• Title/Summary/Keyword: miR-27a

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The Association between Health Behaviors and Mental Health in Middle Aged

  • Choi Mi-Kyoung
    • Korean Journal of Health Education and Promotion
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    • v.21 no.4
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    • pp.109-119
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    • 2004
  • This study was conducted to examine factors influencing mental health of middle-aged adults(N=203) in relation to sociodemographic variables, health behaviors, and social support. The survey with questionnaire was carried out for the subjects of the residents in two communities of a local city located in Gangwon-do, Korea from September 3 to 15, 2003. Data analysis procedure included stepwise multiple regression using mental health as the dependent variable, and sociodemographic variables, health behaviors, and social support as independent variables. There were significant differences in the mental health by birth place(t=-1.67, p<0.10), religion (t=2.27, p<0.05) and subjective economic status(F=2.29, p<0.10). Mental health showed significant positive correlations with both health behavior (r=0.462, p<0.001) and social support (r=0.142, p<0.05). Stepwise multiple regression analysis for mental health revealed that the most powerful predictor was health behavior(β=0.453, p<0.001). Health behavior and religion explained 24% of the variance. The results suggest the necessity of a intervention that considers the health behaviors should be included in middle-aged adults so as to promote mental health.

Clinical Application of Hydrophilic Polyurethane Foam in a Dog with Secondary Infection in the Burned Area (화상부위에 이차감염이 발생한 개에서 Hydrophilic Polyurethane Foam의 임상적 적용)

  • Kim, Se-Eun;Shim, Kyung-Mi;Bae, Chun-Sik;Choi, Seok-Hwa;Kang, Seong-Soo
    • Journal of Veterinary Clinics
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    • v.27 no.1
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    • pp.121-124
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    • 2010
  • Thermal burn occurred in the anesthetized dog as a result of using hot pack to treat hypothermia. After hospital discharge, thermal burn leaded to secondary infection due to dog bites of the other dog in the house. After secondary infection, the treatment was performed with medication and bandaging. Because of the pain and infection from the wound, carprofen (2 mg/kg bid) and amoxicillin (20 mg/kg bid) were administrated orally for 40 days. And for 35 days, wet-to-dry gauze dressing was used to absorb purulent exudate. During this period, the burn eschar was removed completely from the burn site. After 35 days, the hydrophilic polyurethane foam ($Medifoam^{(R)}$, Ildong Pharm, Co., Korea) was admitted to the burn site for 30 days. $Medifoam^{(R)}$ made healing rate of the wound faster because the inner layer did not adhered to the wound, and newly formed tissue was protected. The second layer, hydrophilic absorptive layer absorbed excessive fluid and kept the wound surface moist. After 65 days after thermal burn, the wound was healed completely.

Detection of Ehrlichia chaffeensis pathogen from deer in Korea

  • Lee, Mi-Jin;Li, Ying-Hua;Yu, Do-Hyeon;Lee, Jong-Hyun;Yoon, Ji-Seon;Song, Hee-Jong;Chae, Joon-Seok;Park, Jin-Ho
    • Korean Journal of Veterinary Service
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    • v.31 no.2
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    • pp.187-193
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    • 2008
  • Ehrlichia chaffeensis infects human and animals, and causes human monocytotropic ehrlichiosis (HME). It is emerging as a tick-borne zoonosis of concern. Although deer are important natural reservoir hosts of E chaffeensis, few surveys of deer in Korea for E chaffeensis have been conducted. Therefore, we conducted this study to confirm the occurrence of E chaffeensis in deer. To accomplish this study, we collected blood from total 27 deer and then polymerase chain reaction (PCR) and 16S rRNA sequence analyse to evaluate the samples for the presence of E chaffeensis. The results of this study indicated that 9 (33%) of the deer were infected with E chaffeensis. This is the first study to demonstrate that deer in Korea are infected with E chaffeensis, which indicates that they can act as a natural reservoir host for E chaffeensis.

Influence of Consciousness of Biomedical Ethics on Nursing Professionalism of Nursing Students (간호대학생의 생명의료윤리의식이 간호전문직관에 미치는 영향에 관한 연구)

  • Yun, Mi Jin
    • The Journal of the Convergence on Culture Technology
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    • v.7 no.4
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    • pp.105-112
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    • 2021
  • The purpose of this study was to investigate the influence of Consciousness of biomedical ethics on nursing professionalism among nursing students. Data were collected among 192 nursing students in G city, from May 20 to 27, 2021. The collected data was analyzed a using t-test, One way ANOVA, Pearson's correation coeffcient and Stepwise multiple regression using SPSS 20.0 WIN program. The average score for Consciousness of biomedical ethics was 3.28±0.41 and nursing professionalism was 3.32±0.85. nursing professionalism showed a positve correlation(r=.55, p=.000) with Consciousness of biomedical ethics, Models including the variables, Organ transplant, Euthanasia, explained 37%, 16.5% of the variance in the nursing professionalism. Based on the outcome of this study, steps should be taken to design intervention program that emphasize a improve nursing professionalism for nursing students.

Factors Influencing Infection Control Performance by Children's Hospital Nurses Infection Control Organizational Culture and Infection Prevention Environment (아동병원 간호사의 감염관리조직문화, 감염예방환경이 감염관리 수행에 미치는 영향)

  • Hyun-Mi Yang
    • Journal of the Korean Society of Industry Convergence
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    • v.27 no.3
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    • pp.675-684
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    • 2024
  • The purpose of the study is to determine the relationship between the infection control organizational culture, infection prevention environment, and infection control performance of nurses at a children's hospital and to identify factors affecting infection control performance. The subjects of the study were 160 nurses from five children's hospitals, and data collection was conducted from February 19 to 29, 2024. Data analysis was performed using frequency, percentage, mean, standard deviation, and difference analysis of variables using t-test, ANOVA, Pearson's correlation analysis, and multiple regression analysis. As a result of the study, infection control performance was positively correlated with infection control organizational culture (r= .610, p< .001) and infection prevention environment (r= .586, p< .001), and as a result of multiple regression analysis, infection control organization The influencing factors appeared in the following order: culture (β= .369), infection prevention environment (β= .312), medical institution accreditation evaluation experience (β= .165), and infection control education experience (β= .137), and the overall explanatory power was It was 50.8% (F=41.966, p< .001). Based on the results of this study, to carry out infection control in children's hospitals, integrated management including the will and effort of individual nurses, support and policy from medical institutions and the government is needed, and the development of an infection control education program that takes into account the special characteristics of children's hospital nurses. Application is necessary.

A Priority Evaluation Methodology for Spin-off of Defense Technology : Patent Analysis and AHP Approach (국방 기술의 민수화 우선순위 평가 방법론 : 특허 분석 및 계층분석과정 (AHP) 기반)

  • Park, Yun-Mi;Seol, Hyeon-Ju
    • Journal of the military operations research society of Korea
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    • v.36 no.3
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    • pp.15-27
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    • 2010
  • Dual-use technology, upon its effective development, can be a highly efficient technology that may be utilized for both achieving industry competitiveness and building National Security. Although research needs for such development methodology and call for corresponding efforts have long been proposed, actual outputs have not reached its desired level. Hence, this paper aims to provide more concrete and quantitative process in technology planning used to activate development of dual-use technology, considering dual usability and transferability of such technologies. In such effort, we propose use of patent analysis and the Analytic Hierarchy Process (AHP) for determining priorities for spin-off defense technology. First, the necessity of R&D and potential spin-off are measured based on patent information. Second, the necessity of R&D results from a quantitative analysis and the potentials spin-off are derived from analysis of patent citations. Then, AHP is used to calculate the importance of evaluating factors, and to assess alternative scores. Finally, we present the result of spin-off priority. A case study on the Korea defense technology is presented to illustrate the proposed method. We expect this study to make contribution in vision making of the military R&D spending.

Healthcare Service Consumers' Perception of Patient Safety (환자안전에 대한 의료서비스 소비자의 인식 조사)

  • Kim, Jeong Eun;Lee, Nam Ju;Jang, Seon Mi;Kim, Young Mee
    • Perspectives in Nursing Science
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    • v.10 no.2
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    • pp.133-140
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    • 2013
  • Purpose: This study aimed to investigate the perspective of consumers in healthcare services regarding patient safety. Methods: The study was a descriptive study using a self-reported questionnaire. The questionnaire was based on the Senior Empowerment and Advocacy in Patient Safety (SEAPS) questionnaire, which was designed to assess patient safety health beliefs. The survey was conducted online and a convenient sample of 302 adults participated in total. The reliability of the measurement (Cronbach's ${\alpha}$) was 0.758 in attitude (ATT), 0.546 in out-come efficacy (OE), 0.757 in self-efficacy (SE), and 0.703 in behaviors (BEH). Results: The average patient safety awareness score of the healthcare service consumers was 2.72 (ATT), 2.91 (OE), 2.87 (SE), and 2.27 (BEH). Our analysis indicated that there were no differences in ATT, BEH, or SE by gender, age, or education level. However, in OE and the total score of the four subscales, there were significant differences by age and gender. Correlations were identified between BEH and SE (r=0.409, p<.01), BEH and OE (r=0.202, p<.01), ATT and SE (r=0.358, p<.01), and OE and SE (r=0.241, p<.01). Conclusion: This study measured consumer perspectives concerning patient safety. The findings demonstrate the need for developing a measurement tool to assess consumer's perception of patient safety, considering Korean healthcare system and cultural context.

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Maternal Low-protein Diet Alters Ovarian Expression of Folliculogenic and Steroidogenic Genes and Their Regulatory MicroRNAs in Neonatal Piglets

  • Sui, Shiyan;Jia, Yimin;He, Bin;Li, Runsheng;Li, Xian;Cai, Demin;Song, Haogang;Zhang, Rongkui;Zhao, Ruqian
    • Asian-Australasian Journal of Animal Sciences
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    • v.27 no.12
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    • pp.1695-1704
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    • 2014
  • Maternal malnutrition during pregnancy may give rise to female offspring with disrupted ovary functions in adult age. Neonatal ovary development predisposes adult ovary function, yet the effect of maternal nutrition on the neonatal ovary has not been described. Therefore, here we show the impact of maternal protein restriction on the expression of folliculogenic and steroidogenic genes, their regulatory microRNAs and promoter DNA methylation in the ovary of neonatal piglets. Sows were fed either standard-protein (SP, 15% crude protein) or low-protein (LP, 7.5% crude protein) diets throughout gestation. Female piglets born to LP sows showed significantly decreased ovary weight relative to body weight (p<0.05) at birth, which was accompanied with an increased serum estradiol level (p<0.05). The LP piglets demonstrated higher ratio of bcl-2 associated X protein/B cell lymphoma/leukemia-2 mRNA (p<0.01), which was associated with up-regulated mRNA expression of bone morphogenic protein 4 (BMP4) (p<0.05) and proliferating cell nuclear antigen (PCNA) (p<0.05). The steroidogenic gene, cytochrome P450 aromatase (CYP19A1) was significantly down-regulated (p<0.05) in LP piglets. The alterations in ovarian gene expression were associated with a significant down-regulation of follicle-stimulating hormone receptor mRNA expression (p<0.05) in LP piglets. Moreover, three microRNAs, including miR-423-5p targeting both CYP19A1 and PCNA, miR-378 targeting CYP19A1 and miR-210 targeting BMP4, were significantly down-regulated (p<0.05) in the ovary of LP piglets. These results suggest that microRNAs are involved in mediating the effect of maternal protein restriction on ovarian function through regulating the expression of folliculogenic and steroidogenic genes in newborn piglets.

Anterior Lumbar Interbody Fusion with Stand-Alone Interbody Cage in Treatment of Lumbar Intervertebral Foraminal Stenosis : Comparative Study of Two Different Types of Cages

  • Cho, Chul-Bum;Ryu, Kyeong-Sik;Park, Chun-Kun
    • Journal of Korean Neurosurgical Society
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    • v.47 no.5
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    • pp.352-357
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    • 2010
  • Objective : This retrospective study was performed to evaluate the clinical and radiological results of anterior lumbar interbody fusion (ALIF) using two different stand-alone cages in the treatment of lumbar intervertebral foraminal stenosis (IFS). Methods : A total of 28 patients who underwent ALIF at L5-S1 using stand-alone cage were studied [Stabilis$^{(R)}$ (Stryker, Kalamazoo, MI, USA); 13, SynFix-LR$^{(R)}$ (Synthes Bettlach, Switzerland); 15]. Mean follow-up period was 27.3 ${\pm}$ 4.9 months. Visual analogue pain scale (VAS) and Oswestry disability index (ODI) were assessed. Radiologically, the change of disc height, intervertebral foraminal (IVF) height and width at the operated segment were measured, and fusion status was defined. Results : Final mean VAS (back and leg) and ODI scores were significantly decreased from preoperative values (5.6 ${\pm}$ 2.3 ${\rightarrow}$ 2.3 ${\pm}$ 2.2, 6.3 ${\pm}$ 3.2 ${\rightarrow}$1.6 ${\pm}$ 1.6, and 53.7 ${\pm}$ 18.6 ${\rightarrow}$ 28.3 ${\pm}$ 13.1, respectively), which were not different between the two devices groups. In Stabilis$^{(R)}$ group, postoperative immediately increased disc and IVF heights (10.09 ${\pm}$ 4.15 mm ${\rightarrow}$ 14.99 ${\pm}$ 1.73 mm, 13.00 ${\pm}$ 2.44 mm ${\rightarrow}$ 16.28 ${\pm}$ 2.23 mm, respectively) were gradually decreased, and finally returned to preoperative value (11.29 ${\pm}$ 1.67 mm, 13.59 ${\pm}$ 2.01 mm, respectively). In SynFix-LR$^{(R)}$ group, immediately increased disc and IVF heights (9.60 ${\pm}$ 2.82 mm ${\rightarrow}$ 15.61 ${\pm}$ 0.62 mm, 14.01 ${\pm}$ 2.53 mm ${\rightarrow}$ 21.27 ${\pm}$ 1.93 mm, respectively) were maintained until the last follow up (13.72 ${\pm}$ 1.21 mm, 17.87 ${\pm}$ 2.02 mm, respectively). The changes of IVF width of each group was minimal pre- and postoperatively. Solid arthrodesis was observed in 11 patients in Stabilis group (11/13, 84.6%) and 13 in SynFix-LR$^{(R)}$ group (13/15, 86.7%). Conclusion : ALIF using stand-alone cage could assure good clinical results in the treatment of symptomatic lumbar IFS in the mid-term follow up. A degree of subsidence at the operated segment was different depending on the device type, which was higher in Stabilis$^{(R)}$ group.

Factors Influencing the Retention intention of Home visiting nurses with Long-term care insurance system in Korea: Focusing on Professionalism, Job satisfaction and Resilience (노인장기요양보험 방문간호사의 재직의도에 영향을 미치는 요인 : 전문직업성, 직무만족도, 회복탄력성을 중심으로)

  • Yoo, Jae Soon;Kim, Je Hyun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.20 no.12
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    • pp.322-332
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    • 2019
  • This is a descriptive research study that aims to identify the effects of professionalism, job satisfaction, and resilience on the retention intention of home visiting nurses from the long-term care insurance system of Korea. Data were collected from self-administered surveys completed by 141 home visiting nurses of registered visiting-nursing institutions in the long-term care insurance database (April 1-May 31, 2019). Analyses were independent t-tests, one-way analysis of variance (ANOVA), the Scheffé test, Pearson's correlation analysis using SPSS/WIN 22.0, and multiple hierarchical regression analyses. Results showed that the mean professionalism score was 3.51/5, 3.27/5 for job satisfaction, 3.79/5 for resilience, and 4.04/5 for retention intention. A positive correlation existed between retention intention and professionalism (r = .272), job satisfaction (r = .201), and resilience (r = .530). The final regression model showed that resilience (β = .455, p < .001) and job satisfaction (β = .175, p = .016) significantly affect retention intention. The variables' model explanation power was 32.0% (F = 11.968, p < .001). The results show the need for strategies to improve resilience, followed by strategies to improve job satisfaction to increase the retention intentions of these home visiting nurses.