• Proceedings of the Korean Society of Applied Pharmacology
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• 1998.11a
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• pp.137-137
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• 1998

Stability, efficacy, absorption and toxicity of a new nasal spray formulation including salmon calcitonin were studied in the laboratory animals. After the effects of many excipients on the stability of salmon calcitonin were evaluated using HPLC system, we selected taurine. Our experimental composition of salmon calcitonin contains taurine as a stabilizer and HPMC (hydroxypropylmethyl cellulose) as an adhesive polymer. After intranasal administration of salmon calcitonin formulations, Mia$\^$(R)/, Men$\^$(R)/ and experimental composition, 22 IU to rats, the reduction percentages of calcium concentration in plasma (ΔD%) were 16.3%, 12.9% and 20.8%, respectively. After intranasal administration of Mia$\^$(R)/, Men$\^$(R)/ and experimental composition to rats, C$\sub$MAX/ (205${\pm}$161, 244${\pm}$117, and 330${\pm}$202 pg/$m\ell$, respectively) and AUC (41585${\pm}$22070, 41191${\pm}$19125, and 63357${\pm}$43126 pg. min/$m\ell$, respectively) were calculated. The permeation coefficients 10$\^$-7/,cm/sec) of salmon calcitonin in Mia$\^$(R)/, Men$\^$(R)/ and experimental composition using Ussing chamber with rabbit nasal mucosa were 4.7${\pm}$1.5, 0.75${\pm}$0.4 and 5.3${\pm}$1.1, respectively. The experimental composition with taurine and HPMC was proved to be excellent because it improved the stability of salmon calcitonin and inhanced the absorption of salmon calcitonin and was not irritative to the nasal mucosa.

• Proceedings of the Korea Contents Association Conference
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• 2012.05a
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• pp.345-346
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• 2012

본 연구는 치과진료실의 실내 공기질에 영향을 미치는 요인과 종사자의 실내자각증상과 관련성을 조사하여 치과위생사 개인의 발전과 건강 증진에 필요한 기초자료를 마련하고자 본 연구를 시행하였다. 전국(서울, 경기, 대구, 포항)의 종합병원, 치과병원, 치과의원의 치과위생사 210명을 대상으로 2011년 10월 1일부터 20일까지 자기기입식 설문지 조사를 시행한 후 회수하여 응답이 불분명한 5명을 제외한 205명에 대해서 분석 하였다. 수집된 자료는 SPSS WIN 15.0 프로그램을 이용하여 분석하였다. 그 결과 근무 중 휴식시간 유무별로는 근무 중 휴식시간이 없는 치과위생사가 67.3%로 높은 분포를 보였고, 건물 밖 외출 여부별로는 때때로가 54.6%로 절반 이상을 차지하였으며, 건물 밖 외출횟수별로는 1회 86.1%로 대부분을 차지하였으며, 근무기관의 계절별 자연환기 정도별로는 봄, 여름, 가을, 겨울 모두 1일 2회 이내가 절반 이상을 차지하였으며, 다음으로 1일 4회 이내 19.0%, 기타 9.8%, 1일 10회 이내와 하루 종일 2.4% 순이었다. 실내자각증상 호소율에 대해 살펴본 결과는 4점 만점 중 전체 평균이 2.45로 나타났다. 먼저 영역별로는 평균이 '목증상'과 '눈증상'이 각각 2.54로 가장 높았으며, 문항 중에는 평균이 '눈이 잘 피로해진다'가 3.00으로 가장 높게 나타났다. 근무환경 특성에 따른 실내자각증상은 야간진료 여부별로는 야간진료를 하는 치과위생사가 그렇지 않은 치과위생사보다 실내자각증상이 낮았으며, 야간진료 여부에 따라 유의한 차이를 보였다(t=2.07, p<.05). 실내자각증상과 직무스트레스의 관계는 물리환경(r=.259, p<.001)과 직무요구(r=.311, p<.001), 관계갈등(r=.172, p<.05), 조직체계(r=.158, p<.05), 보상 부적절(r=.197, p<.01), 그리고 직무스트레스(r=.275, p<.001)와 통계적으로 유의한 상관관계를 보였다.

• Journal of Chest Surgery
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• v.54 no.3
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• pp.200-205
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• 2021

Background: Various methods have been used to reduce postoperative pain after thoracic surgery. However, these methods may affect the patient's respiratory response and delay recovery from anesthesia. We aimed to evaluate the effects of fentanyl and remifentanil during extubation after video-assisted thoracic surgery (VATS). Methods: This study included 45 randomly-selected male patients who underwent VATS for pneumothorax between July 2011 and August 2012. We divided the participants into 3 groups: the F group, which received a bolus injection of 1.0 ㎍/kg of fentanyl; the R1 group, which received a 0.04 ㎍/kg/min remifentanil infusion; and the R2 group, which received a 0.08 ㎍/kg/min remifentanil infusion. Hemodynamics, pain, cough, consciousness level, and nausea were assessed for each group. Results: The number and severity of coughs were lower in the R1 and R2 groups than in the F group, and there were no differences between the R1 and R2 groups. Respiratory depression and loss of consciousness were not observed in any of the patients, and there were no differences in hemodynamics. Conclusion: In comparison with fentanyl, remifentanil did not result in a wide fluctuation of blood pressure and heart rate upon emergence from general anesthesia. Moreover, remifentanil contributed to cough suppression and postoperative pain control. Remifentanil seems to be a safe and effective analgesic after VATS.

• Journal of Korean Clinical Nursing Research
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• v.22 no.2
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• pp.205-216
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• 2016

Purpose: This study was performed to develop a valid and reliable Korean Patient Classification System for Neonatal care nurses (KPCSN). Methods: The study was conducted in tertiary and general hospitals with 1~2 grade according to nursing fee differentiation policy for NICU (neonatal intensive care unit) nurse staffing. The reliability was evaluated for the classification of 218 patients by 10 nurse managers and 56 staff nurses working in NICUs from 10 hospitals. To verify construct validity, 208 patients were classified and compared for the type of stay, gestational age, birth weight, and current body weight. Nursing time was measured by nurses, nurse managers, and nurse aids. For the calculation of conversion index (total nursing time divided by the KPCSN score), 426 patients were classified using the KPCSN. Data were collected from September 5 to October 28, 2015, and analyzed using t-test, ANOVA, intraclass correlation coefficient, and non-hierarchial cluster analysis. Results: The final KPCSN consisted of 11 nursing categories, 71 nursing activities and 111 criteria. The reliability of the KPCSN was r=.83 (p<.001). The construct validity was established. The KPCSN score was classified into four groups; group $1:{\leq}57points$, group 2: 58~80 points, group 3: 81~108 points, and group $4:{\geq}109points$ in the KPSCN score. The conversion index was calculated as 7.45 minutes/classification score. Conclusion: The KPCSN can be utilized to measure specific and complex nursing demands for infants receiving care in the NICUs.

• Journal of Korean society of Dental Hygiene
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• v.15 no.2
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• pp.205-216
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• 2015

Objectives: The purpose of the study is to investigate the psychological state of the patients according to skeletal class III malocclusion symptoms. Methods: The subjects were 200 skeletal class III malocclusion patients. The questionnaire consisted of general characteristics, clinical manifestation, and T score of Korean version of self-rated Symptom Checklist-90-Revision modified by Jae-hwan Kim. The data were analyzed using SAS version 9.2 and t-test, ANOVA, and ANCOVA were used. Clinical manifestation included subjective recognition and radiological analysis. The subjective recognition of the patients consisted of self-satisfaction of the appearance, phonation, mastication, and temporomandibular joint pain. T score consisted of somatization, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation, and psychoticism. Results: The most serious factor in 9 scales was the severe TMJ pain by ANCOVA. Male patients had a higher T score in phobic anxiety, psyochoticism, somatization and depression than female patients. Those having low appearance satisfaction had the problem in interpersonal sensitivity. Obsessive-compulsive symptoms were conspicuous in phonation difficulty and temporomandibular pain. Conclusions: The patients with skeletal class III malocclusion have more satisfaction with appearance, pronunciation, and phonation than those with skeletal class III malocclusion and overjet. Proper dental treatment will improve the communication and quality of life.

• Journal of dental hygiene science
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• v.15 no.6
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• pp.825-835
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• 2015

The purpose of this study was to examine the relationships between depression, stress, self-esteem, oral health-related quality of life (OHIP-14) in middle-aged women. Data were as collected by self-reported questionnaires from 205 middle-age women. The instruments were the Center for Epidemiologic Studies Depression scale (CES-D), Brief Encounter Psychosocial Instrument (BEPSI), Self-Esteem Scale (SES). The data were analyzed using t-test, one-way ANOVA, Pearson correlation coefficients and multiple regression with IBM SPSS Statistics ver. 21.0. Pearson correlation coefficient analysis found that oral health impact profile (OHIP) was significantly associated with depression (r=-0.560, p<0.001), stress (r=-0.595, p<0.001), self-esteem (r=0.522, p<0.001). The OHIP was explained 39.4% by stress (${\beta}$=-0.362, p<0.001), self-esteem (${\beta}$=0.203, p=0.009) using multiple regression analysis. These results indicate that the intervention program of oral health promotion for community-middle- aged women is needed from now on.

• Child Health Nursing Research
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• v.16 no.4
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• pp.259-267
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• 2010

Purpose: This study was conducted to identify late school-aged children‘s knowledge, and practical will in the practice of cancer prevention lifestyle, and to examine the relations between these variables and factors that influence practice. Methods: The participants included 525 fifth and sixth grade students from 8 elementary schools in J and S cities. Data were collected in December 2008 using self-report questionnaires developed by the authors and were analyzed using the SPSS program. Results: Mean scores were, for knowledge of cancer prevention lifestyle, $0.76{\pm}0.11$ out of a possible 1, practical will, $4.05{\pm}0.55$ out of a possible 5, and practice, $3.66{\pm}0.41$ also out of 5. There were differences in knowledge (F=4.39, p=.013), practical will (F=18.35, p<.001), and practice (F=29.13, p<.001) according to academic achievement and in practical will (F=3.68, p<.001) and practice (F=3.01, p=.003) according to grade. There were positive correlations between knowledge and practical will (r=.205, p<.001), knowledge and practice (r=.181, p<.001), practical will and practice (r=.628, p<.001). Practice will and knowledge of cancer prevention lifestyle showed a significant influence on practice. Conclusion: Results of this study indicate that effective strategies should be developed to motivate the practical will for the practice of cancer prevention lifestyle during childhood.

• Animal cells and systems
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• v.7 no.3
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• pp.197-205
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• 2003

White snakeroot (Ageratina altissima (L.) R. King & H. Robinson) as an invasive alien plant appeared more abundantly at lower elevations where frequent artificial interferences prevailed than at higher elevations where such impacts were less. They appeared abundantly in introduced forests such as black locust plantation but they did not appear or were rare in natural forests such as oak forest. But an exceptional phenomenon where white snakeroot did not appear was found in a Korean pine stand with dense cover afforested recently. Appearance status of white snakeroot in each section of trampling path depended on breadth of the path and relative light intensity. Growth of white snakeroot measured as the number of ramet per genet, height, and biomass was better near the trampling path and was reduced toward the forest interior. The growth was proportionate to the relative light intensity measured according to distance from the trampling path. Such results support the fact generally known in relation invasion and expansion of the invasive alien plants. From this viewpoint, we suggest a management plan that applies ecological restoration principles to address ecosystems infected with white snakeroot by restoring the integral feature of the degraded nature and more thoroughly conserving the remaining nature.

• The Journal of the Korea Contents Association
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• v.10 no.12
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• pp.205-215
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• 2010

The purposed of this study was to examine the relation between dental hygienists' treatment posture and body pain by surveying 120 dental hygienists working at dental hospitals and clinics in Busan and to suggest desirable treatment postures and pain prevention methods for dental hygienists' health and job performance. Data obtained from the questionnaire survey were analyzed using SPSS 18.0 for Windows. The taller the hygienists were the less pains they had in their 'back' and 'hips' (p<0.05). The shorter the hygienists were the more pains they had in their 'back,' 'waist,' 'hips,' 'legs' and 'ankles/feet'(p<0.05). There was no difference in pains in each body part according to weight. In the results of analyzing correlations among pains in different body parts, a very strong positive correlation was observed between the pains in the 'knees' and 'legs' (r=0.71)(p<0.01). The hygienists of 56.7% had experience in education on treatment posture, and 62.5% were not doing exercise regularly. To the question on what should be done for health welfare in their workplace, the hygienists of 47.9% mentioned improvement in the environment of the workplace.

• The Journal of Korean Academic Society of Nursing Education
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• v.7 no.1
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• pp.7-21
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• 2001

The purpose of this study was identify the level of stress, anger and anger expression in the clinical setting and identify the relation ships between anger and stress of nursing students in the clinical setting. A convenient sample of 213 junior college of nursing students was used for the study. The data were analyzed by descriptive statistics and Pearson Correlation Coefficients. The results of this study were summarized as follows : 1. The average stress score in the clinical setting of subjects was 3.87. The higher level of stress in the clinical setting was 4.10 in domain of nurses, 4.10 in domain of human relationships, 4.07 in domain of report and 3.89 in domain of relationship between nursing theory and practice. 2. The average state-anger score of subjects was 1.54. 3. The average anger-out score of anger expression mode was 1.66 and 2.36 in anger-in. 4. The state-anger was found significantly related to stress of nursing students in the clinical setting (r=0.256 p<0.001). In the relationship between state- anger and stress in the clinical setting, environment, patient relationship, between nursing theory and practice, nurses, report, orientation were significantly positive correlation . 5. The anger-out of anger expression mode was not found significantly related to stress of nursing students in the clinical setting. 6. The anger-in of anger expression mode was found significantly related to stress of nursing students in the clinical setting (r=0.205 p<0.01). In the relationship between anger-in of anger expression mode and stress in the clinical setting, environment, patient, nurses, human relationships, conference were significantly positive correlation.