• Toxicological Research
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• v.14 no.4
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• pp.577-585
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• 1998

Cadmium is an important industrial and environmental pollutant and has adverse effects on cell growth and metabolism, although the mechanisms of its cellular toxicity are still unclear. This study was performed to elucidate the cytotoxic mechanism of cadmium in the viewpoint of oxidative stress and cytoskeleton alterations in WB-F344 rat liver epithelial cells. 200 $\mu\textrm{M}$ $CdCl_2$ caused a severe disassembling of microtubule and micro filament and an apparent cell retraction under an observation with fluorescence micoscope. (equation omitted)-tubulin and F-actin protein were highly thiolated at 20 min and then disappeared from 1 hour after the treatment of 200 $\mu$M CdCl$_2$in the immunoblot analysis. Intracellular GSH was decreased from 1hr to 24 hrs by 66.6 or 200 $\mu\textrm{M}$ of $CdCl_2$. Intracellular protein thiol was also decreased by 22.2, 66.6 and 200 $\mu\textrm{M}$ of $CdCl_2$ at 1 hour after its treatment. The product of lipid peroxidation (malondialdehyde) was increased from 4 hrs by 66.6 and 200$\mu\textrm{M}$ of $CdCl_2$. These data indicate that cadmium induces oxidative stress involving disassembling of microtubule and micro filament, thiolation of (equation omitted)-tubulin and actin protein, depletion of GSH and protein thiol, and increase of lipid peroxidation.

• Transactions of Materials Processing
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• v.14 no.5 s.77
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• pp.432-438
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• 2005

Among the most of manufacturing process, plastic deformation method offers a significant advantage in productivity and enable mass production with controlled quality and low cost. From the point of view, micro forming is a well suited technology in manufacturing very small metallic parts, in particular for mass production, as they are required in many industrial products. Meanwhile, Al 5083 superplastic alloy with very small grains has a great advantage in achieving micro deformation under low stress due to its relatively low strength at a specific high temperature range. This paper describes the micro formability of Al 5083 superplastic alloy and its application to die forging of micro patterns. Micro formability tests of Al 5083 superplastic alloy were carried out with the specially designed micro forging system by using V-grooved micro dies and pyramidal dies made of (100) silicon. With these dies, micro forging was conducted by varying the applied load, material temperature and forging time The micro formability of Al 5083 superplastic alloy was evaluated by comparing $R_f$ value, where $R_f\;=\;A_f/A_v$ ($A_v$ : cross-sectional area of the flowed metal, $A_v$ : cross sectional area of V-groove). The micro formability of 3 dimensional Patterns was also evaluated using Pyramidal type micro dies.

• Journal of the Korean Society for Nondestructive Testing
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• v.22 no.2
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• pp.193-197
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• 2002

The frequency dependency of the Rayleigh surface wave was investigated indirectly by measuring the angular dependency of the backward radiation of the incident ultrasonic wave in the abrasion specimens, which was explained in view of the residual stress distribution. The peak intensity of the backward radiation profile decreased and the right half width of the profile increased with an increase of the variational rate of residual stress for the scuffing specimen. The peak intensity was also affected by the surface wave scattering during the propagation around the micro-damages. The peak angle might depend on not only the amount of residual stress but also the micro-structure. The result observed in this study demonstrates the high potential of the backward radiated ultrasound as a tool for the nondestructive evaluation of the subsurface gradients of materials.

• Interaction and multiscale mechanics
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• v.2 no.3
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• pp.321-332
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• 2009

Recent development in composites containing phase-transforming particles, such as vanadium dioxide or barium titanate, reveals the overall stiffness and viscoelastic damping of the composites may be unbounded (Lakes et al. 2001, Jaglinski et al. 2007). Negative stiffness is induced from phase transformation predicted by the Landau phase transformation theory. Although this unbounded phenomenon is theoretically supported with the composite homogenization theory, detailed stress analyses of the composites are still lacking. In this work, we analyze the stress distribution of the Hashin-Shtrikman (HS) composite and its two-dimensional variant, namely a circular inclusion in a square plate, under the assumption that the Young's modulus of the inclusion is negative. Assumption of negative stiffness is a priori in the present analysis. For stress analysis, a closed form solution for the HS model and finite element solutions for the 2D composite are presented. A static loading condition is adopted to estimate the effective modulus of the composites by the ratio of stress to average strain on the loading edges. It is found that the interfacial stresses between the circular inclusion and matrix increase dramatically when the negative stiffness is so tuned that overall stiffness is unbounded. Furthermore, it is found that stress distributions in the inclusion are not uniform, contrary to Eshelby's theorem, which states, for two-phase, infinite composites, the inclusion's stress distribution is uniform when the shape of the inclusion has higher symmetry than an ellipse. The stability of the composites is discussed from the viewpoint of deterioration of perfect interface conditions due to excessive interfacial stresses.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.05a
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• pp.820-823
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• 2002

MEMS structures Generally have been fabricated using surface-machining, but the interface failure between silicon substrate and evaporated thin film frequently takes place due to difference of linear coefficient of thermal expansion. Therefore this paper studied the effect of the residual stress caused by variable external loads. This study did not analyzed accurate quantity of the residual stress but trend for the effect of residual stress. Several specimens were fabricated using other material(Al, Au and Cu) and thermal load was applied. The residual stress was measured by nano-indentation using AFM. The results showed the existence of the residual stress due to thermal load. The indentation area of the thermal loaded thin film reduced about 3.5% comparing with the virgin thin film caused by residual stress. The finite element analysis results are similar to indentation test.

• Advances in materials Research
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• v.11 no.4
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• pp.279-298
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• 2022

In this paper, the important novelty and the defining a physical phenomenon of the resent research is the development of nonlocal stress and strain parameters on the porous sandwich beam with functionally graded materials in the top and bottom face sheets.Also, various beam models including Euler-Bernoulli, Reddy and the generalized formulation of two-variable beam theories are obtained in this research. According to a nonlocal strain elasticity theory, the strain at a reference point in the body is dependent not only on the stress state at that point, but also on the stress state at all of the points throughout the body. Thus, the nonlocal stress-strain elasticity theory is defined that can be actual at micro/nano scales. It can be seen that the critical buckling load and transverse deflection of sandwich beam by considering both nonlocal stress-strain parameters is higher than the nonlocal stress parameter. On the other hands, it is noted that by considering the nonlocal stress-strain parameters simultaneously becomes the actual case.

• Structural Engineering and Mechanics
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• v.64 no.5
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• pp.527-541
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• 2017

In this work, a new hyperbolic shear deformation beam theory is proposed based on a modified couple stress theory (MCST) to investigate the bending and free vibration responses of functionally graded (FG) micro beam made of porous material. This non-classical micro-beam model introduces the material length scale coefficient which can capture the size influence. The non-classical beam model reduces to the classical beam model when the material length scale coefficient is set to zero. The mechanical material properties of the FG micro-beam are assumed to vary in the thickness direction and are estimated through the classical rule of mixture which is modified to approximate the porous material properties with even and uneven distributions of porosities phases. Effects of several important parameters such as power-law exponents, porosity distributions, porosity volume fractions, the material length scale parameter and slenderness ratios on bending and dynamic responses of FG micro-beams are investigated and discussed in detail. It is concluded that these effects play significant role in the mechanical behavior of porous FG micro-beams.

• Journal of Ocean Engineering and Technology
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• v.2 no.2
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• pp.104-111
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• 1988

This paper deals with the micro-surface-cracks behavior on the unnotched smooth specimens of Type 304 stainless steel at $593^{\circ}C$ in air under creep and creep-fatigue conditions that have 10 mim and 1 min load holding times respectively. The behaviors of the micro-surface-cracks have been visualized by means of surface replica method and optical micro-photography. The quantitative characteristics of initiation, growth and coalescence of micro-surface-cracks have been investigated by observing and measuring the crack growth behaviors. some of the important results are as follows: Main crack initiates at grain boundary in the early stage(10 to 20%)of its life time and grows through coalescence and finally leads to fracture. The distribution of micro-surface-crack length, 2a, can be plotted against the composite Weibull distribution. The growth rate of the main crack can be plotted against the stress intensity factor, crack tip opering displacement and J integral.

• Steel and Composite Structures
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• v.33 no.1
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• pp.93-109
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• 2019

In the present study, vibration analysis of double bonded micro sandwich cylindrical shells with saturated porous core and carbon/boron nitride nanotubes (CNT/BNNT) reinforced composite face sheets under multi-physical loadings based on Cooper-Naghdi theory is investigated. The material properties of the micro structure are assumed to be temperature dependent, and each of the micro-tubes is placed on the Pasternak elastic foundations, and mechanical, moisture, thermal, electrical, and magnetic forces are effective on the structural behavior. The distributions of porous materials in three distributions such as non-linear non-symmetric, nonlinear-symmetric, and uniform are considered. The relationship including electro-magneto-hydro-thermo-mechanical loadings based on modified couple stress theory is obtained and moreover the governing equations of motion using the energy method and the Hamilton's principle are derived. Also, Navier's type solution is also used to solve the governing equations of motion. The effects of various parameters such as material length scale parameter, temperature change, various distributions of nanotube, volume fraction of nanotubes, porosity and Skempton coefficients, and geometric parameters on the natural frequency of double bonded micro sandwich cylindrical shells are investigated. Increasing the porosity and the Skempton coefficients of the core in micro sandwich cylindrical shell lead to increase the natural frequency of the structure. Cylindrical shells and porous materials in the industry of filters and separators, heat exchangers and coolers are widely used and are generally accepted today.

• Structural Engineering and Mechanics
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• v.71 no.5
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• pp.485-502
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• 2019

In this research, the nonlinear static, buckling and vibration analysis of viscoelastic micro-composite beam reinforced by various distributions of boron nitrid nanotube (BNNT) with initial geometrical imperfection by modified strain gradient theory (MSGT) using finite element method (FEM) are presented. The various distributions of BNNT are considered as UD, FG-V and FG-X and also, the extended rule of mixture is used to estimate the properties of micro-composite beam. The components of stress are dependent to mechanical, electrical and thermal terms and calculated using piezoelasticity theory. Then, the kinematic equations of micro-composite beam using the displacement fields are obtained. The governing equations of motion are derived using energy method and Hamilton's principle based on MSGT. Then, using FEM, these equations are solved. Finally the effects of different parameters such as initial geometrical imperfection, various distributions of nanotube, damping coefficient, piezoelectric constant, slenderness ratio, Winkler spring constant, Pasternak shear constant, various boundary conditions and three material length scale parameters on the behavior of nonlinear static, buckling and vibration of micro-composite beam are investigated. The results indicate that with an increase in the geometrical imperfection parameter, the stiffness of micro-composite beam increases and thus the non-dimensional nonlinear frequency of the micro structure reduces gradually.