numerical method to analyze the general contact-line problems, incorporating dynamic contact angle models. The method is based on the conservative level set method to capture the interface of two fluids without loss of mass. We applied the method to the analysis of spreading process of a sessile droplet for step input voltages and oscillation of the droplet for alternating input voltages in electrowetting. The result was compared with experimental data. It is shown that contact line friction significantly affects the contact line motion and the oscillation amplitude. The pinning process of contact line was well represented by including the hysteresis effect in the contact angle models.